Hilton Santa Fe Historic Plaza Hotel Floorplan

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This meeting took place in 2012



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Protein-RNA Interactions in Biology and Disease (C1)


Organizer(s) Thomas Tuschl, Mikiko C. Siomi and Gideon Dreyfuss
March 4—9, 2012
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, New Mexico USA
Abstract Deadline: Nov 2, 2011
Late Abstract Deadline: Dec 8, 2011
Scholarship Deadline: Nov 2, 2011
Early Registration Deadline: Jan 5, 2012

Supported by the Directors’ Fund

Summary of Meeting:
Cellular functions depend on numerous protein-coding and noncoding RNAs and the RNA-binding proteins (RBPs) associated with them, which form ribonucleoprotein complexes (RNPs). Mutations that disrupt either the RNA or protein components of RNPs or the factors required for their assembly can be deleterious. The discovery of disease-causing mutations in RNAs or their interacting RBPs not only adds to our growing understanding of RNA biology and chemistry, but also offers new therapeutic targets and contributes to ongoing efforts in developing mRNA-targeting antisense and RNAi therapeutics. This meeting focuses on a general understanding of post-transcriptional gene regulation and how perturbation of complex networks of RNA-protein and RNA-RNP interactions triggers disease.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 4

15:00—19:30
Registration

Promenade
18:15—19:15
Refreshments

Promenade
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Gideon Dreyfuss, HHMI/University of Pennsylvania School of Medicine, USA

Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Switzerland
Mechanism and Regulation of microRNA Repression in Mammalian Cells


MONDAY, MARCH 5

07:00—08:00
Breakfast

Chamisa/Ortiz
08:00—11:15
Genetic Diseases Caused by Alterations of RBP or RNA Sequence: Part 1
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Reinhard Lührmann, Max Planck Institute for Biophysical Chemistry, Germany

Tom Maniatis, Columbia University, USA
The Role of RNA-Binding Proteins in ALS

Francisco E. Baralle, International Center for Genetic Engineering, Italy
New Apects of TDP 43 Self-Regulation Mechanisms and their Connection with Neurological Disease

Maurice S. Swanson, University of Florida, USA
RNA Toxicity in Microsatellite Expansion Disease

Nancy M. Bonini, University of Pennsylvania, USA
RNA Pathways and their Impact on Brain Degeneration: Insight from Drosophila

Susan L. Ackerman, University of California, San Diego, USA
Short Talk: Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration

Cara L. Lunn, Washington University School of Medicine, USA
Short Talk: U2AF1 Mutations in Myelodysplastic Syndromes

09:20—09:40
Coffee Break

Promenade
11:15—13:00
Poster Setup

Mesa C
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Mesa C
16:30—17:00
Coffee Available

Promenade
17:00—19:15
Genetic Diseases Caused by Alterations of RBP or RNA Sequence: Part 2
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Thomas R. Cech, HHMI/University of Colorado, USA

Randi J. Hagerman, University of California, Davis Health System, USA
Fragile X Syndrome and FXTAS

Miguel Angel Moreno-Pelayo, Hospital Ramón y Cajal, Spain
miR-96 and Hereditary Hearing Loss: First Example of Point Mutations in the Mature Sequence of a miRNA with an Ethiopathogenetic Role in a Human Mendelian Disease

Gideon Dreyfuss, HHMI/University of Pennsylvania School of Medicine, USA
Function and Mechanism of the SMN Complex: Insights into snRNP Biogenesis, mRNA Regulation and SMA Pathogenesis

Shuo-Chien Ling, University of California, San Diego, USA
Short Talk: Progressive Lower Motor Neuron Defects in Mice Expressing Wild Type or ALS-Linked Mutants of FUS/TLS

J. Paul Taylor, St. Jude Children's Research Hospital, USA
Short Talk: Mutations in Prion-Like Domains Found in hnRNPA2B1 and hnRNPA1 Cause Multisystem Proteinopathy

19:15—20:15
Social Hour with Lite Bites

Chamisa/Ortiz
19:30—22:00
Poster Session 1

Mesa C

TUESDAY, MARCH 6

07:00—08:00
Breakfast

Chamisa/Ortiz
08:00—11:15
Defining the Elements and Interactions of Post-Transcriptional Networks
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* James L. Manley, Columbia University, USA

Chris B. Burge, Massachusetts Institute of Technology, USA
Regulation of Splicing and Localization of mRNAs by Muscleblind Proteins

Thomas Tuschl, HHMI/Rockefeller University, USA
Defining Post-Transcriptional Regulatory Networks

Falk Butter, Max Planck Institute for Biochemistry, Germany
Mass Spectrometry for Complete Proteome Identification and Post-Transcriptional Regulation

Stephanie C. Huelga, University of California, San Diego, USA
Short Talk: Integrative Genome-Wide Analysis Reveals Cooperative Regulation of Alternative Splicing by hnRNP Proteins

Andreas R. Gruber, University of Basel, Switzerland
Short Talk: Global Maps of Pre-mRNA 3’ End Processing Factor Binding and Polyadenylation Sites

09:20—09:40
Coffee Break

Promenade
11:15—13:00
Poster Setup

Mesa C
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Mesa C
16:30—17:00
Coffee Available

Promenade
17:00—19:00
RNAi Mechanism and miRNAs
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Elena Conti, Max Planck Institute of Biochemistry, Germany

Mikiko C. Siomi, University of Tokyo, Japan
Biogenesis of PIWI-Interacting Small RNAs in Drosophila

V. Narry Kim, Seoul National University, South Korea
Regulation of MicroRNA via Monouridylation of Pre-miRNA

Bryan R. Cullen, Duke University Medical Center, USA
Viruses and microRNAs

Doron Betel, Weill Cornell Medical College, USA
Short Talk: Genome Wide Identification of miRNA Target Sites by CLIP-Based Methods

19:00—20:00
Social Hour with Lite Bites

Chamisa/Ortiz
19:30—22:00
Poster Session 2

Mesa C

WEDNESDAY, MARCH 7

07:00—08:00
Breakfast

Chamisa/Ortiz
08:00—11:15
RNPs and RNA Processing: Part 1
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* V. Narry Kim, Seoul National University, South Korea

Alberto R. Kornblihtt, Universidad de Buenos Aires, Argentina
Chromatin, Epigenetics and Alternative Splicing

James L. Manley, Columbia University, USA
Processing of mRNA Precursors and Links to Human Disease

Joan A. Steitz, HHMI, Yale University, USA
Probing Viral Noncoding RNAs to Illuminate Novel microRNA Processing Pathways, Mechanisms of RNA Stability and microRNA Function

Thomas R. Cech, HHMI/University of Colorado, USA
Two Noncoding RNPs, Telomerase and FUS/TLS

Ashley T. Neff, Colorado State University, USA
Short Talk: Global Analysis Reveals Pathways of Unique Regulation of mRNA Decay in Human Induced Pluripotent Stem Cells

Mauro Costa-Mattioli, Baylor College of Medicine, USA
Short Talk: Suppression of PKR Promotes Network Hypersynchrony and Enhanced Cognition by Interferon-gamma Mediated Disinhibition

09:20—09:40
Coffee Break

Promenade
11:15—13:00
Poster Setup

Mesa C
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Mesa C
16:30—17:00
Coffee Available

Promenade
17:00—19:00
RNPs and RNA Processing: Part 2
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Nancy M. Bonini, University of Pennsylvania, USA

Nahum Sonenberg, McGill University, Canada
Cap-Binding Proteins and their Role in Translation Initiation

Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

Benjamin J. Blencowe, University of Toronto, Canada
Systematic Analysis of the Function and Regulation of Alternative Exon Networks

Ram Kannan, Stowers Institute For Medical Research, USA
Short Talk: Telomerase RNA Biogenesis: Splicing versus Spliceosomal Cleavage

19:00—20:00
Social Hour with Lite Bites

Chamisa/Ortiz
19:30—22:00
Poster Session 3

Mesa C

THURSDAY, MARCH 8

07:00—08:00
Breakfast

Chamisa/Ortiz
08:00—11:00
RNA Localization and Transport
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Maurice S. Swanson, University of Florida, USA

Robert H. Singer, Albert Einstein College of Medicine, USA
Imaging the Life Cycle of a Single mRNA Molecule

Anne Ephrussi, European Molecular Biology Laboratory, Germany
Nuclear Events Critical for Oskar mRNA Transport in the Oocyte

David S. Booth, University of California San Francisco, USA
Short Talk: Reconstitution of the HIV1 Nuclear Export Particle

Thomas Gonatopoulos-Pournatzis, University of Dundee, UK
Short Talk: RAM: A Novel and Essential Component of the Human mRNA Cap Methyltransferase

Takeshi Chujo, Hokkaido University, Japan
Short Talk: Molecular Mechanism to Regulate mRNA Metabolism in Human Mitochondria

Pooja M. Desai, Emory University School of Medicine, USA
Short Talk: Molecular Mechanisms of Substrate Recognition by m1A1408 Aminoglycoside-Resistance rRNA Methyltranserases

09:20—09:40
Coffee Break

Promenade
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Promenade
17:00—19:00
Structural Biology of RBPs and RNPs
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Joan A. Steitz, HHMI, Yale University, USA

Kiyoshi Nagai, Medical Research Council, UK
Structural Studies of the Spliceosomal snRNPs

Reinhard Lührmann, Max Planck Institute for Biophysical Chemistry, Germany
Structure and Mechanism of the Spliceosome

Elena Conti, Max Planck Institute of Biochemistry, Germany
Structural Insights into the Functions of the Exon-Junction Complex

20:00—21:00
Social Hour with Lite Bites

Mesa Ballroom
20:00—23:00
Entertainment

Mesa Ballroom

FRIDAY, MARCH 9

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS076178-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Integrated DNA Technologies

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

EMBO (European Molecular Biology Organization)

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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