Fairmont Chateau Whistler Floorplan

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This meeting took place in 2012



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Nuclear Receptor Matrix: Reloaded (D3)


Organizer(s) Ronald M. Evans and David J. Mangelsdorf
April 15—20, 2012
Fairmont Chateau Whistler • Whistler, British Columbia Canada
Abstract Deadline: Dec 15, 2011
Late Abstract Deadline: Jan 18, 2012
Scholarship Deadline: Dec 15, 2011
Early Registration Deadline: Feb 15, 2012

Supported by the Directors’ Fund

Summary of Meeting:
Nuclear receptors (NRs) represent a large superfamily of transcription factors that function as ligand-dependent sensors for a diverse set of fat-soluble hormones, vitamins and dietary lipids. Together, NRs govern expression of genes involved in a broad range of reproductive, developmental, metabolic and immune response programs. For this reason, NRs have been investigated for over 20 years as promising targets for drugs to treat a multitude of therapeutic indices, including cancer, diabetes, obesity, cardiovascular disease, hypertension, inflammation and cholestasis. However, despite the success of numerous NR-based therapies, there remain significant hurdles exploiting NRs to develop newer classes of therapies that achieve targeted benefits with reduced side effects. Thus, understanding the mechanisms, transcriptional targets and networks of physiologic pathways that govern NR action has become an important new strategy for evaluating the role of NRs in health and disease. This “reloaded” effort is now beginning to produce exciting new avenues of research in the field. This meeting will bring together a key group of junior and senior investigators that are exploring these new directions and provide participants with a matrix of unique possibilities for them to investigate in both academic and pharmaceutical laboratory settings.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, APRIL 15

15:00—19:30
Registration

Macdonald Foyer
18:15—19:15
Refreshments

Macdonald Foyer
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Macdonald DEF
Lewis C. Cantley, Weill Cornell Medicine, USA
PI3K and Nutrient Homeostasis in Physiology and Disease


MONDAY, APRIL 16

07:00—08:00
Breakfast

Macdonald ABC
07:30—08:00
Poster Setup

Macdonald ABC
08:00—11:00
NRs and Control of Nutrient Metabolism
Meeting has ended...abstracts no longer viewable online.

Macdonald DEF
* Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
PPARs and FGF21: From Feast to Famine

Adriana Maggi, University of Milan, Italy
ER and Nutrient Sensing

Pere Puigserver, Dana-Farber Cancer Institute, Harvard Medical School, USA
PGC1 and Energy Homeostasis

Kristina Schoonjans, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
Bile Acid Signaling: Connecting Nutrition to Metabolism

Lillian J. Eichner, The Salk Institute, USA
Short Talk: ERRalpha in ERBB2-Driven Mammary Tumorigenesis: In vivo Functions in Oncogenesis of a Metabolic Nuclear Receptor

08:00—17:00
Poster Viewing

Macdonald ABC
09:20—09:40
Coffee Break

Macdonald Foyer
11:00—12:00
Lunch

Macdonald ABC
12:00—15:00
Poster Session 1

Macdonald ABC
15:00—16:30
Workshop 1: Hot Topics

Macdonald DEF
* Anastasia Kralli, Johns Hopkins Medical School, USA
Identification of a Novel Regulatory Pathway for Energy Expenditure in Brown Adipose Tissue

Angie L. Bookout, University of Texas Southwestern Medical Center, USA
FGF21 Alters Metabolism and Diurnal Behavior via the Nervous System

Kevin J. Phillips, Methodist Hospital Research Institute, USA
The Thyroid Hormone Analogue GC-1 Ameliorates Metabolic Syndrome by Rescuing Defects in Adaptive Thermogenesis

Shingo Kajimura, University of California, San Francisco, USA
PPAR-gamma Ligands Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

Thomas Q. de Aguiar Vallim, University of California, Los Angeles, USA
MicroRNA-Mediated Control of Plasma HDL Cholesterol by the Nuclear Receptor FXR

Liming Pei, Children's Hospital of Philadelphia/University of Pennsylvania, USA
Thyroid Hormone Receptor Repression is Linked to Type I Pneumocyte–associated Respiratory Distress Syndrome

16:30—17:00
Coffee Available

Macdonald Foyer
17:00—19:00
Circadian Rhythm and Metabolism
Meeting has ended...abstracts no longer viewable online.

Macdonald DEF
* Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA
Nuclear Receptors and the Clock: Resetting Metabolism

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Regulation of Circadian Rhythm and Metabolism by Rev-erbs and Corepressors

Paolo Sassone-Corsi, University of California, Irvine, USA
Epigenetics, Metabolism and the Circadian Clock

Katja A. Lamia, The Scripps Research Institute, USA
Short Talk: Cryptochromes Rhythmically Repress the Glucocorticoid Receptor

19:00
On Own for Dinner


TUESDAY, APRIL 17

07:00—08:00
Breakfast

Macdonald ABC
08:00—11:15
NRs and Epigenomic Reprogramming
Meeting has ended...abstracts no longer viewable online.

Macdonald DEF
* David D. Moore, Baylor College of Medicine, USA
LRH-1: Stress Redressed

Ray MacDonald, University of Texas Southwestern Medical Center, USA
Lrh1 Control of Pancreatic Development

Debu Chakravarti, Northwestern University, Feinberg School of Medicine, USA
Short Talk: Nuclear Receptors in Reproductive Diseases

Huck-Hui Ng, Genome Institute of Singapore, Singapore
Nuclear Receptors and Stem Cells

Sophia Y. Tsai, Baylor College of Medicine, USA
The Role of COUP-TFII in Tumor Growth and Metastasis in Prostate Cancer

Gilles Buchwalter, Dana-Farber Cancer Institute, USA
Short Talk: PDEF Regulation and Role as a Survival Factor in ER Positive Breast Cancer Cells

09:20—09:40
Coffee Break

Macdonald Foyer
11:15—13:00
Poster Setup

Macdonald ABC
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Macdonald ABC
15:00—16:30
Workshop 2: Hot Topics

Macdonald DEF
* Susanne Mandrup, University of Southern Denmark, Denmark
Cross-Talk between LXR and PPARalpha through Extensive Sharing of Binding Sites in Liver

Christopher D. Byrne, Royal College of Surgeons in Ireland, Ireland
Global Characterization of the SRC-1 Transcriptome Identifies ADAM22 as an ER-Independent Mediator of Endocrine Resistant Breast Cancer

Jordan A. Beard, St. Jude Children's Research Hospital, USA
Targeting Nur77 and Cell Death in Pediatric Solid Tumors

Azusa Fujita, Kobe University Graduate School of Health Sciences, Japan
Mediator Subunits MED1 and MED24 Cooperatively Contribute to Pubertal Mammary Gland Development and Growth of Breast Carcinoma Cells

Yuanzheng (Ajian) He, Van Andel Institute, USA
Identification of a Lysosomal Pathway that Modulates Glucocorticoid Signaling and the Inflammatory Response

Frances M. Sladek, University of California, Riverside, USA
Nuclear Receptor DNA Binding Specificity and Affinity Altering SNPs: A High Throughput Approach

16:30—17:00
Coffee Available

Macdonald Foyer
17:00—19:00
NRs and Cancer
Meeting has ended...abstracts no longer viewable online.

Macdonald DEF
* Donald P. McDonnell, Duke University School of Medicine, USA
NRs as Therapeutic Targets in Cancer: Tried, True and Ready for Retesting

Richard A. Heyman, ORIC Pharmaceuticals, USA
Developing ER Degraders for the Treatment of Hormone Resistant Breast Cancer

Kevin P. White, University of Chicago, USA
A Comprehensive NR Network in Breast Cancer Cells

Dawn R. Cochrane, University of Colorado Denver, USA
Short Talk: MDV3100, an Androgen Receptor Signaling Inhibitor, Abrogates Androgen- and Estrogen-Mediated Tumor Growth of ER+ Breast Cancer Cells

19:00—20:00
Social Hour with Lite Bites

Macdonald ABC
19:30—22:00
Poster Session 2

Macdonald ABC

WEDNESDAY, APRIL 18

07:00—08:00
Breakfast

Macdonald ABC
08:00—11:15
Genomic Mechanism
Meeting has ended...abstracts no longer viewable online.

Macdonald DEF
* John W. R. Schwabe, University of Leicester, UK
Assembly and Regulation of HDAC: Corepressor Complexes

Bruno P. Klaholz, Institut de Génétique et de Biologie Moléculaire et Cellulaire, France
The 3D Architecture of Full DNA-Bound Nuclear Receptors

Fraydoon Rastinejad, Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Intact Nuclear Receptor Complexes Visualized in High Resolution

Yanhong Shi, Beckman Research Institute of City of Hope, USA
The TLX-Wnt Signaling in Neurogenesis and Behavioral Output of the Brain

X. Shirley Liu, Dana-Farber Cancer Institute, Harvard School of Public Health, USA
Predicting Transcription Factor Binding and Drug Response from Chromatin Dynamics

Patrick R. Griffin, The Scripps Research Institute, USA
Short Talk: Chemical Biology of Nuclear Receptors

09:20—09:40
Coffee Break

Macdonald Foyer
11:15—13:00
Poster Setup

Macdonald ABC
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Macdonald ABC
15:00—16:30
Workshop 3: Hot Topics

Macdonald DEF
* Martin L. Privalsky, University of California, Davis, USA
Regulation of Corepressor Function by Alternative mRNA Splicing

Noriaki Shimizu, University of Tokyo, Japan
Crosstalk between Glucocorticoid and Nutrition in Skeletal Muscle Fibers

Ziad Al Tanoury, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), France
Nuclear Retinoic Acid Receptors Phosphorylation and Mouse ES Cell Neuronal Differentiation

Mark B. Meyer, University of Wisconsin, Madison, USA
Blocking Osteogenic Differentiation: A Struggle between VDR and RUNX2 in the Mouse Mesenchymal Stem Cells

Li Wang, University of Connecticut, USA
Epigenetic Regulation of Liver Cancer by Nuclear Receptor SHP

Yukitomo Arao, NIEHS, National Institutes of Health, USA
alphaERKO Male Infertility is Rescued by ERalpha AF-1 Activation

16:30—17:00
Coffee Available

Macdonald Foyer
17:00—19:00
NRs Do the Darnedest Things
Meeting has ended...abstracts no longer viewable online.

Macdonald DEF
* Antonio Moschetta, Clinica Medica Frugoni, University of Bari, Italy
Enterocyte Lifespan, Nuclear Receptors and Co-Regulators

Yihong Wan, University of Texas Southwestern Medical Center, USA
A Bone to Pick with PPARgamma

Douglas Forrest, NIDDK, National Institutes of Health, USA
Thyroid Hormone Receptors and the Development of Sensory Function

Ira G. Schulman, University of Virginia Health System, USA
Short Talk: LXR Agonists Decrease Heart Disease without Stimulating Reverse Cholesterol Transport

19:00—20:00
Social Hour with Lite Bites

Macdonald ABC
19:30—22:00
Poster Session 3

Macdonald ABC

THURSDAY, APRIL 19

07:00—08:00
Breakfast

Macdonald ABC
08:00—11:15
NR Cofactors and Disease
Meeting has ended...abstracts no longer viewable online.

Macdonald DEF
* Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA
AR - Cell Cycle Crosstalk: Axis of Evil in CRPC

W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Identification and Functional Characterization of Estrogen-Regulated Non-Coding RNAs

Inez Rogatsky, Weill Medical College of Cornell University, USA
Short Talk: A Transcriptional Coregulator GRIP1 in Shaping Macrophage Transcriptome and Systemic Inflammation

Bert W. O'Malley, Baylor College of Medicine, USA
NR Coactivators: Surprises Uncovered by in vitro Dissection of the Coregulator Transcriptional ‘Initiation Complex’

Peter Tontonoz, University of California, Los Angeles, USA
Groucho Marks in Fat

Claudia M. van Tiel, Academic Medical Center, Netherlands
Short Talk: Novel Co-Regulators of Nur77 and Enhanced Atherosclerosis upon Bone Marrow-Specific Nur77-Deficiency

09:20—09:40
Coffee Break

Macdonald Foyer
11:15
On Own for Lunch and Recreation

15:00—16:30
Workshop 4: Hot Topics

Macdonald DEF
* Seth Boudreaux, Baylor College of Medicine, USA
An Integrative Approach to Therapeutic Discovery: Targeting NR4A Orphan Nuclear Receptor Reactivation in AML

Carolyn L. Cummins, University of Toronto, Canada
Liver X Receptor Modulates Diabetic Retinopathy Outcome in a Mouse Model of Streptozotocin Induced Diabetes

Eric A. Ortlund, Emory University, USA
Structural Mechanism for Activation of the Orphan Nuclear Receptor LRH-1 by Anti-Diabetic Lipid Agonists

Eva Estebanez-Perpiña, University of Barcelona, Spain
The Ligand Binding Domain of Nuclear Orphan Receptor TLX Recruits the Zinc Finger Oncoprotein BCL11A and Corepressor Atrophin1

Yukimasa Takeda, NIEHS, National Institutes of Health, USA
Retinoic Acid-related Orphan Receptor gamma, RORgamma, Coordinates Circadian Regulation of Energy Homeostasis through Control of Hepatic Lipid Metabolism

Neil J. McKenna, Baylor College of Medicine, USA
Transcriptomine: The Nuclear Receptor Signaling Transcriptome Database

16:30—17:00
Coffee Available

Macdonald Foyer
17:00—19:00
Inflammation
Meeting has ended...abstracts no longer viewable online.

Macdonald DEF
* Christopher K. Glass, University of California, San Diego, USA
Regulation of Neuroinflammation by Nurr1 and ERbeta

Dan R. Littman, HHMI/New York University School of Medicine, USA
RORgamma in Inflammatory Lymphoid Cells

Pierre H. Chambon, Institut de Génétique Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), France
Positive and Negative Control of Transcription by Nuclear Receptors

Thomas P. Burris, Saint Louis University School of Medicine, USA
Short Talk: Regulation of Circadian Behavior and Metabolism by Synthetic REV-ERB Agonists

19:00—20:00
Social Hour with Lite Bites

Macdonald ABC
20:00—23:00
Entertainment

Macdonald ABC

FRIDAY, APRIL 20

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK084688-03

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Aragon Pharmaceuticals, Inc.


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