Sheraton Steamboat Resort Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

This meeting took place in 2012



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Synapses and Circuits: From Formation to Disease (D2)


Organizer(s) Tony Koleske, Hollis T. Cline, Stefan Herlitze and Linda Van Aelst
April 1—6, 2012
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Dec 1, 2011
Late Abstract Deadline: Jan 6, 2012
Scholarship Deadline: Dec 1, 2011
Early Registration Deadline: Feb 1, 2012

Supported by the Directors’ Fund

Summary of Meeting:
A fundamental goal of neuroscience is to understand the molecular, cellular and activity-based mechanisms that control the formation and maintenance of neural circuits and determine how these mechanisms become compromised in neurodevelopmental, psychiatric and neurodegenerative disorders. Over the past two decades, molecular neuroscientists have identified key molecules and mechanisms that underlie synapse development, activity and stability. Meanwhile, the study of neuronal circuits has been revolutionized by new methods to visualize and map circuits in living animals, as well as the development of approaches to control neuronal activity using optical approaches (so called optogenetics). Finally, disease researchers have identified genes associated with neurodevelopmental and psychiatric disorders and neurodegenerative diseases. Animal models of these diseases are proving useful to understand how dysfunction of affected genes and proteins contributes to disease pathology. Although these fields are working on the same processes, no small highly interactive meeting brings these three groups together. The Keystone Symposia meeting on Synapses and Circuits: From Formation to Disease will address this need by bringing together leaders working on synapse development and function, circuit structure and function and the study of brain disease. We anticipate that mutually beneficial insights will emerge from discussions at this meeting.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, APRIL 1

15:00—19:30
Registration

Foyer
18:15—19:15
Refreshments

Foyer
19:15—21:00
Welcome and Keynote Session
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Tony Koleske, Yale University, USA

Stefan Herlitze, Ruhr-Universität Bochum, Germany
Investigation of Motor and Modulatory Circuits by Light

* Hollis T. Cline, The Scripps Research Institute, USA

Roger Y. Tsien, HHMI/University of California, San Diego, USA
Breeding and Building Molecules to Image Synapses, Protein Synthesis, and Action Potentials


MONDAY, APRIL 2

07:00—08:00
Breakfast

Foyer
08:00—11:00
Synapse Development and Function
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Sreeganga S. Chandra, Yale University, USA

Linda Van Aelst, Cold Spring Harbor Laboratory, USA
Rho Regulators in Synapse Development and Disease

Iryna M. Ethell, University of California Riverside, USA
Spatial Control of Cofilin Activity in NMDA-Dependent Dendritic Spine Plasticity, LTD and Learning

Matthew B. Dalva, Thomas Jefferson University, USA
Short Talk: A Novel Extracellular Mechanism Controls the EphB-NMDAR Interaction

Shannon Farris, University of California, Irvine, USA
Short Talk: Activity Induces Arc mRNA Degradation that is Dependent upon Translation and NMDA Receptor Activation

Michael L. Wallace, University of North Carolina, Chapel Hill, USA
Short Talk: Maternal Loss of Ube3a Produces an Excitatory/Inhibitory Imbalance through Cell Type-Specific Synaptic Defects

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine
11:00
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sunshine
16:30—17:00
Coffee Available

Foyer
17:00—19:15
Synapse Plasticity and Maintenance
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Matthew B. Dalva, Thomas Jefferson University, USA

Tony Koleske, Yale University, USA
Adhesive and Cytoskeletal Control of Synapse and Dendrite Stability.

Sika Zheng, University of California, Riverside, USA
Short Talk: A Novel Post-Transcriptional Regulatory Mechanism Mediates Psd-95 Expression and Synapse Maturation

J. Julius Zhu, University of Virginia, USA
Ras and Rap Signaling in Synaptic Plasticity and Mental Disorders

Juan Sebastian Espinosa, University of California, San Francisco, USA
Short Talk: Structural and Functional Plasticity in Juvenile Mouse Visual Cortex

Sreeganga S. Chandra, Yale University, USA
Short Talk: Presynaptic Mechanisms of Synapse Maintenance

19:15—20:15
Social Hour with Lite Bites

Sunshine
19:30—22:00
Poster Session 1

Sunshine

TUESDAY, APRIL 3

07:00—08:00
Breakfast

Foyer
08:00—11:00
Circuit Development and Function
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Stefan Herlitze, Ruhr-Universität Bochum, Germany

Herwig Baier, Max Planck Institute of Neurobiology, Germany
Genetic and Optical Targeting of Neural Circuits in Zebrafish

Martha Constantine-Paton, Massachusetts Institute of Technology, USA
Developmental Mechanisms of Synaptogenesis when Direct and Indirect Visual Pathways Converge

Hollis T. Cline, The Scripps Research Institute, USA
Activity-Dependent Mechanisms in Visual System Plasticity

Edwin W. Rubel, University of Washington, USA
Regulation of Dendritic Patterning by Synaptic Activity in Binaural Brainstem Auditory Neurons

Ethan Scott, University of Queensland, Australia
Short Talk: Cerebellar Contributions to Motor Learning in Zebrafish

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine
11:00
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sunshine
16:30—17:00
Coffee Available

Foyer
17:00—18:00
Molecular and Optogenetic Approaches to Probe Synapse Development and Neural Circuitry
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Hollis T. Cline, The Scripps Research Institute, USA

Gero Miesenböck, University of Oxford, UK
Optogenetic Control of Behavior

Dirk Trauner, New York University, USA
Optochemical Genetics

18:00—19:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Huda Y. Zoghbi, HHMI/Baylor College of Medicine, USA
Pathogenesis Studies of Rett Syndrome: Surprises and Insights

19:00—20:00
Social Hour with Lite Bites

Sunshine
19:30—22:00
Poster Session 2

Sunshine

WEDNESDAY, APRIL 4

07:00—08:00
Breakfast

Foyer
08:00—11:00
Inhibitory Neurons in Circuit Function
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Linda Van Aelst, Cold Spring Harbor Laboratory, USA

Elly Nedivi, Massachusetts Institute of Technology, USA
Structural Plasticity of GABAergic Circuits in Adult Visual Cortex

Massimo Scanziani, University of California, San Diego, USA
Addressing Cortical Processing by Perturbing the Activity of Individual Layers

Dan H. Sanes, New York University, USA
Developmental Plasticity of Inhibitory Circuits in Auditory Cortex

Marissa S. Kuzirian, University of Pittsburgh, USA
Short Talk: Elucidating the Role of Semaphorin4D and PlexinB1 in GABAergic Synapse Development

Michael J. Higley, Yale School of Medicine, USA
Short Talk: GABAergic Inhibition in Neocortical Dendrites

09:20—09:40
Coffee Break

Foyer
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Foyer
17:00—19:15
Neurodevelopmental Disorders
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Michael J. Higley, Yale School of Medicine, USA

Bo Li, Cold Spring Harbor Laboratory, USA
Attention: The Reticular Nucleus of the Thalamus and ErbB4

Claudia Bagni, KU Leuven, Belgium
mRNA Metabolism at Synapses in Neurodevelopmental and Psychiatric Disorders

Kimberly M. Huber, University of Texas Southwestern Medical Center, USA
Role of Metabotropic Glutamate Receptor-Homer Scaffolds in Synaptic and Circuit Function: Implications for Fragile X Syndrome

Joshua Ainsley, Tufts University, USA
Short Talk: Characterizing Dendritic Translation Using RNA-Seq

Adam J. Iliff, University of Michigan, USA
Short Talk: Hebbian and Homeostatic Plasticity Interact at the Same Synaptic Inputs: Metaplasticity Mediated by Local Protein Synthesis

19:15—20:15
Social Hour with Lite Bites

Sunshine

THURSDAY, APRIL 5

07:00—08:00
Breakfast

Foyer
08:00—11:00
Circuit Dysfunction in Disease
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Morgan H. Sheng, Genentech, Inc., USA

Stephen M. Strittmatter, Yale University, USA
Mechanisms of Synaptic Dysfunction Induced by Amyloid Beta Oligomers

Nicolas Tritsch, Harvard Medical School, USA
Dopaminergic Neurons Inhibit Striatum via Non-Canonical Release of GABA

Lisa M. Monteggia, University of Texas Southwestern Medical Center, USA
Mechanism of Rapid Antidepressant Action

Joanne Berger-Sweeney, Tufts University, USA
The One-Carbon (C1) Metabolic Cycle and Altered Neural Circuits in Autism

09:20—09:40
Coffee Break

Foyer
11:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Neurotrophic Factors and Neuron-Glia Interactions
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Joanne Berger-Sweeney, Tufts University, USA

Erik M. Ullian, University of California, San Francisco, USA
Activity-Dependent and Molecular Mechanisms Regulating the Stability and Segregation of Mammalian Visual Circuits

Morgan H. Sheng, Genentech, Inc., USA
Life, Death and Disease of Synapses

Ania Majewska, University of Rochester Medical School, USA
The Role of Microglia in Shaping the Synapse

19:00—20:00
Social Hour with Lite Bites

Sunshine
20:00—23:00
Entertainment

Sunshine

FRIDAY, APRIL 6

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS077593-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676