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This meeting took place in 2012



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Rheumatoid Arthritis: Molecular and Clinical Insights (A4)


Organizer(s) David M. Lee, Gary S. Firestein and Ellen M. Gravallese
January 19—24, 2012
Eldorado Hotel & Spa • Santa Fe, New Mexico USA
Abstract Deadline: Sep 21, 2011
Late Abstract Deadline: Oct 24, 2011
Scholarship Deadline: Sep 21, 2011
Early Registration Deadline: Nov 21, 2011

Organized with the support of the American College of Rheumatology Research and Education Foundation

Summary of Meeting:
Recent advances in genetic, cellular and molecular methodologies provide both new insights into disease pathogenesis and opportunities for therapeutic advances. Despite broad interest in rheumatoid arthritis (RA) within the immunology and clinical communities, there exists no focused venue for investigators with an interest in this disease to interact with each other, sharing ideas and developing productive collaborations. The Keystone Symposia format will fill this burgeoning need. This meeting will provide a venue for discussion of cutting-edge research topics in basic science and clinical science areas relevant to RA research. By fostering interactions between basic, translational and clinical investigators, we anticipate that this meeting will lead to new studies – as well as new approaches to studying – the pathogenesis and treatment of RA. The meeting will also serve to promote scientific development of early-career investigators, including those in training; their work will be among the selected presentations, creating an opportunity for interaction between junior investigators and outstanding senior scientists and mentors.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, JANUARY 19

15:00—19:30
Registration

Zia Concourse
18:15—19:15
Refreshments

Zia Concourse
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
David M. Lee, F. Hoffmann-La Roche AG, Switzerland
Introductory Remarks

Gary S. Firestein, University of California, San Diego, USA
Moving the Field Forward: RA Research and Impact on Disease

* Ellen M. Gravallese, University of Massachusetts Medical School, USA
Introduction of Keynote Speaker

William P. Arend, University of Colorado School of Medicine, USA
Disease Mechanisms and Treatments: A Historic Benchtop to Bedside Perspective


FRIDAY, JANUARY 20

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
Integrated Biology of the Joint in Rheumatoid Arthritis
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Alisa Koch, University of Michigan, USA

* William F. Rigby, Dartmouth Medical School, USA

Michael B. Brenner, Harvard Medical School, USA
Cadherin-11 Modulates Synovial Fibroblast Inflammation and Degradation

Gary S. Firestein, University of California, San Diego, USA
Signaling Mechanisms in Synovial Inflammation

Ellen M. Gravallese, University of Massachusetts Medical School, USA
Osteoclasts and Osteoblasts in Rheumatoid Arthritis

Georg Schett, University of Erlangen-Nuremberg, Germany
Osteoimmunology: Cells and Factors that Impact Bone

09:20—09:40
Coffee Break

Zia Concourse
11:00—13:00
Poster Setup

Sunset Room
11:00
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sunset Room
16:30—17:00
Coffee Available

Zia Concourse
17:00—19:15
Innate Immunity in Rheumatoid Arthritis
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Maripat Corr, University of California, San Diego, USA

Nina Bhardwaj, Ichan School of Medicine at Mt Sinai, USA
Dendritic Cell-Mediated Modulation of Treg Function

Peter A. Nigrovic, Brigham and Women's Hospital, USA
Mast Cells in Arthritis: If, When and How

David M. Lee, F. Hoffmann-La Roche AG, Switzerland
Platelets, Microvesicles and Inflammatory Synovitis

Steffen Gay, University Hospital Zürich, Switzerland
Epigenetics, microRNA and Innate Immunity

19:15—20:15
Social Hour with Lite Bites

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 1

Sunset Room

SATURDAY, JANUARY 21

07:00—08:00
Breakfast

Eldorado Court
08:00—11:15
Autoimmunity I
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* S. Louis Bridges, Jr., University of Alabama, Birmingham, USA

* Robert H. Carter, NIAMS, National Institutes of Health, USA

Jennifer H. Anolik, University of Rochester, USA
Autoantibody Dependent vs. Independent Roles for B Cells in RA

Gregg J. Silverman, New York University Langone Medical Center, USA
Pathogenic and Protective Autoantibodies in Inflammatory Synovitis

Andrew C. Chan, Genentech, Inc., USA
Redefining Human Disease to Meet the Challenges of Drug Discovery and Clinical Practice

David G. Winkler, Infinity Pharmaceuticals, Inc., USA
Taking PI3Kdelta and PI3Kgamma for the Treatment of Immune-Mediated Inflammatory Diseases

Narendiran Rajasekaran, Stanford University, USA
Short Talk: Host-Derived CD4+ T Cells Protect Lethally Irradiated B6.g7 Mice from Stem Cell Mediated Transfer of Autoimmunity

Safiehkhatoon Moshkani, University of Rochester, USA
Short Talk: CD23+CD21High B Cells in Inflamed Lymph Nodes of TNF-Transgenic Mice Are a Locally Differentiated Population with Increased Antigen Capture and Activation Potential

09:20—09:40
Coffee Break

Zia Concourse
11:15—13:00
Poster Setup

Sunset Room
11:15
On Own for Lunch and Recreation

13:00—22:00
Poster Viewing

Sunset Room
16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
Systemic Disease in Rheumatoid Arthritis
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* William P. Arend, University of Colorado School of Medicine, USA

Camilla I. Svensson, Karolinska Institutet, Sweden
How Inflammatory Synovitis Produces Persistent Pain

Kevin L. Winthrop, Oregon Health & Science University, USA
Anti-TNF Therapy and Beyond: Serious Infections and Mechanisms of Suppressed Host Defense in RA

Joan M. Bathon, Columbia University, USA
Accelerated Atherosclerosis and Cardiovascular Disease

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 2

Sunset Room

SUNDAY, JANUARY 22

07:00—08:00
Breakfast

Eldorado Court
08:00—11:15
Autoimmunity II
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Hani El-Gabalawy, University of Manitoba, Canada

* Soumya Raychaudhuri, Brigham and Women's Hospital, Harvard Medical School, USA

Dhavalkumar D. Patel, Inflazome, Switzerland
Role of IL-17A in Rheumatoid Arthritis and Other Autoimmune Diseases.

V. Michael Holers, University of Colorado Denver, USA
When Does RA Begin: Inflammatory and Autoimmune Signatures Precede Clinical Onset

David A. Fox, University of Michigan Medical School, USA
Pathogenic and Protective T Cell Subsets in Rheumatoid Arthritis

William H. Robinson, Stanford University School of Medicine, USA
Citrullination of Fibrinogen: Generation of Neoepitopes and Enhancement of Immunostimulatory Properties

Eric Boilard, CRCHUQ, Universite Laval, Canada
Short Talk: Novel Platelet Function during Inflammatory Arthritis

Khaled Amara, Karolinska Institutet, Sweden
Short Talk: Generation and Characterization of Monoclonal Antibodies from Single RA Synovial B Cells

09:20—09:40
Coffee Break

Zia Concourse
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
Imaging and Biomarkers
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Ingrid E. Lundberg, Karolinska Institutet, Sweden

Dennis McGonagle, University of Leeds, St. James’s University Hospital, UK
From Pathogenesis to Disease Remission-How MRI and Ultrasound Have Transformed the Understanding of RA

Michael L. Dustin, University of Oxford, UK
In vivo Tracking of Regulatory T Cell Dynamics in Models of Autoimmune Disease

Michael Centola, Oklahoma Medical Research Foundation, USA
Utilizing Biomarkers of RA Disease Activity to Identify Patients at Risk of Joint Damage

19:00—20:00
Social Hour with Lite Bites

Eldorado Court/Sunset Room

MONDAY, JANUARY 23

07:00—08:00
Breakfast

Eldorado Court
08:00—11:15
Omics and Informatics
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* David R. Karp, University of Texas Southwestern Medical Center, USA

* Erik J. Peterson, University of Minnesota, USA

Iain B. McInnes, University of Glasgow, UK
Therapeutic Opportunities in Innate Immunity in Inflammatory Arthritis

Soumya Raychaudhuri, Brigham and Women's Hospital, Harvard Medical School, USA
Translating Rheumatoid Arthritis Genetic Loci into Pathogenic Processes

Lars Klareskog, Karolinska Institutet, Sweden
Susceptibility Is More Than Our Genes: Roles of Environment and Genes in Triggering Disease-Related Autoimmunity

Robert M. Plenge, Celgene, USA
"The Cycle" of Discovery Research in Rheumatoid Arthritis: Integrating Next-Generation Genomics with Next-Generation Clinical Data from Electronic Health Records

Ronald N. Germain, NIAID, National Institutes of Health, USA
A New Omics: System-Wide Analysis of the Human Immune System in Health and Disease

09:00—09:20
Coffee Break

Zia Concourse
 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
Clinical Developments in Rheumatoid Arthritis
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Michael J. Townsend, Genentech, Inc, USA
Short Talk: Rheumatoid Arthritis Patients Possess Distinct Molecular and Cellular Synovial Phenotypes that Impact Clinical Outcome

Cécile T. J. Holweg, Genentech, Inc., USA
Short Talk: Pretreatment Synovial Transcriptional Profile Correlates with Early and Late Clinical Response in Rheumatoid Arthritis Patients Treated with Rituximab

Eric M. Ruderman, Northwestern University, USA
Placebos, Active Comparators and Creative Trial Design in RA

* E. William St. Clair, Duke University Medical Center, USA
Therapeutic Targeting of Adaptive Immunity in Rheumatoid Arthritis: Successes and Limitations

19:00—19:05
Closing Remarks
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
David M. Lee, F. Hoffmann-La Roche AG, Switzerland

Gary S. Firestein, University of California, San Diego, USA

Ellen M. Gravallese, University of Massachusetts Medical School, USA

19:15—20:15
Social Hour with Lite Bites

Eldorado Court/Sunset Room
20:00—23:00
Entertainment

Eldorado Court/Sunset Room

TUESDAY, JANUARY 24

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

American College of Rheumatology Research and Education Foundation

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AR061874-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Rigel Pharmaceuticals, Inc.
Takeda California


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


Novartis Pharma AG


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

The Journal of Rheumatology

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676