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This meeting took place in 2013
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Meeting Details
Noncoding RNAs in Development and Cancer (A7)
Organizer(s) Joshua T. Mendell, Phillip A. Sharp, Judy Lieberman and Howard Y. Chang
January 20 - January 25, 2013
Fairmont Hotel Vancouver • Vancouver, British Columbia Canada
Abstract Deadline: September 20, 2012
Late Abstract Deadline: October 22, 2012
Scholarship Deadline: September 20, 2012
Early Registration Deadline: November 15, 2012
Sponsored by Cell Research, EMD Millipore and Isis Pharmaceuticals, Inc.
CME Information
Summary of Meeting:
A recurrent principle in cancer biology is the co-option of pathways that function during development to promote aberrant tumor cell behavior. This principle clearly applies to the roles of noncoding RNAs in cancer. Examples of noncoding RNAs that modify tumor phenotypes include the microRNA (miRNA) let-7, a key regulator of developmental timing in C. elegans, and the miR-17-92 cluster, which conducts essential regulatory functions during mammalian development. However, we currently have only a rudimentary understanding of how diverse classes of noncoding RNAs function in physiologic and pathophysiologic states. This meeting will bring together experts focused on the roles of noncoding RNAs in development and cancer with the broad goals of: 1) Illuminating new connections between developmental and cancer pathways controlled by miRNAs and long noncoding RNAs; 2) Uncovering novel mechanisms by which developmental and cancer pathways influence noncoding RNA processing and activity; 3) Revealing the molecular mechanisms through which miRNAs and long noncoding RNAs function in these pathways; and 4) Highlighting how our understanding of noncoding RNA-regulated pathways can be applied in the development of novel therapeutic strategies for cancer and perhaps other diseases. To accomplish these goals, this meeting will bring together experts from disparate fields ranging from organismal-level developmental and cancer biology to biochemical and molecular studies of RNA function to share their newest data and ideas. It is anticipated that the diverse views, approaches and results presented by participants will foster new lines of investigation and collaborations which will be critical to dissect the myriad functions of noncoding RNAs in health and disease.
CME Information
A recurrent principle in cancer biology is the co-option of pathways that function during development to promote aberrant tumor cell behavior. This principle clearly applies to the roles of noncoding RNAs in cancer. Examples of noncoding RNAs that modify tumor phenotypes include the microRNA (miRNA) let-7, a key regulator of developmental timing in C. elegans, and the miR-17-92 cluster, which conducts essential regulatory functions during mammalian development. However, we currently have only a rudimentary understanding of how diverse classes of noncoding RNAs function in physiologic and pathophysiologic states. This meeting will bring together experts focused on the roles of noncoding RNAs in development and cancer with the broad goals of: 1) Illuminating new connections between developmental and cancer pathways controlled by miRNAs and long noncoding RNAs; 2) Uncovering novel mechanisms by which developmental and cancer pathways influence noncoding RNA processing and activity; 3) Revealing the molecular mechanisms through which miRNAs and long noncoding RNAs function in these pathways; and 4) Highlighting how our understanding of noncoding RNA-regulated pathways can be applied in the development of novel therapeutic strategies for cancer and perhaps other diseases. To accomplish these goals, this meeting will bring together experts from disparate fields ranging from organismal-level developmental and cancer biology to biochemical and molecular studies of RNA function to share their newest data and ideas. It is anticipated that the diverse views, approaches and results presented by participants will foster new lines of investigation and collaborations which will be critical to dissect the myriad functions of noncoding RNAs in health and disease.
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, JANUARY 20
19:15—21:30
Welcome and Keynote Session
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Jeannie T. Lee,
Massachusetts General Hospital, USA
The Roles of Long Noncoding RNA in Epigenetic Regulation
The Roles of Long Noncoding RNA in Epigenetic Regulation
08:00—11:15
MicroRNAs in Development
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*
Andrea Ventura,
Memorial Sloan-Kettering Cancer Center, USA
Victor R. Ambros,
University of Massachusetts, USA
MicroRNA Pathways Linking Development and Stress Responses in C. elegans
MicroRNA Pathways Linking Development and Stress Responses in C. elegans
Eric N. Olson,
University of Texas Southwestern Medical Center, USA
miRNAs in Cardiac Development and Disease
miRNAs in Cardiac Development and Disease
Ying Tian,
University of Pennsylvania, USA
Short Talk: miRNA Regulation of Myocyte Proliferation and the Hippo Pathway
Short Talk: miRNA Regulation of Myocyte Proliferation and the Hippo Pathway
Michele Trabucchi,
University of Nice Sophia-Antipolis, France
Short Talk: Specific MicroRNAs Regulate AU-Rich mRNA Element Mediated Degradation during Mouse Pituitary Development
Short Talk: Specific MicroRNAs Regulate AU-Rich mRNA Element Mediated Degradation during Mouse Pituitary Development
14:30—16:30
Workshop 1: Additional Highlights of Abstract Submissions
*
Antonio J. Giraldez,
Yale University School of Medicine, USA
Bethany A. Janowski,
University of Texas Southwestern Medical Center, USA
Long Noncoding RNAs Link Transcriptional Regulation of Inflammatory Pathway Genes
Long Noncoding RNAs Link Transcriptional Regulation of Inflammatory Pathway Genes
J. Mauro Calabrese,
University of North Carolina at Chapel Hill, USA
Site-Specific Silencing of Regulatory Elements as a Mechanism of X-Inactivation
Site-Specific Silencing of Regulatory Elements as a Mechanism of X-Inactivation
Nadya Dimitrova,
Massachusetts Institute of Technology, USA
Functional Characterization of p53-Regulated lincRNAs
Functional Characterization of p53-Regulated lincRNAs
Yuen-Yi Tseng,
University of Minnesota, USA
PVT1 is an Oncogenic Noncoding RNA that Promotes Breast Cancer by Stabilizing c-MYC
PVT1 is an Oncogenic Noncoding RNA that Promotes Breast Cancer by Stabilizing c-MYC
Quan Zhu,
The Salk Institute of Biological Studies, USA
BRCA1 Maintains Genomic Stability via Silencing the Expression of Heterochromatic Repetitive RNA
BRCA1 Maintains Genomic Stability via Silencing the Expression of Heterochromatic Repetitive RNA
Timothy E. Audas,
University of Ottawa, Canada
Ribosomal Intergenic Noncoding RNA Suppresses Tumorgenesis
Ribosomal Intergenic Noncoding RNA Suppresses Tumorgenesis
Carlos A. Melo,
Netherlands Cancer Institute, Netherlands
eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription
eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription
Sergei Ryazansky,
Institute of Molecular Genetics RAS, Russia
Testis-Specific Cluster of miRNAs Controls Individualization of Spermatids in Drosophila
Testis-Specific Cluster of miRNAs Controls Individualization of Spermatids in Drosophila
17:00—19:00
Mechanisms of Small RNA Functions
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*
Gregory J. Hannon,
Cold Spring Harbor Laboratory, USA
Phillip A. Sharp,
Massachusetts Institute of Technology, USA
Regulation and Function of Small RNA Pathways
Regulation and Function of Small RNA Pathways
Judy Lieberman,
Immune Disease Institute, USA
miR-34a – A Small, but Mighty, Tumor Suppressor that Suppresses Growth Factor Signaling
miR-34a – A Small, but Mighty, Tumor Suppressor that Suppresses Growth Factor Signaling
Irene Bozzoni,
University La Sapienza, Rome, Italy
Role of Noncoding RNAs in Muscle Differentiation and in Duchenne Muscular Dystrophy
Role of Noncoding RNAs in Muscle Differentiation and in Duchenne Muscular Dystrophy
Olivia Rissland,
Whitehead Institute, USA
Short Talk: Global Analyses of the Effect of Different Cellular Contexts on MicroRNA Targeting
Short Talk: Global Analyses of the Effect of Different Cellular Contexts on MicroRNA Targeting
08:00—11:15
Long Noncoding RNAs in Development
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Victor R. Ambros,
University of Massachusetts, USA
Phillip Grote,
Max Planck Institute for Molecular Genetics, Germany
The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse
The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse
Geneviève Almouzni,
Centre National de la Recherche Scientifique, France
Chromatin Assembly from Nucleosome to Heterochromatin: The Issue of DNA Damage
Chromatin Assembly from Nucleosome to Heterochromatin: The Issue of DNA Damage
Kathrin Plath,
University of California, Los Angeles, USA
The Inactive X Chromosome as a Marker of Reprogramming
The Inactive X Chromosome as a Marker of Reprogramming
Saba Valadkhan,
Case Western Reserve University, USA
Short Talk: Neuronal Reprogramming of Mesodermal Cells by a Long Noncoding RNA
Short Talk: Neuronal Reprogramming of Mesodermal Cells by a Long Noncoding RNA
Markus Kretz,
University of Regensburg, Germany
Short Talk: Control of Epidermal Tissue Homeostasis by Long Noncoding RNAs
Short Talk: Control of Epidermal Tissue Homeostasis by Long Noncoding RNAs
17:00—19:15
Small RNAs in Pluripotent Cells
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*
Richard I. Gregory,
Harvard Medical School, USA
Gregory J. Hannon,
Cold Spring Harbor Laboratory, USA
The piRNA Pathway: A Small RNA-based Innate Immune System
The piRNA Pathway: A Small RNA-based Innate Immune System
Katalin Fejes-Tóth,
California Institute of Technology, USA
Short Talk: piRNA-Independent Recruitment of Piwi to Chromatin Leads to piRNA-Guided Repression of Transcription
Short Talk: piRNA-Independent Recruitment of Piwi to Chromatin Leads to piRNA-Guided Repression of Transcription
Robert H. Blelloch,
University of California, San Francisco, USA
MicroRNA-Regulated Networks in the Maintenance and Induction of Pluripotency
MicroRNA-Regulated Networks in the Maintenance and Induction of Pluripotency
Nils Pfaff,
Hannover Medical School, Germany
Short Talk: Deciphering the Molecular Mechanisms of Reprogramming using miRNA Screens
Short Talk: Deciphering the Molecular Mechanisms of Reprogramming using miRNA Screens
Ron Parchem,
University of California, San Francisco, USA
Short Talk: Reprogramming Bypasses
Short Talk: Reprogramming Bypasses
08:00—11:15
MicroRNAs in Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Robert H. Blelloch,
University of California, San Francisco, USA
Tyler Jacks,
Massachusetts Institute of Technology, USA
miRNA Expression and Function in Cancer
miRNA Expression and Function in Cancer
Joshua T. Mendell,
University of Texas Southwestern Medical Center, USA
miRNAs in Oncogenic Signaling Pathways
miRNAs in Oncogenic Signaling Pathways
Andrea Ventura,
Memorial Sloan-Kettering Cancer Center, USA
On the Many Roles of Oncomir-1 in Cancer and in Development
On the Many Roles of Oncomir-1 in Cancer and in Development
Lin He,
University of California, Berkeley, USA
Short Talk: A Polycistronic miRNA Oncogene mir17-92 Confers Balance between Proliferation and Apoptosis
Short Talk: A Polycistronic miRNA Oncogene mir17-92 Confers Balance between Proliferation and Apoptosis
James F. Amatruda,
University of Texas Southwestern Medical Center, USA
Short Talk: Recurrent Mutations at Multiple Levels of the microRNA Biogenesis Pathway in Childhood Wilms Tumors
Short Talk: Recurrent Mutations at Multiple Levels of the microRNA Biogenesis Pathway in Childhood Wilms Tumors
14:30—16:30
Workshop 2: Therapeutic Applications of Noncoding RNAs
*
Judy Lieberman,
Immune Disease Institute, USA
Michael R. Hodges,
Santaris Pharma, USA
Clinical Development of Miravirsen for HCV Infection
Clinical Development of Miravirsen for HCV Infection
Anita Seto,
miRagen Therapeutics, USA
Targeting miRNAs in Cardiovascular Disease
Targeting miRNAs in Cardiovascular Disease
Masahiko Kuroda,
Tokyo Medical University, Japan
Systemically Injected Exosomes Targeted to EGFR Deliver Anti-Tumor microRNA to Breast Cancer Cells
Systemically Injected Exosomes Targeted to EGFR Deliver Anti-Tumor microRNA to Breast Cancer Cells
Keita Uchino,
National Cancer Center Research Institute, Japan
Therapeutic Application of microRNA-582-5p and -3p in the Treatment of Invasive Bladder Cancer
Therapeutic Application of microRNA-582-5p and -3p in the Treatment of Invasive Bladder Cancer
17:00—19:00
Processing of Noncoding RNAs
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*
Phillip A. Sharp,
Massachusetts Institute of Technology, USA
Manel Esteller,
Belvitge Biomedical Research Institute (IDIBELL), Spain
Epigenetic and Genetic Disruption of ncRNAs in Cancer
Epigenetic and Genetic Disruption of ncRNAs in Cancer
Richard I. Gregory,
Harvard Medical School, USA
Regulation of miRNA Processing by Lin28
Regulation of miRNA Processing by Lin28
Alexei A. Aravin,
California Institute of Technology, USA
Small RNA: From Bacteria to Metazoan Germline
Small RNA: From Bacteria to Metazoan Germline
Elyse Kozlowski,
Boston University, USA
Short Talk: Widespread Uridylation of Mature microRNAs by Zcchc11 Governs Murine Growth and Survival
Short Talk: Widespread Uridylation of Mature microRNAs by Zcchc11 Governs Murine Growth and Survival
08:00—11:15
Long Noncoding RNAs in Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Joshua T. Mendell,
University of Texas Southwestern Medical Center, USA
Arul M. Chinnaiyan,
University of Michigan, USA
LncRNAs Discovery and Use as Noninvasive Biomarkers in Prostate Cancer
LncRNAs Discovery and Use as Noninvasive Biomarkers in Prostate Cancer
John S. Mattick,
Garvan Institute of Medical Research, Australia
The Role of Regulatory RNA in Human Development and Disease
The Role of Regulatory RNA in Human Development and Disease
Michael G. Rosenfeld,
HHMI, University of California, San Diego School of Medicine, USA
LncRNAs in Strategies for Controlling Regulated Gene Programs in Cancer Cells
LncRNAs in Strategies for Controlling Regulated Gene Programs in Cancer Cells
Sven Diederichs,
German Cancer Research Center (DKFZ), Germany
Short Talk: MALAT1 Is an Essential Gene Regulator for Lung Cancer Metastasis in a Novel Human Knockout Model
Short Talk: MALAT1 Is an Essential Gene Regulator for Lung Cancer Metastasis in a Novel Human Knockout Model
Erwei Song,
Sun-Yat-Sen Memorial Hospital, China
Short Talk: A Cytoplasmic NFkappaB Interacting Long Noncoding RNA Directly Blocks IkappaB Phosphorylation and Suppresses Breast Cancer Metastasis
Short Talk: A Cytoplasmic NFkappaB Interacting Long Noncoding RNA Directly Blocks IkappaB Phosphorylation and Suppresses Breast Cancer Metastasis
17:00—19:00
ncRNAs in Transcriptional Control and Chromatin
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*
Howard Y. Chang,
Stanford University, USA
Antonin Morillon,
Institut Curie, France
Yeast Cryptic lncRNAs Modulate Gene Expression via Chromatin Modifications
Yeast Cryptic lncRNAs Modulate Gene Expression via Chromatin Modifications
Gary Felsenfeld,
NIDDK, National Institutes of Health, USA
Organization of Chromatin Domains and the Role of RNA
Organization of Chromatin Domains and the Role of RNA
Shiv I. S. Grewal,
NCI, National Institutes of Health, USA
Epigenetic Genome Control by Heterochromatin and RNAi Machinery
Epigenetic Genome Control by Heterochromatin and RNAi Machinery
Marc Bühler,
Friedrich Miescher Institute for Biomedical Research, Switzerland
Short Talk: RNA-Mediated Eviction of a Heterochromatin Protein
Short Talk: RNA-Mediated Eviction of a Heterochromatin Protein
*Session Chair †Speaker invited, not yet responded.
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