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Fairmont Hotel Vancouver Floorplan

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This meeting took place in 2013


Here are the related meetings in 2014:
Long Noncoding RNAs: Marching toward Mechanism (B5)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Noncoding RNAs in Development and Cancer (A7)


Organizer(s) Joshua T. Mendell, Phillip A. Sharp, Judy Lieberman and Howard Y. Chang
January 20—25, 2013
Fairmont Hotel Vancouver • Vancouver, British Columbia Canada
Abstract Deadline: Sep 20, 2012
Late Abstract Deadline: Oct 22, 2012
Scholarship Deadline: Sep 20, 2012
Early Registration Deadline: Nov 15, 2012

Sponsored by Cell Research, EMD Millipore and Isis Pharmaceuticals, Inc.

Summary of Meeting:
A recurrent principle in cancer biology is the co-option of pathways that function during development to promote aberrant tumor cell behavior. This principle clearly applies to the roles of noncoding RNAs in cancer. Examples of noncoding RNAs that modify tumor phenotypes include the microRNA (miRNA) let-7, a key regulator of developmental timing in C. elegans, and the miR-17-92 cluster, which conducts essential regulatory functions during mammalian development. However, we currently have only a rudimentary understanding of how diverse classes of noncoding RNAs function in physiologic and pathophysiologic states. This meeting will bring together experts focused on the roles of noncoding RNAs in development and cancer with the broad goals of: 1) Illuminating new connections between developmental and cancer pathways controlled by miRNAs and long noncoding RNAs; 2) Uncovering novel mechanisms by which developmental and cancer pathways influence noncoding RNA processing and activity; 3) Revealing the molecular mechanisms through which miRNAs and long noncoding RNAs function in these pathways; and 4) Highlighting how our understanding of noncoding RNA-regulated pathways can be applied in the development of novel therapeutic strategies for cancer and perhaps other diseases. To accomplish these goals, this meeting will bring together experts from disparate fields ranging from organismal-level developmental and cancer biology to biochemical and molecular studies of RNA function to share their newest data and ideas. It is anticipated that the diverse views, approaches and results presented by participants will foster new lines of investigation and collaborations which will be critical to dissect the myriad functions of noncoding RNAs in health and disease.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 20

15:00—19:30
Arrival and Registration

18:15—19:15
Refreshments

19:15—21:30
Welcome and Keynote Session
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Jeannie T. Lee, Massachusetts General Hospital, USA
The Roles of Long Noncoding RNA in Epigenetic Regulation

V. Narry Kim, Seoul National University, South Korea
Biogenesis and Regulation of MicroRNA


MONDAY, JANUARY 21

07:00—08:00
Breakfast

08:00—11:15
MicroRNAs in Development
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Andrea Ventura, Memorial Sloan-Kettering Cancer Center, USA

Victor R. Ambros, University of Massachusetts, USA
MicroRNA Pathways Linking Development and Stress Responses in C. elegans

Antonio J. Giraldez, Yale University School of Medicine, USA
miRNAs in Zebrafish Development

Frank J. Slack, Yale University, USA
RNA Targets of the Stemness Factor Lin28

Eric N. Olson, University of Texas Southwestern Medical Center, USA
miRNAs Role in Cardiac Development and Disease

Ying Tian, University of Pennsylvania, USA
Short Talk: miRNA Regulation of Myocyte Proliferation and the Hippo Pathway

Michele Trabucchi, University of Nice Sophia-Antipolis, France
Short Talk: Specific MicroRNAs Regulate AU-Rich mRNA Element Mediated Degradation during Mouse Pituitary Development

09:20—09:40
Coffee Break

11:15—16:30
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

14:30—16:30
Workshop 1: Additional Highlights of Abstract Submissions

* Antonio J. Giraldez, Yale University School of Medicine, USA

Bethany A. Janowski, University of Texas Southwestern Medical Center, USA
Long Noncoding RNAs Link Transcriptional Regulation of Inflammatory Pathway Genes

J. Mauro Calabrese, University of North Carolina at Chapel Hill, USA
Site-Specific Silencing of Regulatory Elements as a Mechanism of X-Inactivation

Nadya Dimitrova, Massachusetts Institute of Technology, USA
Functional Characterization of p53-Regulated lincRNAs

Yuen-Yi Tseng, University of Minnesota, USA
PVT1 is an Oncogenic Noncoding RNA that Promotes Breast Cancer by Stabilizing c-MYC

Quan Zhu, The Salk Institute of Biological Studies, USA
BRCA1 Maintains Genomic Stability via Silencing the Expression of Heterochromatic Repetitive RNA

Timothy E. Audas, University of Ottawa, Canada
Ribosomal Intergenic Noncoding RNA Suppresses Tumorgenesis

Carlos A. Melo, Netherlands Cancer Institute, Netherlands
eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription

Sergei Ryazansky, Institute of Molecular Genetics RAS, Russia
Testis-Specific Cluster of miRNAs Controls Individualization of Spermatids in Drosophila

16:30—17:00
Coffee Available

17:00—19:00
Mechanisms of Small RNA Functions
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gregory J. Hannon, Cold Spring Harbor Laboratory, USA

Phillip A. Sharp, Massachusetts Institute of Technology, USA
Transcription of Long Non-Coding RNAs and the Functions of MicroRNAs in Cancer

Judy Lieberman, Immune Disease Institute, USA
Capture of miRNA Bound mRNAs Identifies Oncomir Networks

Irene Bozzoni, University La Sapienza, Rome, Italy
Noncoding RNAs in Muscle Differentiation and in Duchenne Muscular Dystrophy

Olivia Rissland, Whitehead Institute, USA
Short Talk: Global Analyses of the Effect of Different Cellular Contexts on MicroRNA Targeting

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, JANUARY 22

07:00—08:00
Breakfast

08:00—11:15
Long Noncoding RNAs in Development
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Victor R. Ambros, University of Massachusetts, USA

Phillip Grote, Max Planck Institute for Molecular Genetics, Germany
The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse

Caroline Dean, John Innes Centre, UK
Antisense RNAs in the Control of Flowering Time

Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Noncoding RNA and Chromatin Dynamics During Early Mouse Development

Kathrin Plath, University of California, Los Angeles, USA
Using the Inactive X Chromosome to Understand Reprogramming

Saba Valadkhan, Case Western Reserve University, USA
Short Talk: Long Non Coding RNA-Mediated Transdifferentiation of Adult Cells into Neurons

Markus Kretz, University of Regensburg, Germany
Short Talk: Control of Epidermal Tissue Homeostasis by Long Noncoding RNAs

09:20—09:40
Coffee Break

11:15—16:30
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

16:30—17:00
Coffee Available

17:00—19:15
Small RNAs in Pluripotent Cells
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Richard I. Gregory, Harvard Medical School, USA

Gregory J. Hannon, Cold Spring Harbor Laboratory, USA
The piRNA Pathway: A Small RNA-based Innate Immune System

Katalin Fejes-Tóth, California Institute of Technology, USA
Short Talk: piRNA-Independent Recruitment of Piwi to Chromatin Leads to piRNA-Guided Repression of Transcription

Robert H. Blelloch, University of California, San Francisco, USA
miRNA Regulation of Embryonic Stem Cells

George Q. Daley, HHMI/Children's Hospital Boston, USA
The LIN28/let-7 in Development and Disease

Nils Pfaff, Hannover Medical School, Germany
Short Talk: Deciphering the Molecular Mechanisms of Reprogramming using miRNA Screens

Ron Parchem, University of California, San Francisco, USA
Short Talk: Reprogramming Bypasses

19:15—20:15
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, JANUARY 23

07:00—08:00
Breakfast

07:30—08:00
Poster Setup

08:00—17:00
Poster Viewing

08:00—11:15
MicroRNAs in Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Robert H. Blelloch, University of California, San Francisco, USA

Tyler Jacks, Massachusetts Institute of Technology, USA
Small RNAs in Lung Cancer Development and Therapy

Joshua T. Mendell, University of Texas Southwestern Medical Center, USA
miRNAs in Oncogenic Signaling Pathways

Andrea Ventura, Memorial Sloan-Kettering Cancer Center, USA
On the Many Roles of Oncomir-1 in Cancer and in Development

Chang-Zheng Chen, Stanford University, USA
MicroRNAs in Lymphocytes and Leukemias

Lin He, University of California, Berkeley, USA
Short Talk: A Polycistronic miRNA Oncogene mir17-92 Confers Balance between Proliferation and Apoptosis

James F. Amatruda, University of Texas Southwestern Medical Center, USA
Short Talk: Recurrent Mutations at Multiple Levels of the microRNA Biogenesis Pathway in Childhood Wilms Tumors

09:20—09:40
Coffee Break

11:15—12:00
Lunch

12:00—14:30
Poster Session 3

14:30—16:30
Workshop 2: Therapeutic Applications of Noncoding RNAs

* Judy Lieberman, Immune Disease Institute, USA

Michael R. Hodges, Santaris Pharma, USA
Clinical Development of Miravirsen for HCV Infection

Eric G. Marcusson, Microlin Bio, USA
Discovery and Development of Anti-miRNA Therapeutics

Andreas G. Bader, Mirna Therapeutics, Inc., USA
miRNA Replacement Therapy

Anita G. Seto, miRagen Therapeutics, USA
Targeting miRNAs in Cardiovascular Disease

Masahiko Kuroda, Tokyo Medical University, Japan
Systemically Injected Exosomes Targeted to EGFR Deliver Anti-Tumor microRNA to Breast Cancer Cells

Keita Uchino, National Cancer Center Research Institute, Japan
Therapeutic Application of microRNA-582-5p and -3p in the Treatment of Invasive Bladder Cancer

16:30—17:00
Coffee Available

17:00—19:00
Processing of Noncoding RNAs
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Phillip A. Sharp, Massachusetts Institute of Technology, USA

Manel Esteller, Belvitge Biomedical Research Institute (IDIBELL), Spain
Epigenetic and Genetic Disruption of ncRNAs in Cancer

Richard I. Gregory, Harvard Medical School, USA
Regulation of miRNA Processing by Lin28

Alexei A. Aravin, California Institute of Technology, USA
Small RNA: From Bacteria to Metazoan Germline

Elyse Kozlowski, Boston University, USA
Short Talk: Widespread Uridylation of Mature microRNAs by Zcchc11 Governs Murine Growth and Survival

19:00—
On Own for Dinner


THURSDAY, JANUARY 24

07:00—08:00
Breakfast

08:00—11:15
Long Noncoding RNAs in Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Joshua T. Mendell, University of Texas Southwestern Medical Center, USA

Howard Y. Chang, Stanford University, USA
Genome Regulation by Long Noncoding RNAs

Arul M. Chinnaiyan, University of Michigan, USA
LncRNAs Discovery and Use as Noninvasive Biomarkers in Prostate Cancer

John S. Mattick, Garvan Institute of Medical Research, Australia
The Role of Regulatory RNA in Human Development and Disease

Michael G. Rosenfeld, HHMI, University of California, San Diego, USA
LncRNAs in Strategies for Controlling Regulated Gene Programs in Cancer Cells

Sven Diederichs, German Cancer Research Center DKFZ, Germany
Short Talk: MALAT1 Is an Essential Gene Regulator for Lung Cancer Metastasis in a Novel Human Knockout Model

Erwei Song, Sun-Yat-Sen Memorial Hospital, China
Short Talk: A Cytoplasmic NFkappaB Interacting Long Noncoding RNA Directly Blocks IkappaB Phosphorylation and Suppresses Breast Cancer Metastasis

09:00—09:20
Coffee Break

11:15—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
ncRNAs in Transcriptional Control and Chromatin
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Howard Y. Chang, Stanford University, USA

Antonin Morillon, Institut Curie, France
Yeast Cryptic lncRNAs Modulate Gene Expression via Chromatin Modifications

Gary Felsenfeld, NIDDK, National Institutes of Health, USA
Organization of Chromatin Domains and the Role of RNA

Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Epigenetic Genome Control by Heterochromatin and RNAi Machinery

Marc Bühler, Friedrich Miescher Institute for Biomedical Research, Switzerland
Short Talk: RNA-Mediated Eviction of a Heterochromatin Protein

19:00—20:00
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


FRIDAY, JANUARY 25

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Cell Research EMD Millipore
Isis Pharmaceuticals, Inc.
 

We gratefully acknowledge additional support for this conference from:

Exiqon A/S Sigma Life Science

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA171307-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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