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This meeting took place in 2013
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Meeting Details
The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells and Cancer (E2)
Organizer(s) Marius Sudol, Helen McNeill, Georg A. Halder and Giovanni Blandino
May 19 - May 23, 2013
Hyatt Regency Monterey • Monterey, California USA
Abstract Deadline: January 17, 2013
Late Abstract Deadline: February 18, 2013
Scholarship Deadline: January 17, 2013
Early Registration Deadline: March 19, 2013
Supported by the Directors' Fund
CME Information
Summary of Meeting:
Over the past several years, the Hippo tumor suppressor pathway has emerged as a complex signaling network that has significant implications for our understanding of the molecular mechanisms of cancer development and stem cell biology. The main effectors of this pathway, YAP and TAZ, are transcriptional co- activators, which act as stemness factors and potent oncogenes. Recent studies have revealed that abnormal expression of components of the network can lead to cancer. Therefore, the pathway and its networking molecules are attractive targets for the development of cancer drugs and unconventional therapeutic interventions.
Several paradoxes have emerged in the field in recent years, and fast progress in this field is due, in large part, to an active dialog between Drosophila geneticists and mammalian signalers. The overwhelming interest of researchers in the function of the Hippo pathway in stem cells and cancer prompted us to seek a larger forum. At the Keystone Symposia meeting on The Hippo Tumor Suppressor Network we aim to: (i) Define why YAP and TAZ function as either oncogenes or tumor suppressors; (ii) Identify membrane complexes, which activate the Hippo pathway in mammals, as the orthology with the fly receptors is not clear; (iii) Define targets for small molecule inhibitors and activators within pathway components based on structured modules, including WW, PDZ and SARAH domains. The meeting will be unique in bringing together Drosophila geneticists, basic and clinical cancer researchers, and the stem cell research community. We anticipate that this meeting will help to consolidate the emerging field and have an impact on development of new cancer therapies.
CME Information
Over the past several years, the Hippo tumor suppressor pathway has emerged as a complex signaling network that has significant implications for our understanding of the molecular mechanisms of cancer development and stem cell biology. The main effectors of this pathway, YAP and TAZ, are transcriptional co- activators, which act as stemness factors and potent oncogenes. Recent studies have revealed that abnormal expression of components of the network can lead to cancer. Therefore, the pathway and its networking molecules are attractive targets for the development of cancer drugs and unconventional therapeutic interventions. Several paradoxes have emerged in the field in recent years, and fast progress in this field is due, in large part, to an active dialog between Drosophila geneticists and mammalian signalers. The overwhelming interest of researchers in the function of the Hippo pathway in stem cells and cancer prompted us to seek a larger forum. At the Keystone Symposia meeting on The Hippo Tumor Suppressor Network we aim to: (i) Define why YAP and TAZ function as either oncogenes or tumor suppressors; (ii) Identify membrane complexes, which activate the Hippo pathway in mammals, as the orthology with the fly receptors is not clear; (iii) Define targets for small molecule inhibitors and activators within pathway components based on structured modules, including WW, PDZ and SARAH domains. The meeting will be unique in bringing together Drosophila geneticists, basic and clinical cancer researchers, and the stem cell research community. We anticipate that this meeting will help to consolidate the emerging field and have an impact on development of new cancer therapies.
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, MAY 19
08:00—09:00
Welcome and Keynote Address
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*
Joseph L. Kissil,
The Scripps Research Institute, USA
Kun-Liang Guan,
University of California, San Diego, USA
Regulation of YAP/TAZ in the Hippo Pathway by G-Protein Coupled Receptor Signaling
Regulation of YAP/TAZ in the Hippo Pathway by G-Protein Coupled Receptor Signaling
09:00—11:30
Membrane and Upstream Signals
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*
Nicolas Tapon,
Cancer Research UK London Research Institute, UK
Helen McNeill,
Samuel Lunenfeld Research Institute, Canada
YAP and Fat Cadherins in Kidney Development
YAP and Fat Cadherins in Kidney Development
Fernando D. Camargo,
Children's Hospital Boston, USA
Hippo/YAP Signaling in Somatic Stem Cells
Hippo/YAP Signaling in Somatic Stem Cells
Tony Pawson,
Samuel Lunenfeld Research Institute, Canada
Regulation of Rho GTPases and Kinases in Hippo Signaling
Regulation of Rho GTPases and Kinases in Hippo Signaling
Jacob J. Adler,
Indiana University School of Medicine, USA
Short Talk: Amot Adapts the Ubiquitin Ligase AIP4 to Inhibit YAP Signaling and Cell Growth
Short Talk: Amot Adapts the Ubiquitin Ligase AIP4 to Inhibit YAP Signaling and Cell Growth
Isabel Serrano,
British Columbia Cancer Research Center, Canada
Short Talk: Integrin-Liked Kinase (ILK) Is a Critical Regulator of the Hippo/YAP Signaling Pathway
Short Talk: Integrin-Liked Kinase (ILK) Is a Critical Regulator of the Hippo/YAP Signaling Pathway
17:00—19:00
Hippo in Flies and Mammals: Orthology and Diversity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Helen McNeill,
Samuel Lunenfeld Research Institute, Canada
*
Yosef Shaul,
Weizmann Institute of Science, Israel
Duojia D.J. Pan,
Johns Hopkins University School of Medicine, USA
Control of Organ Size and Tumorigenesis by the Hippo Signaling Pathway
Control of Organ Size and Tumorigenesis by the Hippo Signaling Pathway
Nicolas Tapon,
Cancer Research UK London Research Institute, UK
Screening for New Hippo Tumor Suppressor Pathway Regulators
Screening for New Hippo Tumor Suppressor Pathway Regulators
Jeffrey Schindler,
Massachusetts Institute of Technology, USA
Short Talk: Determining the Role of Merlin Isoforms in Upstream Regulation of YAP
Short Talk: Determining the Role of Merlin Isoforms in Upstream Regulation of YAP
08:00—11:15
Junctional Complexes and the Hippo Pathway
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Filippo G. Giancotti,
Memorial Sloan-Kettering Cancer Center, USA
*
Sabrina Strano,
Regina Elena National Cancer Institute, Italy
Joseph L. Kissil,
The Scripps Research Institute, USA
The Role of Angiomotins and Merlin in Regulation of the Hippo Pathway
The Role of Angiomotins and Merlin in Regulation of the Hippo Pathway
Wan Jin Hong,
Institute of Molecular and Cell Biology, Singapore
Angiomotins as Substrates of Hippo Core Kinases
Angiomotins as Substrates of Hippo Core Kinases
Yosef Shaul,
Weizmann Institute of Science, Israel
Why Crowded Cell Cultures Are Radioresistant: A Direct Cross-Talk between Hippo and DNA Damage Response Pathways
Why Crowded Cell Cultures Are Radioresistant: A Direct Cross-Talk between Hippo and DNA Damage Response Pathways
Hiroshi Sasaki,
Kumamoto University, Institute of Molecular Embryology and Genetics, Japan
Mechanisms of Position-Dependent Specification of Cell Fates in Preimplantation Embryos
Mechanisms of Position-Dependent Specification of Cell Fates in Preimplantation Embryos
Georgina C. Fletcher,
Cancer Research UK, UK
Short Talk: Positive Feedback and Mutual Antagonism Combine to Polarize Crumbs in the Drosophila Follicle Cell Epithelium
Short Talk: Positive Feedback and Mutual Antagonism Combine to Polarize Crumbs in the Drosophila Follicle Cell Epithelium
Bernhard Schermer,
University Hospital of Cologne, Germany
Short Talk: Nephrocystin Proteins Control Nuclear Translocation and Activation of YAP/TAZ Implicating Deregulated Hippo Signaling in the Pathogenesis of Cystic Kidney Disease and Related Ciliopathies
Short Talk: Nephrocystin Proteins Control Nuclear Translocation and Activation of YAP/TAZ Implicating Deregulated Hippo Signaling in the Pathogenesis of Cystic Kidney Disease and Related Ciliopathies
17:00—19:00
Hippo Network in Organ Size Control
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Kenneth Irvine,
Rutgers University, USA
*
Giovanni Blandino,
Regina Elena Cancer Institute, Italy
Junichi Sadoshima,
University of Medicine and Dentistry of New Jersey, USA
Coordinated Regulation of Autophagy and Apoptosis by Mst1 in Cardiomyocytes
Coordinated Regulation of Autophagy and Apoptosis by Mst1 in Cardiomyocytes
Georg A. Halder,
Katholieke Universiteit Leuven, Belgium
Mask Is Required for the Activity of the Hippo Pathway Effector Yki/YAP
Mask Is Required for the Activity of the Hippo Pathway Effector Yki/YAP
Stefano Piccolo,
University of Padua, Italy
Regulation of TAZ and YAP by Wnt Signaling and Cell Shape
Regulation of TAZ and YAP by Wnt Signaling and Cell Shape
Diane D. Shao,
Harvard Medical School, USA
Short Talk: Genome-Scale Expression Screen Reveals Role for YAP1 in KRAS Oncogenic Addiction
Short Talk: Genome-Scale Expression Screen Reveals Role for YAP1 in KRAS Oncogenic Addiction
08:00—11:15
Deregulation of Hippo Pathway in Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Georg A. Halder,
Katholieke Universiteit Leuven, Belgium
*
Duojia D.J. Pan,
Johns Hopkins University School of Medicine, USA
Kieran Harvey,
Peter MacCallum Cancer Centre, Australia
Control of Tissue Growth by the Hippo Pathway
Control of Tissue Growth by the Hippo Pathway
Yael Aylon,
Weizmann Institute of Science, Israel
The Lats2-p53 Tumor Suppressor Axis
The Lats2-p53 Tumor Suppressor Axis
Giovanni Blandino,
Regina Elena Cancer Institute, Italy
Crosstalk between p53 Family and YAP in DNA Damage and Senescence
Crosstalk between p53 Family and YAP in DNA Damage and Senescence
Filippo G. Giancotti,
Memorial Sloan-Kettering Cancer Center, USA
Molecular Underpinnings of Merlin-Mediated Tumor Suppression in Mammals
Molecular Underpinnings of Merlin-Mediated Tumor Suppression in Mammals
Cathie M. Pfleger,
Mount Sinai School of Medicine, USA
Short Talk: Dietary Alcohol Enhances Tissue Overgrowth Associated with Loss of Hippo Signaling But Not Over-Expression of Yorkie
Short Talk: Dietary Alcohol Enhances Tissue Overgrowth Associated with Loss of Hippo Signaling But Not Over-Expression of Yorkie
Yiting Qiao,
Cancer Science Institute, Singapore
Short Talk: The Interplay between RUNX3 and TEADs in Gastric Cancer
Short Talk: The Interplay between RUNX3 and TEADs in Gastric Cancer
17:00—18:10
From Structure-Function Analysis to Details of the Mechanisms that Govern Hippo Signaling
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*
Fernando D. Camargo,
Children's Hospital Boston, USA
Xaralabos (Bob) Varelas,
Boston University, USA
Crosstalk between the Hippo and TGFbeta Pathways Directs Tumor-Initiating Signals
Crosstalk between the Hippo and TGFbeta Pathways Directs Tumor-Initiating Signals
Marius Sudol,
Weis Center for Research, USA
Hippo Pathway as the WW Domain-Mediated Network of Signals
Hippo Pathway as the WW Domain-Mediated Network of Signals
18:10—19:00
Closing Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Joseph Avruch,
Massachusetts General Hospital, USA
The Mammalian Hippo Tumor Suppressor Pathway-Negative Regulation of the YAP Oncogene
The Mammalian Hippo Tumor Suppressor Pathway-Negative Regulation of the YAP Oncogene
*Session Chair †Speaker invited, not yet responded.
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