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This meeting took place in 2013


Here are the related meetings in 2015:
Epigenetics and Cancer (A4)
Epigenomics (Z2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Epigenetic Marks and Cancer Drugs (C8)


Organizer(s) Ali Shilatifard
March 20—25, 2013
Eldorado Hotel & Spa • Santa Fe, New Mexico USA
Abstract Deadline: Nov 19, 2012
Late Abstract Deadline: Dec 21, 2012
Scholarship Deadline: Nov 19, 2012
Early Registration Deadline: Jan 22, 2013

Sponsored by AVEO Oncology, Celgene Corporation, Genentech, Inc. and H3 Biomedicine Inc.

Summary of Meeting:
To regulate the precise pattern of gene expression during development, eukaryotic cells have evolved to have multifaceted transcriptional machineries and chromatin states. The DNA within the eukaryotic nucleus is found in complex with histone proteins to form nucleosomes, the basic unit of chromatin. Detailed structural studies demonstrated that the N-terminal tails of each of the histones protrude outward beyond the gyres of DNA and can be posttranslationally modified. The modifications of histone tails could provide a landing pad for a diverse array of transcription factors, chromatin remodelers, and DNA-interacting proteins to regulate gene expression. Translocations and/or mutations in chromatin-modifying machineries that perturb the timing and/or pattern of gene expression can result in the pathogenesis of human diseases including cancer. Recent studies demonstrate that the misregulation of several of the histone-modifying enzymes can contribute to changes in the epigenetic state leading to disease development. Therefore, both the scientific and the pharmaceutical communities have concentrated on identifying the molecular function for many of the histone-modifying machineries and are in the process of developing small molecular inhibitors of their activities in the hope of their use for targeted therapeutics of cancer. This Keystone Symposia meeting on Epigenetic Marks and Cancer Drugs serves as a much-needed platform for bringing both the scientific and the pharmaceutical communities together to discuss recent advances in this very exciting area.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, MARCH 20

16:00—20:00
Arrival and Registration


THURSDAY, MARCH 21

07:00—08:00
Breakfast

08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Stuart L. Schreiber, HHMI/Harvard University, USA
Linking Genetic Features of Human Cancers and Histone-Modifying Enzymes for Future Cancer Therapies

09:00—11:00
Chromosomes, Chromatin and Transcription I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Shelley L. Berger, University of Pennsylvania, USA

B. Franklin Pugh, Pennsylvania State University, USA
Hemisomes and Nucleosomal Assymeetry across the Saccharomyces cerevisiae Genome

Patrick Cramer, Max Planck Institute for Biophysical Chemistry, Germany
New Insights into the Mechanisms of Transcription and its Regulation

Anne Brunet, Stanford University, USA
Epigenetic Regulation of Aging

Siavash K. Kurdistani, University of California, Los Angeles, USA
Short Talk: Regulation of Intracellular pH by Histone Acetylation

Alejandro Vaquero, Bellvitge Institute for Biomedical Research, Spain
Short Talk: SirT2 Regulates Cell Cycle Progression and Genome Stability by Modulating Mitotic Deposition of H4K20 Methylation

09:40—10:00
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

14:30—16:30
Workshop 1

* Mary Ann Osley, University of New Mexico School of Medicine, USA

Masami Horikoshi, University of Tokyo, Japan
“Modification Web” and “Signal Router” Theories on Histone Modification System and their Application to Development of Cancer Drugs

Cigall Kadoch, Dana-Farber Cancer Institute and Harvard Medical School, USA
Reversible Disruption of mSWI/SNF-Like BAF Complexes by the SS18-SSX Oncogenic Fusion in Synovial Sarcoma

Gary Hon, University of California, San Diego, USA
Whole Genome Bisulfite Sequencing Reveals Tissue-Specific DNA Methylation in a Normal Mouse

Tal H. Salz, University of Florida, USA
hSET1 Regulates the Canonical Wnt-Signaling Pathway and Plays a Role in Colorectal Cancer

Eleni Maniati, Queen Mary University of London, UK
Functional Effect of Aberrant Mll2/3 Gene Expression in Pancreatic Cancer

Cheng-Fu Kao, Academia Sinica, Taiwan
H2B Monoubiquitylation Regulates the Replication Stress Response

16:30—17:00
Coffee Available

17:00—19:00
Chromosomes, Chromatin and Transcription II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ali Shilatifard, Northwestern University Feinberg School of Medicine, USA

Richard A. Young, Whitehead Institute for Biomedical Research, USA
Connecting Transcription, Chromatin and Cancer

Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Epigenetic Genome Control by RNAi and Heterochromatin Proteins

Anne Schaefer, Mount Sinai School of Medicine, USA
Short Talk: PRC2 is Essential for Adult Brain Function

Johnathan R. Whetstine, Massachusetts General Hospital, USA
Short Talk: Looking at Cancer through the Eyes of Histone Demethylases

Charles Lin, Dana-Farber Cancer Institute, USA
Short Talk: Transcription Amplification in Tumor Cells with Elevated c-Myc

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


FRIDAY, MARCH 22

07:00—08:00
Breakfast

08:00—11:00
Polycomb and Trithorax in Gene Expression and Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Shiv I. S. Grewal, NCI, National Institutes of Health, USA

Ali Shilatifard, Northwestern University Feinberg School of Medicine, USA
Chromatin Modifications, Transcriptional Elongation Control and Childhood Leukemia

Danny F. Reinberg, HHMI/New York University, USA
PRC1 in Drosophila and Mammals

Jürg Müller, Max Planck Institute of Biochemistry, Germany
Molecular Mechanisms of the Polycomb System

Peter Verrijzer, Erasmus University Medical Center, Netherlands
Antagonism between Polycomb and Trithorax in Development and Disease

Kami Ahmad, Harvard Medical School, USA
Short Talk: The Chromatin Configuration of Polycomb Response Elements (PREs) Define Epigenetic States

Francois Fuks, University of Brussels, Belgium
Short Talk: Molecular Basis of Tets: In Search of their Protein Partners

Zhiguo Zhang, Mayo Clinic, USA
Short Talk: Histone Modifications Regulate DNA Replication Coupled Nucleosome Assembly

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Histone Marks in Development and Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ramin Shiekhattar, University of Miami, USA

Thomas Jenuwein, Max Planck Institute of Immunobiology and Epigenetics, Germany
Making and Breaking Heterochromatin

Tony Kouzarides, University of Cambridge, UK
Chromatin Modification Pathways and their Role in Cancer

Alexander (Sasha) Tarakhovsky, Rockefeller University, USA
Signaling Control of Epigenetic Fitness

Shelley L. Berger, University of Pennsylvania, USA
Chromatin Landscape in Cellular Aging

Mary Ann Osley, University of New Mexico School of Medicine, USA
Short Talk: The Histone Modification Landscape of Quiescent Yeast Cells Formed during Chronological Aging

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


SATURDAY, MARCH 23

07:00—08:00
Breakfast

08:00—11:00
DNA Methylation in Development and Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* B. Franklin Pugh, Pennsylvania State University, USA

Yi Zhang, HHMI/Harvard Medical School, Children's Hospital Boston, USA
Role of Tet1-Mediated 5mC Oxidation in PGC Reprogramming and Meiosis

Peter A. Jones, Van Andel Institute, USA
DNA Methylation and Cancer Therapy

Jean-Pierre Issa, Temple University School of Medicine, USA
Epigenetic Reprogramming as Cancer Therapy

Roger A. Greenberg, University of Pennsylvania Perelman School of Medicine, USA
Short Talk: Acetylation Determines Double-Strand Break Repair Choice and Response to PARP Inhibition

Gregory David, New York University School of Medicine, USA
Short Talk: Epigenetic Regulation of Inflammation Modulates KRas-Driven Pancreatic Cancer Progression

Diana Hargreaves, Stanford University, USA
Short Talk: BAF Complexes Cooperate with Topoisomerase II alpha to Decatenate DNA

Li-Jung Juan, Academia Sinica, Taiwan
Short Talk: Mechanisms of DNA Demethylation Enzymes TET Family Proteins in Suppressing Tumor Malignancy

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Enhancers and ncRNAs in Development and Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Peter Verrijzer, Erasmus University Medical Center, Netherlands

Ramin Shiekhattar, University of Miami, USA
Brave New World of Noncoding RNA

Jeannie T. Lee, Massachusetts General Hospital, USA
Xist RNA in the Establishment and Maintenance of X Chromosome Inactivation

Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Inheritance and Reprogramming of Heterochromatin with Small RNA

Celso A. Espinoza, Ludwig Institute for Cancer Research, USA
Short Talk: Architectural Studies of Intramolecular Interactions between Enhancers and Promoters via ChIP-HiC

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


SUNDAY, MARCH 24

07:00—08:00
Breakfast

08:00—11:00
Myc, Transcriptional Regulation and Development
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Kapil N. Bhalla, Houston Methodist Hospital Research Institute, USA

Robert N. Eisenman, Fred Hutchinson Cancer Research Center, USA
Cooperative Transcriptional Regulation of Metabolism Mediated by the Myc-Max/MondoA-Mlx Network

Michael D. Cole, Dartmouth Medical School, USA
An Epigenetic Model for Myc Autoregulation and Gene Repression

Bruno Amati, IFOM-IEO Campus, Italy
Epigenome and Transcriptome Regulation in Myc-Driven Tumors

James E. Bradner, Dana-Farber Cancer Institute, USA
Targeting Gene Regulatory Pathways

Lin-Feng Chen, University of Illinois at Urbana-Champaign, USA
Short Talk: Brd4 Maintains Constitutively Active NF-kappaB in Cancer Cells by Binding to Acetylated RelA

Junwei Shi, Cold Spring Harbor Laboratory, USA
Short Talk: Collaboration between the BAF Complex and Brd4 Maintains Myc Expression in Leukemia

Katherine A. Jones, The Salk Institute, USA
Short Talk: Beta-Catenin Ubiquitylation and Release from LEF-1/TCF by a Novel alpha-Catenin:APC Complex

09:20—09:40
Coffee Break

 
On Own for Lunch and Recreation

14:30—16:30
Workshop 2

* Roger A. Greenberg, University of Pennsylvania Perelman School of Medicine, USA

Klaas Kok, University Medical Center Groningen, Netherlands
The Impact of SETD2-Inactivating Mutations and Loss of H3K36 Trimethylation on Gene Expression in Clear Cell Renal Cell Carcinoma Progenitor Cells

Hao A. Duong, Harvard Medical School, USA
Temporal Coordination of Histone De-Acetylase and Methyl-Transferase in Circadian Transcriptional Repression

Seung Hyuk Choi, The Salk Institute, USA
Role for alpha-Catenin in APC-Mediated Repression at Wnt Target Genes

Emily A. Clough, NIDDK, National Institutes of Health, USA
The H4K16 Histone Acetyltransferase Chameau Is a Putative Target of Doublesex

Anil K. Panigrahi, Baylor College of Medicine, USA
Dissecting the Role of H3K79 Methylation in Transcription Elongation and Leukemia

16:30—17:00
Coffee Available

17:00—19:15
Transcription, Chromatin and Epigenetics in Cancer Therapy
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Robert N. Eisenman, Fred Hutchinson Cancer Research Center, USA

Laurie A. Boyer, Massachusetts Institute of Technology, USA
Developmental Transitions in Heart Development

Robert J. Gould, Epizyme, Inc., USA
Drugging the Human Methylome: Discovery and Characterization of Inhibitors of Protein Methyltransferases for the Treatment of Genetically Defined Cancers

Patrick Trojer, Constellation Pharmaceuticals, USA
Targeting Histone Lysine Methylation in Cancer

Marie Classon, Genentech, Inc., USA
Short Talk: Chromatin Modifications and the Establishment of Drug-Tolerance

Kapil N. Bhalla, Houston Methodist Hospital Research Institute, USA
Short Talk: Highly Effective Combination of LSD1 Antagonist SP-2509 and Pan-HDAC Inhibitor Against Human AML Cells

19:15—20:15
Social Hour with Lite Bites

20:00—23:00
Entertainment


MONDAY, MARCH 25

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

AVEO Oncology Celgene Corporation
Genentech, Inc. H3 Biomedicine Inc.

We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Epizyme, Inc.
Novus Biologicals, Inc. ROCKLAND IMMUNOCHEMICALS, Inc.
Zymo Research Corporation
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA177246-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Constellation Pharmaceuticals


Epizyme, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676