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This meeting took place in 2013


Here are the related meetings in 2015:
Mitochondria, Metabolism and Heart Failure (J5)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Mitochondria, Metabolism and Myocardial Function — Basic Advances to Translational Studies (B1)


Organizer(s) Michael N. Sack and Roberta A. Gottlieb
February 3—8, 2013
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 3, 2012
Late Abstract Deadline: Oct 31, 2012
Scholarship Deadline: Oct 3, 2012
Early Registration Deadline: Dec 3, 2012

Supported by the Directors' Fund

Summary of Meeting:
The most common causes of heart failure are coronary artery disease, high blood pressure and diabetes. Mitochondrial perturbations have been associated with heart failure itself and with most of the other preceding risk factors. In some cases mitochondrial dysfunction may play a causal role while in others mitochondria are a central target responsible for organ dysfunction. Understanding mitochondrial pathophysiology and identifying ways to ameliorate mitochondrial dysfunction are critical to therapy for cardiovascular disease. The continuous contractile function of the heart is required to sustain blood oxygenation, systemic circulation and nutrient supply to the body. This activity results in an unrelenting demand for energy production that is predominantly supported by mitochondrial oxidative phosphorylation. It is therefore not surprising that the mitochondria comprise about one third of cardiomyocyte volume, exhibit a promiscuous capacity to use energy substrates and possess biologic plasticity to maintain bioenergetic homeostasis. The centrality of mitochondria to sustain cardiac bioenergetics is additionally reflected in the development of cardiac pathology when mitochondria are dysfunctional. To counter this, a myriad of innate adaptive mitochondrial homeostatic programs are being identified. In the last two decades the investigations into mitochondrial biology with ever-increasing discovery technologies have enabled the scientific community to identify many novel programs controlling mitochondrial and metabolic function. The objectives of this conference are to: 1) Highlight the emerging adaptive programs identified in the heart orchestrating optimal mitochondrial homeostasis; 2) Review how the emerging risk factors of obesity and diabetes disrupt mitochondrial and cardiac function; and 3) Explore emerging metabolic targets for therapeutic interventions to modulate mitochondrial and metabolic perturbations associated with cardiac pathology.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 3

16:00—20:00
Arrival and Registration

MONDAY, FEBRUARY 4

07:00—08:00
Breakfast
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Michael N. Sack, NHLBI, National Institutes of Health, USA

* Roberta A. Gottlieb, Cedars-Sinai Medical Center, USA

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Selective Autophagy and the Cellular Energetic Balance

09:00—12:00
The Biology of Mitochondrial Homeostatic Regulatory Programs and Cardiac Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* E. Dale Abel, University of Iowa, Carver College of Medicine, USA

* Anne A. Knowlton, University of California, Davis, USA

Roberta A. Gottlieb, Cedars-Sinai Medical Center, USA
Mitophagy and Biogenesis

Gökhan S. Hotamisligil, Harvard University, USA
Interactions between ER Stress and Mitochondrial Dysfunction in Metabolic Control

Kinya Otsu, King's College London, UK
Mitochondrial DNA in the Development of Cardiac Inflammation and Dysfunction

Joseph A. Hill, University of Texas Southwestern Medical Center, USA
Autophagy in Cardiac Plasticity

Abhinav Diwan, Washington University School of Medicine, USA
Short Talk: Transcription Factor EB Coordinates Mitochondrial Autophagy with Biogenesis

09:40—10:00
Coffee Break
12:00—13:00
Poster Setup
13:00—22:00
Poster Viewing
12:00—16:30
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:00
Regulation of Redox Stress in Cardiovascular Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Lorrie A. Kirshenbaum, University of Manitoba, St. Boniface Hospital Research Center, Canada

* Satoaki Matoba†, Kyoto Prefectural University of Medicine, Japan

Junichi Sadoshima, Rutgers New Jersey Medical School, USA
Alternative Autophagy Mediates Mitochondrial Clearance in Response to Energy Stress

Gerald S. Shadel, Yale University, USA
Mitochondrial Stress Signaling in Disease and Aging

John W. Elrod, Temple School of Medicine, USA
Building a Roadmap of Necrotic Cell Death

Jan Dudek, University of Goettingen, Germany
Short Talk: Cardiolipin Deficiency Affects Respiratory Chain Organization and Function

19:00—20:00
Social Hour with Lite Bites
19:30—22:00
Poster Session 1

TUESDAY, FEBRUARY 5

07:00—08:00
Breakfast
08:00—11:00
Metabolic Modulation in the Pathogenesis and Treatment of Cardiac Hypertrophy and Heart Failure
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jason R. B. Dyck, University of Alberta, Canada

* P. Christian Schulze, Columbia University, USA

Jan F. C. Glatz, Maastricht University, Netherlands
Novel Signaling Pathways Regulating Substrate Switching in the Heart

Martin E. Young, University of Alabama at Birmingham, USA
The Circadian Clock, Metabolic Regulation and Cardiac Pathology

Gary D. Lopaschuk, University of Alberta, Canada
Modulation of Malonyl-CoA and Cardiac Metabolic Consequences

William C. Stanley, University of Sydney, Australia
Mitochondrial Pathology in Heart Failure: Novel Therapeutic Approaches

Konstantinos Drosatos, Temple University School of Medicine, USA
Short Talk: PPARgamma Activation Prevents Cardiac Dysfunction in Sepsis via Stimulation of Energy Production and Prevention of Mitochondrial Loss

09:20—09:40
Coffee Break
11:00—13:00
Poster Setup
13:00—22:00
Poster Viewing
11:00—16:30
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:00
Emerging Regulatory Programs in the Control of Mitochondria and Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Robert S. Balaban, NHLBI, National Institutes of Health, USA

* Johan Auwerx, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland

Elizabeth Murphy, NHLBI, National Institutes of Health, USA
S-Nitrosylation and Regulation of the Mitochondrial Stress Response

Michael N. Sack, NHLBI, National Institutes of Health, USA
Acetylation in the Control of Mitochondrial Homeostasis and Mitophagy

Eric N. Olson, University of Texas Southwestern Medical Center, USA
A Myocardial Metabolic Axis Controlled by Med13

Christoph Koentges, University of Freiburg, Germany
Short Talk: SIRT3 Deficiency Impairs Mitochondrial and Contractile Function But Not Post-Ischemic Contractile Recovery in the Heart

19:00—20:00
Social Hour with Lite Bites
19:30—22:00
Poster Session 2

WEDNESDAY, FEBRUARY 6

07:00—08:00
Breakfast
08:00—11:00
Nutrient Stressors and the Modulation of Cardiovascular Function
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Michael N. Sack, NHLBI, National Institutes of Health, USA

* Edward Miller, Boston University, USA

Orian S. Shirihai, Boston University, USA
Mitochondrial Dynamics in Quality Control and Bioenergetics

E. Dale Abel, University of Iowa, Carver College of Medicine, USA
Obesity and Fatty Acid-Mediated Disruption of Cardiac Mitochondrial Function and Autophagy

Jason R. B. Dyck, University of Alberta, Canada
Caloric Restriction, Resveratrol and Cardiovascular Function

Daniel P. Kelly, Sanford-Burnham Medical Research Institute, USA
Myocyte Lipotoxicity Screening to Delineate Mechanisms and Drug Targets

P. Christian Schulze, Columbia University, USA
Short Talk: Inhibition of de novo Ceramide Synthesis Improves Myocardial Function in Chronic Ischemic Cardiomyopathy

09:20—09:40
Coffee Break
11:00—13:00
Poster Setup
13:00—22:00
Poster Viewing
11:00—16:30
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:00
Emerging Technologies to Characterize Mitochondrial and Metabolic Functioning
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Daniel P. Kelly, Sanford-Burnham Medical Research Institute, USA

* Elizabeth Murphy, NHLBI, National Institutes of Health, USA

Robert S. Balaban, NHLBI, National Institutes of Health, USA
Systems Biology of the Mitochondria Coordinated Moldulation of Complex Activity

Peipei Ping, University of California, Los Angeles, USA
Large-Scale Proteomics Characterization of Cardiac Mitochondria: Molecular Function and Dynamics

Christopher B. Newgard, Duke University Medical Center, USA
Metabolomics Applied to Mitochondrial Dysfunction in Metabolic Diseases

Miguel A. Aon, Johns Hopkins University, USA
Short Talk: Metabolomics Unveils the Adverse Metabolic Remodeling Elicited by Hyperglycemia and Mitochondrial Dysfunction, and its Relief by Palmitate in T2DM Heart

19:00—20:00
Social Hour with Lite Bites
19:30—22:00
Poster Session 3

THURSDAY, FEBRUARY 7

07:00—08:00
Breakfast
08:00—11:00
Novel Programs Controlling Mitochondria and Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Martin E. Young, University of Alabama at Birmingham, USA

* Peter A. Crawford, Sanford Burnham Medical Research Institute, USA

Jared Rutter, University of Utah, USA
Mitochondrial Pyruvate Metabolism and Human Disease

Christine Des Rosiers, Montreal Heart Institute (MHI), Canada
Metabolomics: What Have We Learned from Heart Failure Patients?

Johan Auwerx, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland
Mitochondrial Function and Aging

Thomas Langer, CECAD Research Center, Germany
Mitochondrial Quality Control and Phospholipid Metabolism

Catherine Le, Colorado State University, USA
Short Talk: Integration of Respirometry and Metabo-Proteomic Profiling Reveal an Unexpected Mechanism of Cardiac Mitochondrial Dysfunction in Taz-Deficient Mice

09:20—09:40
Coffee Break
11:00—16:30
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:00
Clinical Studies to Advance Biological Insight and Therapeutic Targets
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Roberta A. Gottlieb, Cedars-Sinai Medical Center, USA

* Seigo Izumo†, Takeda Pharmaceutical Company, Japan

Lawrence H. Young, Yale University, USA
AMPK Regulates Mitochondrial Function during Myocardial Ischemia-Reperfusion

Patrick Schrauwen, Maastricht University Medical Center, Netherlands
Lipotoxicity, Mitochondria and Cardiac Function: Insight from Human Clinical Intervention Studies

Anthony J. Muslin, Novartis Institutes for BioMedical Research, USA
Akt2 Regulates Cardiac Structure and Function

Yan Liu, Massachusetts General Hospital, Harvard Medical School, USA
Short Talk: Discovering Cardioprotective Drugs with Zebrafish

19:00—19:15
Closing Remarks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Michael N. Sack, NHLBI, National Institutes of Health, USA

Roberta A. Gottlieb, Cedars-Sinai Medical Center, USA

19:15—20:15
Social Hour with Lite Bites
20:00—23:00
Entertainment

FRIDAY, FEBRUARY 8

 
Departure

*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support for this conference from:


American Heart Association's Council on Basic Cardiovascular Sciences

Seahorse Bioscience, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676