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Fairmont The Queen Elizabeth Floorplan

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This meeting took place in 2013


Here are the related meetings in 2015:
Autophagy (E6)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Autophagy, Inflammation and Immunity (B4)


Organizer(s) Herbert (Skip) W. Virgin, Beth Levine and Gökhan S. Hotamisligil
February 17—22, 2013
Fairmont The Queen Elizabeth • Montreal, QC Canada
Abstract Deadline: Oct 16, 2012
Late Abstract Deadline: Nov 15, 2012
Scholarship Deadline: Oct 16, 2012
Early Registration Deadline: Dec 13, 2012

Sponsored by AbbVie Inc., Cell Research, EMD Millipore, Shire Human Genetic Therapies and Vertex Pharmaceuticals Incorporated

Summary of Meeting:
Autophagy is a lysosomal degradation pathway by which eukaryotic cells break down their own components to adapt to nutrient deprivation. In multicellular organisms, autophagy and autophagy proteins also play a key role in the orchestration of diverse aspects of cellular and organismal responses to multiple dangerous stimuli, including infection. Thus, autophagy and autophagy proteins represent a key nexus within the cell through which multiple cellular and organismal stresses are integrated. This emerging understanding has led to exciting recent advances that, together, begin to paint a picture of how autophagy and autophagy proteins are involved in multiple diseases. Of particular interest, recent studies reveal a crucial role for autophagy pathways and proteins in immunity and inflammation. They balance the beneficial and detrimental effects of immunity and inflammation, and thereby may protect against infectious, autoimmune, and inflammatory diseases. The time is therefore ripe for a Keystone Symposia meeting that brings together researchers from a variety of fields to focus on emerging themes and concepts in 'Autophagy, Inflammation, and Immunity'. Key advances in this area include the identification of signaling pathways that regulate autophagy, inflammation, and immunity and the finding that inflammation, immunity and autophagy are tightly, and reciprocally, intertwined. The goal of this meeting is to relate the cell biology and signaling pathways that regulate autophagy and autophagy proteins to fundamental aspects of immunity and inflammation, as well as to diseases associated with alterations in these processes such as autoimmunity, infection, cancer, diabetes, the metabolic syndrome, and cardiovascular disease.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 17

16:00—20:00
Arrival and Registration

Alcove

MONDAY, FEBRUARY 18

07:30—08:30
Breakfast

Hochelaga 1-3
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Le Grand Salon
Douglas R. Green, St. Jude Children's Research Hospital, USA
Autophagy and the Immunological Impact of Dying Cells

09:30—11:45
Mechanisms of Autophagy
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Le Grand Salon
* Beth Levine, University of Texas Southwestern Medical Center, USA

Noboru Mizushima, University of Tokyo, Graduate School of Medicine, Japan
Molecular Mechanisms of Formation of the Autophagosome and its Fusion with the Lysosome

Sharon A. Tooze, London Research Institute, UK
Initiation of the Autophagosome Membrane

Mark J. Daly, Harvard Medical School, USA
Autophagy Genes in Human Disease

Takanori Otomo, The Scripps Research Institute, USA
Short Talk: Structure of the Human ATG12~ATG5 Conjugate Required for LC3 Lipidation in Autophagy

10:10—10:30
Coffee Break

Hochelaga 1-3
11:45—13:00
Poster Setup

Hochelaga 1-3
13:00—22:00
Poster Viewing

Hochelaga 1-3
11:45—16:30
On Own for Lunch and Recreation

14:30—16:30
Workshop

Le Grand Salon
* Ken H. Cadwell, New York University School of Medicine, USA

* Eun-Kyeong Jo, Chungnam National University, South Korea

Jamaal Benjamin, University of Texas Southwestern Medical Center, USA
Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine

Juliane Becher, Santa Lucia Foundation, Italy
AMBRA1 is Upregulated during T Cell Stimulation to Avoid Excessive Proliferation and Stabilizes the Regulatory T Cell Phenotype

Tiffany Horng, Harvard School of Public Health, USA
A Critical Role for Calcium Mobilization in Activation of the NLRP3 Inflammasome

Rhea M. Sumpter, Jr., University of Texas Southwestern Medical Center, USA
FANCC Is a Novel Selective Autophagy Factor

Audrey Esclatine, INSERM, France
A Viral Protein Represses Autophagy by Interacting with the Protein Kinase PKR

You-Wen He, Duke University Medical Center, USA
Inositol Phosphatases and Class I PI3K Synergize to Induce Autophagy in T Cells

Jane Symington, Washington University in St. Louis, USA
ATG16L1 Regulates Host Defense to Uropathogenic Escherichia coli Infection by Controlling Macrophage-Mediated Bacterial Clearance

Ingo Schmitz, Otto von Guericke University Magdeburg, Germany
The Gadd45beta-MEKK4-p38 Pathway Mediates Phosphorylation of Atg5 and Autophagy Inhibition

16:30—17:00
Coffee Available

Hochelaga 1-3
17:00—19:00
Selective Autophagy and Infection
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Le Grand Salon
* Sharon A. Tooze, London Research Institute, UK

Michael J. Ragusa, NIDDK, National Institutes of Health, USA
Short Talk: Architecture of the Atg17 Complex as a Scaffold for Autophagosome Biogenesis

Ivan Dikic, Goethe University Medical School, Germany
Structure-Function Analysis of Selective Autophagy Receptors

Jeffery S. Cox, University of California, San Francisco, USA
The Ubiquitin Ligase PARKIN Is Required for Autophagy and Host Resistance to Intracellular Pathogens

Yuuki Fujiwara, National Institute of Neuroscience, NCNP, Japan
Short Talk: A Novel Type of Autophagy that Targets RNA

19:00—20:00
Social Hour with Lite Bites

Hochelaga 1-3
19:30—22:00
Poster Session 1

Hochelaga 1-3

TUESDAY, FEBRUARY 19

07:30—08:30
Breakfast

Hochelaga 1-3
08:00—08:30
Poster Setup

Hochelaga 1-3
08:30—17:00
Poster Viewing

Hochelaga 1-3
08:30—11:45
Autophagy and Infection
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Le Grand Salon
* Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA

Pascale Cossart, Institut Pasteur, France
Autophagy and the Cytoskeleton: Links Revealed by Cytosolic Bacteria

Robert L. Modlin, University of California, Los Angeles, USA
Vitamin D, Autophagy and Tuberculosis

Beth Levine, University of Texas Southwestern Medical Center, USA
A Candidate Therapeutic Autophagy-Inducing Peptide for Viral Infections

Fulvio Reggiori, University Medical Centre Utrecht, Netherlands
Coronaviruses Hijack LC3-I-Positive EDEMosome Membranes for Replication

Augustine H. Choy, Yale University, USA
Short Talk: The Legionella Effector RavZ Inhibits Host Autophagy through Irreversible Atg8 Deconjugation

Eun-Kyeong Jo, Chungnam National University, South Korea
Short Talk: AMP-Activated Protein Kinase Activator AICAR Activates Innate Host Defense through Antibacterial Autophagy and Mitochondrial Biogenesis

09:50—10:10
Coffee Break

Hochelaga 1-3
11:45—12:30
Lunch

Hochelaga 1-3
12:30—15:00
Poster Session 2

Hochelaga 1-3
15:00—15:30
Coffee Available

Hochelaga 1-3
15:30—17:30
Autophagy and Immunity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Le Grand Salon
* Augustine Choi, Harvard Medical School, USA

Herbert W. Virgin, Washington University School of Medicine, USA
Autophagy Proteins and Macrophage-Based Immunity to Infection

Vojo Deretic, University of New Mexico Health Sciences Center, USA
Autophagy Protects Against Active Tuberculosis by Suppressing Bacterial Burden and Inflammation

Tatsuya Saitoh, Osaka University, Japan
Regulation of Inflammatory Innate Immune Response by Autophagy-Related Protein

Amanda Marchiando, New York University School of Medicine, USA
Short Talk: Atg16L1 Mutation Protects Against Bacterial Gastroenteritis

17:30—
On Own for Dinner


WEDNESDAY, FEBRUARY 20

07:30—08:30
Breakfast

Hochelaga 1-3
08:30—11:45
Autophagy and the Inflammasome
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Le Grand Salon
* Lora V. Hooper, University of Texas Southwestern Medical Center, USA

Gökhan S. Hotamisligil, Harvard University, USA
Metabolic Inflammasome and Mechanisms of Immunometabolic Integration

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
NLRs, Inflammasome and Autophagy

Augustine Choi, Harvard Medical School, USA
Mitophagy, Mitochondria and the Inflammasome

Nobuhiko Kayagaki, Genentech, Inc., USA
The Non-Canonical Inflammasome and Caspase 11

Catherine Gidley Weindel, Tufts University Sackler School of Biomedical Sciences, USA
Short Talk: Autophagy: A Dichotomous Player in TLR7-Mediated Autoimmunity

Miguel A. Sanjuan, Medimmune/Astrazeneca, USA
Short Talk: LC3-Associated Phagocytosis Mediates IFN-alpha Secretion in Response to DNA-Immune Complexes

09:50—10:10
Coffee Break

Hochelaga 1-3
11:45—13:00
Poster Setup

Hochelaga 1-3
13:00—22:00
Poster Viewing

Hochelaga 1-3
11:45—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Hochelaga 1-3
17:00—19:00
Autophagy and Inflammatory Signaling
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Le Grand Salon
* Eileen P. White, Rutgers University, USA

Masaaki Komatsu, Tokyo Metropolitan Institute of Medical Science, Japan
Selective Autophagy Is Coupled to Nrf2-Keap1 Pathway

Jorge Moscat, Sanford-Burnham Medical Research Institute, USA
p62: A Multifunctional Signaling Molecule in Inflammation and Metabolism

Sergio Grinstein, Hospital for Sick Children, Canada
Phospholipids Mediate Immune Surveillance by Macrophages and Dendritic Cells

Christina Bell, Université de Montréal, Canada
Short Talk: Quantitative Proteomics Reveals the Specific Autophagic Elimination of Mitochondria in TNF-alpha Activated Macrophages

19:00—20:00
Social Hour with Lite Bites

Hochelaga 1-3
19:30—22:00
Poster Session 3

Hochelaga 1-3

THURSDAY, FEBRUARY 21

07:30—08:30
Breakfast

Hochelaga 1-3
08:30—11:45
Autophagy in Metabolic and Inflammatory Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Le Grand Salon
* Vojo Deretic, University of New Mexico Health Sciences Center, USA

Mark J. Czaja, Albert Einstein College of Medicine, USA
Autophagy and Lipid Metabolism

Clay F. Semenkovich, Washington University School of Medicine, USA
Autophagy, Atherosclerosis, and the Metabolic Syndrome

Lora V. Hooper, University of Texas Southwestern Medical Center, USA
Intestinal Epithelial Cell Autophagy and the Microbiota

Thaddeus S. Stappenbeck, Washington University School of Medicine, USA
Autophagy Proteins and Regulation of Intestinal Homeostasis

Assaf Rudich, Ben-Gurion University, Israel
Short Talk: Transcriptional Basis for Inflammatory Activation of Adipose Tissue Autophagy in Obesity

Donna M. Conlon, Columbia University, USA
Short Talk: Inhibition of VLDL Secretion by Apolipoprotein B Antisense Oligonucleotides Stimulates Autophagy of Endoplasmic Reticulum in the Liver, Preventing Steatosis

09:50—10:10
Coffee Break

Hochelaga 1-3
11:45—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Hochelaga 1-3
17:00—19:15
Autophagy in Inflammatory Disease and Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Le Grand Salon
* Noboru Mizushima, University of Tokyo, Graduate School of Medicine, Japan

Ramnik Xavier, Massachusetts General Hospital and Broad Institute, USA
Autophagy Genes and Inflammatory Bowel Disease

Heinz Jungbluth, Newcomen Centre at St. Thomas', St. Thomas' Hospital, UK
Vici Syndrome, a Novel Multisystem Disorder Associated with Defective Autophagy

Eileen P. White, Rutgers University, USA
Autophagy in Tumor Cell Survival

Guido Kroemer, Institut Gustave Roussy, France
Autophagy-Dependent Anti-Tumor Immunity

19:15—20:15
Social Hour with Lite Bites

Hochelaga 1-3
20:00—23:00
Entertainment

Hochelaga 1-3

FRIDAY, FEBRUARY 22

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

AbbVie Inc. Cell Research
EMD Millipore Shire Human Genetic Therapies
Vertex Pharmaceuticals Incorporated
 

We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Tourisme Montréal

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK084688-04

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Tokyo Metropolitan Institute of Medical Science


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676