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Beaver Run Resort Floorplan

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This meeting took place in 2013



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Metabolic Control of Inflammation and Immunity (A9)


Organizer(s) Vishva M. Dixit, Douglas R. Green and Maya Saleh
January 21—26, 2013
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Sep 24, 2012
Late Abstract Deadline: Oct 24, 2012
Scholarship Deadline: Sep 24, 2012
Early Registration Deadline: Nov 19, 2012

Sponsored by EMD Millipore

Summary of Meeting:
Inflammation and immune responses are energetically costly, as are the infections that elicit them. The interplay of these metabolic demands are complex, and frequently ‘hard-wired’ into the responses. An emerging field is illuminating this interplay of metabolism, inflammation and immunity, and therefore there couldn’t be a better time to have a meeting where scientists who study inflammation and immunity in this context encounter their "metabolic" counterparts from other fields. IL-1b and IL-18 are potent proinflammatory cytokines that are synthesized as pro-forms and matured by the aspartate-specific cysteine protease, IL-1-converting enzyme (ICE or caspase-1). The caspase-1 activation platform, or inflammasome, contains one of a number of "sensor" proteins that respond to a bewildering array of inflammatory insults, including the presence of intracellular pathogens, disruption of membrane integrity and mitochondrial reactive oxygen species. Many of these sensors, but not all, are members of the NOD family of intracellular proteins. There are upwards of 30 such proteins encoded in the human genome. This molecular apparatus generates active caspase-1 responsible not only for the proteolytic maturation of IL-1b and IL-18, but also pyroptosis, a pro-inflammatory mode of cell death. While mutations in the NOD sensors have been associated with relatively rare periodic fever syndromes, there is newfound interest in them with the realization that one member (NOD2) is the most commonly mutated gene in inflammatory bowel disease (IBD). Further, there has been the recent insight that mutations in other IBD susceptibility genes, such as ATG16L, lead to activation of the inflammasome, possibly due to a deficit in autophagic efficiency and consequent increase in reactive oxygen species that trigger a NOD sensor. Superimposed on this exciting insight has been the understanding that the NOD sensors also respond to metabolic stress, the hallmark of disease states such as Type 2 diabetes. Inflammasome-mediated inflammation likely drives insulin resistance, as suggested by a recent clinical trial where neutralizing IL-1b led to a decrease in systemic markers of inflammation and improved glycemic control. Other recently emergent data concerns the interplay of metabolism and the innate and adaptive immune responses. Together, these have dramatically underscored the importance of inflammation and immunity in metabolic disease states.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, JANUARY 21

16:00—19:30
Arrival and Registration
18:15—19:15
Refreshments
19:15—20:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Vishva M. Dixit, Genentech, Inc., USA

* Douglas R. Green, St. Jude Children's Research Hospital, USA

Richard A. Flavell, HHMI, Yale University School of Medicine, USA
Inflammasome, Microbiota and Disease


TUESDAY, JANUARY 22

07:00—08:00
Breakfast
08:00—11:15
Metabolism and Signaling
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA

Jaemyoung Suh, The Salk Institute for Biological Studies, USA
Nuclear Receptor Control of Rhythm and Metabolism

Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Regulation of Cell Metabolism to Support Proliferation

Ajay Chawla, University of California, San Francisco, USA
Innate Control of Metabolism

Mitchell A. Lazar, University of Pennsylvania School of Medicine, USA
Battle of the Master Regulators PPARgamma and PU.1

Holly Legault, Biogen Idec, USA
Short Talk: IRAK4 Inhibition Results in Amelioration of Disease in Diet-Induced Obesity Model

Shannon M. Reilly, University of Michigan, USA
Short Talk: An Inhibitor of the Protein Kinases TBK1/IKKepsilon Improves Obesity-Related Metabolic Dysfunctions

09:20—09:40
Coffee Break
11:15—13:00
Poster Setup
13:00—22:00
Poster Viewing
11:15—16:30
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:15
The Inflammasome and Metabolism I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Maya Saleh, McGill University, Canada

Vishva M. Dixit, Genentech, Inc., USA
Non-Canonical Inflammasome Activation Targets Caspase-11

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
Fatty Acid-Induced NLRP3 Inflammasome

Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Mediators of Inflammatory Responses

Eicke Latz, University of Bonn, Germany
Inflammasome Activation in Atherosclerosis and Alzheimer's Disease

19:15—20:15
Social Hour with Lite Bites
19:30—22:00
Poster Session 1

WEDNESDAY, JANUARY 23

07:00—08:00
Breakfast
08:00—11:15
The Inflammasome and Metabolism II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA

Charles A. Dinarello, University of Colorado Health Sciences Center, USA
How Does the IL-1 Family Control its Own Members?

Luke A. J. O'Neill, Trinity College Dublin, Ireland
Metabolic Control of Innate Immunity and Inflammation

Marc Y. Donath, University Hospital Basel, Switzerland
Islet Inflammation in Type 2 and Diabetes

Vishwa Deep Dixit, Yale University, USA
Inflammasomes and the Regulation of Healthspan

Menno P. J. de Winther, Academic Medical Center, Netherlands
Short Talk: Myeloid IL-10R1 Deficiency Attenuates Atherosclerosis in Hyperlipidemic LDLR-/- Mice

Dov Ben Ballak, Radboud University Medical Centre, Netherlands
Short Talk: A Novel IL-1 Family Member: Anti-Inflammatory Actions of IL-37 Protect Against Obesity-Induced Inflammation and Insulin Resistance

09:20—09:40
Coffee Break
11:15—13:00
Poster Setup
13:00—22:00
Poster Viewing
11:15—16:30
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:15
Inflammation and Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Luke A. J. O'Neill, Trinity College Dublin, Ireland

Gökhan S. Hotamisligil, Harvard University, USA
Mechanisms of Metabolic Inflammation and ER Dysfunction

Tiffany Horng, Harvard School of Public Health, USA
Short Talk: A Critical Role for Calcium Mobilization in Activation of the NLRP3 Inflammasome

Michael Karin, University of California, San Diego, USA
NF-kappaB, Inflammation and Metabolism

Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Targeting Inflammation in Insulin Resistance and Diabetes

Greg R. Steinberg, McMaster University, Canada
Short Talk: AMP-Activated Protein Kinase (AMPK) Links Lipid Metabolism with Innate Immunity and the Therapeutic Effects of Salicylate

19:15—20:15
Social Hour with Lite Bites
19:30—22:00
Poster Session 2

THURSDAY, JANUARY 24

07:00—08:00
Breakfast
08:00—11:15
NOD, Microbiota and Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Kate A. Fitzgerald, University of Massachusetts Medical School, USA

Maya Saleh, McGill University, Canada
Innate Detection Mechanisms and Inflammation in Obesity and Type 2 Diabetes

Stephen E. Girardin, University of Toronto, Canada
Invasive Bacteria, mTOR and Amino Acid Starvation

Herbert W. Virgin, Washington University School of Medicine, USA
Autophagy Proteins in Inflammation and Disease

Gabriel Nuñez, University of Michigan, USA
Metabolic Control of Pathogen Eradication by the Gut Microbiota

Jonathan D. Schertzer, McMaster University, Canada
Short Talk: Immunometabolism of NOD1 and NOD2: Yin and Yang of Insulin Resistance during Obesity

Janelle S. Ayres, The Salk Institute, USA
Short Talk: Microbiota Control of Wasting Associated with Inflammation and Infection

09:20—09:40
Coffee Break
11:15—16:30
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:00
Mitochondria, Inflammation and Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gabriel Nuñez, University of Michigan, USA

Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Cytosolic Immune Surveillance

Fraser Soares, University of Toronto, Canada
Short Talk: Investigating the Role of NLRX1 in Innate Immunity

Richard M. Siegel, NIAMS, National Institutes of Health, USA
Mitochondrial ROS: Fuel for the Fire of Autoinflammation

Chih-hao Chang, Washington University in St. Louis, USA
Short Talk: Specific Control of T Cell Effector Function by Warburg Metabolism

19:00—20:00
Social Hour with Lite Bites

FRIDAY, JANUARY 25

07:00—08:00
Breakfast
08:00—11:15
Metabolic Control of Adaptive Immunity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Michael Karin, University of California, San Diego, USA

Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
HIF1 in the Treg/Th17 Axis

Jonathan D. Powell, Johns Hopkins University School of Medicine, USA
A New Model of T Cell Differentiation based on Metabolism

Douglas R. Green, St. Jude Children's Research Hospital, USA
No Free Lunches: LC3-Associated Phagocytosis, a Process that Links Phagocytosis and Autophagy, and its Possible Roles in Inflammation, Innate Immunity, and Homeostasis

Jeffrey C. Rathmell, Duke University, USA
Glucose Metabolism in T Cell Activation and CD4 Subsets

Laura J. Dixon, Cleveland Clinic, USA
Short Talk: Role of Caspase-1 in High Fat-Induced Non-Alcoholic Steatohepatitis in Mice

Tim Hendrikx, Maastricht University, Netherlands
Short Talk: Caspase-1 as a Novel Target for the Detection and Treatment of Non-Alcoholic Steatohepatitis

09:20—09:40
Coffee Break
11:15—16:30
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:00
Cell Death, Immunity and Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Drew M. Pardoll, Johns Hopkins University School of Medicine, USA

Kodi S. Ravichandran, University of Virginia, USA
Apoptotic Cell Clearance and the Phagocyte Metabolism

Nika N. Danial, Dana-Farber Cancer Institute, USA
A Role for Bcl2 Family Members in Diabetes

Rachel J. Roth Flach, University of Massachusetts Medical School, USA
Short Talk: MAP4K4 Is a Novel Regulator of Vascular Inflammation in Insulin Resistance and Atherosclerosis

Da Young Oh, University of California, San Diego, USA
Short Talk: Differential Role of Kupffer Cell vs. Recruited Hepatic Macrophage on Liver Insulin Resistance

19:00—20:00
Social Hour with Lite Bites
20:00—23:00
Entertainment

SATURDAY, JANUARY 26

 
Departure

*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

EMD Millipore

We gratefully acknowledge additional support for this conference from:

AdipoGen International R&D Systems, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK084688-04

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