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This meeting took place in 2013
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Meeting Details
Stem Cell Regulation in Homeostasis and Disease (B7)
Organizer(s) Sean J. Morrison, Iannis Aifantis and Yukiko M. Yamashita
February 24 - March 1, 2013
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: October 24, 2012
Late Abstract Deadline: November 27, 2012
Scholarship Deadline: October 24, 2012
Early Registration Deadline: December 18, 2012
Sponsored by Cell Research, EMD Millipore and Life Technologies Corporation
CME Information
Summary of Meeting:
Stem cell regulation is critical for tissue development and maintenance. Defects in stem cell regulatory mechanisms are thought to contribute to many diseases, including congenital diseases, cancer and diseases of aging; therefore, these mechanisms are of interest to a diverse audience. Recent stem cell meetings have tended to focus on the interface of stem cells and cancer, or on reprogramming. This has left the majority of stem cell biologists with fewer forums that focus on the basic mechanisms that regulate stem cell function. And yet critical advances are occurring that give glimpses of new molecular mechanisms that regulate stem cell and tissue homeostasis. The goal of this Keystone Symposia meeting is to identify new and common mechanisms governing stem cell function and differentiation across tissues and across species. To address this, the meeting is organized into sessions according to distinct modes of stem cell regulation, without regard to species, in a way that might highlight novel paradigms of regulation. Speakers were chosen, first and foremost, based on research quality, and then to cover broad areas of stem cell research. The program for this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact. The focus on stem cell regulation in general provides an umbrella under which speakers from different areas of research (e.g., developmental biology, tissue growth and homeostasis, regeneration, cancer and aging) are being brought together in an environment that is highly conducive to cross-talk.
CME Information
Stem cell regulation is critical for tissue development and maintenance. Defects in stem cell regulatory mechanisms are thought to contribute to many diseases, including congenital diseases, cancer and diseases of aging; therefore, these mechanisms are of interest to a diverse audience. Recent stem cell meetings have tended to focus on the interface of stem cells and cancer, or on reprogramming. This has left the majority of stem cell biologists with fewer forums that focus on the basic mechanisms that regulate stem cell function. And yet critical advances are occurring that give glimpses of new molecular mechanisms that regulate stem cell and tissue homeostasis. The goal of this Keystone Symposia meeting is to identify new and common mechanisms governing stem cell function and differentiation across tissues and across species. To address this, the meeting is organized into sessions according to distinct modes of stem cell regulation, without regard to species, in a way that might highlight novel paradigms of regulation. Speakers were chosen, first and foremost, based on research quality, and then to cover broad areas of stem cell research. The program for this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact. The focus on stem cell regulation in general provides an umbrella under which speakers from different areas of research (e.g., developmental biology, tissue growth and homeostasis, regeneration, cancer and aging) are being brought together in an environment that is highly conducive to cross-talk.
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, FEBRUARY 24
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
09:00—11:45
Pluripotency and Disease Modeling
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Alysson R. Muotri,
University of California, San Diego, USA
Modeling Autism Spectrum Disorders Using Human Neurons
Modeling Autism Spectrum Disorders Using Human Neurons
Evangelos Kiskinis,
Harvard Stem Cell Institute, USA
Short Talk: Motor Neurons Generated from ALS Patient-Specific iPS Cells Recapitulate Key Aspects of the Disease
Short Talk: Motor Neurons Generated from ALS Patient-Specific iPS Cells Recapitulate Key Aspects of the Disease
Deepak Srivastava,
Gladstone Institute of Cardiovascular Disease, USA
Direct Reprogamming of Fibroblasts to Cardiomyocyte-Like Cells
Direct Reprogamming of Fibroblasts to Cardiomyocyte-Like Cells
Danwei Huangfu,
Memorial Sloan-Kettering Cancer Institute, USA
Short Talk: Homologous Recombination DNA Repair Genes Play a Critical Role in Reprogramming to a Pluripotent State
Short Talk: Homologous Recombination DNA Repair Genes Play a Critical Role in Reprogramming to a Pluripotent State
Kathrin Plath,
University of California, Los Angeles, USA
Understanding Mechanisms of Reprogramming
Understanding Mechanisms of Reprogramming
Thea D. Tlsty,
University of California, San Francisco, USA
Extensive Plasticity in Rare Somatic Cells Found in Adult Human Tissue
Extensive Plasticity in Rare Somatic Cells Found in Adult Human Tissue
17:00—19:00
Stem Cells and Regeneration
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*
Allan C. Spradling,
HHMI/Carnegie Institute, USA
Alejandro Sánchez Alvarado,
HHMI/Stowers Institute for Medical Research, USA
The Developmental Biology of a Totipotent, Adult Stem Cell Population
The Developmental Biology of a Totipotent, Adult Stem Cell Population
Trista E. North,
Beth Israel Deaconess Medical Center, USA
Metabolic Regulation of Hematopoietic Stem Cell Formation and Function
Metabolic Regulation of Hematopoietic Stem Cell Formation and Function
Bruce M. Wang,
Stanford University, USA
Short Talk: Wnt Signaling and the Stem Cell Niche in Progenitor Cell Mediated Liver Regeneration
Short Talk: Wnt Signaling and the Stem Cell Niche in Progenitor Cell Mediated Liver Regeneration
David T. Scadden,
Massachusetts General Hospital and Harvard University, USA
The Pysiological Function of Mesenchymal Stem Cells
The Pysiological Function of Mesenchymal Stem Cells
08:00—11:15
Niche Regulation of Stem Cell Function. Session sponsored by Development.
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
NOTE: Support for these organized-selected speakers generously provided by this journal.
*
David T. Scadden,
Massachusetts General Hospital and Harvard University, USA
Sean J. Morrison,
HHMI/University of Texas Southwestern Medical Center, USA
Hematopoietic Stem Cells and Lymphoid Progenitors Occupy Distinct Niches in the Bone Marrow
Hematopoietic Stem Cells and Lymphoid Progenitors Occupy Distinct Niches in the Bone Marrow
Myriam Grunewald,
Hebrew University, Israel
Short Talk: The Vascular Endothelial Growth Factor Generates a Fully Functional Hematopoietic Stem Cells Niche in the Spleen
Short Talk: The Vascular Endothelial Growth Factor Generates a Fully Functional Hematopoietic Stem Cells Niche in the Spleen
Fiona Doetsch,
Columbia University, USA
Stem Cells and their Niche in the Adult Mammalian Brain
Stem Cells and their Niche in the Adult Mammalian Brain
Brett Shook,
Yale University, USA
Extrinsic Regulation of Skin Stem Cells
Extrinsic Regulation of Skin Stem Cells
Peter Andersen,
Johns Hopkins School of Medicine, USA
Short Talk: Lineage-Specific Mosaicism Identifies Renewing Cardiac Progenitor Cells and their Niche
Short Talk: Lineage-Specific Mosaicism Identifies Renewing Cardiac Progenitor Cells and their Niche
17:00—19:00
Emerging Regulatory Mechanisms
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*
Alejandro Sánchez Alvarado,
HHMI/Stowers Institute for Medical Research, USA
Iannis Aifantis,
HHMI/New York University School of Medicine, USA
Regulation of Stem Cell Pluripotency and Cellular Reprogramming by the Ubiquitin-Proteasome System
Regulation of Stem Cell Pluripotency and Cellular Reprogramming by the Ubiquitin-Proteasome System
K. J. Patel,
MRC Laboratory of Molecular Biology, UK
Mechanisms to Prevent DNA Damage by Metabolites in Stem Cells
Mechanisms to Prevent DNA Damage by Metabolites in Stem Cells
Yukiko M. Yamashita,
University of Michigan, Ann Arbor, USA
Asymmetric Chromosome Segregation during Stem Cell Division in Drosophila Male Germline
Asymmetric Chromosome Segregation during Stem Cell Division in Drosophila Male Germline
Jean-Pierre Etchegaray,
Massachusetts General Hospital Harvard Medical School, USA
Short Talk: The Histone Deacetylase SIRT6 Plays a Critical Role in Mouse Embryonic Stem Cell Differentiation
Short Talk: The Histone Deacetylase SIRT6 Plays a Critical Role in Mouse Embryonic Stem Cell Differentiation
08:00—11:15
RNA Regulation and Stem Cells
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*
Yukiko M. Yamashita,
University of Michigan, Ann Arbor, USA
Haifan Lin,
Yale University, USA
The Yb Body, a Novel Organelle Involved in Niche Signaling of Germline Stem Cell Self-Renewal
The Yb Body, a Novel Organelle Involved in Niche Signaling of Germline Stem Cell Self-Renewal
Robert H. Blelloch,
University of California, San Francisco, USA
MicroRNA Regulation of Pluripotency
MicroRNA Regulation of Pluripotency
Richard I. Gregory,
Harvard Medical School, USA
Lin28, Let-7 and Stem Cells
Lin28, Let-7 and Stem Cells
Robert A.J. Signer,
University of Texas Southwestern Medical Center, USA
Short Talk: The Rate of Protein Translation Regulates Hematopoietic Stem Cell Self-Renewal
Short Talk: The Rate of Protein Translation Regulates Hematopoietic Stem Cell Self-Renewal
Noelia Urban,
National Institute for Medical Research, UK
Short Talk: Degradation of Ascl1 by Huwe1 Is Essential for Stem Cells Maintenance and Neurogenesis in the Adult Hippocampus
Short Talk: Degradation of Ascl1 by Huwe1 Is Essential for Stem Cells Maintenance and Neurogenesis in the Adult Hippocampus
Judith E. Kimble,
University of Wisconsin-Madison, USA
Notch Signaling and an RNA Regulatory Network Control C. elegans Germline Stem Cells
Notch Signaling and an RNA Regulatory Network Control C. elegans Germline Stem Cells
17:00—19:00
Stem Cells and Cancer
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*
Iannis Aifantis,
HHMI/New York University School of Medicine, USA
Richard J. Gilbertson,
St. Jude Children's Research Hospital, USA
Organism-Wide Mapping of Stem Cells and Cancer Origins
Organism-Wide Mapping of Stem Cells and Cancer Origins
Austin Gurney,
OncoMed Pharmaceuticals, USA
Targeting Stem Cell Pathways in Cancer
Targeting Stem Cell Pathways in Cancer
Luis F. Parada,
University of Texas Southwestern Medical Center, USA
A Defined Subpopulation of Glioblastoma Cells Is Responsible for Tumor Recurrence following Chemotherapy
A Defined Subpopulation of Glioblastoma Cells Is Responsible for Tumor Recurrence following Chemotherapy
Hans-Guido Wendel,
Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Differential MYC Requirement in Healthy and Malignant Tissues Derived from Induced-Pluripotent Stem (iPS) Cells
Short Talk: Differential MYC Requirement in Healthy and Malignant Tissues Derived from Induced-Pluripotent Stem (iPS) Cells
08:00—11:15
The Aging of Mitotic Cells
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*
Alexandra Joyner,
Memorial Sloan-Kettering Cancer Center, USA
Andrew G. Dillin,
University of California, Berkeley, USA
Protein Quality Control in Stem Cells and Aging
Protein Quality Control in Stem Cells and Aging
Jan M. van Deursen,
Mayo Clinic, USA
Stem and Progenitor Cell Senescence in Aging
Stem and Progenitor Cell Senescence in Aging
Norman E. Sharpless,
University of North Carolina School of Medicine, USA
Expression of Markers of Senescence, Aging and Self-Renewal
Expression of Markers of Senescence, Aging and Self-Renewal
Elizabeth A. Pollina,
Stanford University, USA
Short Talk: Discovering Novel Regulators of Adult Neural Stem Cell Aging Using a Chromatin Signature
Short Talk: Discovering Novel Regulators of Adult Neural Stem Cell Aging Using a Chromatin Signature
Tohru Itoh,
IMCB, University of Tokyo, Japan
Short Talk: FGF7 Is a Functional Niche Signal Required for Stimulation of Adult Liver Progenitor Cells that Support Liver Regeneration
Short Talk: FGF7 Is a Functional Niche Signal Required for Stimulation of Adult Liver Progenitor Cells that Support Liver Regeneration
15:00—16:30
Workshop: Emerging Insights into Stem Cells and Niches
*
Iannis Aifantis,
HHMI/New York University School of Medicine, USA
Eirini P. Papapetrou,
University of Washington, USA
Modeling Myelodysplasia Using Human Pluripotent Stem Cells
Modeling Myelodysplasia Using Human Pluripotent Stem Cells
Gabrielle Kardon,
University of Utah, USA
Wnt/beta-Catenin Signaling Is Active, But Not Required for Stem Cell Function during Muscle Regeneration
Wnt/beta-Catenin Signaling Is Active, But Not Required for Stem Cell Function during Muscle Regeneration
E. Camilla Forsberg,
University of California, Santa Cruz, USA
Robo4-Mediated Vascular Integrity Promotes Hematopoietic Stem Cell Engraftment
Robo4-Mediated Vascular Integrity Promotes Hematopoietic Stem Cell Engraftment
Valentina Greco,
Yale School of Medicine, USA
Cellular and Signaling Mechanisms that Regulate Hair Follicle Stem Cells by Live Imaging
Cellular and Signaling Mechanisms that Regulate Hair Follicle Stem Cells by Live Imaging
17:00—19:00
Self-Renewal Pathways and Disease
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*
Norman E. Sharpless,
University of North Carolina School of Medicine, USA
Alexandra Joyner,
Memorial Sloan-Kettering Cancer Center, USA
Differential Regulation of Adult Stem Cells by Sonic Hedgehog Signaling
Differential Regulation of Adult Stem Cells by Sonic Hedgehog Signaling
Fernando D. Camargo,
Children's Hospital Boston, USA
Hippo/YAP Signaling in Stem Cells, Regeneration and Cancer
Hippo/YAP Signaling in Stem Cells, Regeneration and Cancer
Kai Kessenbrock,
University of California, San Francisco, USA
Short Talk: A Novel Role for Matrix Metalloproteinases In Regulating Mammary Stem Cell Function via the Wnt Signaling Pathway
Short Talk: A Novel Role for Matrix Metalloproteinases In Regulating Mammary Stem Cell Function via the Wnt Signaling Pathway
Ulrich Steidl,
Albert Einstein College of Medicine, USA
Short Talk: Special AT-Rich Sequence-Binding Protein 1 (Satb1) Regulates Hematopoietic Stem Cell Fate
Short Talk: Special AT-Rich Sequence-Binding Protein 1 (Satb1) Regulates Hematopoietic Stem Cell Fate
*Session Chair †Speaker invited, not yet responded.
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