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This meeting took place in 2013


Here are the related meetings in 2015:
Hematopoiesis (B6)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Hematopoiesis (A4)


Organizer(s) Leonard I. Zon, Stuart H. Orkin and Nancy A. Speck
January 14—19, 2013
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Sep 13, 2012
Late Abstract Deadline: Oct 16, 2012
Scholarship Deadline: Sep 13, 2012
Early Registration Deadline: Nov 13, 2012

Sponsored by Celgene Corporation

Summary of Meeting:
Hematopoiesis is the process by which hematopoietic stem cells self-renew and differentiate to form the peripheral blood lineages. This meeting seeks to develop a broad view of this process in terms of the self-renewal process, development of the hematopoietic system and differentiation. Plenary sessions will encompass the birth of hematopoietic stem cells all the way through development of mature cell lineages throughout adult life. They will include sessions on developmental hematopoiesis that will explore the birth of the blood system in embryos, sessions on adult stem cell self-renewal and sessions on stem cell niches and novel hematopoietic regulators. Particularly exciting areas of research that will be covered in the meeting include the identification of new growth factors that enhance stem cell decisions, advances in our understanding of transcription mechanisms using new genetic and genomic technologies, and new epigenetic mechanisms that regulate leukemic stem cell populations. The meeting will also address drug strategies that are being developed for clinical trials. Taken together, we anticipate that this conference will yield novel insights into the biology and potential therapeutic uses of hematopoietic stem cells and their progeny for the control of cancer and disease.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, JANUARY 14

16:00—20:00
Arrival and Registration


TUESDAY, JANUARY 15

07:00—08:00
Breakfast

08:00—11:15
Developmental Hematopoiesis Including ES and iPS to Blood
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* David Traver, University of California, San Diego, USA

Catherine Porcher, University of Oxford, UK
The SCL Complex in Haematopoiesis

Elaine A. Dzierzak, University of Edinburgh, Netherlands
Development of Adult HSCs and the Involvement of Gata2

Joanna M. Tober, University of Pennsylvania, USA
Runx1 is Required through E11.5 for Hematopoietic Progenitor and HSC Formation

Gordon M. Keller, University Health Network, MaRS Centre, Canada
Generation of Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Thierry Jaffredo, University Pierre and Marie Curie, CNRS UMR7622, France
Short Talk: In vivo Multilineage Hematopoietic Production by Bone Marrow-Derived Hemogenic Endothelium

Christopher M. Sturgeon, McEwen Centre for Regenerative Medicine, Canada
Short Talk: Human Definitive and Primitive Hematopoiesis Are Specified Simultaneously from Human Pluripotent Stem Cells

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—16:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Stem Cell Self-Renewal

* Thierry Jaffredo, University Pierre and Marie Curie, CNRS UMR7622, France

Lev Silberstein, Massachusetts General Hospital, USA
Single Cell RNA-Seq Analysis Identifies a Novel Embigin+ CD106+ Population of the Osteolineage Cells which Modulate HSPC Behavior

Dan Su, NIEHS, National Institutes of Health, USA
Chromatin State Primes Stress Specific p53-Regulated Gene Responses in Human Lymphoblastoid Cells

Saghi Ghaffari, Mount Sinai School of Medicine, USA
SIRT1 Deacetylase is Essential for Hematopoietic Stem Cell Activity via Regulation of Foxo3

Anna E. Beaudin, University of California, Santa Cruz, USA
Discovery of a Novel, Developmentally Restricted Hematopoietic Stem Cell

Eric M. Pietras, University of California, San Francisco, USA
Type I Interferons Induce Transient Proliferation and Antagonize HSC Function by Altering Interactions with the Bone Marrow Niche

Rong Lu, Stanford University, USA
Systems-Level Clonal Tracking of Mouse Hematopoietic Stem Cells in Vivo

Shalin H. Naik, Walter & Eliza Hall Institute, Australia
Diverse and Heritable Lineage Priming in Early Hematopoietic Progenitors

16:30—17:00
Coffee Available

17:00—18:40
Novel Hematopoietic Regulators
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Margaret A. Goodell, Baylor College of Medicine, USA

Leonard I. Zon, HHMI/Children's Hospital Boston, USA
The Role of Angiopoietin-like Proteins in Hematopoietic Stem Cell Development

David Traver, University of California, San Diego, USA
The Function of Junctional Adhesion Molecules in Hematopoietic Stem Cell Development

Sean J. Morrison, HHMI/University of Texas Southwestern Medical Center, USA
Haematopoietic Stem Cells and Lymphoid Progenitors Occupy Distinct Niches in the Bone Marrow

18:40—19:30
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

George Q. Daley, HHMI/Children's Hospital Boston, USA
Milestones and Barriers in HSC Production from Pluripotent Stem Cells

19:30—20:30
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


WEDNESDAY, JANUARY 16

07:00—08:00
Breakfast

08:00—11:15
Adult Stem Cell Self-Renewal and Function
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Elaine A. Dzierzak, University of Edinburgh, Netherlands

Emmanuelle Passegué, University of California, San Francisco, USA
DNA Damage in Old Hematopoietic Stem Cells

Amy J. Wagers, Harvard University, USA
Local and Systemic Regulation of Blood Stem Cell Function throughout Life

Margaret A. Goodell, Baylor College of Medicine, USA
Regulation of Hematopoietic Stem Cells by de novo DNA Methyltransferases

Daniel G. Tenen, Cancer Science Institute, Singapore
Regulation of Myeloid Transcription Factors and DNA Methylation by Noncoding RNAs

Catherine S. Spina, Boston University & Wyss Institute, USA
Short Talk: A Bone Marrow-on-a-Chip that Maintains Hematopoietic Regenerative Capacity in vitro

Jian Huang, University of Pennsylvania, USA
Short Talk: Maintenance of Hematopoietic Stem Cells through Regulation of Wnt and mTOR Pathways

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Microenvironment
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gordon M. Keller, University Health Network, MaRS Centre, Canada

David T. Scadden, Massachusetts General Hospital and Harvard University, USA
Bone Cell Governance of T Lymphopoiesis

Toshio Suda, Keio University, Japan
A Metabolic Guide to Stem Cell Homeostasis

Michael P. Cooke, Genomics Institute of the Novartis Research Foundation, USA
Regulation of HSC Self-Renewal by the Aryl Hydrocarbon Receptor

Michael D. Ginsberg, Weill Cornell Medical College, USA
Short Talk: Efficient Transcriptional Reprogramming of Mature Amniotic Cells into Vascular Niche Cells that Support Hematopoiesis

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


THURSDAY, JANUARY 17

07:00—08:00
Breakfast

08:00—11:00
Erythroid and Megakaryocyte Development
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Berthold Gottgens, Cambridge Institute for Medical Research, UK

Stuart H. Orkin, Dana-Farber Cancer Institute, USA
Regulation of Erythroid Stage Transcription and Globin Gene Switching

Christopher Thom, Children's Hospital of Philadelphia, USA
Short Talk: Trim58 is an E3 Ubiquitin Ligase that Regulates Terminal Erythropoiesis

Harvey Lodish, Whitehead Institute for Biomedical Research, USA
Regulation of the Terminal Stages of Red Cell Development

Hanna K. A. Mikkola, University of California, Los Angeles, USA
Hematopoietic Stem Cell Specification and Self-Renewal

Soraya Carrancio, Celgene, USA
Short Talk: Sotatercept, an Activin Receptor IIA (ActRIIA) Ligand Trap, Promotes Late-Stage Erythropoiesis and a Rapid Induction of Red Blood Cell Number and Hemoglobin

Jalal Ahmed, Mount Sinai School of Medicine, USA
Short Talk: Characterization of the Fetal Liver Hematopoietic Stem Cell Niche

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Differentiation of Hematopoietic Cells

* Hanna K. A. Mikkola, University of California, Los Angeles, USA

Wilson K. Clements, St. Jude Children's Research Hospital, USA
Atypical Wnt Receptor Involvement in Hematopoietic Stem Cell Specification and Leukemia

Yehudit Birger, Sheba Medical Center, Israel
Perturbation of Fetal Mega-Erythropoiesis in a Mouse Model of Down Syndrome Transient Myeloproliferative Disorder

Tiago C. Luis, Weatherall Institute of Molecular Medicine, UK
Embryonic Thymopoiesis Is Initiated by Immune-Restricted Lympho-Myeloid Progenitor Cells

Victoria R. Moignard, University of Cambridge, UK
Single Cell Gene Expression Analysis in Primary Blood Stem and Progenitor Cells Reveals Dynamic Transcriptional Network States and Identifies New Links between Key Regulators

Ryo Yamamoto, University of Tokyo, Japan
In vivo Clonal Analysis of Hematopoietic Stem Cells Unveils Novel Non-Stepwise Differentiation Pathways

Hsuan-Ting Huang, Children's Hospital Boston, USA
Suppression of chd7 Enhances Hematopoietic Development

16:30—17:00
Coffee Available

17:00—19:00
Hematopoietic Cell Differentiation and Function
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Iannis Aifantis, HHMI/New York University School of Medicine, USA

Berthold Gottgens, Cambridge Institute for Medical Research, UK
Combinatorial Transcriptional Control of Blood Stem and Progenitor Cells

Meinrad Busslinger, Research Institute of Molecular Pathology, Austria
Control of Immunoglobulin Diversity through Spatial Regulation of V(D)J Recombination

Irving L. Weissman, Stanford University, USA
Normal and Neoplastic Stem Cell

Emery H. Bresnick, University of Wisconsin School of Medicine and Public Health, USA
Short Talk: Establishing the Definitive Hematopoietic Stem/Progenitor Cell Compartment

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


FRIDAY, JANUARY 18

07:00—08:00
Breakfast

08:00—11:15
Leukemogenesis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Harvey Lodish, Whitehead Institute for Biomedical Research, USA

Ross L. Levine, Memorial Sloan-Kettering Cancer Center, USA
Role of Mutations in Epigenetic Regulators in Pathogenesis of Myeloid Malignancies

Scott A. Armstrong, Memorial Sloan-Kettering Cancer Center, USA
Molecular Characterization of Leukemia Stem Cell Development

Iannis Aifantis, HHMI/New York University School of Medicine, USA
Short Talk: Ubiquitin-Mediated Protein Half-Life and its Impact on Leukemia-Initiating Cell Function

John E. Dick, Princess Margaret Cancer Centre, Canada
Toward Unification of the Genetic and Cancer Stem Cell Models of Leukemia

Wei Tong, Children's Hospital of Philadelphia, USA
Investigation of Novel Signaling Pathways in Hematopoietic Stem Cells

Anwesha Dey, Genentech Inc., USA
Short Talk: Bap1: An Emerging Player in Epigenetics, Cancer, and Hematopoiesis

09:00—09:20
Coffee Break

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Lymphoid
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Meinrad Busslinger, Research Institute of Molecular Pathology, Austria

Avinash S. Bhandoola, CCR, National Cancer Institute, USA
Establishing T Cell Identity: T-Cells and T-Cell like Innate Cells

Sten Eirik W. Jacobsen, University of Oxford, UK
Emergence of Immune Restricted Lympho-Myeloid Progenitors Prior to Definitive Hematopoietic Stem Cells

Ellen V. Rothenberg, California Institute of Technology, USA
Sequential Operation of Gene Regulatory Networks in the Stem Cell to T Cell Commitment Process

Louise M. Treanor, St. Jude Children's Research Hospital, USA
Short Talk: Genetic Lesions that Drive Early T-Cell Precursor Leukemia in Multipotent Primitive Thymocytes

19:00—20:00
Social Hour with Lite Bites

20:00—23:00
Entertainment


SATURDAY, JANUARY 19

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Celgene Corporation

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL115837-01

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