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Granlibakken Resort Floorplan

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This meeting took place in 2014



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Cilia, Development and Human Disease (C1)


Organizer(s) Elizabeth Petri Henske, Jeremy F. Reiter and Joel Rosenbaum
March 2—7, 2014
Granlibakken Resort • Tahoe City, California USA
Discounted Abstract Deadline: Nov 4, 2013
Abstract Deadline: Dec 4, 2013
Scholarship Deadline: Nov 4, 2013
Discounted Registration Deadline: Jan 7, 2014

Supported by the Directors' Fund

Summary of Meeting:
Our understanding of the cilium and ciliary-based signaling continue to rapidly advance, providing novel insights into diseases in which ciliary defects appear to play a dominant role in disease initiation ("ciliopathies"), as well as diseases such as cancer in which ciliary defects appear to play a critical role in disease progression. Increasingly, an understanding of ciliary disease mechanisms is leading to novel therapeutic strategies. This Keystone Symposia meeting brings together leaders in basic mechanisms, translational research, and clinical research, with the objective of bridging the gaps between basic discovery and human disease.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 2

16:00—20:00
Arrival and Registration
18:00—20:00
Light Meal - Provided by Granlibakken

MONDAY, MARCH 3

07:00—08:00
Breakfast
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Kathryn V. Anderson, Memorial Sloan-Kettering Cancer Center, USA
Regulation of Cilia Structure and Cilia Formation during Mouse Development

09:00—11:30
Ciliary Structure, Formation and Resorption
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Joel Rosenbaum, Yale University, USA

* Bradley K. Yoder, University of Alabama at Birmingham, USA

Wallace Marshall, University of California, San Francisco, USA
The Flagellar Length Control System

Paul A. Lefebvre, University of Minnesota, USA
The Role of Flagellar and Cytoplasmic Protein Kinases in the Control of Flagellar Length in Chlamydomonas

Cheryl L. Walker, Texas A&M Health Science Center, USA
Targeting of Aurora Kinase A (AURKA) by the von Hippel-Lindau (VHL) Tumor Suppressor in Maintenance of the Primary Cilia

Christine Insinna Kettenhofen, NCI-Frederick National Laboratory, USA
Short Talk: EHD and Rab Proteins Coordinate the Initiation of Ciliary Membrane Assembly

Mustafa k. Khokha, Yale University, USA
Short Talk: The Heterotaxy Gene, GALNT11, Glycosylates Notch to Orchestrate Cilia Type and Laterality

09:40—10:00
Coffee Break
11:30—13:00
Poster Setup
Bay
13:00—22:00
Poster Viewing
Bay
11:30—17:00
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—18:45
Left-Right Patterning and Hedgehog Signaling
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gregory J. Pazour, University of Massachusetts Medical School, USA

* Michael J. Caplan, Yale University, USA

Bradley K. Yoder, University of Alabama at Birmingham, USA
A Role for the Mammalian DRC Protein Gas8 in Left-Right Asymmetry and Cilia Motility

Yingzi Yang, NHGRI, National Institutes of Health, USA
Planar Cell Polarity of Node Cells and Symmetry Breaking

Bomi Jung, Institute of Diabetes and Regeneration, Germany
Short Talk: Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation

18:45—19:45
Dinner
19:30—22:00
Poster Session 1
Bay
20:00—21:00
Social Hour
Bay

TUESDAY, MARCH 4

07:00—08:00
Breakfast
08:00—11:15
Vesicle Transport and Trafficking
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jean Bennett, University of Pennsylvania, USA

* Michel R. Leroux, Simon Fraser University, Canada

Peter K. Jackson, Stanford University, USA
Linking Cilia to Insulin Signaling in Preadipocytes

Oliver Blacque, University College Dublin, Ireland
New Transport Regulators at Cilia Base

Gregory J. Pazour, University of Massachusetts Medical School, USA
IFT25 and IFT27 Are Required for Maintenance of the Ciliary Signaling Compartment

Markus Delling, Children's Hospital Boston; Harvard, USA
The Primary Cilium is a Specialized Calcium Signaling Organelle

Ellen J. Ezratty, Rockefeller University, USA
Short Talk: An Emerging Role for Arl/Arf Family GTPases in Regulation of Cilia Function during Notch Signaling and Epidermal Differentiation

John A. Martignetti, Mount Sinai School of Medicine, USA
Short Talk: Inactivation of the Ciliary Protein CEP19 Results in a Novel Morbid Obesity Syndrome in Humans and Mice

09:20—09:40
Coffee Break
11:15—13:00
Poster Setup
Bay
13:00—22:00
Poster Viewing
Bay
11:15—17:00
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:00
Therapeutic Advances in Treating Ciliopathies
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Elizabeth Petri Henske, Brigham and Women's Hospital, USA

Jean Bennett, University of Pennsylvania, USA
Ciliopathies Causing Blindness as Gene Therapy Targets: Progress and Prospects

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
The Dual Interplay between Ciliogenesis and Autophagy

Frederic J. de Sauvage, Genentech, Inc., USA
Innate and Acquired Resistance to Hedgehog Pathways Inhibitors

Ching-Hwa Sung, Cornell University, USA
Short Talk: Light Regulates the Ciliary Protein Transport and Outer Segment Disc Renewal of Mammalian Photoreceptors

19:00—20:00
Dinner
19:30—22:00
Poster Session 2
Bay
20:00—21:00
Social Hour
Bay

WEDNESDAY, MARCH 5

07:00—08:00
Breakfast
08:00—11:15
Cilia, Proliferation and Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Cheryl L. Walker, Texas A&M Health Science Center, USA

Elizabeth Petri Henske, Brigham and Women's Hospital, USA
Cilia and the Pathogenesis of Tuberous Sclerosis Complex

Jeremy F. Reiter, University of California, San Francisco, USA
Do Cilia Participate in Common Diseases?

Brian D. Dynlacht, New York University School of Medicine, USA
Regulation of the Centrosome-Cilium Cycle

Erica A. Golemis, Fox Chase Cancer Center, USA
Probing the Relationship between Cilia and Cystogenesis in Models of ADPKD

Mattias Alenius, Linkoping University, Sweden
Short Talk: Cilia-Mediated Hedgehog Signaling in Drosophila

Daniel B. Constam, École Polytechnique Fédérale de Lausanne, Switzerland
Short Talk: Regulation of Bicc1-Mediated mRNA Silencing by Calcium

09:20—09:40
Coffee Break
11:15—13:00
Poster Setup
Bay
13:00—22:00
Poster Viewing
Bay
11:15—17:00
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:15
Cystic Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Erica A. Golemis, Fox Chase Cancer Center, USA

* Jeremy F. Reiter, University of California, San Francisco, USA

Friedhelm Hildebrandt, Howard Hughes Medical Institute and Boston Children’s Hospital
DNA Damage Response Signaling in Ciliopathies

Michael J. Caplan, Yale University, USA
The Polycystins and Ciliary Sensing

Kimberly M. McDermott, University of Arizona, Arizona Cancer Center, USA
Investigating the Role of Primary Cilia in Hedgehog Pathway Drug Resistance

Sandra Hakim, Monash University, Australia
Short Talk: Inpp5e Regulates Cilia and mTOR Signaling in Renal Epithelial Cells to Suppress Polycystic Kidney Disease

Rannar Airik, Boston Children’s Hospital, USA
Short Talk: Renal-Retinal Ciliopathy Gene Sdccag8 Regulates DNA Damage Response signaling

19:15—20:15
Dinner
19:30—22:00
Poster Session 3
Bay
20:00—21:00
Social Hour
Bay

THURSDAY, MARCH 6

07:00—08:00
Breakfast
08:00—11:00
Signaling to and from the Cilium
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Kathryn V. Anderson, Memorial Sloan-Kettering Cancer Center, USA

Adrian Salic, Harvard Medical School, USA
Hedgehogs and Sterols

Philip A. Beachy, HHMI/Stanford University, USA
Hedgehog Signaling, Cilia and Cancer

Tao Zhong, Fudan University School of Life Sciences, China
Short Talk; Prostaglandin Signaling Regulates Ciliogenesis through Modulating Intraflagellar Transport

Elle C. Roberson, University of California, San Francisco, USA
Short Talk: Tmem231 is a Ciliopathy Protein Required for Ciliary Membrane Protein Composition

Ruhee Dere, Institute of Biosciences and Technology, Texas A&M Health Science Center, USA
Short Talk: Aurora Kinase A (AURKA) Inhibition Rescues Renal Cystogenesis, Independent of mTORC1 Activation, in a Ciliopathy Model of Tsc2

* Cosima T. Baldari, University of Siena, Italy
Short Talk: The Atypical Rab GTPase, Rab29, Is a Common Regulator of Immune Synapse Assembly and Ciliogenesis

09:20—09:40
Coffee Break
11:00—17:00
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:00
Protein Localization to Cilia
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Kimberly M. McDermott, University of Arizona, Arizona Cancer Center, USA

Michel R. Leroux, Simon Fraser University, Canada
Formation and Function of the Transition Zone, a Ciliary Gate

* Kristen Verhey, University of Michigan, USA
Regulating Entry into the Ciliary Compartment

Stefan Somlo, Yale School of Medicine, USA
Polycystic Kidney and Liver Diseases: From Gene Discovery to Mechanism

Ahmet Yildiz, University of California, Berkeley, USA
Short Talk: Direct Observation of IFT Turnover at the Flagellar Tip and Base using the Photobleaching Gate Assay

19:00—19:15
Closing Remarks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Elizabeth Petri Henske, Brigham and Women's Hospital, USA

Jeremy F. Reiter, University of California, San Francisco, USA

Joel Rosenbaum, Yale University, USA

19:15—20:15
Dinner
19:15—20:15
Social Hour
20:00—23:00
Entertainment

FRIDAY, MARCH 7

 
Departure

*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

March of Dimes Foundation Grant No. 4-FY14-469

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK101223-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

EMBO (European Molecular Biology Organization)

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676