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This meeting took place in 2013



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Lung Development, Cancer and Disease (B2)


Organizer(s) Brigid L.M. Hogan, Jeffrey A. Whitsett and Christine Kim Garcia
February 5—10, 2013
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Oct 8, 2012
Late Abstract Deadline: Nov 5, 2012
Scholarship Deadline: Oct 8, 2012
Early Registration Deadline: Dec 5, 2012

Sponsored by Infinity Pharmaceuticals and Pfizer Inc.

Summary of Meeting:
Respiratory pathologies, including asthma, chronic obstructive pulmonary disease, lung cancer and fibrosis, impose significant healthcare burdens on populations throughout the world. The goal of this meeting is to bring together basic and clinical scientists studying a range of topics including: mechanisms underlying the embryonic development and maturation of the normal lung, endogenous stem cells and their role in repair and regeneration, the genetics of human lung diseases, and the cells-of-origin and progression of cancer and fibrosis. The format will be designed to promote critical discussion and debate and collaboration among participants who do not traditionally go to the same scientific meetings. The emphasis will be to stimulate new ways of thinking about old problems and new ideas about potential therapies. A common theme will be the question of how the different cell types in the lung – the epithelium, vasculature, mesenchyme and immune cells – interact during development and how these mechanisms may be disrupted or re-activated in association with disease initiation and progression. Based on participant feedback from the 2011 Keystone Symposia meeting on Lung Development and Repair, there will be more workshop-style sessions in which specific technical issues will be critically discussed, and junior clinician scientists and trainees can learn about different models of lung development, lung injury and repair, and lung stem cells. Other sessions will address emerging issues in lung biology, including new cellular therapies, the effect of environmental factors and the identification of genes and pathways associated with rare lung diseases that have the potential to throw light on broader issues of lung biology.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 5

16:00—20:00
Arrival and Registration

Chamisa Lobby

WEDNESDAY, FEBRUARY 6

07:00—08:00
Breakfast

Los Vaqueros
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Brigid L. M. Hogan, Duke University Medical Center, USA

* Christine Kim Garcia, University of Texas Southwestern Medical Center at Dallas, USA

Anton J. M. Berns, Netherlands Cancer Institute, Netherlands
Mouse Models for Small Cell and Non-Small Cell Lung Cancer

09:00—12:00
Lung Development
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Brigid L. M. Hogan, Duke University Medical Center, USA

Mark A. Krasnow, Stanford University School of Medicine, USA
Genetic Dissection of Lung Development and Disease

James M. Wells, Cincinnati Children's Hospital Research Foundation, USA
Deriving Complex Endodermal Organ Tissues from Human Pluripotent Stem Cell for Disease Research

Xin Sun, University of California, San Diego, USA
Branching Morphogenesis of the Lung

Yi Wang, University of Pennsylvania, USA
Development and Regeneration of Sox2+ Endoderm Progenitors Is Regulated by a Hdac1/2-Bmp4/Rb1 Regulatory Pathway

Marie-Liesse Asselin-Labat, Walter and Eliza Hall Institute, Australia
Short Talk: LMO4 in the Lung: Roles in Development, Repair and Tumorigenesis

09:40—10:00
Coffee Break

Chamisa Lobby
12:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
 
On Own for Lunch and Recreation

15:00—16:30
Workshop 1: Lung Cell Replacement
Topics to include differentiation of iPSCs into lung endoderm and derivation of iPSCs from diseased lung, making artificial airways, and synthetic biopolymers as scaffolds for building new airways.

Chamisa Ballroom 1
* James M. Wells, Cincinnati Children's Hospital Research Foundation, USA

Michael J. Riedel, STEMCELL Technologies, Canada
Highly Efficient Differentiation of Human Pluripotent Stem Cells to Definitive Endoderm Using a Novel Animal Component-Free Medium

Christina Mauritz, Hannover Medical School, Germany
Dexamethasone Plus cAMP-Elevating Agents Support Airway Epithelial Differentiation of Embryonic and Induced Pluripotent Stem Cells

Samuel J. Wadsworth, University of British Columbia, Canada
Bio-Airway Research Offering New Concepts in Health (BRONCH) Partnership – Building a Bio-Engineered Airway

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Specification, Differentiation and Patterning of Airway Epithelial Cell Lineages
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Mark A. Krasnow, Stanford University School of Medicine, USA

Mitsuru Morimoto, RIKEN Center for Developmental Biology, Japan
Two Types of Notch Signaling Coordinate the Distribution of the Major Bronchial Clara, Ciliated and Neuroendocrine Cells

Eszter K. Vladar, Stanford University School of Medicine, USA
Mechanisms Regulating Epithelial Planar Cell Polarity in the Developing Lung

John F. Engelhardt, University of Iowa, USA
Development and Maintenance of the Submucosal Gland Stem/Progenitor Cell Niche

Nicholas Manzo, Duke University, USA
Short Talk: Epithelial-Stromal Interactions in the Adult Murine Lung

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

THURSDAY, FEBRUARY 7

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:15
Lung Cancer and COPD
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Tushar J. Desai, Stanford University, USA

David M. Ornitz, Washington University School of Medicine, USA
Multiple Roles for FGF9 in Lung Development and the Pathogenesis of Cancer

Christin S. Kuo, Stanford University, USA
Cellular and Genetic Dissection of Pulmonary Neuroepithelial Body (NEB) Development

Mary Armanios, Johns Hopkins University School of Medicine, USA
Telomerase and its Role in Emphysema-Fibrosis Pathogenesis

Avrum Spira, Boston University, USA
The Airway Field of Injury in Lung Cancer and COPD

Jichao Chen, University of Texas MD Anderson Cancer Center, USA
Short Talk: Sox-Dependent Kras Signaling Network in Lung Development and Cancer

09:20—09:40
Coffee Break

Chamisa Lobby
11:15—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Lung Mesodermal Lineages and Vascularization
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Xin Sun, University of California, San Diego, USA

Anne-Karina T. Perl, Cincinnati Children's Hospital, USA
Regulation of Contractile and Synthetic Fibroblast Phenotypes during Realveolarization

Bruce C. Trapnell, University of Cincinnati College of Medicine, USA
GM-CSF, Lung Macrophages, and Pulmonary Alveolar Proteinosis

Tien Peng, University of Pennsylvania, USA
Multipotent Wnt2+/Gli1+ Posterior Second Heart Field Progenitors Give Rise to the Pulmonary Vasculature through a Hedgehog Mediated Pathway

Joo-Hyeon Lee, Children's Hospital Boston, USA
Short Talk: TSP-1 Mediated TGF-beta Signaling from Endothelial Cells Drives Lung Stem Cell Differentiation

Trudy G. Oliver, Huntsman Cancer Institute, USA
Short Talk: Using Mouse Models of Lung Cancer to Identify Pathways Involved in Chemotherapy Resistance

19:15—20:15
Social Hour with Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

FRIDAY, FEBRUARY 8

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Alveolar Development, Vascular Remodeling and Alveolar Disease
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Lynn Y. Sakai, Shriner's Hospital and Oregon Health & Science University, USA

Tushar J. Desai, Stanford University, USA
Alveolar Epithelial Progenitor Cells in Maintenance and Disease

Daniel B. Rifkin, New York University, USA
The Role of TGF-beta Binding Proteins in Lung Development

Mark R. Looney, University of California, San Francisco, USA
Real-Time Imaging of Cell Trafficking in Lung Alveoli

Vladimir V. Kalinichenko, Cincinnati Children's Hospital Medical Center, USA
Transcriptional Regulation of Endothelial Cells during Lung Development and Alveolar Disease

09:20—09:40
Coffee Break

Chamisa Lobby
 
On Own for Lunch and Recreation

15:00—16:00
Workshop 2: Models of Injury and Repair in the Lung: Basic Science and Novel Therapeutics
Topics to include chemical induced injury and screens for small molecules promoting repair.

Chamisa Ballroom 1
* Aron B. Jaffe, Novartis Institutes for BioMedical Research, USA

Jenni S. P. Lahtela, Institution for Molecular Medicine Finland, Finland
Identification of EPHA3 as a Candidate Tumor Suppressor in a Screen for Cellular Senescence

Geraldine A. Strasser, Genentech, Inc., USA
Chemical Genetics ex vivo Reveals that Lkb1 Regulates Lung Branching and Pancreatic Morhpogenesis along AMPK-Dependent and -Independent Pathways

Kimberly Walter, Genentech, USA
Quantitative DNA Methylation Analysis Reveals Consistent Epigenetic Changes during an Induced Mesenchymal Transition of Lung Epithelial Cells

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:15
Lung Progenitor Cells and Lung Disease
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* John F. Engelhardt, University of Iowa, USA

Brigid L. M. Hogan, Duke University Medical Center, USA
Stem Cells of the Adult Lung

Frank McKeon, The Jackson Laboratory for Genomic Medicine
Regiospecific Stem Cells of the Human Upper and Lower Airways and their Role in Lung Regeneration

Aron B. Jaffe, Novartis Institutes for BioMedical Research, USA
Regulation of Cell Fate Decisions in the Airway

Jayakar V. Nayak, Stanford University School of Medicine, USA
Short Talk: Basal Progenitor Cell Dynamics of the Nasal Cavity and Sinuses

Matthew Walters, Weill Cornell Medical College, USA
Short Talk: Endothelial Expressed Matrix Metallopeptidase 14 Is Required for Endothelial Dependent Growth Support of Human Airway Basal Cells

19:15—20:15
Social Hour with Lite Bites

Chamisa Ballroom 2

SATURDAY, FEBRUARY 9

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Lung and Tissue Fibrosis
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Mary Armanios, Johns Hopkins University School of Medicine, USA

Christine Kim Garcia, University of Texas Southwestern Medical Center at Dallas, USA
Genetics and Pathways of Lung Fibrosis

Andreas Günther, University Hospital Giessen, Germany
Signaling Mechanisms in Lung Fibrosis

Nick Hutchison, University of Washington, USA
Pericytes in Tissue Fibrosis and Disease

Kenneth E. Lipson, Fibrogen, USA
Inhibition of CTGF Prevents and Reverses Lung Remodeling in a Mouse Model of Radiation-Induced Fibrosis

Ari Jon Arason, University of Iceland, Iceland
Short Talk: Human Bronchial Basal Epithelial Cells as Candidate EMT Precursors in Idiopathic Pulmonary Fibrosis

09:20—09:40
Coffee Break

Chamisa Lobby
 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
New Insights from Genetic Analysis of Rare Lung Diseases
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Christine Kim Garcia, University of Texas Southwestern Medical Center at Dallas, USA

Enid R. Neptune, Johns Hopkins University, USA
The Active Matrix in Airspace Disorders

Rachael M. Andrie, Oregon Health & Science University, USA
Emphysema in a Mouse Model of Marfan Syndrome

Esteban C. Dell'Angelica, University of California, Los Angeles, USA
Molecular Basis of Hermansky-Pudlak Syndrome

19:00—20:00
Social Hour with Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

SUNDAY, FEBRUARY 10

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Infinity Pharmaceuticals Pfizer Inc.

We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. March of Dimes Foundation Grant No. 4-FY12-556

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



FibroGen Incorporated


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676