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This meeting took place in 2013
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Meeting Details
Molecular Clockworks and the Regulation of Cardio-Metabolic Function (C9)
Organizer(s) Garret A. FitzGerald and Joseph S. Takahashi
April 3 - April 7, 2013
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: December 3, 2012
Late Abstract Deadline: January 3, 2013
Scholarship Deadline: December 3, 2012
Early Registration Deadline: January 28, 2013
Supported by the Directors' Fund
CME Information
Summary of Meeting:
Several discoveries point to the importance of the molecular clockworks as an integrative system in biology. The molecular clock is highly conserved and remarkably robust in resisting disruption; it is highly regulated and is placed centrally amongst biological networks that communicate between tissues. In recent years it has become apparent that peripheral clocks, widely distributed, retain the capacity for independence as well as operating under the direction of the master clock in the supracharismatic nucleus (SCN). Indeed, evidence has begun to emerge that peripheral clocks talk to each other and back to the SCN. As we begin to understand the impact of major environmental influences, such as food restriction and fluctuations in body temperature, on clock integration and behavior, so we will begin to elucidate the roles of fine adjusters, such as hormones, physical forces and nutritional ingredients, all of which can impact asymmetrically individual peripheral clocks and potentially signal between them. Much remains to be learned about the multiple levels of regulation of clockworks at the transcriptional, translational, post translational and epigenomic levels, information that lends itself to systems wide analysis. Indeed, increasing insight into the systems biology of the molecular clock promises to rationalize selection of drug targets whereby we might modulate clock function. High throughput screens have already yielded novel approaches to regulating the phase and amplitude of molecular clocks. Evocation of clock dependent phenotypes in humans has come of age with recognition that the oscillatory nature of the metabolome and the ability to track gene oscillations in several tissues ex vivo will complement increasingly sophisticated approaches to segregating endogenous rhythms from tracking time dependent changes in tissue function in humans. Experiments in a range of model systems have pointed to the importance of the molecular clock in carbohydrate and lipid metabolism, cardiovascular function and aging. This program will assemble investigators who work in multiple model systems, including humans to share information on the multiple ways in which the molecular clock is regulated, how its systems are integrated and how that knowledge might be harvested to enhance our understanding of human physiology and to yield novel treatments for human disease.
CME Information
Several discoveries point to the importance of the molecular clockworks as an integrative system in biology. The molecular clock is highly conserved and remarkably robust in resisting disruption; it is highly regulated and is placed centrally amongst biological networks that communicate between tissues. In recent years it has become apparent that peripheral clocks, widely distributed, retain the capacity for independence as well as operating under the direction of the master clock in the supracharismatic nucleus (SCN). Indeed, evidence has begun to emerge that peripheral clocks talk to each other and back to the SCN. As we begin to understand the impact of major environmental influences, such as food restriction and fluctuations in body temperature, on clock integration and behavior, so we will begin to elucidate the roles of fine adjusters, such as hormones, physical forces and nutritional ingredients, all of which can impact asymmetrically individual peripheral clocks and potentially signal between them. Much remains to be learned about the multiple levels of regulation of clockworks at the transcriptional, translational, post translational and epigenomic levels, information that lends itself to systems wide analysis. Indeed, increasing insight into the systems biology of the molecular clock promises to rationalize selection of drug targets whereby we might modulate clock function. High throughput screens have already yielded novel approaches to regulating the phase and amplitude of molecular clocks. Evocation of clock dependent phenotypes in humans has come of age with recognition that the oscillatory nature of the metabolome and the ability to track gene oscillations in several tissues ex vivo will complement increasingly sophisticated approaches to segregating endogenous rhythms from tracking time dependent changes in tissue function in humans. Experiments in a range of model systems have pointed to the importance of the molecular clock in carbohydrate and lipid metabolism, cardiovascular function and aging. This program will assemble investigators who work in multiple model systems, including humans to share information on the multiple ways in which the molecular clock is regulated, how its systems are integrated and how that knowledge might be harvested to enhance our understanding of human physiology and to yield novel treatments for human disease.
Conference Program Print | View meeting in 12 hr (am/pm) time
WEDNESDAY, APRIL 3
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Garret A. FitzGerald,
University of Pennsylvania, USA
*
Joseph S. Takahashi,
HHMI/University of Texas Southwestern Medical Center, USA
Eric Schadt,
Pacific Biosciences/Mount Sinai School of Medicine, USA
Systems Integration by the Molecular Clock
Systems Integration by the Molecular Clock
09:00—11:00
Clockworks I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Garret A. FitzGerald,
University of Pennsylvania, USA
Joseph S. Takahashi,
HHMI/University of Texas Southwestern Medical Center, USA
Transcriptional Architecture and Chromatin Dynamics of the Circadian Clock
Transcriptional Architecture and Chromatin Dynamics of the Circadian Clock
John Hogenesch,
University of Pennsylvania School of Medicine, USA
A Transcriptional Map of Mouse Circadian Time and Space
A Transcriptional Map of Mouse Circadian Time and Space
Jerome Menet,
Brandeis University, USA
Mechanistic Insights from Genome-Wide Circadian Regulation of Chromatin
Mechanistic Insights from Genome-Wide Circadian Regulation of Chromatin
11:00—12:00
Workshop: Program Tips from NIDDK
*
Corinne M. Silva,
NIDDK, National Institutes of Health, USA
17:00—19:00
Clockworks II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Carla B. Green,
University of Texas Southwestern Medical Center, USA
Thomas P. Burris,
The Scripps Research Institute, USA
Chemical Biology of the Clock
Chemical Biology of the Clock
Martha Merrow,
University of Groningen, Netherlands
Rhythms from Molecules to Behavior in C. elegans
Rhythms from Molecules to Behavior in C. elegans
Immanuel Lerner,
Hebrew University, Israel
Short Talk: Clk mRNA Turnover de-Noises Circadian Transcription and Behavior in Time and Space
Short Talk: Clk mRNA Turnover de-Noises Circadian Transcription and Behavior in Time and Space
08:00—11:00
Cardio-Metabolic I
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*
Ueli Schibler,
University of Geneva, Switzerland
Mukesh K. Jain,
Case Western Reserve University, USA
KLF15 Links Circadian Rhythms to Cardiometabolic Function
KLF15 Links Circadian Rhythms to Cardiometabolic Function
David Rotter,
University of Texas Southwestern Medical Center, USA
Short Talk: Regulator of Calcineurin 1 (Rcan1) Confers Time-of-Day Protection to the Heart from Ischemia/Reperfusion Damage
Short Talk: Regulator of Calcineurin 1 (Rcan1) Confers Time-of-Day Protection to the Heart from Ischemia/Reperfusion Damage
Felix Naef,
École Polytechnique Fédérale de Lausanne (EPFL), Switzerland
Mechanisms of Phase-Specific Circadian Transcription in Mouse Liver
Mechanisms of Phase-Specific Circadian Transcription in Mouse Liver
Carla B. Green,
University of Texas Southwestern Medical Center, USA
Circadian Post-Transcriptional Regulation of Metabolic Pathways
Circadian Post-Transcriptional Regulation of Metabolic Pathways
17:00—19:00
Clockworks III
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Martha Merrow,
University of Groningen, Netherlands
Susan S. Golden,
University of California, San Diego, USA
Regulation of and by the Circadian Oscillator in the Cyanobacterial Cell
Regulation of and by the Circadian Oscillator in the Cyanobacterial Cell
Akhilesh B. Reddy,
University of Cambridge, UK
EMBO Young Investigator Lecture: Redox Oscillations and the Clockwork
EMBO Young Investigator Lecture: Redox Oscillations and the Clockwork
Hiroki R. Ueda,
Center for Developmental Biology, Japan
Systems and Synthetic Biology of Biological Timings
Systems and Synthetic Biology of Biological Timings
Pagkapol Y. Pongsawakul,
University of California, San Diego, USA
Short Talk: The Role of Cytoplasmic CRYPTOCHROME in Regulating the cAMP Signaling Pathway
Short Talk: The Role of Cytoplasmic CRYPTOCHROME in Regulating the cAMP Signaling Pathway
08:00—11:00
Cardio-Metabolic II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
John Hogenesch,
University of Pennsylvania School of Medicine, USA
R. Daniel Rudic,
Georgia Regents University, USA
The Vascular Biology of the Molecular Clock
The Vascular Biology of the Molecular Clock
Satchidananda Panda,
The Salk Institute for Biological Studies, USA
Time-Restricted Feeding Protects Against Nutrition Challenges
Time-Restricted Feeding Protects Against Nutrition Challenges
Martin E. Young,
University of Alabama at Birmingham, USA
Clock Control of Cardiac Metabolism and Function
Clock Control of Cardiac Metabolism and Function
Frank A.J.L. Scheer,
Harvard Medical School, USA
Endogenous Biological Rhythms of Cardiovascular Function in Humans
Endogenous Biological Rhythms of Cardiovascular Function in Humans
Hélène Duez,
Institut Pasteur Lille - INSERM - University of Lille, France
Short Talk: The Clock Component Rev-erbalpha Modulates Skeletal Muscle Oxidative Capacity by Regulating Mitochondrial Biogenesis and Autophagy
Short Talk: The Clock Component Rev-erbalpha Modulates Skeletal Muscle Oxidative Capacity by Regulating Mitochondrial Biogenesis and Autophagy
17:00—19:00
Cardio-Metabolic III
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Joseph S. Takahashi,
HHMI/University of Texas Southwestern Medical Center, USA
Amita Sehgal,
University of Pennsylvania Perelman School of Medicine, USA
Reciprocal Relationship between Clocks and Metabolism in Drosophila
Reciprocal Relationship between Clocks and Metabolism in Drosophila
Annie Lee Hsieh,
Johns Hopkins University, USA
Short Talk: Oncogenic c- and N-Myc Disrupt Circadian Rhythm
Short Talk: Oncogenic c- and N-Myc Disrupt Circadian Rhythm
Garret A. FitzGerald,
University of Pennsylvania, USA
Cardiometabolic Implications of Peripheral Clocks
Cardiometabolic Implications of Peripheral Clocks
*Session Chair †Speaker invited, not yet responded.
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