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Hilton Santa Fe Historic Plaza Hotel Floorplan

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This meeting took place in 2013



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Nutrition, Epigenetics and Human Disease (B5)


Organizer(s) Robert A. Waterland, David S. Rosenblatt and Patrick J. Stover
February 19—24, 2013
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, New Mexico USA
Abstract Deadline: Oct 17, 2012
Late Abstract Deadline: Nov 19, 2012
Scholarship Deadline: Oct 17, 2012
Early Registration Deadline: Dec 17, 2012

Sponsored by Cell Research, Nestlé Institute of Health Sciences and Takeda Pharmaceutical Company Limited

Summary of Meeting:
Transient nutritional exposures during critical developmental periods can induce permanent alterations in epigenetic regulation which program metabolic and other biological networks, with lifelong consequences. During other life stages nutrition can dynamically regulate epigenetic processes. There is increasing evidence that gene-nutrient interactions underlie susceptibility to various human diseases, through mechanisms that include interindividual variation in epigenomic profiles. The interaction of nutrition, epigenetics, and human disease is a rapidly evolving area of research with many fundamental outstanding questions and abundant opportunities to translate basic science discoveries to clinical and public health application. A meeting that brings together leaders in human nutrition, human genetics and epigenetics, clinical and animal studies of disease pathogenesis, inborn errors of metabolism, methyl metabolism, stem cell programming, genome stability, transcription, and developmental biology will accelerate and potentially transform research in this field.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 19

16:00—20:00
Arrival and Registration


WEDNESDAY, FEBRUARY 20

08:00—09:00
Breakfast

09:00—11:45
Nutrition and Epigenetics in Development and Disease of the CNS
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Disruption of methyl metabolism resulting from vitamin B12 and folate deficiencies and aging are associated with neurodegenerative disorders ranging from peripheral neuropathies to subacute combined degeneration of the spinal cord. This session will focus on the interaction of nutrition and metabolism and epigenetic processes in diseases of the CNS, and its role in neurogenesis and aging.

* David S. Rosenblatt, McGill University, Canada

Robert A. Waterland, Baylor College of Medicine, USA
Welcome Remarks

Arthur L. Beaudet, Baylor College of Medicine, USA
A Neuronal Carnitine Deficiency Hypothesis for Autism

Peng Jin, Emory University School of Medicine, USA
Cytosine Modifications in Neurodevelopment and Diseases

Steven H. Zeisel, University of North Carolina at Chapel Hill, USA
Diet Variation and Metabolic Inefficiencies in Choline and 1-Carbon Metabolism: Important Modifiers of Epigenetic Marks?

Sivan Vadakkadath Meethal, University of Wisconsin-Madison, USA
Short Talk: Methylation/Demethylation Mechanisms Are Key to Folate-Induced Axon Regeneration in the Injured Central Nervous System

Koji Hayakawa, University of Tokyo, Japan
Short Talk: Epigenetic Switching by Nutrition-Sensing Factor Ogt, Sirt1 and Mgea5 in Generation of Orexin Neurons from Mouse ES Cells and Human iPS Cells

10:15—10:35
Coffee Break

11:45—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Nutrient Regulation of the Epigenetic Machinery
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
The establishment and maintenance of chromatin methylation is influenced by the total cellular methylation capacity. This capacity is determined by the expression level of DNA and histone methyltransferases, demethylases and the availability of the methyl donor S-adenosylmethionine.` There is increasing evidence that the expression of DNA and histone methyltransferases are responsive to dietary methionine, choline and other nutrients, and modest changes in methyltransferase expression levels have profound impact on chromatin methylation and gene expression. This session will investigate the mechanisms underlying the regulation of methyltransferase expression by nutrients, and its effect on chromatin methylation, gene expression and stem cell programming.

* Patrick J. Stover, Cornell University, USA

Roderick Dashwood, Oregon State University, USA
Mechanisms Underlying Bioactive Food Components and Histone Modifications

Paolo Sassone-Corsi, University of California, Irvine, USA
Joining the Dots: Epigenetics, Metabolism and the Circadian Clock

Andrea Fuso, Universita' di Roma, La Sapienza, Italy
Nutrient Regulation of One-Carbon Metabolism Modulates Gene-Specific Methylation: The Alzheimer’s Disease Model

Joeva Barrow, Harvard, USA
Short Talk: Artificial Zinc Finger DNA-Binding Domains Can Be Effective Tools to Identify Nutrient-Dependent Functional cis Elements in vivo

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


THURSDAY, FEBRUARY 21

07:00—08:00
Breakfast

07:30—08:00
Poster Setup

08:00—17:00
Poster Viewing

08:00—11:15
Nutrition and Epigenetics in Obesity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Epigenetic mechanisms are likely to play an important role in body weight regulation. Animal models and emerging human data indicate that early environmental exposures (e.g. high-calorie diets, maternal obesity, etc.) can influence the development of body weight regulatory mechanisms, and thereby affect risk of obesity throughout life. The role of epigenetics in central and peripheral body weight regulatory mechanisms is attracting extensive attention. This session will cover the latest advances in clinical studies and animal models of ‘nutritional programming’ of obesity, and epigenetic mechanisms in central and peripheral body weight regulation.

* Miguel Constância, University of Cambridge, UK

Richard B. Simerly, University of Southern California, USA
Nutritional-Endocrine Interactions in Postnatal Hypothalamic Development

Peter Kuehnen, Institute for Experimental Pediatric Endocrinology, Germany
A POMC Methylation Variant Associated with Childhood Obesity

Matthew V. Cannon, Cleveland Clinic Lerner Research Institute, USA
Short Talk: Genome-Wide Gene Expression and Epigenetic Analyses of Mice Born From Lean and Obese Mothers

Stephen T. Bradford, CSIRO/Garvan Institute of Medical Research, Australia
Short Talk: Analysis of the Methylome of Purified Visceral and Subcutaneous Adipocytes, Visceral Adipose Tissue and Blood from Three Lean Humans

Robert A. Waterland, Baylor College of Medicine, USA
Developmental Epigenetics and Obesity

Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard University, USA
Epigenomic Analysis of Adipose Biology

09:20—09:40
Coffee Break

11:15—12:00
Lunch

12:00—14:30
Poster Session 2

16:30—17:00
Coffee Available

17:00—19:00
Nutrient, Methyl Metabolism and Epigenetic Interactions
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
S-adenosylmethionine (SAM) is the universal methyl donor for chromatin methylation. S-adenosylhomocysteine (SAH) is the product of methylation reactions, and is a potent inhibitor of both DNA and histone methyltransferases. Therefore, the SAM/SAH ratio has been described as the cellular metabolic methylation potential. The SAM/SAH ratio is regulated over a broad dynamic range, and is sensitive and responsive to multiple nutrients. This session will cover recent advances in our understanding of nutrient regulation of the SAM/SAH ratio in the cell, and its impact on genome methylation, stem cell programming and transcription.

* Jasper D. Rine, University of California, Berkeley, USA

David S. Rosenblatt, McGill University, Canada
Discovering New Genes in the One Carbon Pathway Using Exome Sequencing-a RaDiCAL Approach

Patrick J. Stover, Cornell University, USA
Nuclear One-Carbon Metabolism and Neural Tube Defects

Rima Rozen, McGill University, Canada
Impact of Genetic and Nutritional Variation in Folate Metabolism on Cellular Methylation Capacity

Erica D. Watson, University of Cambridge, UK
Short Talk: Transgenerational Epigenetic Effects of Folate Metabolism on Fetal and Placental Development

19:00—
On Own for Dinner


FRIDAY, FEBRUARY 22

07:00—08:00
Breakfast

08:00—11:15
Nutrition and Developmental Epigenetics in the Endocrine Pancreas
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
The vast majority of type 2 diabetes is associated with obesity, a nutritionally-induced disease. Understanding epigenetic regulation in the endocrine pancreas could open the door to effective approaches to preventing or treating type 2 diabetes. This session will highlight recent mechanistic insights obtained by epigenomic profiling of human endocrine pancreas cell-types, epigenetic hallmarks of endocrine pancreas dysfunction, and epigenetic mechanisms of nutritional programming of impaired glucose homeostasis.

* Robert A. Waterland, Baylor College of Medicine, USA

Miguel Constância, University of Cambridge, UK
Epigenetic Programming of Metabolic Health across the Life-Course

Frans C. Schuit, Katholieke Universiteit Leuven, Belgium
Beta-Cell Specific Repression of Disallowed Genes: Implications for Development and Disease

Ge Li, Baylor College of Medicine, USA
Short Talk: Early Postnatal Overnutrition Persistently Alters DNA Methylation in Pancreatic Islets

Stephanie-May Ruchat, Université de Sherbrooke, Canada
Short Talk: Genome-Wide DNA Methylation Profile Analyses in Placenta and Cord Blood Exposed or Not to Gestational Diabetes Mellitus

Francois Fuks, University of Brussels, Belgium
The Epigenome of Pancreatic Islets from T2D Patients

Jorge Ferrer, Imperial College London, UK
Charting the Genomic Dark Matter in Human Beta Cells

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Nutrients and Allelic Targeting of Epigenetic Signatures
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Various nutrient exposures can influence the expression of discrete genes and pathways by altering methylation patterns at specific genetic loci. Nutrients target specific loci for alterations in chromatin methylation and/or demethylation through nuclear receptors, signal transduction pathways and nuclear import processes. This session will focus on the fundamental mechanisms whereby nutrients regulate gene expression by targeted alterations in chromatin methylation, and its role in physiological adaptation maintaining cellular homeostasis.

* Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard University, USA

J. Kim Kemper, University of Illinois at Urbana-Champaign, USA
The Role of PTMS of SHP in Transmitting Bile Acid Signaling to Epigenomic Regulation of Liver Metabolism

Chen-Yu Zhang, Nanjing University, China
Extracellular microRNA: Function and Mechanism of Action

Tomi Pastinen, McGill University, Canada
Integrated Analysis of Genetic and Epigenetic Variation in Humans

Elin Grundberg, McGill University and Genome Quebec Innovation Centre, Canada
Short Talk: Global DNA Methylation Patterns in Adipose Tissue from Twins and its Effect on Gene Expression and Disease

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


SATURDAY, FEBRUARY 23

07:00—08:00
Breakfast

08:00—11:15
Nutritional Modulation of Stem Cell Programming
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Stem cells have the capacity to both self-renew and differentiate into specific cell types. In contrast to the pluripotent stem cells found only in the early embryo, lineage-restricted stem cells such as hematopoietic stem cells and neural stem cells persist into adulthood, and have the ability to differentiate into limited specific cell types. Embryonic and lineage-restricted stem cells offer excellent opportunities to understand fundamental mechanisms underlying nutritional influences on differentiation. Moreover, in cell types that are continuously replaced throughout life (like blood and intestinal epithelium) persistent effects of early nutrition must occur at the stem cell level. This session will focus on developmental epigenetics in embryonic and lineage-restricted stem cells, and nutritional influences on these processes.

* Jean-Pierre Issa, Temple University School of Medicine, USA

Guoliang Xu, Chinese Academy of Sciences, China
DNA Oxidation towards Totipotency in Mammalian Development

Yi Eve Sun, University of California, Los Angeles, USA
Epigenetic Regulation of Stem Cell Differentiation

Elizabeth Radford, University of Cambridge, UK
Short Talk: Paternal Intergenerational Transmission of an in utero Nutrition Induced Phenotype Is Associated with Altered DNA Methylation in Adult Germ Cells

Philippe Collas, University of Oslo, Norway
Short Talk: Repositioning of Lamin A/C-Associated Genes after Adipogenic Differentiation

Lanlan Shen, Baylor College of Medicine, USA
Nutritional Influences on Stem Cell Developmental Epigenetics in the Colonic Crypt

Chad A. Cowan, Harvard University, USA
Genome Editing to Generate Human Cellular Models of Metabolic Disease

09:20—09:40
Coffee Break

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Present and Future: Pressing Issues in Environmental Epigenetics
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Dennis M. Bier, Baylor College of Medicine, USA

Jean-Pierre Issa, Temple University School of Medicine, USA
Epigenetic Drift

Andrew M. Prentice, London School of Hygiene and Tropical Medicine, UK
Long-Term Consequences of Maternal and Child (Mal)-Nutrition in Developing Countries

Sarah Finer, Queen Mary, University of London, UK
Short Talk: Epigenetic Variants Are Detectable in Young Adult Offspring Exposed to Famine in Early Development

Scott F. Gilbert, Swarthmore College, USA
The Global Environment and Ecological Developmental Biology: The Holobiont Perspective

19:00—19:15
Closing Remarks and Future Directions
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

David S. Rosenblatt, McGill University, Canada

Patrick J. Stover, Cornell University, USA

20:00—21:00
Social Hour with Lite Bites

20:00—23:00
Entertainment


SUNDAY, FEBRUARY 24

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Cell Research Nestlé Institute of Health Sciences
Takeda Pharmaceutical Company Limited
 

We gratefully acknowledge additional support for this conference from:

Abcam plc March of Dimes Foundation Grant No. 4-FY12-556
Zymo Research Corporation
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK084688-04

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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