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This meeting took place in 2013



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Pathogenic Processes in Asthma and COPD (J2)


Organizer(s) Marsha Wills-Karp, Jay K. Kolls and Sebastian L. Johnston
January 10—15, 2013
Santa Fe Community Convention Center • Santa Fe, New Mexico USA
Abstract Deadline: Sep 10, 2012
Late Abstract Deadline: Oct 10, 2012
Scholarship Deadline: Sep 10, 2012
Early Registration Deadline: Nov 8, 2012

Supported by the Directors' Fund


Summary of Meeting:
Chronic obstructive pulmonary disease (COPD) and asthma continue to be important causes of morbidity, mortality, and healthcare costs worldwide. However, the underlying causes of asthma and COPD remain poorly understood, even as the incidence of such diseases continues to increase. Recent discoveries have uncovered strong associations between both lung function and immune responses in early life and the subsequent development of persistent asthma and chronic airway obstruction in adulthood. However, to date, no meeting has taken advantage of these recent discoveries. The overall goal of this meeting is to draw together investigators from multiple disciplines doing work relevant to understanding the genetic, epigenetic and environmental factors and mechanisms that affect the development of asthma and COPD. The specific goals of the meeting are to: 1) explore recent insights into the genetic and epigenetic origins of asthma and COPD; 2) understand the relationship between early life environmental exposures and impaired lung function throughout life; 3) understand the relationship between lung infections as well as changes in the intestinal microbiome and the development of chronic lung diseases; 4) understand the role of newly described innate immune cell populations and pathways in the development of lung inflammation; 5) understand recent insights into the mechanisms of lung development, repair and remodeling; and 6) explore unique pathways of resolution of lung inflammation. By bringing together a critical mass of multidisciplinary researchers, this symposium should provide an ideal forum for exploring novel prevention and treatment strategies for these chronic respiratory diseases based on the identification of the genetic and environmental factors that interactively cause these disorders. Moreover, this meeting will serve to provide an in-depth exposure for junior investigators (graduate students and post-docs) to a fast-moving, fruitful area of medical research, as well as enticing such scientists into the field. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology, which will share a keynote address and two plenary sessions with this meeting.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, JANUARY 10

15:00—19:30
Arrival and Registration

Sweeney Ballroom Foyer
18:15—19:15
Refreshments

Sweeney F, Main Level Breakouts
19:15—20:30
Welcome and Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-E
Bart N. Lambrecht, VIB, Ghent University, Belgium
The Lung Dendritic Cell Network and the Response to Allergens


FRIDAY, JANUARY 11

07:00—08:00
Breakfast

Main Level Breakouts
08:00—11:15
New Insights into the Pathogenesis of Lung Diseases
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom C-E
* Donata Vercelli, University of Arizona, USA

Sally Wenzel-Morganroth, University of Pittsburgh, USA
Emerging Concepts on Asthma Heterogeneity

Fernando D. Martinez, University of Arizona, USA
Early-Life Origins of Chronic Obstructive Pulmonary Disease

Avrum Spira, Boston University, USA
Molecular Insights into COPD via Transcriptomic Profiling

Ian M. Adcock, Imperial College London, UK
Epigenetic Regulation of Lung Disease

Peter McErlean, Kings College London, UK
Short Talk: Asthma Exacerbations during Acute Respiratory Illness are Characterized by Distinct Expression Profiles of Immunoregulatory and Cellular Repair Genes in the Nasal Mucosa

Gabriela Wlasiuk, University of Arizona, USA
Short Talk: Epigenetic Predictors of Childhood Asthma are Detectable in the Methylome at Birth

08:00—11:00
Adaptations to Chronic Helminth Infection
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-B
* Judith E. Allen, University of Manchester, UK

Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
Human Helminth Infections, Immune Responses and Inflammatory Diseases

Ajay Chawla, University of California, San Francisco, USA
Metabolic (Regenerative) Consequences of Type 2 Immunity

Andrew S. MacDonald, University of Manchester, UK
Short Talk: Epigenetic Control of Th2 Induction by Dendritic Cells

Ilaria Mosconi, EPFL SV GHI UPHARRIS, Switzerland
Short Talk: Differential Role of Peyer’s Patches and Mesenteric Lymph Nodes during Helminth Infection

Hermelijn H. Smits, Leiden University Center, Netherlands
Short Talk: Human Schistosome-Induced IL-10 Producing CD1dhi B Cells Regulate Effector T Cell Responses

Mark A. Travis, University of Manchester, UK
Short Talk: The TGFbeta-Activating Integrin alphavbeta8 on Dendritic Cells Regulates Type 2 Immunity in the Intestine to Promote Chronic Parasitic Infection

Barbara Platzer, Boston Children's Hospital, USA
Short Talk: Dendritic Cells use IgE as an Antigen Sensor for Regulating Th2 Immunity

09:20—09:40
Coffee Break

Sweeney F, Main Level Breakouts
11:15—13:00
Poster Setup

Sweeney F
13:00—22:00
Poster Viewing

Sweeney F
11:15—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Sweeney F
17:00—19:00
Infectious Origins of Lung Disease
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom C-E
* Jay K. Kolls, Tulane School of Medicin, USA

James E. Gern, University of Wisconsin, USA
Virus Infections and Asthma Inception and Exacerbation

Sebastian L. Johnston, Imperial College London, UK
Mechanisms of Rhinovirus-Induced Exacerbations in Asthma and COPD

Michael J. Holtzman, Washington University in St. Louis, USA
Epithelial-Immune Cell Collaboration for Chronic Airway Disease

Derek E. Byers, Washington University, USA
Short Talk: Predominant Role of IL-33 as the Upstream Inducer of IL-13-Mediated Chronic Airway Disease

17:00—19:00
Regulating the Type 2 Cytokines
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-B
* Thomas A. Wynn, Pfizer, USA

Dirk E. Smith, Insight Bioconsulting, USA
The Role of IL-33 in Regulating Innate Airway Inflammation

Steven F. Ziegler, Benaroya Research Institute, University of Washington School of Medicine, USA
TSLP in the Regulation of Type 2 Immunity

Richard M. Maizels, University of Edinburgh, UK
Modulation of the Host Immune Response by Parasitic Helminths

Toshinori Nakayama, Chiba University, Japan
Short Talk: Sox4 Acts as a Downstream Target of TGFbeta and Suppresses GATA3-Induced Th2 Cell Differentiation

19:00—20:00
Social Hour with Lite Bites

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 1

Sweeney F

SATURDAY, JANUARY 12

07:00—08:00
Breakfast

Main Level Breakouts
07:30—08:00
Poster Setup

Sweeney F
08:00—17:00
Poster Viewing

Sweeney F
08:00—11:00
Innate Helper Cells in Type 2 Immunity (Joint)
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-E
* David Voehringer, University Hospital of Erlangen, Germany

Andrew N. J. McKenzie, MRC Laboratory of Molecular Biology, UK
IL-25 and IL-33 Regulation of ILC2 in Protective Immunity and Allergy

Hergen Spits, University of Amsterdam, Netherlands
The Spectrum of Human Innate Lymphoid Cells

Richard M. Locksley, HHMI/University of California, San Francisco, USA
Function-Marking the Cells of Allergic Immunity

Shigeo Koyasu, Keio University School of Medicine, Japan
Critical Role of GATA3 in the Differentiation and Function Natural Helper Cells, a Member of the Group 2 ILCs

Laurel Monticelli, Weill Cornell Medicine, USA
Short Talk: Innate Lymphoid Cells Promote Airway Epithelial Repair through the Amphiregulin-EGFR Pathway

09:20—09:40
Coffee Break

Sweeney F, Main Level Breakouts
11:00—12:00
Lunch

Sweeney F, Main Level Breakouts
12:00—14:30
Poster Session 2

Sweeney F
14:30—16:30
Workshop 1: Molecular Regulation of Allergic Responses

Sweeney Ballroom C-E
* Clare M. Lloyd, Imperial College London, UK

Jennifer L. Ather, University of Vermont, USA
Serum Amyloid A Downregulates Bim Expression and Caspase-3 Activation in Serum-Starved Bone Marrow Derived Dendritic Cells and Induces Glucocorticoid Resistance in CD4+ T Cells

Sofia Tousa, Biomedical Research Foundation of the Academy of Athens, Greece
Activin-A-Induced Human Regulatory T Cells: Novel Controllers of Allergic Asthma

Elizabeth A. Jacobsen, Mayo Clinic, USA
Activated Pulmonary Eosinophils Are Necessary for Th2 Pulmonary Inflammation

Hiromasa Inoue, Kagoshima University, Japan
Role of Leukotriene B4 Receptor BLT2 in Allergic Airway Inflammation

Purvi Mehrotra, Indiana University School of Medicine, USA
PARP-14 and its Enzyme Activity Regulates Th2 Differentiation and Allergic Airway Disease

David J. Cousins, King's College London, UK
In vitro Differentiation and Transcriptome Profiling of Human Th9 Cells

Tao Liu, Brigham and Women’s Hospital, Harvard Medical School, USA
Deficiency of Inducible PGE2 is Sufficient to Cause Aspirin Sensitivity in the Setting of Pulmonary Inflammation

16:30—17:00
Coffee Available

Sweeney F
17:00—19:00
Role of Th17 Cells in the Regulation of Lung Immunity
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom C-E
* Hergen Spits, University of Amsterdam, Netherlands

Jay K. Kolls, Tulane School of Medicin, USA
Th17 Cells in the Regulation of Lung Immunity

Susan V. Lynch, University of California, San Francisco, USA
Airway Microbiota and Lung Disease

Marsha Wills-Karp, Johns Hopkins Bloomberg School of Public Health, USA
Colonization with Segmented Filamentous Bacteria Drives Severe Asthma through an IL-17A-Dependent Mechanism

Saheli Chowdhury, Academic Medical Center, Netherlands
Short Talk: Exposure to IL-17 Reveals Defective mRNA Degradation by Bronchial Epithelial Cells in 70% of Patients with Asthma

17:00—19:15
Adaptive Th2 and TFH Cells
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-B
* Richard M. Locksley, HHMI/University of California, San Francisco, USA

K. Mark Ansel, University of California San Francisco
MicroRNA Regulation of TFH and Th2 Cell Development

Shane Crotty, La Jolla Institute for Allergy and Immunology, USA
The Relationship between Th2 and Tfh Cells: Defining Characteristics of Tfh Cell Differentiation and Function

Matthew D. Taylor, University of Edinburgh, Scotland
Short Talk: Th2 Cell Intrinsic Hypo-Responsiveness Determines Susceptibility to Helminth Infection via the PD-1/PD-L2 Pathway

Fabienne Andris, Université Libre de Bruxelles, Belgium
Short Talk: The Capacity of Th2 Lymphocytes to Deliver B Cell Help Requires Expression of the Transcription Factor STAT3

Nicholas van Panhuys, NIAID, National Institutes of Health, USA
Short Talk: TCR Strength of Signal is Upstream of and Dominates Over Cytokine Effects in Controlling CD4+ T Cell Polarization in Vivo

Christopher D. C. Allen, University of California, San Francisco, USA
Short Talk: Regulation of IgE+ B Cell Responses Revealed by Novel Fluorescent Reporter Mice


SUNDAY, JANUARY 13

07:00—08:00
Breakfast

Main Level Breakouts
08:00—11:15
Lung Development, Repair and Remodeling
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom C-E
* Fernando D. Martinez, University of Arizona, USA

Jeffrey A. Whitsett, Cincinnati Children's Hospital Medical Center, USA
Epigenetic and Genetic Regulation of Goblet Cell Metaplasia and Antiviral Innate Immunity by FOXA3

Paul W. Noble, Cedars-Sinai Medical Center, USA
Matrix Regulation of Lung Injury, Inflammation and Repair

Stephanie C. Eisenbarth, Yale University, USA
NOD-Like Receptors and the Regulation of Lung Inflammation

Joanne L. Wright, University of British Columbia, Canada
Cigarette Smoke Induced COPD - Use of Animal Models

Hesam Movassagh, University of Manitoba, Canada
Short Talk: Semaphorin 3E Inhibits Human Airway Smooth Muscle Cell Proliferation and Migration

Sejal Saglani, Imperial College London, UK
Short Talk: Interleukin-33 Promotes Airway Remodelling in Paediatric Severe Steroid Resistant Asthma

08:00—11:15
Commensals, Immunity and Epithelial Homeostasis
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-B
* Hajime Karasuyama, Tokyo Medical and Dental University, Graduate School, Japan

Wenjun Ouyang, Amgen, Inc., USA
Regulation and Function of IL-22 on Epithelial Cells

Yasmine Belkaid, NIAID, National Institutes of Health, USA
Commensal-Pathogen Interactions in Skin Immunity

Sabine Eming, University of Cologne, Germany
Tissue Repair and Type 2 Immunity

De' Broski R. Herbert, University of Pennsylvania, USA
Short Talk: Trefoil Factor 2 Initiates IL-33 Production for Non-Canonical Type 2 Immunity against Murine Hookworm Infection

Soichiro Yoshikawa, Tokyo Medical and Dental University, Japan
Short Talk: Mechanisms Underlying the Recruitment, Accumulation and Activation of Basophils at Tick-Feeding Sites for Protective Immunity to Tick Re-Infestation

P'ng Loke, NYU School of Medicine
Short Talk: Type 2 Immunity in Helminth Treatment for Inflammatory Bowel Diseases

09:20—09:40
Coffee Break

Sweeney F, Main Level Breakouts
11:15—13:00
Poster Setup

Sweeney F
13:00—22:00
Poster Viewing

Sweeney F
11:15—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Sweeney F
17:00—19:00
Mechanisms of Chronic Obstructive Pulmonary Disease
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom C-E
* Sebastian L. Johnston, Imperial College London, UK

Shyam Biswal, Johns Hopkins University, USA
Oxidative Stress Regulation of Lung Inflammation in COPD

Augustine Choi, Harvard Medical School, USA
Regulation and Function of Autophagy in COPD

Farrah Kheradmand, Baylor College of Medicine, USA
Autoreactive T Cells in The Pathophysiology of Human and Mouse Emphysema

Chandran Nagaraj, Ludwig Boltzmann Institute for Lung Vascular Research, Austria
Short Talk: p22phox Regulates House Dust Mite (HDM) Induced Allergic Airway Inflammation

17:00—19:00
Myeloid Cells in Tissue Homeostasis
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-B
* Richard M. Maizels, University of Edinburgh, UK

Judith E. Allen, University of Manchester, UK
Macrophages in Helminth Infection: Where Inflammation is Anti-Inflammatory

David Voehringer, University Hospital of Erlangen, Germany
Eosinophil and Basophil Responses to Allergens and Helminths

Hajime Karasuyama, Tokyo Medical and Dental University, Graduate School, Japan
Basophil as a Crucial Player in Acquired Immune Responses

Carla V. Rothlin, Yale University, USA
Short Talk: TAMing Type 2 Immunity

19:00—20:00
Social Hour with Lite Bites

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 3

Sweeney F

MONDAY, JANUARY 14

07:00—08:00
Breakfast

Main Level Breakouts
08:00—11:00
Initiating Type 2 Immunity (Joint)
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-E
* Andrew N. J. McKenzie, MRC Laboratory of Molecular Biology, UK

Jean-Philippe Girard, Institute of Pharmacology and Structural Biology, France
IL-33 Processing and Activation by Inflammatory Proteases

Marco Idzko, University Hospital Freiburg, Germany
ATP and P2X Receptors in Type 2 Immunity

Jack A. Elias, Yale School of Medicine, USA
Chitinase-like Moieties in Lung Inflammation, Injury and Repair

Laura J. Simpson, Stanford University, USA
Short Talk: miRNA Expression in CD4 T Cells from Asthmatic Airways

Takehiko Shibata, University of Michigan Medical School, USA
Short Talk: Gas6/TAM Signaling Differentially Modulates Chronic Fungal Asthma with the Expansion of Myeloid Regulatory Cell Subsets in Mice

09:00—09:20
Coffee Break

Sweeney F, Main Level Breakouts
11:15—16:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Viral Infections and Exacerbations of Lung Disease

Sweeney Ballroom C-E
* Marsha Wills-Karp, Johns Hopkins Bloomberg School of Public Health, USA

Charles S. Dela Cruz, Yale University, USA
Cigarette Smoke Exposure Enhances Interleukin-15, NK and CD8 T Cell Responses during Influenza Virus Infection in Models of COPD

Sumit Ghosh, North Dakota State University, USA
Hyaluronic Acid Impacts B Lymphocyte Recruitment and Function in a Murine Fungal Allergic Asthma Model

Amali E. Samarasinghe, University of Tennessee Health Science Center, USA
Allergic Eosinophils Enhance Anti-Viral Defenses in a Murine Co-Morbidity Model of Asthma and Influenza

Tamlyn Peel, Imperial College London, UK
IL-17 Modulation of Rhinovirus-Induced Allergic Airways Disease

Lara Ravanetti, Academic Medical Center, Netherlands
Influenza-Induced Exacerbation in a Murine Chronic House Dust Mite (HDM) Asthma Model

Kristen N. Kindrachuk, National Institutes of Health, USA
Muc5ac-Deficiency Exacerbates Bleomycin-Induced Airway Inflammation

16:30—17:00
Coffee Available

Sweeney F
17:00—19:00
Therapeutic Opportunities in Asthma and COPD
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom C-E
* Sally Wenzel-Morganroth, University of Pittsburgh, USA

Aili Lazaar, GlaxoSmithKline, USA
Challenges and Opportunities in COPD Drug Development

John G. Matthews, Genentech, Inc., USA
Treatment of Adult Asthmatics with the Anti-IL-13 Lebrikizumab

Alison L. Budelsky, Janssen Pharmaceutical Companies of Johnson & Johnson, USA
Blockade of IL-17RA in Asthma

Sofie Lock Johansson, Institut for Molecular Medicine, Denmark
Short Talk: Microfibril Associated Protein 4 (MFAP4) Is Associated to Dyspnea and the Composite BODE Index in COPD

17:00—19:15
Pathologic Syndromes
Meeting has ended...abstracts no longer viewable online.

Sweeney Ballroom A-B
* Yasmine Belkaid, NIAID, National Institutes of Health, USA

Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Lymphocyte Defects in Hyper-IgE Syndromes

Thomas A. Wynn, Pfizer, USA
Macrophages and Mucins in the Pathogenesis of Type 2 Immunity

Lawren C. Wu, Amgen Inc., USA
Therapeutic Targeting of IgE-Switched Cells in Asthma

Mark S. Wilson, Genentech, Inc., USA
Short Talk: miR-182 and miR-10a Are Key Regulators of Treg Specialisation and Stability during Th2 and Th1-Associated Inflammation

Adam Matson, University of Connecticut Health Center, USA
Short Talk: Maternal Allergy Is Associated with Surface-Bound IgE on Cord Blood Basophils

19:00—20:00
Social Hour with Lite Bites

Sweeney F, Main Level Breakouts
20:00—23:00
Entertainment

Sweeney F, Main Level Breakouts

TUESDAY, JANUARY 15

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-2676