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This meeting took place in 2013


Here are the related meetings in 2018:
Myeloid Cells (D2)

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Myeloid Cells: Regulation and Inflammation (B6)


Organizer(s) Vincenzo Cerundolo, Gwendalyn J. Randolph and David M. Mosser
February 19—24, 2013
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 18, 2012
Late Abstract Deadline: Nov 19, 2012
Scholarship Deadline: Oct 18, 2012
Early Registration Deadline: Dec 17, 2012

Sponsored by Novo Nordisk A/S

Summary of Meeting:
Recent results have shown that during inflammatory processes, myeloid cells exhibit extensive plasticity of their phenotype in response to numerous stimuli. This characteristic directly affects lymphocyte polarization and activity and is controlled by changes both at transcriptional and translational level. This previously unanticipated degree of epigenetic control of myeloid cells, which affects both innate and adaptive immune responses, is likely to impact several aspects of future studies in human immunology and to inform on immunotherapeutic strategies. This Keystone Symposia meeting will cover topical aspects of basic myeloid cell biology and their interface with clinical research, bringing together scientists and clinicians working on all the subtypes of myeloid cells in health and disease, from neutrophils and monocytes to macrophages and dendritic cells. The speakers will provide an overview of myeloid cell ontogeny, role of different myeloid cell subtypes in the modulation of innate and adaptive immunity, antigen capture and presentation, mobilization from the bone marrow and trafficking during inflammatory responses. The symposium will touch on multiple areas central to contemporary immunology and cell biology, including the interface between innate and adaptive immunity, as well as the mechanisms enforcing immunosuppression in cancer and infectious diseases.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 19

16:00—20:00
Arrival and Registration

Keystone Lodge Lobby

WEDNESDAY, FEBRUARY 20

07:00—08:00
Breakfast

Shavano/Torreys
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Vincenzo Cerundolo, University of Oxford, UK

Siamon Gordon, University of Oxford, UK
The Versatile Macrophage: Immune Receptors and Novel Functions

09:00—12:15
Myeloid Lineage Differentiation
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Christopher K. Glass, University of California, San Diego, USA

Irving L. Weissman, Stanford University, USA
Normal and Neoplastic Stem Cells

Paul S. Frenette, Albert Einstein College of Medicine, USA
Myeloid Cell-Induced Migration and Function in the Stem Cell Niche

Paresh Vyas, University of Oxford, UK
Lineage Differentiation of AML

Michael H. Sieweke, Centre d'Immunologic Marseille-Luming, France
Transcriptional Control of Macrophage Activity and Self-Renewal

Florent Ginhoux, Singapore Immunology Network, Singapore
Short Talk: Revisiting the Ontogeny of the Mononuclear Phagocyte System: Embryonic and Adult Hematopoietic Contributions

Craig Smuda, Feinberg School of Medicine, Northwestern University, USA
Short Talk: Ikaros Regulates Basophil and Mast Cell Development

09:40—10:00
Coffee Break

Longs Peak Foyer
12:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Plasticity of Myeloid Cells
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Gwendalyn J. Randolph, Washington University, USA

David M. Mosser, University of Maryland, USA
Macrophage Plasticity and Intrinsic Control of the Activation Response

Vincenzo Cerundolo, University of Oxford, UK
Ability of Invariant NKT Cells to Modulate the Phenotype and Function of Myeloid Cells

Judith E. Allen, University of Manchester, UK
Local Macrophage Proliferation in Type 2 Immunity

Dmitry Ostanin, Bristol Myers Squibb, USA
Short Talk: Reprogramming of Myeloid Cells to Treat Inflammatory Bowel Diseases

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 1

Shavano/Torreys

THURSDAY, FEBRUARY 21

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Myeloid Cells during Inflammation
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* David M. Mosser, University of Maryland, USA

Eric G. Pamer, Memorial Sloan Kettering Cancer Center, USA
Ly6Chi Monocytes and Immune Defense Against Mycobacterium Tuberculosis Infection

Jeffrey W. Pollard, Queen's Medical Research Institute, UK
Macrophages and Tumor Progression

Arturo Zychlinsky, Max Planck Institute for Infection Biology, Germany
NETs – From Infection to Autoimmunity

John R. Grainger, NIAID, National Institutes of Health, USA
Short Talk: Inflammatory Monocytes Regulate Pathologic Responses to Commensals during Acute Gastrointestinal Infection

Jing Wang, Augusta University, USA
Short Talk: Neutrophil Infiltration during Inflammation is Regulated by PILRalpha via Modulation of Integrin Activation

Romain Olekhnovitch, Pasteur Institute, France
Short Talk: The Control of an Intracellular Parasite by iNOS Is Regulated at the Tissue Level Rather than in a Cell-Intrinsic Manner

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
 
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Inflammation and Chemokine Receptors

Grays Peak
* Eric G. Pamer, Memorial Sloan Kettering Cancer Center, USA

Ludovic Arnold, Pierre and Marie Curie University-UPMC, France
CCR2/CCL2 and CX3CL1/CX3CR1 Chemokine Pathways Play Opposing Roles during Muscle Regeneration

Junjie Mei, Children's Hospital of Philadelphia, USA
Platelet CXCL7 and CXCL4 Inhibit Chemokine Scavenging and Increase Neutrophil transmigration

Melody Wei-Ning Chang, University of Melbourne, Australia
Interferon Regulatory Factor 4 and Inflammation

Boaz van Driel, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Role Slamf1 in Colitis

Eva Van Overmeire, VIB-Vrije Universiteit Brussel, Belgium
Assessment of the CCL17/CCR4 Axis, Regulated by the MHC II(high) Tumor-Associated Macrophage Subset, in Shaping the Inflammatory Tumor Infiltrate

Kavitha Subramanian, University of Cincinnati, USA
Sequestration of Zinc in Macrophages Is Essential to Restrict Survival of an Intracellular Pathogen

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Myeloid Cell Migration and Trafficking
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Matteo Iannacone, Vita-Salute San Raffaele University, Italy

Miriam Merad, Mount Sinai School of Medicine, USA
Myeloid Cell Control of Hematopoietic Cell Transplant Outcome

Paul Kubes, University of Calgary, Canada
Neutrophil Trafficking in vivo in Different Vascular Beds and to Different Stimuli

Leo M. Carlin, Imperial College London, UK
Inflammatory Monocytes

Ricardo A. Luz, Federal University of Rio de Janeiro, Brazil
Short Talk: 5-Lipoxygenase-Dependent Recruitment of Neutrophils by Eotaxin-Stimulated Murine Eosinophils

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 2

Shavano/Torreys

FRIDAY, FEBRUARY 22

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
Signaling Events
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA

Mikael J. Pittet, Massachusetts General Hospital, USA
Control of Macrophage Production by Cancer

Caetano Reis e Sousa, Francis Crick Institute, UK
Innate Immune Recognition of Cell Death

Alan Aderem, Center for Infectious Disease Research, USA
A Systems Approach to Dissecting Immunity

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
The NLR Proteins and Myeloid-Macrophage Functions

John J. Seeley, Columbia University, USA
Short Talk: miR-222 Suppresses Inflammation during Macrophage LPS Tolerance by Targeting Tnfa and the Chromatin Remodeler Brg1

Steven C. Ley, Francis Crick Institute, UK
Short Talk: Regulation of Tpl-2 Signaling by IkappaB Kinase

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
 
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Myeloid Regulatory Cells

Grays Peak
* Siamon Gordon, University of Oxford, UK

Sidney M. Morris, Jr., University of Pittsburgh, USA
Tuning the Murine Macrophage M2 Phenotype: IL-4 and cAMP Synergistically Activate the Arginase I Promoter

Andreas Alber, University of Edinburgh, UK
PHD Inhibition Induces M2 Macrophage Polarization and Has Differential Effects on Lung Fibrosis

Erik Thiele Orberg, Johns Hopkins School of Medicine, USA
Hif-1alpha and the Regulation of Pro-Tumoral Function of MDSC in Colitis-Induced Colon Cancer

Richard N. Hanna, MedImmune, USA
NR4A1 (Nur77) Dependent Monocytes Patrol the Lung Vasculature and Inhibit Tumor Cell Invasion

Elio Schouppe, Vrije Universiteit Brussel, VIB, Belgium
Distinct Tumor-Induced Myeloid-Derived Suppressor Cell Subsets Differentially Affect Multiple Aspects of CD8+ T-Cell Activation

Ruth A. Franklin, Yale School of Medicine, USA
Tumor Growth Induces the Differentiation of a Novel Subset of Tumor-Associated Macrophages from CCR2+ Monocytes

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Myeloid Cells during Pathogen Infections
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Judith E. Allen, University of Manchester, UK

Alan Sher, NIAID, National Institutes of Health, USA
Regulation of Myeloid Cell Differentiation and Function in the Innate Response to Toxoplasma gondii

Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA

John W. Schoggins, University of Texas Southwestern Medical Center, USA
Dengue Virus-Host Interactions and the Antiviral Interferon Response

Denise M. Monack, Stanford University, USA
The Battle within Macrophages: Mechanisms of Intracellular Salmonella Recognition and Evasion

19:15—20:15
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 3

Shavano/Torreys

SATURDAY, FEBRUARY 23

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Myeloid Cells Modulating Adaptive Immune Responses
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Vincenzo Cerundolo, University of Oxford, UK

Gwendalyn J. Randolph, Washington University, USA
Monocyte Emigration and Differentiation in the Steady State versus Acute Inflammatory Responses

Ronald N. Germain, NIAID, National Institutes of Health, USA
Imaging Myeloid Cell Dynamics, Tissue Positioning, and Function

Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA
DC and Adaptive Immune Response

Matteo Iannacone, Vita-Salute San Raffaele University, Italy
Lymph Node Macrophages and Antiviral Immune Responses

Astrid E. Cardona, University of Texas at San Antonio, USA
Short Talk: Regulation of Adaptive Immunity by the Fractalkine Receptor during Autoimmune Inflammation

Olga Barreiro, National Center of Cardiovascular Research, Spain
Short Talk: A Novel Subset of Skin Extramedullary Blood-Auditor Macrophages Able to Generate CD8 Memory T Cells Specific for Circulating Antigens

09:00—09:20
Coffee Break

Longs Peak Foyer
 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Myeloid Cells in Pathologies and in the Clinic
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Ronald N. Germain, NIAID, National Institutes of Health, USA

Virginia Pascual, Cornell University, USA
Neutrophils and SLE

Christopher K. Glass, University of California, San Diego, USA
A Genome-Wide View of Macrophage Activation

Ajay Chawla, University of California, San Francisco, USA
Monocyte Subsets and Metabolic Disease

Lai Guan Ng, Singapore Immunology Network, Singapore
Short Talk: G-CSF and AMD 3100 Induce Mobilization of Neutrophils to the Blood from Different Neutrophil Pools through Distinct Cellular Mechanisms

19:00—19:15
Concluding Remarks
Meeting has ended...abstracts no longer viewable online.

Grays Peak
Gwendalyn J. Randolph, Washington University, USA

19:15—20:15
Social Hour with Lite Bites

Shavano/Torreys
20:00—23:00
Entertainment

Shavano/Torreys

SUNDAY, FEBRUARY 24

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Novo Nordisk A/S

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI104221-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676