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This meeting took place in 2013


Here are the related meetings in 2015:
Dendritic Cells and Macrophages Reunited (C4)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Understanding Dendritic Cell Biology to Advance Disease Therapies (C2)


Organizer(s) Miriam Merad and Bart N. Lambrecht
March 3—8, 2013
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Nov 6, 2012
Late Abstract Deadline: Dec 3, 2012
Scholarship Deadline: Nov 6, 2012
Early Registration Deadline: Dec 20, 2012

Supported by the Directors' Fund

Summary of Meeting:
Tissue macrophages and dendritic cells (DC) are tissue hematopoietic cells that share the ability to sample the environment but have distinct function in tissue immunity. Controversies remain on the best way to distinguish macrophages from DC in vivo. Results in recent months have established that DC derive from a specific hematopoietic lineage in the bone marrow controlled by a unique molecular program distinct from other myeloid programs. Recent results have also established that DC are heterogeneous in origin and function and that dysregulated biology of DC subsets contribute to the pathogenesis of immune disease. The main goal of this Keystone Symposia meeting is to review recent developments in our understanding of basic DC biology and to discuss the relevance of these findings to the pathogenesis of human immune disease. Specifically, we will discuss the mechanisms that control DC differentiation in lymphoid and non-lymphoid tissues during the steady state and diseased state, both at the cellular and transcriptional levels. We will discuss recent developments in our understanding of the molecular control of three unique DC functions that include migration to of the lymph nodes, presentation antigens, and polarization of T cell immune responses. We will debate the role of DC in immune disease – including auto-immunity, inflammation and allergic disease – and address the recent controversy on the role of DC versus basophils in the induction of Th2 response. Specifically, we will discuss the recent discovery of the molecular signature of Langerhans cell histiocytosis, a poorly understood disease that results from the accumulation/proliferation of langerin+ DC. Finally, we will review the relevance of DC in therapy and the basic mechanisms of action of the cell vaccine “Provenge” that has recently been approved by the FDA for the treatment of prostate cancer. The Keystone Symposia meeting on Understanding Dendritic Cell Biology to Improve Human Disease will bring together physicians experts in autoimmune disease, allergy and cancer, immunologists, geneticists, cancer biologists and vaccinologists. We will also invite scientists from the pharmaceutical industry as well as Journal Editors to maximize the interactions between different members of our community and thereby improve our understanding of the key role that DC play in the modulation of human disease and in medicine.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 3

16:00—20:00
Arrival and Registration

MONDAY, MARCH 4

07:00—08:00
Breakfast
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Miriam Merad, Mount Sinai School of Medicine, USA
Welcome Remarks

* Bart N. Lambrecht, VIB, Ghent University, Belgium

Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Ralph Steinman and the Dendritic Cell Discovery

09:00—12:15
Development of Tissue-Resident and Inflammatory DC
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Miriam Merad, Mount Sinai School of Medicine, USA
Nature versus Nurture Control of the Dendritic Cells Lineage

Boris Reizis, Columbia University Medical Center, USA
Regulation of Plasmacytoid Dendritic Cell Development and Function

Bernard Malissen, Centre d'Immunologie de Marseille-Luminy, France
Fine-Grained Analysis of the Macrophages and Dendritic Cells Present in the Mouse Skin

* Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA
Transcriptional Control of DC Development

Florent Ginhoux, Singapore Immunology Network, Singapore
Short Talk: Revisiting the Ontogeny of the Mononuclear Phagocyte System: Embryonic and Adult Hematopoietic Contributions

Richard A. Kroczek, Robert Koch Institute, Germany
Short Talk: The Chemokine Receptor XCR1 Is a Lineage Marker for Cross-Presenting DCs

09:40—10:00
Coffee Break
12:15—13:00
Poster Setup
13:00—22:00
Poster Viewing
 
On Own for Lunch and Recreation
14:30—16:30
Workshop 1: Transcriptional Control of DC Development and Function
* Bernard Malissen, Centre d'Immunologie de Marseille-Luminy, France

* Nir Hacohen, Massachusetts General Hospital, USA

Venetia Bigley, Newcastle University, UK
Dendritic Cells in Human Primary Immunodeficiencies: Insights into DC Biology

Herbert Strobl, Medical University Vienna, Austria
Identification of the Receptor Tyrosine Kinase Axl as a Downstream Effector of TGF-beta1 during Langerhans Cell Differentiation and Epidermal Homeostasis

Romain F. Banchereau, Baylor Institute for Immunology Research, USA
A Modular Transcriptional Framework Characterizes Human Dendritic Cell Responses to Pathogens and Vaccines

Gaëlle Breton, Rockefeller University, USA
Gene Profiling of Dendritic Cell Subsets after in vivo Administration of TLR3 Agonist in Healthy Human Volunteers

Charlotte L. Scott, University of Ghent & VIB, Belgium
Conventional Dendritic Cell Precursors Give Rise to Four Distinct Subsets of Dendritic Cells in the Steady State Intestine

Laura Gutiérrez, Sanquin Research and Landsteiner Laboratory, Netherlands
What Does Gata1 Do to Dendritic Cells?

Alan D. Guerrero, NIDDK, National Institutes of Health, USA
IL-2 Inhibits Dendritic Cell Development by Acting on Precursors and Altering DC-Associated Transcription Factors

Evangelos Andreakos, Biomedical Research Foundation-Academy of Athens, Greece
IL-28A (IFN-lambda2) Modulates Lung DC Function to Promote Th1 Immune Skewing and Suppress Allergic Airway Disease

16:30—17:00
Coffee Available
17:00—19:00
Transcriptional Control of DC Development and Function
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Hideki Ueno, Baylor Institute for Immunology Research, USA
Functional Specialization of Human DC Subsets

Nir Hacohen, Massachusetts General Hospital, USA
Genes and Networks Underlying Dendritic Cell Activation

* Bali Pulendran, Emory University, USA
Systems Vaccinology: Enabling Rational Vaccine Design with Systems Biology

Shalin H. Naik, Walter & Eliza Hall Institute, Australia
Short Talk: Single Hematopoietic Progenitor Tracing Reveals Dendritic Cells Are a Distinct Lineage

19:00—20:00
Social Hour with Lite Bites
19:30—22:00
Poster Session 1

TUESDAY, MARCH 5

07:00—08:00
Breakfast
08:00—11:00
Cell Biology and Antigen Processing
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Bart N. Lambrecht, VIB, Ghent University, Belgium
Dendritic Cells and the Unfolded Protein Response

* Averil I. Ma, University of California, San Francisco, USA
Ubiquitination and DC Functions

Davor Frleta, Mt. Sinai Medical Center, USA
Short Talk: HIV-1 Infection-Induced Apoptotic Microparticles Inhibit Human Dendritic Cells via CD44

Pablo Vargas, Institut Curie, France
Short Talk: Developmental Regulation of Dendritic Cell Migration

Lesley Ann Smyth, King's College London, UK
Short Talk: Intercellular Transfer of Regulatory T Cell Specific MicroRNA to Dendritic Cells Leads to Modulation of Dendritic Cell Function

Diana Matheoud, Université de Montréal, Canada
Short Talk: Leishmania Inhibits Crosspresentation through the Cleavage of VAMP8

Marianne L. Boes, University Medical Centre Utrecht, Wilhelmina Children's Hospital, Netherlands
Short Talk: Potentiation of Cross-Presentation by Human Blood and Lymphoid Tissue BDCA-3+ Dendritic Cells

09:20—09:40
Coffee Break
11:00—13:00
Poster Setup
13:00—22:00
Poster Viewing
 
On Own for Lunch and Recreation
14:30—16:30
Workshop 2: Regulation of DC Function
* Nicolas Manel, Institut Curie, France

* Peter T. Lee, Immunity, Cell Press, USA

Yasuyuki Saito, University Hospital Zürich, Switzerland
Dendritic Cell Homeostasis Is Maintained by Non-Hematopoietic and T Cell-Produced Flt3-Ligand in Steady-State and during Antigen-Specific Immune Responses

Sonja I. Buschow, Nijmegen Centre for Molecular Life Sciences
The Human Dendritic Cell Phagosome Proteome: Novel Players and Implications for the Regulation of Receptor Mediation Phagocytosis

Cary D. Austin, Genentech, Inc., USA
Mice with Conditional Deletion of NF-kappaB–Inducing Kinase (NIK) in Dendritic Cells Show Defective CD40-Dependent Antigen Cross-Priming of CD8+ T Cells

Jeoung-Sook Shin, University of California, San Francisco, USA
Ubiquitin-Mediated MHCII Turnover Promotes Dendritic Cell Selection of Natural Regulatory T Cells

Zhe Wang, Purdue University, USA
Critical Role of Linear Ubiquitin Regulator SHARPIN in NF-kappaB Signaling and Induction of TH1 Cells by Dendritic Cells

Ilaria Tassi, NIAID, National Institutes of Health, USA
The NF-kappaB Regulator Bcl-3 Plays a Critical Role in the Initiation of Adaptive Immune Responses

Mitsuo Hashimoto, University of California, San Francisco, USA
The Role of alphanubeta8-Mediated Activation of TGF-beta by Fibroblasts in Directing Dendritic Cell Migration

Guy Shakhar, Weizmann Institute of Science, Israel
Dynamic Imaging Reveals Promiscuous Cross-Presentation of Blood-Borne Antigens to Naïve CD8+ T Cells in the Bone Marrow

16:30—17:00
Coffee Available
17:00—19:00
Molecular and Functional Aspects of DC Migration
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gwendalyn J. Randolph, Washington University, USA
Normal Dendritic Cell Mobilization to Lymph Nodes under Conditions of Severe Lymphatic Hypoplasia

Reinhold Förster, Hannover Medical School, Germany
Lymph Node Homing of DCs, pDCs, and Activated T Cells via Afferent Lymphatics

Michael Sixt, Institute of Science and Technology Austria, Austria
Cytoskeletal Dynamics of Dendritic Cells

Stephanie C. Eisenbarth, Yale University, USA
Short Talk: NOD-Like Receptor NLRP10 Regulates Migration of CD11b-Positive Dendritic Cells

19:00—20:00
Social Hour with Lite Bites
19:30—22:00
Poster Session 2

WEDNESDAY, MARCH 6

07:00—08:00
Breakfast
08:00—11:15
DC Sensing of the Environment
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Eicke Latz, University of Bonn, Germany
Inflammasome Activation in Macrophages and Dendritic Cells

* Laurence Zitvogel, Institut Gustave Roussy, France
Gut Microbiota Influences T Cell-Dependent Anticancer Immunity during Chemotherapy

Romina S. Goldszmid, NCI, National Institutes of Health, USA
Short Talk: Commensal Microbiota Modulates the Innate Response to Cancer Immunotherapy and Chemotherapy

* Yong-Jun Liu, MedImmune, USA
Biochemical Characterization of Nucleic Acid Sensors in Dendritic Cells

Nicolas Manel, Institut Curie, France
Short Talk: HIV Capsid Dissociates Cytosolic Sensing and Productive Infection in Dendritic Cells

09:20—09:40
Coffee Break
11:15—13:00
Poster Setup
13:00—22:00
Poster Viewing
 
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
17:00—19:00
Role of PDC in Immunity and Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Brian D. Brown, Mount Sinai School of Medicine, USA
MicroRNA Control of DC Development

* Marco Colonna, Washington University School of Medicine, USA
pDC in Host Defense

Toshiaki Ohteki, Tokyo Medical and Dental University, Japan
New DC Progenitors with Prominent pDC Differentiation Potential

Miguel A. Sanjuan, Medimmune/Astrazeneca, USA
Short Talk: LC3-Associated Phagocytosis Mediates IFN-alpha Secretion in Response to DNA-Immune Complexes

19:00—20:00
Social Hour with Lite Bites
19:30—22:00
Poster Session 3

THURSDAY, MARCH 7

07:00—08:00
Breakfast
08:00—11:15
Role of DC in Pathogenesis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Matthew L. Albert, Institut Pasteur, France
Influence of Cell Death on Tumor Immunity

* William R. Heath, University of Melbourne, Australia
Dendritic Cells, Receptors and Initiation of Immunity

* Steffen Jung, Weizmann Institute of Science, Israel
Critical Dendritic Cell / Macrophage Crosstalk in the Intestinal Lamina Propria

Hamida Hammad, VIB, Belgium
Role of Dendritic Cells in the Pathogenesis of Asthma

Carl Allen, Baylor College of Medicine, USA
Short Talk: BRAF-V600E Is Identified in Circulating Myelomonocytic Precursors in Patients with High-Risk Langerhans Cell Histiocytosis

Jesse W. Williams, University of Chicago, USA
Short Talk: Interferon Regulatory Factor 4 (IRF4) in Dendritic Cells (DCs) Promotes Th2 Responses and Regulates IL-10 and IL-33 Production

09:00—09:20
Coffee Break
 
On Own for Lunch and Recreation
14:30—16:30
Workshop 3: Role of DC in Pathogenesis
* Florent Ginhoux, Singapore Immunology Network, Singapore

* Zoltan Fehervari, Nature Publishing Group, UK

Heidi A. Schreiber, Rockefeller University, USA
Comparing pre-DC and Monocyte-Derived Cell Heterogeneity and Function in Non-Lymphoid Organs

Wing-Hong Kwan, Mount Sinai School of Medicine, USA
Complement Proteins Produced by Dendritic Cells Control Effector T Cell Differentiation and Regulatory T Cell Function

Sotaro Ochiai, Malaghan Institute of Medical Research, New Zealand
TSLP-Dependent and Independent Induction of Th2 Responses via Dermal Dendritic Cells

Juliana Idoyaga, Rockefeller University, USA
Specialized Role of Migratory Dendritic Cells in Peripheral Tolerance Induction

Nir Yogev, University of Mainz, Germany
Dendritic Cells Control CNS Autoimmunity by Induction of Tregs through PD-L/PD-1 Interaction

Nathalie Bendriss-Vermare, Cancer Research Center of Lyon, France
Plasmacytoid Dendritic Cells Deficient in IFN-alpha Production Promote the Amplification of FOXP3+ Regulatory T Cells though ICOS/ICOS-L Interaction in Breast Cancer

Suryasarathi Dasgupta, Harvard Medical School, USA
Critical Role of Plasmacytoid Dendritic Cells in Immunoregulation Initiated by a Commensal Microbial Polysaccharide

Teja Celhar, Singapore Immunology Network, Singapore
Enhanced RNA-Sensing in Dendritic Cells (DCs) Is Required for the Development of Severe Disease in SLE-Prone Mice

16:30—17:00
Coffee Available
17:00—18:30
Harnessing DC Biology to Advance Disease Therapies
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ira Mellman, Genentech, Inc., USA

* A. Karolina Palucka, The Jackson Laboratory for Genomic Medicine, USA
Reprogramming the Immune Environment in Cancer via Dendritic Cells

Bana Jabri, University of Chicago, USA
DC in Celiac Disease

Franck J. Barrat, Hospital for Special Surgery, USA
TLR Recognition of Self Nucleic Acids in Acute and Chronic Inflammation

18:30—19:15
Concluding Remarks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Ira Mellman, Genentech, Inc., USA
Translating DC Biology into Medicine

19:15—20:15
Social Hour with Lite Bites
20:00—23:00
Entertainment

FRIDAY, MARCH 8

 
Departure

*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

Chroma Technology Corporation

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI104118-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


Tokyo Medical and Dental University


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676