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This meeting took place in 2013


Here are the related meetings in 2015:
The Golden Anniversary of B Cell Discovery (X6)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

B Cell Development and Function (X1)


Organizer(s) Max D. Cooper, Andrea Cerutti and Carola G. Vinuesa
February 10—15, 2013
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 10, 2012
Late Abstract Deadline: Nov 12, 2012
Scholarship Deadline: Oct 10, 2012
Early Registration Deadline: Dec 10, 2012

Sponsored by Onyx Pharmaceuticals, Inc.

Joint Meeting: HIV Vaccines (X2)

Summary of Meeting:
This meeting will provide an overview of the most recent advances in the biology of B cells. In addition to covering the function of B cells under steady-state conditions and infection, the meeting will provide an update on the alterations of B cells in autoimmunity, leukemia and lymphoma. The mechanisms by which B cells crosstalk with different components of the innate and adaptive immune systems and the contribution of distinct B cell subsets to systemic and mucosal immunity remain unclear, particularly in humans. This meeting has the following specific aims: 1) to define the factors involved in B cell lineage specification and reprogramming; 2) to elucidate the evolution and mechanisms of the processes underpinning antibody gene diversification; 3) to better understand the B cell pathways required for systemic and mucosal antibody responses against T cell-dependent and T cell-independent antigens; 4) to clarify the mechanisms by which antibodies provide protection against HIV; 5) to broaden our understanding of the molecular alterations associated with autoimmune and neoplastic B cell disorders; and 6) to provide an interactive forum to involve early stage investigators and highlight their discoveries. By addressing these problems, this meeting will not only generate new knowledge on the biology of B cells in health and disease states, but it will also provide a framework for investigators and clinicians to generate new ideas, initiate new collaborations, and eventually introduce changes in clinical practice. In addition, this meeting will provide a unique opportunity to “take a closer look” at B cells by linking experts in B cell biology with experts in stem cell biology, comparative immunology, molecular biology, and in vivo imaging. Additional opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on HIV Vaccines, which will share a keynote session and two plenary sessions with this meeting.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 10

15:00—19:30
Arrival and Registration

18:15—19:15
Refreshments

19:15—21:30
Welcome and Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Max D. Cooper, Emory University, USA

* Georgia Doris Tomaras, Duke University Medical Center, USA

Myron S. Cohen, University of North Carolina at Chapel Hill, USA
HIV Prevention 2013: Preparing for a Vaccine

Michel C. Nussenzweig, HHMI/Rockefeller University, USA
The Human Antibody Response to HIV


MONDAY, FEBRUARY 11

07:00—08:00
Breakfast

08:00—11:15
B Cell Genesis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Max D. Cooper, Emory University, USA
Evolution of Adaptive Immunity in Vertebrates

Rudolf Grosschedl, Max Planck Institute of Immunobiology and Epigenetics, Germany
Mechanisms Underlying Transcriptional Control of B Cell Differentiation

Tasuku Honjo, Kyoto University Graduate School of Medicine, Japan
Acquired Immunity, Genome Instability, and Cancer

Frederick W. Alt, Boston Children's Hospital, USA
V(D)J Recombination, IgH Class Switch Recombination, and Genomic Instability

Bao Q. Vuong, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: A DNA Double Strand Break and Phosphorylation-Dependent Positive Feedback Loop Promotes Class Switch Recombination

Patricia J. Gearhart, NIA, National Institutes of Health, USA
Short Talk: Transcriptional Stalling of RNA Polymerase II Gives AID Access to Immunoglobulin Variable Genes


Following Session is for HIV Vaccines (X2)

08:00—11:15
Protective Responses in Animal Models
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* James A. Hoxie, University of Pennsylvania, USA

David H. O'Connor, University of Wisconsin-Madison, USA
Understanding SIV Control in Macaques with Restricted Genetic Diversity

Genoveffa Franchini, NCI, National Institutes of Health, USA
Innate and Adaptive Immune Correlate of Protection Against SIVmac251

Kevin O. Saunders, NIAID, National Institutes of Health, USA
Short Talk: Lasting Protection Against SHIV by VRC01 Protein Immunoprophylaxis in Indian Rhesus Macaques

* Jeffrey D. Lifson, Leidos Biomedical Research, Inc, Frederick National Laboratory, USA
Recent Developments in Non-human Primate Models for AIDS-related Vaccine Studies

Sallie R. Permar, Duke University Medical Center, USA
Immune Protection against Postnatal HIV-1/SIV Transmission

David B. Weiner, University of Pennsylvania School of Medicine, USA
Short Talk: Non-Human Primate Challenge Model to Study the Role of Serum and Vaginal IgA in Acquisition of Infection

09:20—09:40
Coffee Break


Following Session is for HIV Vaccines (X2)

11:15—12:45
Hands On Computer Workshop on Los Alamos Sequence Database and Tools

NOTE: Maximum attendance: 60. Interested participants must sign up at the meeting on a first-come, first-serve basis.
Instructor: Brian Foley, Los Alamos National Laboratory

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: B Cell Development and Signaling

* David J. Rawlings†, University of Washington / Seattle Children's Hospital Research Institute, USA

Anupam Banerjee, University of Pennsylvania, USA
Transcriptional Repression of Gata3 Is Essential for Early B Cell Commitment

Matteo Villa, MRC National Institute for Medical Research, UK
The Role of Aryl Hydrocarbon Receptor in B Cell-Mediated Immunity

* Mary Ellen Conley, University of Tennessee College of Medicine
A Dominant Negative Mutation in the Transcription Factor E2A in Patients with Agammaglobulinemia

Stéphane J. C. Mancini, Centre d'Immunologie de Marseille-Luminy, France
The Development of the Pro-B and Pre-B Cell Subsets Depends on Distinct Bone Marrow Stromal Cell Niches

Thomas Beck, Yale University, USA
Molecular Mechanisms of Developing B Cell Egress from the Bone Marrow

Andre Limnander, University of California, San Francisco, USA
Unraveling the Molecular Mechanisms of Developmental Checkpoints during B Cell Selection in the Bone Marrow

Marc Schwartz, University of Washington, USA
The Role of CD40 in Peripheral B Cell Development


Following Session is for HIV Vaccines (X2)

14:30—16:30
Workshop 1: Antibody Effector Functions and Env Based Immunogen Design

* George K. Lewis, University of Maryland, Institute of Human Virology, USA

* Mark Connors, NIAID, National Institutes of Health, USA

James E. Voss, The Scripps Research Institute, USA
SIV Vaccine Induces Local AntibodyProduction and Delivery Correlate with Protection in Female Reproductive Tract Protection.

Justin Pollara, Duke University, USA
Synergy between C1 Conformational and Anti-V2 Monoclonal Antibodies for Cell Surface Binding and ADCC

Chiara Orlandi, University of Maryland, USA
Potent ADCC Mediated by Human Monoclonal Antibodies (mAbs) Against Multiple Conserved Epitopes of HIV-Env

Ross W. Lindsay, International AIDS Vaccine Initiative, USA
An Inactivated Viral Vaccine that Displays Conformationally Intact HIV-1 Envelope Trimers Elicits Neutralizing Antibodies

Andrew McGuire, Seattle Biomed, USA
Engaging of the Germline BCRs of Anti-HIV bNAbs with Modified Recombinant Env Immunogens

Andrew B. Ward, The Scripps Research Institute, USA
Evaluating HIV Envelope Trimers as Structural Scaffolds and Immunogens

Joseph R. Francica, Vaccine Research Center, National Institutes of Health, USA
Genetic Assessment of B Cell Responses in NHP following HIV Env Immunization

14:30—16:30
Workshop 2: Molecular Basis of Antibody Diversification

* Patrick C. Wilson, University of Chicago, USA

* George Georgiou, University of Texas at Austin, USA

Robert W. Maul, NIA, National Institutes of Health, USA
B Cell Receptor Stimulation Induces Uracil DNA Glycosylase and Inhibits Class Switch Recombination

Leng-Siew Yeap, Boston Children's Hospital, USA
Mechanisms by which DNA Sequences Influence Activation Induced Cytidine Deaminase (AID) Activity in Somatic Hypermutation and Class Switch Recombination

Jeroen E. Guikema, Academic Medical Center Amsterdam, Netherlands
Genome-Wide Analysis of RAG-Induced DNA Breaks in Developing B Cells

Stephen P. Methot, Institut de Recherches Cliniques de Montreal (IRCM), Canada
Differentiating the Roles of Activation Induced Deaminase Cytoplasmic Retention and Nuclear Export

Menno C. van Zelm, Erasmus MC, Netherlands
B Cell Antigen Receptor and CD40 Signaling Together Direct Human Antibody Maturation and Selection

Maria A. Curotto de Lafaille, Singapore Immunology Network, Singapore
How the Failure-to-Thrive of IgE Germinal Centers Cells Paves the Way for the Unique Role of Sequential Switching in Generating IgE Plasma Cells

16:30—17:00
Coffee Available

17:00—19:15
Early Events in B Cell Activation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Facundo D. Batista, Cancer Research UK, London Research Institute, UK
Dynamic Imaging of Lymphocyte Activation - From Single Molecule to Living Tissue

Michael Reth, Max Planck Institute of Immunobiology and Epigenetics, Germany
Role of Protein Islands for the Activation of B Cells

Susan K. Pierce, NIAID, National Institutes of Health, USA
How B Cells Remember

Michael C. Carroll, Boston Children's Hospital, Harvard Medical School, USA
Short Talk: Endocytosis and Recycling of Immune Complexes by Follicular Dendritic Cells Enhances B Cell Binding and Activation

Victor L.J. Tybulewicz, MRC National Institute for Medical Research, UK
Short Talk: The B Cell Antigen Receptor Transduces Signals from the BAFF Receptor Required for B Cell Survival


Following Session is for HIV Vaccines (X2)

17:00—19:00
Potentially Protective Responses in Human Clinical Trials
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Georgia Doris Tomaras, Duke University Medical Center, USA

* Lawrence Corey, Fred Hutchinson Cancer Research Center, USA

Merlin L. Robb, Walter Reed Army Institute of Research, USA
Military HIV Research Program Clinical Studies and the Search for Correlates

Glenda Gray, University of the Witwatersrand, South Africa
Efficacy Trials in South Africa: Factors Affecting Vaccine Induced Immune Response in HIV Clinical Trials

Barney S. Graham, NIAID, National Institutes of Health, USA
Active and Passive Immunity Against HIV

Susan Zolla-Pazner, New York University School of Medicine, USA
Short Talk: RV144-Induced V1V2 Antibodies Reactive with Multiple Subtypes Correlated with Decreased Risk of HIV-1 Infection

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, FEBRUARY 12

07:00—08:00
Breakfast

08:00—11:15
B Cell Evolution and Repertoire Selection
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ana Cumano, Pasteur Institute, France
Lineage Commitment in Fetal Hematopoiesis

Michael S. Neuberger, Medical Research Council, UK
The AID/APOBEC Family of DNA Deaminases: Balancing Immunity versus Cancer

Garnett H. Kelsoe, Duke University Medical Center, USA
Genetic Control of the First Tolerance Checkpoint in B Cells

Hedda Wardemann, Max-Planck Institute for Infection Biology, Germany
An Atlas of the Murine B Cell Repertoire: From Immunoglobulin Sequence to B Cell Differentiation State and Histo-Anatomical Localization

Ziv Shulman, Rockefeller University, USA
Short Talk: T Follicular Helper Cell Dynamics in Germinal Centers

Christopher D. C. Allen, University of California, San Francisco, USA
Short Talk: IgE-Expressing B Cells Are Restrained by an Intrinsic Cell Fate Predisposition


Following Session is for HIV Vaccines (X2)

08:00—11:00
Quality of Immune Response (Immune Geography and Memory)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Barbara L. Shacklett, University of California, Davis, USA

* Daniel C. Douek, NIAID, National Institutes of Health, USA

Ronald N. Germain, NIAID, National Institutes of Health, USA
Imaging Immune Cell Dynamics and Function

Jacob D. Estes, SAIC-Frederick, Inc., USA
Early Events following SIV Mucosal Challenge

Shane Crotty, La Jolla Institute for Allergy and Immunology, USA
Designing Vaccines: The Role of CD4 follicular T-helper Cells

Mario Roederer, NIAID, National Institutes of Health, USA
Single Cell Transcriptomics: Measuring Quality and Quantity

Qingsheng Li, University of Nebraska Center for Virology, USA
Short Talk: Distribution and Dissemination of Transmitted SIV Viruses in the Early Infection of Rhesus macaques via Anal/Rectal Route

09:20—09:40
Coffee Break


Following Session is for HIV Vaccines (X2)

11:00—12:30
Hands On Computer Workshop on Los Alamos Immunology Database and Tools

NOTE: Maximum attendance: 60. Interested participants must sign up at the meeting on a first-come, first-serve basis.
Instructor: Brian Foley, Los Alamos National Laboratory

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

14:30—16:30
Joint Workshop: B Cell Responses to Vaccines and HIV

* Leonidas Stamatatos, Fred Hutchinson Cancer Research Center, USA

* Jonathan W. Yewdell, NIAID, National Institutes of Health, USA

David Nemazee, The Scripps Research Institute, USA
Knock-In Mice Expressing Broadly Neutralizing HIV Antibodies b12 and 4E10

Katherine Nicholas, Vanderbilt University Medical Center, USA
The Effect of Chronic HIV-1 Infection on pTFH Cells

Josiane Chagnon-Choquet, Université de Montréal, Canada
Maintenance of Breg Capacity and Increased LT-alpha Expression by First Line MZ-Like B Cells Is Associated with Control of HIV Disease Progression

Adam K. Wheatley, NIAID, National Institutes of Health, USA
Prime-Boost Vaccination Against Influenza H5N1 Elicits the Expansion of Potentially Neutralizing H5/H1 Cross-Reactive Memory B Cells

Hongyan Liao, University of Nebraska Medical Center, USA
Dominant Production of Polyreactive Antibodies by Circulating Plasmablasts in HIV-Infected Individuals

Sarah F. Andrews, University of Chicago, USA
Adaptibility of the Human Influenza-specific Antibody Response

Sean P. McBurney, Oregon Health Sciences University, USA
Elicitation of MPER-Specific Neutralizing Antibodies following Vaccination with an MPER-Targeted Vaccine Strategy

John B. Schell, Yale School of Medicine, USA
An Env-Only Vaccine Does Not Provide Sterilizing Protection of Rhesus macaques Against High-Dose SIVsmE660 Challenge

14:30—16:30
Workshop 4: Mucosal B Cell Responses

* Sidonia Fagarasan, RIKEN Research Center for Allergy and Immunology, Japan

Samuel K. Lai, University of North Carolina at Chapel Hill, USA
Mucosal Immunity Mediated by Antibody-Mucin Crosslinking

Georg F. Weber, Center for Systems Biology, USA
Protective Function of Pleural B Cells in Pneumonia

Mats Bemark, Gothenburg University, Sweden
Oral Immunization Induces Long-Lived Intestinal and Bone Marrow Plasma Cells and Memory B Cells Destined for Mucosal Homing

Øyvind Steinsbø, Oslo University Hospital - Rikshospitalet, Norway
Limited Somatic Hypermutation in IgA of Transglutaminase 2 Specific as well as Gluten Specific Plasma Cells of Celiac Disease Intestinal Lesions

Giuliana Magri, Institut Hospital del Mar d'Investigacions Médiques, Spain
A Novel Subset of GM-CSF-Producing Innate Lymphoid Cells Links Splenic B Cell-Helper Neutrophils with Marginal Zone B Cells

16:30—17:00
Coffee Available

17:00—19:15
Mucosal Antibody Responses (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Barton F. Haynes, Duke University Medical Center, USA

* Andrea Cerutti, Mount Sinai School of Medicine, USA
Mucus and Goblet Cells : New Insights in Intestinal Homeostasis Homeostasis

Sidonia Fagarasan, RIKEN Research Center for Allergy and Immunology, Japan
IgA Synthesis: A Form of Functional Immune Adaptation Extending Beyond Gut

Andrew J. Macpherson, University of Bern, Switzerland
Mucosal and Systemic Antibody Responses to Commensal Microbes – Induction and Function

Duane R. Wesemann, Brigham and Women's Hospital, USA
Short Talk: Early B Lineage Cell Develompment in the Gut Lamina Propria

Olga Malykhina, Northwestern University, USA
Short Talk: Cervical and Cervicovaginal Mucus Show Differential Retention of IgA But Similar Retention of IgG -- Implication for HIV Vaccine

19:15—20:15
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, FEBRUARY 13

07:00—08:00
Breakfast

08:00—11:15
Germinal Center, Plasma Cell and Memory B Cell Differentiation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Carola G. Vinuesa, Australian National University, Australia
Regulation of Tfh Cell-Mediated Selection in Germinal Centers

Jason G. Cyster, HHMI/University of California, San Francisco, USA
Lipid Cues and Cell Migration during the Humoral Immune Response

Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Dendritic Cells and Macrophages Help the Generation of Human Plasma Cells

Tomohiro Kurosaki, WPI Immunology Frontier Research Center, Osaka University, Japan
B Cell Intrinsic and Extrinsic Mechanisms for Rapid Responsiveness of IgG1 Type Memory B Cells

Christopher C. Goodnow, Australian National University, Australia
Short Talk: Clonal Anergy, the Function of IgD, and Redemption of Self-Reactive Antibodies in Germinal Centers

Hai Qi, Tsinghua University, China
Short Talk: Parenchymal Bystander B Cells Control ICOS-Dependent Follicular Recruitment of Helper T Cells


Following Session is for HIV Vaccines (X2)

08:00—11:15
CD8 and CD4 T Cell Immunity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Douglas F. Nixon, University of California, San Francisco, USA

* Stephen A. Migueles, NIAID, National Institutes of Health, USA

Hendrik Streeck, US Military HIV Research Program
HIV-Specific CD4 T-Cells

Olivier Lambotte, University Paris South, France
T-cells in HIV Controllers and the Perspectives for HIV Cure Strategies

Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
Properties of Protective CD8 T Cell Responses

Barbara L. Shacklett, University of California, Davis, USA
Mucosal T-Cell Responses and HIV Infection

Brenna J. Hill, Vaccine Research Center, NIAID, National Institutes of Health, USA
Short Talk: Characterization of SIV-Specific T Cells after Heterologous Mucosal Vaccination

Tomas Hanke, Jenner Institute, UK
Short Talk: Targeting HIV-1 Where It Hurts: Phase I/ IIa Clinical Trials

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

14:30—16:30
Workshop 5: Germinal Center B Cell Response

* Ulf Klein, Columbia University, USA

Alexander Dent, Indiana University School of Medicine, USA
Dissecting the Role of BCL6 in Normal B Cells

Lisa G. Barnett, Genomics Institute of the Novartis Research Foundation, USA
Temporally Defined Cognate T Cell-B Cell Interactions Regulate Germinal Center Development

Gabriel D. Victora, Whitehead Institute for Biomedical Research, USA
c-MYC Is Required for Germinal Center Selection and Cyclic Re-Entry

Zahra Sabouri, Australian National University, Australia
Antibody Redemption: Removal of Self-Reactivity from IgD+ Anergic B Cells by Purifying Selection in Germinal Centers

Kai-Michael Toellner, University of Birmingham Medical School, UK
Asymmetric B Cell Division Optimises Information Processing in Germinal Centres

* Carol E. Schrader, University of Massachusetts, USA
AP Endonuclease 2 (APE2) Regulates the Expansion of Germinal Center B Cells by Protecting Against Oxidative Damage

Alberto Martin, University of Toronto, Canada
Caspase 8 Activity Regulates Germinal Center B Cell Homeostasis and the Generation of High Affinity Antibodies

Luise Humpert, Institute for Research in Biomedicine, Switzerland
Functional Role of CXCR7 Expression on Late Germinal Center B Cells

14:30—16:30
Workshop 6: Plasma Cell and Memory B Cell Responses

* John C. Cambier, University of Colorado Denver School of Medicine, USA

Wei Xu, Hoffmann-La Roche Ltd., Switzerland
Identification of Human Granzyme B-Expressing Plasma Cells

Ignacio Sanz, Emory University, School of Medicine, USA
Heterogeneity of Antibody Secreting Cell Subsets in Blood after Vaccination and Bone Marrow in Healthy Adults: Identification of Human Long-Lived Plasma Cells

Laura Ann George, University of Birmingham, UK
Differential Regulation of IRF4 during Extrafollicular B Cell Differentiation, and its Role for Ig Class Switching

Mark Wright, Monash University, Australia
Plasma Cells Require CD37-Dependent Integrin Signaling for Long-Term Survival

* Lynn M. Corcoran, Walter and Eliza Hall Institute of Medical Research, Australia
The BTB-ZF Transcription Factor Zbtb20 Is Driven by Irf4 and Promotes Plasma Cell Differentiation

Deepta Bhattacharya, Washington University School of Medicine, USA
Adjuvant-Specific Regulation of Long-Term Antibody Responses by Zbtb20

Daniel Radtke, University of Erlangen, Germany
Grb2 Regulates B Cell Maturation, B Cell Memory Responses and Inhibits B Cell Ca2+ Signaling

Boaz Tirosh, Hebrew University, Israel
mTORC1 Activation Promotes Plasma Cell Differentiation and Bypasses the Unfolded Protein Response for Immunoglobulin Secretion

14:30—16:30
Workshop 7: Autoimmunity and Neoplasia

* Ann Marshak-Rothstein, University of Massachusetts Medical School, USA

* Michael P. Cancro, University of Pennsylvania, USA

Joseph D. Dekker, University of Texas at Austin, USA
Pathways and Mechanisms by which FOXP1 and BCL11A Contribute to Activated B Cell Diffuse Large B Cell Lymphoma (ABC-DLBCL)

Carel J. M. van Noesel, Academic Medical Center, Netherlands
Antigen-Driven Lymphoma Growth: A Novel Mutated B-Cell Chronic Lymphocytic Leukemia Subset that Recognizes and Responds to Fungi

Saravanan Yuvaraj, Erasmus Medical Centrum, Netherlands
The Role of Antigenic Stimulation in the Pathogenesis of Chronic Lymphocytic Leukemia

Simone Bürgler, Rikshospitalet and University of Oslo, Norway
A Chronic Immune Response between B Cells and T Helper Cells Drives Chronic Lymphocytic Leukemia

Nataliya Yeremenko, Academic Medical Center, Netherlands
The Role of Bob1 in Rheumatoid Arthritis: Potential Implications for Autoimmunity

Simanta Pathak, University of Texas Southwestern Medical Center, USA
Overexpression of Fatty Acid Amide Hydrolase Promotes Peripheral B Cell Receptor Revision and Emergence of Polyreactive Antibodies in Lupus Prone Mice

Nancy L. Monson, University of Texas Southwestern Medical Center, USA
B Cells that Display a Particular Somatic Hypermutation Pattern in their Antibody Genes Are Unique to Patients with Multiple Sclerosis and Recognize Neurons and Astrocytes

16:30—17:00
Coffee Available

17:00—19:15
Protective Antibody Responses Against HIV (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Christiane Moog, INSERM and Université of Strasbourg, France

* Diane L. Bolton, US Military HIV Research Program, WRAIR, USA

Barton F. Haynes, Duke University Medical Center, USA
Antibody Virus Co-evolution in Acutely Infected Patients Followed to Broadly Neutralizing Antibody Induction

Peter D. Kwong, NIAID, National Institutes of Health, USA
Structural Biology of Sites of HIV-1 Vulnerability to Neutralizing Antibody

Dennis R. Burton, The Scripps Research Institute, USA
Antibody Protection Against HIV: Broadly Neutralizing MAb PGT121

Georgia Doris Tomaras, Duke University Medical Center, USA
Spectrum of Vaccine-Elicited Humoral Responses

19:15—20:15
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, FEBRUARY 14

07:00—08:00
Breakfast

08:00—11:00
MicroRNAs and B Cell Neoplasias
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
MicroRNAs in Normal and Neoplastic B Cells

Maryaline Coffre, New York University School of Medicine, USA
Short Talk: Role of RNAi in B Cell Development and Maturation

Louis M. Staudt, NCI, National Institutes of Health, USA
Therapeutic Efficacy of B Cell Receptor Signaling Inhibitors in Lymphoma

David Baltimore, California Institute of Technology, USA
MicroRNAs, Inflammation and Cancer


Following Session is for HIV Vaccines (X2)

08:00—11:00
New Concepts in Innate Immunity and Stimulation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Robert A. Seder, NIAID, National Institutes of Health, USA

* Gregg A. Dean, Colorado State University, USA

Peter Johannes Holst, Laboratory of Experimental Vaccinology, Denmark
Short Talk: MHC Class II Associated Invariant Chain as a Genetic Adjuvant in Virus Vectored Vaccines

Nina Bhardwaj, Mt. Sinai Hospital, USA
HIV-DC interactions

Persephone Borrow, University of Oxford, UK
Innate Immune Pressure on Transmitted HIV-1

Karin Loré, Karolinska Institutet, Sweden
Innate mechanisms by which Vaccine Adjuvants Influence HIV Env Immunity in Non-Human Primates

Xu Yu, Massachusetts General Hospital, USA
Short Talk: LILRB2 Interaction with HLA Class I Correlates with Outcomes of HIV-1 Infection

09:00—09:20
Coffee Break

 
On Own for Lunch and Recreation


Following Session is for HIV Vaccines (X2)

14:30—16:30
Workshop 3: CD4+ T Cell Help

* Nicole Frahm, Fred Hutchinson Cancer Research Center, USA

* Spyros A. Kalams, Vanderbilt University Medical Center, USA

Kristin L. Boswell, NIAID, National Institutes of Health, USA
Characterization of Peripheral TFH-like Cells in HIV Infection

Rafael Cubas, Vaccine and Gene Therapy Institute Florida, USA
Impaired Peripheral Tfh-mediated B-cell Function Affects Humoral Defenses in Chronic HIV Infected Individuals

Colin Havenar-Daughton, La Jolla Institute of Allergy and Immunology, USA
Ability to Generate HIV-1 Neutralizing Antibodies Is Correlated with Increases in Activated Memory B Cells and Peripheral T Follicular Helper Cells

Antje Heit, Fred Hutchinson Cancer Research Center, USA
HVTN-Tested Candidate HIV Vaccines Induce Early Plasmablast and Tfh-Like Responses in Peripheral Blood

Kristin Hollister, Indiana University School of Medicine, USA
Enhanced Expansion of Follicular T Helper Cells following Vaccination with gp120-Encoding DNA

Patricia Bourguignon, GlaxoSmithKline Vaccines, Belgium
Co-Administration of an Adjuvanted HIV-1 Gag-Pol-Nef Fusion Protein (F4/AS01) and Adenovirus-35 Gag-RT-Int-Nef (Ad35-GRIN) Induces Potent, Polyfunctional CD4 and CD8 T-Cell Responses

16:30—17:00
Coffee Available

17:00—19:00
Autoimmunity and Regulatory B Cells
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Betty Diamond, Feinstein Institute for Medical Research, USA
Negative Regulation of Peripheral Autoreactive B Cells

Robert Brink, Garvan Institute of Medical Research, Australia
Censoring Self-Reactive B Cells in the Germinal Center Reaction

Edgar G. Engleman, Stanford University School of Medicine, USA
B Cells and Insulin Resistance

Claude-Agnès Reynaud, Necker-Paris Medical School, France
Short Talk: B-Cell Depletion in Immune Thrombocytopenia Induces the Settlement of Splenic Long-Lived Plasma Cells


Following Session is for HIV Vaccines (X2)

17:00—19:00
Antibody Genomics and Immunogen Design
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Marie Pancera, National Institutes of Health, USA

Ruth M. Ruprecht, Texas Biomedical Research Institute, USA
Passive Immunization against Mucosal R5 SHIV Transmission with Different Isotypes of Human Neutralizing Monoclonal Antibodies

John R. Mascola, NIAID, National Institutes of Health, USA
Genetics of Antibody Elicitation

Nicole A. Doria-Rose, NIAID, National Institutes of Health, USA
Short Talk: Highly Potent V2-Directed Antibodies with Exceptionally Long CDRH3 that Neutralize HIV-1 Subtype C Viruses

Rebecca M. Lynch, National Institutes of Health, USA
Short Talk: Effective HIV-1 Neutralization at the CD4-Binding Site through Loop-Based Modes of Antibody Recognition

William Schief, IAVI and The Scripps Research Institute, USA
Epitope-Focused HIV Vaccine Design

* Quentin J. Sattentau, Sir William Dunn School of Pathology, UK
Chemical Modification of Env for HIV-1 Vaccine Design

19:00—20:00
Social Hour with Lite Bites

20:00—23:00
Entertainment


FRIDAY, FEBRUARY 15

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Onyx Pharmaceuticals, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI104097-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676