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Meeting Details
Immunological Mechanisms of Vaccination (S3)
Organizer(s) Adrian V.S. Hill, Dan H. Barouch, John T. Harty and Tania H. Watts
December 13 - December 18, 2012
Fairmont Château Laurier • Ottawa, Ontario Canada
Abstract Deadline: August 13, 2012
Late Abstract Deadline: September 13, 2012
Scholarship Deadline: August 13, 2012
Early Registration Deadline: October 11, 2012
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
CME Information
Summary of Meeting:
Vaccines are remarkably successful in reducing morbidity and mortality from infectious diseases in both developed and developing countries. However, globally, mortality from infectious disease still exceeds 10 million deaths annually, reflecting a need for new, more effective and more deployable vaccination approaches. As many of the relatively easy vaccines have already been made, vaccinology is now tackling more difficult diseases, often caused by complex and genetically variable pathogens. A better understanding of the immunological mechanisms underpinning existing and novel vaccines is therefore required. Fortunately, research efforts to uncover new molecular and cellular techniques offer exceptional opportunities for improved vaccine design.
A better understanding of the immunology of vaccination will be of value in evidence-based design of new vaccines against major global causes of mortality such as HIV, malaria and tuberculosis, and against emerging infections such as swine influenza and dengue. Advances in immunology, genomics and systems biology are beginning to offer a deeper understanding of the molecular and cellular mechanisms of host immunity, and the pivotal role played by the innate immune system in shaping the adaptive immune response. This is providing new opportunities to identify new signatures of vaccine immunogenicity and protective efficacy, which should facilitate vaccine development and guide improved vaccine design. The Keystone Symposia meeting on Immunological Mechanisms of Vaccination will bring together an interdisciplinary group of scientists in vaccinology, immunology and pathogen biology, to address recent advances in these fields and their potential for accelerating vaccine design and development.
CME Information
Vaccines are remarkably successful in reducing morbidity and mortality from infectious diseases in both developed and developing countries. However, globally, mortality from infectious disease still exceeds 10 million deaths annually, reflecting a need for new, more effective and more deployable vaccination approaches. As many of the relatively easy vaccines have already been made, vaccinology is now tackling more difficult diseases, often caused by complex and genetically variable pathogens. A better understanding of the immunological mechanisms underpinning existing and novel vaccines is therefore required. Fortunately, research efforts to uncover new molecular and cellular techniques offer exceptional opportunities for improved vaccine design. A better understanding of the immunology of vaccination will be of value in evidence-based design of new vaccines against major global causes of mortality such as HIV, malaria and tuberculosis, and against emerging infections such as swine influenza and dengue. Advances in immunology, genomics and systems biology are beginning to offer a deeper understanding of the molecular and cellular mechanisms of host immunity, and the pivotal role played by the innate immune system in shaping the adaptive immune response. This is providing new opportunities to identify new signatures of vaccine immunogenicity and protective efficacy, which should facilitate vaccine development and guide improved vaccine design. The Keystone Symposia meeting on Immunological Mechanisms of Vaccination will bring together an interdisciplinary group of scientists in vaccinology, immunology and pathogen biology, to address recent advances in these fields and their potential for accelerating vaccine design and development.
Conference Program Print | View meeting in 12 hr (am/pm) time
THURSDAY, DECEMBER 13
12:00—19:30
Arrival and Registration
Main Lobby
16:00—17:30
Welcome and Keynote Address (Joint with Grand Challenges Meeting)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Canada Hall 1, Ottawa Convention Centre
*
Christopher L. Karp,
Bill & Melinda Gates Foundation, USA
Chris Wilson,
Bill & Melinda Gates Foundation, USA
Translating Immunology into Vaccinology
Translating Immunology into Vaccinology
17:30—20:00
Social Hour w/ Lite Bites
Trillium Ballroom, Ottawa Convention Centre
07:30—09:00
Breakfast
Adam/Drawing Rooms
09:00—12:15
Innate Sensing of Pathogens and Vaccines
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Ballroom
*
Julie Magarian Blander,
Mount Sinai School of Medicine, USA
Stephanie C. Eisenbarth,
Yale University, USA
NLR Regulation of Dendritic Cell Priming during Immunization
NLR Regulation of Dendritic Cell Priming during Immunization
Yan Shi,
, Canada
Immune Activation by Force
Immune Activation by Force
Nicolas Chevrier,
Harvard University, USA
Short Talk: System-Level Analysis of the Toll-Like Receptor Network Delineates Viral and Inflammatory Sensing Circuits
Short Talk: System-Level Analysis of the Toll-Like Receptor Network Delineates Viral and Inflammatory Sensing Circuits
Taryn L. Osmond,
Malaghan Institute of Medical Research, New Zealand
Short Talk: Splenic CD8alpha+Langerin+ Dendritic Cells: Firing up the Immune Environment for CD8+ T Cell Responses
Short Talk: Splenic CD8alpha+Langerin+ Dendritic Cells: Firing up the Immune Environment for CD8+ T Cell Responses
10:20—10:40
Coffee Break
Adam/Drawing Rooms
12:15—13:00
Poster Setup
Adam/Drawing Rooms
12:15—
On Own for Lunch and Recreation
13:00—22:00
Poster Viewing
Adam/Drawing Rooms
14:00—16:00
Workshop 1: Novel Adjuvants
Ballroom
*
Katrina D. Gee,
Queen's University, Canada
*
Sam Basta,
Queen's University, Canada
Frank Wegmann,
University of Oxford, UK
Polyethyleneimine is a Potent Mucosal Adjuvant for Glycoproteins with Innate and Adaptive Immune Activating Properties
Polyethyleneimine is a Potent Mucosal Adjuvant for Glycoproteins with Innate and Adaptive Immune Activating Properties
Sang Mu Shim,
Korea Research Institute of Bioscience and Biotechnology (KRIBB), South Korea
Poly gamma Glutamic Acid-Chitosan Nanogel Dramatically Enhance the Efficacy of Pandemic H1N1 Influenza Vaccine
Poly gamma Glutamic Acid-Chitosan Nanogel Dramatically Enhance the Efficacy of Pandemic H1N1 Influenza Vaccine
Thomas W. Dubensky, Jr.,
Aduro Biotech, USA
Development of Cyclic Dinucleotides (CDNs) as STING-Targeted Molecular Adjuvants
Development of Cyclic Dinucleotides (CDNs) as STING-Targeted Molecular Adjuvants
Karen Smith Korsholm,
Statens Serum Institut, Denmark
The Effect of the Immunostimulating Glycolipid MMG in Cationic Liposomal Vaccine Adjuvants
The Effect of the Immunostimulating Glycolipid MMG in Cationic Liposomal Vaccine Adjuvants
Silvia Vendetti,
Istituto Superiore di Sanità, Italy
Achieving Mucosal and Systemic Immunity by Exploiting Vitamin A Metabolites as Vaccine Co-Adjuvants
Achieving Mucosal and Systemic Immunity by Exploiting Vitamin A Metabolites as Vaccine Co-Adjuvants
Esteban Celis,
Moffitt Cancer Center, USA
BiVax: A Peptide/Poly-IC Subunit Vaccine that Mimics an Acute Infection Elicits Vast and Effective Anti-Tumor CD8 T Cell Responses
BiVax: A Peptide/Poly-IC Subunit Vaccine that Mimics an Acute Infection Elicits Vast and Effective Anti-Tumor CD8 T Cell Responses
Maria L. Knudsen,
Karolinska Institutet, Sweden
Alphavirus Replicons Encoding the TLR5 Ligand Flagellin is a Potent Adjuvant for IgG Response
Alphavirus Replicons Encoding the TLR5 Ligand Flagellin is a Potent Adjuvant for IgG Response
16:00—16:30
Coffee Available
Adam/Drawing Rooms
16:30—19:15
Augmenting Immune Responses to Vaccines
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Ballroom
*
Dan H. Barouch,
Harvard Medical School/Beth Israel Deaconess Medical Center, USA
Robert A. Seder,
NIAID, National Institutes of Health, USA
Differential Effects of Innate Immunity and Antigen Load on CD8 T Cell Immunity Following Viral Vaccination
Differential Effects of Innate Immunity and Antigen Load on CD8 T Cell Immunity Following Viral Vaccination
Tania H. Watts,
University of Toronto, Canada
CD137L (4-1BBL) as an Immune Stimulant in Acute and Chronic Viral Infections
CD137L (4-1BBL) as an Immune Stimulant in Acute and Chronic Viral Infections
Rafick P. Sékaly,
Vaccine & Gene Therapy Institute, USA
RNA Immunoprofiling of Vaccines
RNA Immunoprofiling of Vaccines
Daniel D. Pinschewer,
University of Geneva, Switzerland
LCMV-Based Vaccine Vectors: Viral Immunobiology Teaches Vaccinology
LCMV-Based Vaccine Vectors: Viral Immunobiology Teaches Vaccinology
Nicolas Cuburu,
NCI, National Institutes of Health, USA
Short Talk: Prime/Boost Genital Immunization with Human Papillomaviral Vectors Preferentially Induces CD103+CD8+ Tissue Resident Memory Cells in the Mouse Female Genital Tract
Short Talk: Prime/Boost Genital Immunization with Human Papillomaviral Vectors Preferentially Induces CD103+CD8+ Tissue Resident Memory Cells in the Mouse Female Genital Tract
19:15—20:15
Social Hour w/ Lite Bites
Adam/Drawing Rooms
19:30—22:00
Poster Session 1
Adam/Drawing Rooms
07:30—09:00
Breakfast
Adam/Drawing Rooms
08:00—09:00
Poster Setup
Adam/Drawing Rooms
09:00—17:00
Poster Viewing
Adam/Drawing Rooms
09:00—12:15
T Cell Memory to Vaccines
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Ballroom
*
Nathalie Labrecque,
Maisonneuve-Rosemont Hospital Research Centre, Canada
*
Susan M. Kaech,
Yale University School of Medicine, USA
Ton N. Schumacher,
Netherlands Cancer Institute, Netherlands
Technologies for Tracking T Cell Responses
Technologies for Tracking T Cell Responses
John T. Harty,
University of Iowa, USA
Alternative Strategies for Generating Protective Numbers of Memory CD8 T Cells by Prime-Boost Immunization
Alternative Strategies for Generating Protective Numbers of Memory CD8 T Cells by Prime-Boost Immunization
Ross M. Kedl,
University of Colorado Health Sciences Center, USA
Short Talk: Antigen Persistence after Subunit Vaccination Correlates with the Generation and Maintenance of Protective Cellular Immunity
Short Talk: Antigen Persistence after Subunit Vaccination Correlates with the Generation and Maintenance of Protective Cellular Immunity
David Masopust,
University of Minnesota, USA
CD8 T Cell Memory Induced by Heterologous Prime-Boost Vaccination
CD8 T Cell Memory Induced by Heterologous Prime-Boost Vaccination
Cara Skon,
University of Minnesota, USA
Short Talk: Transcriptional Downregulation of S1PR1 is Required for Establishment of Resident Memory CD8 T Cells
Short Talk: Transcriptional Downregulation of S1PR1 is Required for Establishment of Resident Memory CD8 T Cells
10:20—10:40
Coffee Break
Adam/Drawing Rooms
12:15—13:15
Lunch
Adam/Drawing Rooms
13:00—15:30
Poster Session 2
Adam/Drawing Rooms
15:30—16:00
Coffee Available
Adam/Drawing Rooms
16:00—18:00
B Cell Memory to Vaccines
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Ballroom
*
Jamie K. Scott,
Simon Fraser University, Canada
*
Richard A. Kroczek,
Robert Koch Institute, Germany
Bonnie B. Blomberg,
University of Miami School of Medicine, USA
Biomaker and Molecular Mechanisms for Human B cell and Antibody Responsiveness to Vaccines
Biomaker and Molecular Mechanisms for Human B cell and Antibody Responsiveness to Vaccines
Michel C. Nussenzweig,
HHMI/Rockefeller University, USA
Human Antibody Responses to HIV
Human Antibody Responses to HIV
Shane Crotty,
La Jolla Institute for Allergy and Immunology, USA
Tfh Cells: Providing T Cell Help for B Cell Responses
Tfh Cells: Providing T Cell Help for B Cell Responses
Peter T. Sage,
Harvard Medical School, USA
Short Talk: PD-1 Controls Lymph Node and Blood T Follicular Regulatory Cells
Short Talk: PD-1 Controls Lymph Node and Blood T Follicular Regulatory Cells
17:00—
On Own for Dinner
07:30—09:00
Breakfast
Adam/Drawing Rooms
09:00—11:45
Understanding Signatures of Vaccine Protective Efficacy
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Ballroom
*
Vladimir Badovinac,
University of Iowa, USA
Bali Pulendran,
Emory University, USA
Systems Vaccinology: Enabling Rational Vaccine Design with Systems Biology
Systems Vaccinology: Enabling Rational Vaccine Design with Systems Biology
Ennio De Gregorio,
Novartis Vaccines and Diagnostics, Italy
Immune Profiling of Vaccine Adjuvants
Immune Profiling of Vaccine Adjuvants
Susan M. Kaech,
Yale University School of Medicine, USA
Fate Decisions and Transcriptional Control of Memory CD8 T Cell Differentiation
Fate Decisions and Transcriptional Control of Memory CD8 T Cell Differentiation
Willem A. Hanekom,
University of Cape Town, South Africa
Human Gene Expression Signatures of Risk of Tuberculosis Disease
Human Gene Expression Signatures of Risk of Tuberculosis Disease
Magali Matsumiya,
University of Oxford, UK
Short Talk: Predicting the Immune Response to MVA85A
Short Talk: Predicting the Immune Response to MVA85A
10:20—10:40
Coffee Break
Adam/Drawing Rooms
11:45—13:00
Poster Setup
Adam/Drawing Rooms
11:45—
On Own for Lunch and Recreation
13:00—22:00
Poster Viewing
Adam/Drawing Rooms
14:30—16:30
Workshop 2: Vaccine Delivery
Ballroom
*
Adrian V. S. Hill,
University of Oxford, UK
Peter Lauer,
Aduro BioTech, Inc., USA
Recombinase-Induced Intracellular Death (Lm-RIID): A Novel, Safe, and Potent L. Monocytogenes Vaccine Platform
Recombinase-Induced Intracellular Death (Lm-RIID): A Novel, Safe, and Potent L. Monocytogenes Vaccine Platform
Ana Carolina reis Albuquerque Cajaraville,
FIOCRUZ, Brazil
Characterization of a Malaria Vaccine Candidate Based in the Yellow Fever 17D Virus Vector
Characterization of a Malaria Vaccine Candidate Based in the Yellow Fever 17D Virus Vector
Matthew D. J. Dicks,
University of Oxford, UK
Why Are Some Adenovirus Vaccine Vectors More Immunogenic Than Others?
Why Are Some Adenovirus Vaccine Vectors More Immunogenic Than Others?
*
Allan Randrup Thomsen,
University of Copenhagen, Denmark
Generation of Transgene-Specific CD8 T Cells by Immunization with Adenoviral Vectors Is Markedly Augmented by Co-Expression of Transgene and IL-2 in the Same Vector
Generation of Transgene-Specific CD8 T Cells by Immunization with Adenoviral Vectors Is Markedly Augmented by Co-Expression of Transgene and IL-2 in the Same Vector
Torben Knuschke,
Institute for Medical Microbiology, Germany
Biodegradable Calcium Phosphate Nanoparticles: A New Conjugated Vaccine Approach for Prophylactic and Therapeutic Anti-Viral Treatment
Biodegradable Calcium Phosphate Nanoparticles: A New Conjugated Vaccine Approach for Prophylactic and Therapeutic Anti-Viral Treatment
Masaru Kanekiyo,
NIAID, National Institutes of Health, USA
A Self-Assembling Influenza Nanoparticle Vaccine Elicits Broad and Potent Neutralizing Antibodies
A Self-Assembling Influenza Nanoparticle Vaccine Elicits Broad and Potent Neutralizing Antibodies
Even Fossum,
Institute of Immunology, Norway
Vaccines Designed to Specifically Target Cross-Presenting DCs
Vaccines Designed to Specifically Target Cross-Presenting DCs
Shaomin Tian,
University of North Carolina at Chapel Hill, USA
Rational Design of PRINT Nano-Vaccines
Rational Design of PRINT Nano-Vaccines
16:30—17:00
Coffee Available
Adam/Drawing Rooms
17:00—19:00
Translating Immunity to Vaccines
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Ballroom
*
Tania H. Watts,
University of Toronto, Canada
Dan H. Barouch,
Harvard Medical School/Beth Israel Deaconess Medical Center, USA
Novel HIV Vaccine Strategies
Novel HIV Vaccine Strategies
Helen McShane,
University of Oxford, UK
Clinical Development of TB Vaccines
Clinical Development of TB Vaccines
Daniela Weiskopf,
La Jolla Institute for Allergy & Immunology, USA
Short Talk: Comprehensive Analysis of Dengue Virus-Specific Responses Supports an HLA-Linked Protective Role for CD8+ T Cells, Rather Than a Pathogenic Role Linked to Original Antigenic Sin
Short Talk: Comprehensive Analysis of Dengue Virus-Specific Responses Supports an HLA-Linked Protective Role for CD8+ T Cells, Rather Than a Pathogenic Role Linked to Original Antigenic Sin
Ma Luo,
National Microbiology Laboratory, Canada
Short Talk: Antibody and T Cell Response to the Protease Cleavage Sites Correlated with Protection Against Higher Dose of SIVmac239 Challenge and Disease Progression in Cynomolgus Macaques
Short Talk: Antibody and T Cell Response to the Protease Cleavage Sites Correlated with Protection Against Higher Dose of SIVmac239 Challenge and Disease Progression in Cynomolgus Macaques
Bram Slütter,
University of Iowa, USA
Short Talk: CXCR3+ Memory CD8+ T Cells Localize to the Respiratory Tract and Provide Superior Protection Against Influenza A Virus
Short Talk: CXCR3+ Memory CD8+ T Cells Localize to the Respiratory Tract and Provide Superior Protection Against Influenza A Virus
19:00—20:00
Social Hour w/ Lite Bites
Adam/Drawing Rooms
19:30—22:00
Poster Session 3
Adam/Drawing Rooms
07:30—09:00
Breakfast
Adam/Drawing Rooms
09:00—12:15
Immunity and Vaccines Against Global Threats I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Ballroom
*
John T. Harty,
University of Iowa, USA
*
Helen McShane,
University of Oxford, UK
Rafi Ahmed,
Emory University School of Medicine, USA
Human B Cell Response to Influenza Virus
Human B Cell Response to Influenza Virus
Dennis L. Kasper,
Harvard Medical School, USA
Rethinking Glycocojugate Vaccines: A Knowledge-Based Approach to Vaccine Design
Rethinking Glycocojugate Vaccines: A Knowledge-Based Approach to Vaccine Design
Claire A. Jones,
University of Oxford, UK
Short Talk: Quantification of Antibody Secreting Cell Responses in a Human Model of Salmonella typhi Infection
Short Talk: Quantification of Antibody Secreting Cell Responses in a Human Model of Salmonella typhi Infection
Mark Y. Sangster,
University of Rochester, USA
Short Talk: The B Cell Response to an Inactivated Pandemic H1N1 Influenza Vaccine in Cohorts Differing by Age and Immune Status
Short Talk: The B Cell Response to an Inactivated Pandemic H1N1 Influenza Vaccine in Cohorts Differing by Age and Immune Status
David Furman,
Stanford University, USA
Short Talk: Robust Correlates of an Immune Response to Influenza Vaccination in Young and Old Adults
Short Talk: Robust Correlates of an Immune Response to Influenza Vaccination in Young and Old Adults
10:20—10:40
Coffee Break
Adam/Drawing Rooms
12:15—
On Own for Lunch and Recreation
16:30—17:00
Coffee Available
Adam/Drawing Rooms
17:00—19:00
Immunity and Vaccines Against Global Threats II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Ballroom
*
Adrian V. S. Hill,
University of Oxford, UK
*
Alessandro D. Sette,
La Jolla Institute for Allergy & Immunology, USA
Dany De Grave,
Sanofi Pasteur, USA
The Sanofi Pasteur Tetravalent Dengue Vaccine: An Update
The Sanofi Pasteur Tetravalent Dengue Vaccine: An Update
Louis J. Picker,
Oregon Health & Science University, USA
Unique Immunobiology and Efficacy of SIV Protein-Expressing Cytomegalovirus (CMV) Vectors
Unique Immunobiology and Efficacy of SIV Protein-Expressing Cytomegalovirus (CMV) Vectors
Jerald C. Sadoff,
Crucell NV, Netherlands
Vaccine Vectors for HIV and Other Global Threats
Vaccine Vectors for HIV and Other Global Threats
David M. Lewinsohn,
Portland VA Medical Center, USA
Short Talk: Lessons from a Human Phase I Trial: Vaccination with the Mtb Vaccine AERAS-402 (BCG Prime / Adenoviral Boost) Induces High Frequency, Antigen-Specific CD8 T Cells That Do Not Necessarily Recognize the Mtb-Infected Cell
Short Talk: Lessons from a Human Phase I Trial: Vaccination with the Mtb Vaccine AERAS-402 (BCG Prime / Adenoviral Boost) Induces High Frequency, Antigen-Specific CD8 T Cells That Do Not Necessarily Recognize the Mtb-Infected Cell
19:00—20:00
Social Hour w/ Lite Bites
Adam/Drawing Rooms
20:00—23:00
Entertainment
Adam Room
Departure
*Session Chair †Speaker invited, not yet responded.
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