Beaver Run Resort Floorplan

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This meeting took place in 2013


Here are the related meetings in 2018:
HIV and Co-Infections: Pathogenesis, Inflammation and Persistence (X8)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Immune Activation in HIV Infection: Basic Mechanisms and Clinical Implications (D2)


Organizer(s) Irini Sereti, Michaela Müller-Trutwin, Damian F.J. Purcell and Mauro Schechter
April 3—8, 2013
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Dec 3, 2012
Late Abstract Deadline: Jan 3, 2013
Scholarship Deadline: Dec 3, 2012
Early Registration Deadline: Jan 29, 2013

Sponsored by Sangamo BioSciences, Inc. Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation

Summary of Meeting:
One major hallmark of HIV infection is chronic immune activation that promotes viral replication and drives CD4+ T cell depletion. The mechanisms leading to Immune activation are not well understood, and strategies to dampen it are urgently needed. Immune activation in HIV infection can stem from foreign antigen stimulation, including HIV, microbial products and co-infections as well as compensatory homeostatic mechanisms. Continuous immune stimulation most likely creates a permissive environment for further viral replication, while temporarily allowing successful replenishment of the T-cell pool. Type I interferon, microbial translocation, activated (but ineffective) effector T cells, dysfunctional regulatory T cells and inadequate T helper 17 cells have all been suggested to play important roles in the cycle of activation, functional exhaustion and T-cell death that leads to immunodeficiency. In treated HIV infection, chronic immune activation persists and is implicated in non-infectious clinical complications of HIV that account for most of the morbidity and mortality in patients treated with anti-retroviral therapy. The goal of the meeting will be to update the participants on the new insights of mechanisms of immune activation and its deleterious effects on HIV infection from transmission to chronic treated infection, and how this knowledge could potentially translate to treatment interventions. Our vision is to bring together basic science (even beyond HIV), immunology, virology and clinical science into each session with the hope that participants will interact and be inspired for collaborative translational projects.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, APRIL 3

15:00—19:30
Arrival and Registration

Foyer
18:15—19:15
Refreshments

Foyer
19:15—21:00
Welcome and Keynote Session
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Michaela Müller-Trutwin, Institut Pasteur, France

* Irini Sereti, NIAID, National Institutes of Health, USA
Welcome Remarks

Mary Carrington, Frederick National Laboratory for Cancer Research, USA
Effects of HLA-Class 1 Diversity on HIV control and the Art of Multitasking

Michael M. Lederman, Case Western Reserve University, USA
Residual Immune Dysregulation Syndrome (RIDS) in Treated HIV Infection


THURSDAY, APRIL 4

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Molecular and Cellular Biology of Immune Activation
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Guido Silvestri, Emory University School of Medicine, USA

* Marcus Altfeld, Heinrich-Pette-Institute, Germany

Charles R. Mackay, Monash University, Australia
Diet and Metabolite Sensing GPCRs Regulate Gut Homeostasis and Immune Responses

Susan Moir, NIAID, National Institutes of Health, USA
Immunopathogenesis of B Cells in HIV Infection

George Kassiotis, Francis Crick Institute, UK
Potential Mechanisms of Immune Activation in Immunodeficient Mice

Frank Kirchhoff, University of Ulm, Germany
Possible Role of Viral Properties in HIV-Induced Immune Activation

Gilad Doitsh, J. David Gladstone Institutes, USA
Short Talk: HIV Triggers Pyroptosis, an Intense Inflammatory Form of Programmed Cell Death, Promoting CD4 T Cell Depletion in Lymphoid Tissues

Clovis Steve Palmer, Burnet Institute, Australia
Short Talk: Glucose Metabolism Is an Integral Process in CD4+ T Cell Activation and Inflammation in HIV-1 Infected Subjects

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
 
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Therapeutic Targets of IA

Colorado Ballroom
* Peter W. Hunt, University of California, San Francisco, USA

* Sharon R. Lewin, University of Melbourne, Australia

Marcus Altfeld, Heinrich-Pette-Institute, Germany
In vivo Treatment with a TLR7/9 Antagonist Reduces HIV-1-Associated Immune Activation in a Humanized Mouse Model of HIV-1 Infection

Mingjian Fei, Genentech, USA
The NAD+-Dependent Deacetylase SIRT1 as a New Regulator of T Cell Senescence in HIV Infection

Joseph Hiatt, NIAID, National Institutes of Health, USA
Dynamic Interactions between CD4 and alpha4beta7 on Primary CD4+ T Cells Indicates a Novel Coupling of these Two Costimulatory Receptors

Rui Andre Raposo, George Washington University, USA
Host Correlates Distinguish Low-Risk and High-Risk HIV-1 Disease Progression in HLA-B*5701 Individuals

Gilda Tachedjian, Burnet Institute, Australia
Vaginal Concentrations of Lactic Acid Potently Inactivate HIV

Caroline M. Royle, Imperial College, UK
Comparison of Plasmacytoid Dendritic Cell Activation by HIV-1 and HIV-2: Implications for HIV Immunopathogenesis

Jane Rasaiyaah, University College London, UK
Inhibition of HIV-1-Cofactor Interactions Triggers Innate Sensors and Interferon Secretion

Molly R. Perkins, Bluebird Bio, USA
Ability of SIVagm-Infected African Green Monkeys to Respond to Neo Antigen and Downregulate CD4

16:30—17:00
Coffee Available

Foyer
17:00—19:00
HIV Transmission and Acute Infection
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Michaela Müller-Trutwin, Institut Pasteur, France

* Anthony L. Cunningham, Westmead Institute for Medical Research, Australia

Thomas J. Hope, Northwestern University, Feinberg School of Medicine, USA
Indentification and Characterization of the Initial Targets of Infection in Rhesus Macaque Sex Transmission Models

Gabriella Scarlatti, Global HIV Vaccine Enterprise, USA
Early Events of HIV Transmission at the Intestinal Mucosa and Role of Dendritic Cells

Soni Ramachandra Sankapal, University of Pittsburgh, USA
Short Talk: Unraveling Mechanism of HIV-1 Transmission across Mucosal Epithelia

Sibylle Bernard-Stoecklin, CEA, France
Short Talk: Semen Leukocytes as “Trojan Horses:” Infected CD4+ T Cells and Macrophages Are Present in Semen at Every Stage of SIVmac251 Infection of Cynomolgus macaques

Daniel Claiborne, Ragon Institute of MGH, MIT, and Harvard, USA
Short Talk: Viral Replicative Capacity Contributes Significantly to CD4 Decline Independent of Host Factors

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 1

Breckenridge Ballroom

FRIDAY, APRIL 5

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Viral Reservoirs and Immune Dysfunction
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Eric Hunter, Emory University, USA

* Greg J. Towers, University College London, UK

Michael H. Malim, King's College London, UK
Mechanism of Action of the Innate Antiviral Factor APOBEC3G

Monsef Benkirane, Institut de Genetique Humaine, France
Regulation of Cellular Factors Involved in HIV Virus Gene Expression

Damian F.J. Purcell, University of Melbourne, Australia
Mechanisms for Tat Expression in Virus Latency that Support T-Cell Activation

Una O'Doherty, University of Pennsylvania Medical Center, USA
HIV Infected Resting CD4+ T Cells can Express HIV Proteins and may be Subjected to CTL Clearance

John C. Tilton, Case Western Reserve University, USA
Short Talk: CD4+ Memory Stem Cells (Tscm) Are Productively and Latently Infected by CCR5- and CXCR4-Tropic HIV

Anne Hosmalin, Institut Cochin, INSERM 1016, Université Paris Descartes, France
Short Talk: Pro-Inflammatory M-DC8+ ("slan-DC") Monocyte Accumulation in HIV-1-Infected Patients

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Mucosal Immunity and HIV
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Elena Martinelli, Population Council, USA

* Thomas J. Hope, Northwestern University, Feinberg School of Medicine, USA

Frederic D. Bushman, University of Pennsylvania, USA
The Human Microbiome in Health and Immunodeficient States

Jacob D. Estes, Frederick National Laboratory / LBR, Inc., USA
GI Damage and Immune Activation in SIV

Maria Rescigno, European Institute of Oncology, Italy
Short Talk: Dendritic Cells in Microbe Interactions in the Gut

Mirko Paiardini, Emory University, YNPRC, USA
Homeostasis of CD4+ T Cell Subsets in HIV/SIV Infection

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 2

Breckenridge Ballroom

SATURDAY, APRIL 6

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Immune Activation and Co-Infections
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Giuseppe Tambussi, San Raffaele Scientific Institute, Italy

* Michael M. Lederman, Case Western Reserve University, USA

Michael L. Dustin, University of Oxford, UK
Polarized Release and Retroviral Subversion of TCR-Enriched Microvesicles at the T Cell Immunological Synapse

Michaela Müller-Trutwin, Institut Pasteur, France
Innate Immune Responses in the Acute Phase of Non-Pathogenic SIVagm Infection

Martyn A. French, University of Western Australia, Australia
Immune Reconstitution Inflammatory Syndrome in HIV Infection

Richard A. Koup, NIAID, National Institutes of Health, USA
Role of Co-Pathogens in HIV Immune Dysfunction

Diana Goode, Population Council, USA
Short Talk: HSV-2 Infection of the Vaginal Mucosa ex vivo Increases the Frequency of alpha4beta7+ T Cells

Nathan L. Bowers, University of Alabama, Birmingham, USA
Short Talk: Neutrophils with the Phenotype of Myeloid-Derived Suppressor Cells (MDSCs) Mediate Immune Suppression in HIV-1 Infection

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
 
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Innate and Mucosal Immunity and their Interplay in HIV/SIV Pathogenesis

Colorado Ballroom
* Nicholas Funderburg, Ohio State University, USA

* Jeffrey D. Lifson, Leidos Biomedical Research, Inc., USA

Elizabeth A. Ihms, Johns Hopkins University, USA
Characterization of Plasma Microparticles during the Host Response to Retroviral Infection

Anthony L. Cunningham, Westmead Institute for Medical Research, Australia
The Microvesicle Component of HIV-1 Inocula Modulates Dendritic Cell (DC) Infection, Maturation, Adhesion to T Cells and Viral Transfer

Amy E. Baxter, Centre de Recherche du CHUM, Canada
HIV-1 Transmission between Macrophages and T Cells: Consequences for Viral Pathogenesis

Lucie Barblu, Research Centre of the University of Montreal Hospital Centre, CRCHUM, Canada
Analysis of Myelomonocytic Populations during HIV Infection

Bruno Vaslin, CEA, France
Plasmacytoid DC Dynamics Tune IFNalpha Production during Acute SIV Infection in Cynomolgus macaques

Edwin Leeansyah, Karolinska Institutet, Sweden
Activation, Exhaustion and Persistent Decline of the Anti-Microbial MR1-Restricted MAIT Cell Population in Chronic HIV-1 Infection

Richard M. Dunham, GlaxoSmithKline, USA
Immunologic Nonresponders to HAART Have Elevated Systemic Inflammation and Perturbed Intestinal Myeloid Populations

Irina Grishina, University of California, Davis, USA
SIV Induced Modulation of the Enteric Serotonergic Response Contributes to Chronic Immune Activation

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Genetic and Immunological Regulation
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Mary Carrington, Frederick National Laboratory for Cancer Research, USA

* Cristian Apetrei, University of Pittsburgh, USA

Philip Tarr, University of Basel, Switzerland
Genetic Associations of Non-Infectious Complications of HIV

Lars Pache, Sanford-Burnham Medical Research Institute, USA
Short Talk: Identification of Host Cell Mechanisms Restricting HIV-1 Replication

Rui Pedro Galão, King's College London, UK
Short Talk: Mechanistic Insights into Proinflammatory Signaling Induced by Tetherin-Mediated Restriction of Retroviral Release

Alan J. Korman, Bristol-Myers Squibb, USA
Restoration of T Cell Function by Inhibition of Multiple Negative T Cell Regulators

Mathieu Angin, Institut Pasteur, France
Short Talk: Impairment of Regulatory T Cell Function Following HIV-1 Infection

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 3

Breckenridge Ballroom

SUNDAY, APRIL 7

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Immune Activation in Chronic Infection
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Steven G. Deeks, University of California, San Francisco, USA

* Mauro Schechter, Universidade Federal do Rio de Janeiro, Brazil

Nabila Seddiki, Vaccine Research Institute and Université Paris-Est Créteil, France
Role of Regulatory T Cells in HIV Pathogenesis: What's New?

Irini Sereti, NIAID, National Institutes of Health, USA
Biomarkers in HIV Infection

Ivona Pandrea, University of Pittsburgh, USA
Therapeutic Interventions to Modulate Microbial Translocation, Immune Activation and Cardiovascular Comorbidities. Lessons from Non-Human Primate Models

Joel N. Blankson, Johns Hopkins School of Medicine, USA
Viral Reservoirs and Immune Activation Elite Suppressors

Sulggi Angela Lee, University of California, San Francisco, USA
Short Talk: Phenotypic CD8+ T Cell Defects May Persist in Elite Controllers Despite Viral Control

Karen M. Duus, Albany Medical College, USA
Short Talk: CIITA-Mediated Increased HIV Replication Efficiency Occurs via Two Distinct Cellular Mechanisms

09:20—09:40
Coffee Break

Foyer
 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Future Directions in Therapeutic Interventions
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Irini Sereti, NIAID, National Institutes of Health, USA

* Damian F.J. Purcell, University of Melbourne, Australia

Sharon R. Lewin, University of Melbourne, Australia
Clinical Trials for HIV Eradication: The Role of Immune Activation and Immunotherapies

Mauro Schechter, Universidade Federal do Rio de Janeiro, Brazil
Preventive Efforts, New Directions beyond Vaccines

Steven G. Deeks, University of California, San Francisco, USA
HIV Infection, Inflammation and Aging

19:00—20:00
Social Hour with Lite Bites

Breckenridge Ballroom
20:00—23:00
Entertainment

Breckenridge Ballroom

MONDAY, APRIL 8

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Bill & Melinda Gates Foundation Sangamo BioSciences, Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI104337-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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Bristol-Myers Squibb Company


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