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This meeting took place in 2013
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Meeting Details
Host Response in Tuberculosis (X7)
Organizer(s) Andrea M. Cooper and Robert J. Wilkinson
March 13 - March 18, 2013
Whistler Conference Centre • Whistler, British Columbia Canada
Abstract Deadline: November 13, 2012
Late Abstract Deadline: December 11, 2012
Scholarship Deadline: November 13, 2012
Early Registration Deadline: January 14, 2013
Supported by the Directors' Fund
CME Information
Joint Meeting:
Tuberculosis: Understanding the Enemy (X8)
Summary of Meeting:
Although the host response to tuberculosis has been studied for many years, we still have only a rudimentary working model of the disease process; namely that antigen-specific T cells activate infected macrophages to control bacterial growth. Further progress in the control of tuberculosis will depend on a much more detailed understanding of the nature of the host response to infection. Therefore, the purpose of this Keystone Symposia meeting is to reassess our current understanding of disease mechanisms, discuss the most recent advances in the field, and identify critical questions and future research directions. A key focus of the meeting will be the innate, acquired, and immunopathologic responses that occur in the host following exposure to Mycobacterium tuberculosis. Speakers will be strongly encouraged to move past dogma and promote critical re-analysis of our working model of what constitutes protective immunity to tuberculosis. The conference will be held concurrently with a meeting on Tuberculosis: Understanding the Enemy – covering bacterial genetics, bacterial physiology, systems biology, and drug development. This will provide opportunities for participants from different disciplines to interact with one another forge new collaborations in novel areas of biology. Importantly, the interactive nature of the meetings will promote the new ideas and novel approaches necessary to combat this devastating disease.
CME Information
Although the host response to tuberculosis has been studied for many years, we still have only a rudimentary working model of the disease process; namely that antigen-specific T cells activate infected macrophages to control bacterial growth. Further progress in the control of tuberculosis will depend on a much more detailed understanding of the nature of the host response to infection. Therefore, the purpose of this Keystone Symposia meeting is to reassess our current understanding of disease mechanisms, discuss the most recent advances in the field, and identify critical questions and future research directions. A key focus of the meeting will be the innate, acquired, and immunopathologic responses that occur in the host following exposure to Mycobacterium tuberculosis. Speakers will be strongly encouraged to move past dogma and promote critical re-analysis of our working model of what constitutes protective immunity to tuberculosis. The conference will be held concurrently with a meeting on Tuberculosis: Understanding the Enemy – covering bacterial genetics, bacterial physiology, systems biology, and drug development. This will provide opportunities for participants from different disciplines to interact with one another forge new collaborations in novel areas of biology. Importantly, the interactive nature of the meetings will promote the new ideas and novel approaches necessary to combat this devastating disease.
Conference Program Print | View meeting in 12 hr (am/pm) time
WEDNESDAY, MARCH 13
08:00—11:00
How Do Innate Cells Respond to Mtb (I)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
NOTE: How does the lung respond to infection and how do the phagocyte and bacteria interact?
*
David G. Russell,
Cornell University, USA
Larry S. Schlesinger,
Ohio State University, USA
Unique Immunoregulatory Factors in the Lung Alveolus during the Early Microbe-Host Encounter
Unique Immunoregulatory Factors in the Lung Alveolus during the Early Microbe-Host Encounter
Helen A. Fletcher,
University of Oxford, UK
Correlates of Risk of TB Disease in Infants Vaccinated with BCG
Correlates of Risk of TB Disease in Infants Vaccinated with BCG
Jennifer Philips,
New York University School of Medicine, USA
EsxH ESCRTs TB to Safety by Arresting Phagosome Maturation
EsxH ESCRTs TB to Safety by Arresting Phagosome Maturation
Aurelie A. Ray,
Trudeau Institute, USA
Short Talk: The Splice Variant of IL-12Rbeta1: A New Player in the IL-12 Signaling Network
Short Talk: The Splice Variant of IL-12Rbeta1: A New Player in the IL-12 Signaling Network
Cliona M. Ni Cheallaigh,
Trinity College Dublin, Ireland
Short Talk: My-D88 Adapter Like (Mal) Is Required for Effective Macrophage Responses to Mycobacterium tuberculosis
Short Talk: My-D88 Adapter Like (Mal) Is Required for Effective Macrophage Responses to Mycobacterium tuberculosis
Alissa C. Rothchild,
Brigham & Women's Hospital, USA
Short Talk: iNKT Cell Production of GM-CSF Inhibits Growth of Mycobacterium tuberculosis
Short Talk: iNKT Cell Production of GM-CSF Inhibits Growth of Mycobacterium tuberculosis
08:00—11:00
Mycobacterium tuberculosis – From Single Cells to Systems
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*
Eric J. Rubin,
Harvard School of Public Health, USA
Heran Darwin,
New York University School of Medicine, USA
Pedal to the Metal: Copper Resistance in Mycobacterium tuberculosis
Pedal to the Metal: Copper Resistance in Mycobacterium tuberculosis
Bree B. Aldridge,
Tufts University, USA
Short Talk: Back to Basics: Diversity through Growth and Division in Mycobacteria
Short Talk: Back to Basics: Diversity through Growth and Division in Mycobacteria
Veronique Anne Dartois,
Public Health Research Institute, USA
Pharmacology: The Fate of TB Drugs from Plasma to Lesions and Single Cells
Pharmacology: The Fate of TB Drugs from Plasma to Lesions and Single Cells
Johnjoe McFadden,
University of Surrey, UK
Systems-Based Metabolic Analysis of Intracellular Growth of the TB bacillus
Systems-Based Metabolic Analysis of Intracellular Growth of the TB bacillus
Dany J. V. Beste,
University of Surrey, UK
Short Talk: 13C Isotopomer Spectral Analysis of Cholesterol Metabolism by Mycobacterium tuberculosis Growing in vitro and within Macrophages
Short Talk: 13C Isotopomer Spectral Analysis of Cholesterol Metabolism by Mycobacterium tuberculosis Growing in vitro and within Macrophages
16:00—17:00
Keynote Address - TB: The Continuing Challenge (Joint)
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*
Andrea M. Cooper,
Trudeau Institute, USA
17:00—19:00
How Do Innate Cells Respond to Mtb (II) (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
NOTE: Mononuclear phagocytes are recognized as the host cells for Mtb but what do they really do? Neutrophils have been largely ignored as actors in tuberculosis, what do these cells do to contribute to disease? This session addresses these questions.
Carl F. Nathan,
Weill Cornell Medical College, USA
Can Macrophages Be Super-Activated?
Can Macrophages Be Super-Activated?
Anne O'Garra,
MRC National Institute for Medical Research, UK
Systems Approach to Understand the Immune Response in Tuberculosis
Systems Approach to Understand the Immune Response in Tuberculosis
David G. Russell,
Cornell University, USA
Chemical and Genetic Perturbation of the Intracellular Survival Strategies of Mycobacterium tuberculosis
Chemical and Genetic Perturbation of the Intracellular Survival Strategies of Mycobacterium tuberculosis
08:00—11:00
Acquired Immunity - Beyond the CD4 T Cell/Macrophage Paradigm?
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
NOTE: While antigen-specific CD4 T cells are the target of current vaccines, it is not clear that these cells are the best mediators of protective immunity.
Eric G. Pamer,
Memorial Sloan-Kettering Cancer Center, USA
Ly6Chi Monocytes and Immune Defense Against Mycobacterium tuberculosis Infection
Ly6Chi Monocytes and Immune Defense Against Mycobacterium tuberculosis Infection
*
Samuel M. Behar,
Brigham and Women's Hospital, USA
CD8+ T Cells and Protective Immunity to Tuberculosis
CD8+ T Cells and Protective Immunity to Tuberculosis
Ramakrishna Vankayalapati,
University of Texas Health Center at Tyler, USA
Short Talk: A Subpopulation of CD4+CD25+Foxp3+ T-Cells Inhibits Growth of Mycobacterium tuberculosis
Short Talk: A Subpopulation of CD4+CD25+Foxp3+ T-Cells Inhibits Growth of Mycobacterium tuberculosis
Peter Andersen,
Statens Serum Institut, Denmark
Vaccine Induced Protection Against TB
Vaccine Induced Protection Against TB
Albanus O. Moguche,
Seattle Biomedical Research Institute, USA
Short Talk: Intrinsic CXCR5 Expression Is Required to Maintain Antigen Specific CD4 T Cells during Chronic Mycobacterium tuberculosis Infection
Short Talk: Intrinsic CXCR5 Expression Is Required to Maintain Antigen Specific CD4 T Cells during Chronic Mycobacterium tuberculosis Infection
Shabaana A. Khader,
Children's Hospital of Pittsburgh, USA
Short Talk: Interleukin-17 Mediates Vaccine-Induced Immunity Against Tuberculosis
Short Talk: Interleukin-17 Mediates Vaccine-Induced Immunity Against Tuberculosis
08:00—11:00
Mycobacterial Diversity and Disease
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*
Graham F. Hatfull,
University of Pittsburgh, USA
Nico C. Gey van Pittius,
University of Stellenbosch, South Africa
Evolution of the PE and PPE Multi-Gene Families in the Mycobacteria
Evolution of the PE and PPE Multi-Gene Families in the Mycobacteria
Thomas Ioerger,
Texas A&M University, USA
What Comparative Genomics of Mycobacteria can Tell Us about Drug Resistance
What Comparative Genomics of Mycobacteria can Tell Us about Drug Resistance
Jeffery S. Cox,
University of California, San Francisco, USA
The Ubiquitin Ligase PARKIN Is Required for Autophagy and Host Resistance to Intracellular Pathogens
The Ubiquitin Ligase PARKIN Is Required for Autophagy and Host Resistance to Intracellular Pathogens
Basim R.K. Al Shammari,
Imperial College London, UK
Short Talk: Infection of MMP-1 Transgenic Mice with Virulent Mycobacterium tuberculosis Causes Human-Type Lung Pathology
Short Talk: Infection of MMP-1 Transgenic Mice with Virulent Mycobacterium tuberculosis Causes Human-Type Lung Pathology
Mireia Coscolla,
Swiss Tropical and Public Health Institute, Switzerland
Short Talk: Adaptive Evolution in Different Lineages of the Mycobacterium tuberculosis Complex
Short Talk: Adaptive Evolution in Different Lineages of the Mycobacterium tuberculosis Complex
Christophe Guilhot,
Centre National de la Recherche Scientifique, France
Short Talk: Do Polymorphisms in phoPR Explain the Lower Virulence for Humans of africanum and Animal Strains of the Mycobacterium tuberculosis Complex?
Short Talk: Do Polymorphisms in phoPR Explain the Lower Virulence for Humans of africanum and Animal Strains of the Mycobacterium tuberculosis Complex?
14:30—16:30
Workshop 1: Host Susceptibility (Joint)
*
Hardy Kornfeld,
University of Massachusetts Medical School, USA
Thuong T. T. Nguyen,
Oxford University Clinical Research Unit, Vietnam
A Genome–Wide Association Analysis Investigating the Contribution of Human and M. tuberculosis Genetics on Tuberculous Meningitis Susceptibility
A Genome–Wide Association Analysis Investigating the Contribution of Human and M. tuberculosis Genetics on Tuberculous Meningitis Susceptibility
Anna K. Coussens,
Institute for Infectious Disease and Molecular Medicine, South Africa
Ethnicity Has a Greater Effect than Mycobacterial Lineage on the Identification of Biomarkers for TB
Ethnicity Has a Greater Effect than Mycobacterial Lineage on the Identification of Biomarkers for TB
Joseph Keane,
St. James's Hospital and Trinity College Dublin, Ireland
Cigarette Smoking Impairs Human Pulmonary Tuberculosis Immunity
Cigarette Smoking Impairs Human Pulmonary Tuberculosis Immunity
Randall J. Basaraba,
Colorado State University, USA
Altered Systemic Metabolism Contributes to TB Pathogenesis
Altered Systemic Metabolism Contributes to TB Pathogenesis
Nathella Pavan Kumar,
National Institute for Research in Tuberculosis, India
Expansion of Pathogen - Specific Th1 and Th17 Cells in Pulmonary Tuberculosis with Coincident Type 2 Diabetes Mellitus
Expansion of Pathogen - Specific Th1 and Th17 Cells in Pulmonary Tuberculosis with Coincident Type 2 Diabetes Mellitus
Susan Realegeno,
University of California, Los Angeles, USA
The Role of Vitamin D in IFN-gamma Induced Antimicrobial Responses Against Mycobacterium Infection in Human Macrophages
The Role of Vitamin D in IFN-gamma Induced Antimicrobial Responses Against Mycobacterium Infection in Human Macrophages
Philip Liu,
University of California, Los Angeles, USA
Vitamin A Triggers a Human Antimicrobial Response Dependent on Cellular Cholesterol Composition
Vitamin A Triggers a Human Antimicrobial Response Dependent on Cellular Cholesterol Composition
17:00—19:00
Vaccination Against Mtb (Joint)
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NOTE: The availability of patients in close proximity to high tech tools for analysis of immune responses has resulted in an increase in our understanding of the human response to Mtb infection.
*
Tom H. M. Ottenhoff,
Leiden University Medical Center, Netherlands
Alessandro D. Sette,
La Jolla Institute for Allergy & Immunology, USA
Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed Against Three Antigenic Islands and Largely Contained in a CXCR3+CCR6+ Th1 Subset
Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed Against Three Antigenic Islands and Largely Contained in a CXCR3+CCR6+ Th1 Subset
Thomas G. Evans,
Aeras Global TB Vaccine Foundation, USA
Early Results of Vaccine Trials in Humans
Early Results of Vaccine Trials in Humans
Stefan H. E. Kaufmann,
Max Planck Institute for Infection Biology-Berlin, Germany
Vaccination Against Tuberculosis: Back to Basic Research or Forward with Clinical Trials?
Vaccination Against Tuberculosis: Back to Basic Research or Forward with Clinical Trials?
08:00—11:00
The Consequences of the Immune Response in the Lung
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
NOTE: Cellular responses in the lung start slowly
following challenge with Mtb and the
inflammatory site remains dynamic for the
period of infection. Understanding the
dynamics of the cellular response will allow
for improved intervention.
Denise Kirschner,
University of Michigan, USA
A Systems Biology Approach to Uncovering Mechanisms Governing Host-Mycobacterial Interactions during TB Infection in the Lung and Lymph Nodes
A Systems Biology Approach to Uncovering Mechanisms Governing Host-Mycobacterial Interactions during TB Infection in the Lung and Lymph Nodes
Robert J. Francis,
University of Surrey, UK
Short Talk: Selective ESAT6-Dependent Necrosis of Phosphatidylserine Externalised Neutrophils
Short Talk: Selective ESAT6-Dependent Necrosis of Phosphatidylserine Externalised Neutrophils
Manuela Flórido,
Centenary Institute, Australia
Short Talk: Influenza A Virus Infection Impairs Mycobacteria-Specific T Cell Responses and Mycobacterial Clearance in the Lung during Pulmonary Co-Infection
Short Talk: Influenza A Virus Infection Impairs Mycobacteria-Specific T Cell Responses and Mycobacterial Clearance in the Lung during Pulmonary Co-Infection
Melanie J. Harriff,
Oregon Health & Sciences University/PVAMC, USA
Short Talk: Bronchial Epithelial Cells Take Up Mycobacterium tuberculosis into a Late Endosomal Compartment and Are Highly Efficient at Stimulating IFNgamma Release by CD8+ T Cells
Short Talk: Bronchial Epithelial Cells Take Up Mycobacterium tuberculosis into a Late Endosomal Compartment and Are Highly Efficient at Stimulating IFNgamma Release by CD8+ T Cells
08:00—11:00
Life and Death in Mycobacteria
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*
Jeffery S. Cox,
University of California, San Francisco, USA
Eric J. Rubin,
Harvard School of Public Health, USA
Mycobacterial Proteins: Here Today, Gone… Some Other Time
Mycobacterial Proteins: Here Today, Gone… Some Other Time
Marie I. Samanovic,
New York University School of Medicine, USA
Short Talk: Proteasomal Regulation of Nitric Oxide Resistance in M. tuberculosis
Short Talk: Proteasomal Regulation of Nitric Oxide Resistance in M. tuberculosis
Graham F. Hatfull,
University of Pittsburgh, USA
Mycobacteriophages and Mycobacterium tuberculosis
Mycobacteriophages and Mycobacterium tuberculosis
Kerstin Williams,
Imperial College London, UK
Short Talk: Global Response of Mycobacteria to Nitrogen Stress
Short Talk: Global Response of Mycobacteria to Nitrogen Stress
17:00—19:00
A Global View of Infection (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
NOTE: Unbiased techniques can highlight novel pathways and mechanisms of disease. This session will address the increased understanding of TB that these approaches have generated.
*
Sébastien Gagneux,
Swiss Tropical and Public Health Institute, Switzerland
Evolutionary Forces in Mycobacterium tuberculosis
Evolutionary Forces in Mycobacterium tuberculosis
Scarlet S. Shell,
Harvard School of Public Health, USA
Short Talk: Widespread mRNA Processing Shapes the Mycobacterium tuberculosis Transcriptome
Short Talk: Widespread mRNA Processing Shapes the Mycobacterium tuberculosis Transcriptome
Tom H. M. Ottenhoff,
Leiden University Medical Center, Netherlands
Short Talk: An Unbiased Genome-Wide Mycobacterium tuberculosis Gene-Expression Approach to Discover New Antigens for Human T Cells that Are Expressed during Pulmonary Infection
Short Talk: An Unbiased Genome-Wide Mycobacterium tuberculosis Gene-Expression Approach to Discover New Antigens for Human T Cells that Are Expressed during Pulmonary Infection
Jean-Laurent Casanova,
Rockefeller University, USA
Toward a Genetic Theory of Infectious Diseases
Toward a Genetic Theory of Infectious Diseases
08:00—11:15
Tuberculosis and HIV
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
NOTE: These two pathogens interact to create devastating effects for human health. What is the future for vaccination and control in areas with high incidence of both.
Robert J. Wilkinson,
University of Cape Town, South Africa
The Heart, Mind and Breath of HIV-Associated Tuberculosis
The Heart, Mind and Breath of HIV-Associated Tuberculosis
*
JoAnne L. Flynn,
University of Pittsburgh School of Medicine, USA
Modeling HIV-TB Immune Interaction in Non-Human Primates
Modeling HIV-TB Immune Interaction in Non-Human Primates
Marcelo Kuroda,
Tulane University, USA
Short Talk: Macrophage Damage by SIV as the Cause of TB Reactivation in the TB/SIV Rhesus Co-Infection Model
Short Talk: Macrophage Damage by SIV as the Cause of TB Reactivation in the TB/SIV Rhesus Co-Infection Model
Daniel L. Barber,
NIAID, National Institutes of Health, USA
Mechanisms of Mycobacteria-Associated Immune Reconstitution Inflammatory Syndrome
Mechanisms of Mycobacteria-Associated Immune Reconstitution Inflammatory Syndrome
Richard A. Koup,
NIAID, National Institutes of Health, USA
HIV-Tuberculosis Interaction
HIV-Tuberculosis Interaction
Tracy R. Rosebrock,
Harvard School of Public Health, USA
Short Talk: Single Cell Analysis Reveals Distinct Effects of HIV on Mycobacterium tuberculosis Survival in Co-Infected and Bystander Macrophages
Short Talk: Single Cell Analysis Reveals Distinct Effects of HIV on Mycobacterium tuberculosis Survival in Co-Infected and Bystander Macrophages
08:00—11:00
The Bacterial Surface and its Interaction with the Host
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*
Sarah M. Fortune,
Harvard School of Public Health, USA
Mary Jackson,
Colorado State University, USA
Cell Envelope Glycoconjugates: Metabolism and Interaction with the Host
Cell Envelope Glycoconjugates: Metabolism and Interaction with the Host
Keith M. Derbyshire,
Wadsworth Center, New York State Department of Health, USA
ESX, its Role in Secretion, Sex and Mycobacterial Evolution
ESX, its Role in Secretion, Sex and Mycobacterial Evolution
Michael Niederweis,
University of Alabama at Birmingham, USA
Iron Utilization by M. tuberculosis
Iron Utilization by M. tuberculosis
Christopher S. Ealand,
University of the Witwatersrand, South Africa
Short Talk: The Role of Mycobacterial DD-Carboxypeptidases in Peptidoglycan Remodeling and Turnover
Short Talk: The Role of Mycobacterial DD-Carboxypeptidases in Peptidoglycan Remodeling and Turnover
Ellen Foot Perkowski,
University of North Carolina, USA
Short Talk: Exported In vivo Technology (EXIT) to Identify Mtb Proteins Exported during Infection
Short Talk: Exported In vivo Technology (EXIT) to Identify Mtb Proteins Exported during Infection
Jeppe Mouritsen,
Institute of Molecular Systems Biology, Switzerland
Short Talk: Direct Protein Quantification Reveals that Cholesterol Is a Carbon Source of Mycobacterium tuberculosis during Infection
Short Talk: Direct Protein Quantification Reveals that Cholesterol Is a Carbon Source of Mycobacterium tuberculosis during Infection
14:30—16:30
Workshop 3: Joint Workshop (Joint)
NOTE: Representation from European and NIH Consortia on Systems Biology of TB
*
Heran Darwin,
New York University School of Medicine, USA
*
Andrea M. Cooper,
Trudeau Institute, USA
Jonathan A. G. Cox,
University of Birmingham, UK
Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB
Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB
Allison J. Fay,
Sloan-Kettering Institute, USA
A Nonredundant Essential Role for Mycobacterial DnaK in Native Protein Folding
A Nonredundant Essential Role for Mycobacterial DnaK in Native Protein Folding
Alexandre Gouzy,
ICNRS-University of Toulouse, France
A Novel Amino Acid Permease System for M. tuberculosis Nitrogen Acquisition and Host Colonization
A Novel Amino Acid Permease System for M. tuberculosis Nitrogen Acquisition and Host Colonization
Ludovic P. Desvignes,
New York University School of Medicine, USA
Dynamic Roles of Type I and Type II Interferons in Early Infection with Mycobacterium tuberculosis
Dynamic Roles of Type I and Type II Interferons in Early Infection with Mycobacterium tuberculosis
Katrin D. Mayer-Barber,
NIAID, National Institutes of Health, USA
IL-1 Driven Eicosanoids Mediate Host Resistance to Mycobacterium tuberculosis Infection
IL-1 Driven Eicosanoids Mediate Host Resistance to Mycobacterium tuberculosis Infection
17:00—18:45
Host Susceptibility to Disease (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
NOTE: What are the factors that allow disease to ?develop in some exposed individuals and not ?others?
*
Robert J. Wilkinson,
University of Cape Town, South Africa
Erwin Schurr,
Montreal General Hospital, McGill University, Canada
Host Genetic Control of Resistance to Infection with M. tuberculosis
Host Genetic Control of Resistance to Infection with M. tuberculosis
Helen McShane,
University of Oxford, UK
Boosting BCG with MVA85A – Clinical Trials and Efficacy Data
Boosting BCG with MVA85A – Clinical Trials and Efficacy Data
18:45—19:30
Special Session: Panel Discussion of Results of the Recently Published Efficacy Trial of MVA85A Given as a Boost to BCG in South African Infants
*
Willem A. Hanekom,
University of Cape Town, South Africa
Helen McShane,
University of Oxford, UK
Mark Hatherill,
University of Cape Town, South Africa
Thomas J. Scriba,
University of Cape Town, South Africa
*Session Chair †Speaker invited, not yet responded.
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