Registered Attendees

Registered Attendees

Print This Page

Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online before the meeting...these abstracts will be available in the Abstract Book at the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

Close Window
Whistler Conference Centre Floorplan

Whistler Conference Centre Floorplan

Print This Page



Close Window

This meeting took place in 2013


Here are the related meetings in 2015:
Host Response in Tuberculosis (J3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Host Response in Tuberculosis (X7)


Organizer(s) Andrea M. Cooper and Robert J. Wilkinson
March 13—18, 2013
Whistler Conference Centre • Whistler, British Columbia Canada
Abstract Deadline: Nov 13, 2012
Late Abstract Deadline: Dec 11, 2012
Scholarship Deadline: Nov 13, 2012
Early Registration Deadline: Jan 14, 2013

Supported by the Directors' Fund


Summary of Meeting:
Although the host response to tuberculosis has been studied for many years, we still have only a rudimentary working model of the disease process; namely that antigen-specific T cells activate infected macrophages to control bacterial growth. Further progress in the control of tuberculosis will depend on a much more detailed understanding of the nature of the host response to infection. Therefore, the purpose of this Keystone Symposia meeting is to reassess our current understanding of disease mechanisms, discuss the most recent advances in the field, and identify critical questions and future research directions. A key focus of the meeting will be the innate, acquired, and immunopathologic responses that occur in the host following exposure to Mycobacterium tuberculosis. Speakers will be strongly encouraged to move past dogma and promote critical re-analysis of our working model of what constitutes protective immunity to tuberculosis. The conference will be held concurrently with a meeting on Tuberculosis: Understanding the Enemy – covering bacterial genetics, bacterial physiology, systems biology, and drug development. This will provide opportunities for participants from different disciplines to interact with one another forge new collaborations in novel areas of biology. Importantly, the interactive nature of the meetings will promote the new ideas and novel approaches necessary to combat this devastating disease.

View Scholarships/Awards

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, MARCH 13

16:00—20:00
Arrival and Registration


THURSDAY, MARCH 14

07:00—08:00
Breakfast

08:00—11:00
How Do Innate Cells Respond to Mtb (I)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: How does the lung respond to infection and how do the phagocyte and bacteria interact?

* David G. Russell, Cornell University, USA

Larry S. Schlesinger, Ohio State University, USA
Unique Immunoregulatory Factors in the Lung Alveolus during the Early Microbe-Host Encounter

Helen A. Fletcher, London School of Hygiene and Tropical Medicine, UK
Correlates of Risk of TB Disease in Infants Vaccinated with BCG

Jennifer Philips, New York University School of Medicine, USA
EsxH ESCRTs TB to Safety by Arresting Phagosome Maturation

Ishita Bhattacharya, Garvan Institute for Medical Research, Australia
Short Talk: The Splice Variant of IL-12Rbeta1: A New Player in the IL-12 Signaling Network

Cliona M. Ni Cheallaigh, Trinity College Dublin, Ireland
Short Talk: My-D88 Adapter Like (Mal) Is Required for Effective Macrophage Responses to Mycobacterium tuberculosis

Alissa C. Rothchild, Brigham & Women's Hospital, USA
Short Talk: iNKT Cell Production of GM-CSF Inhibits Growth of Mycobacterium tuberculosis

08:00—11:00
Mycobacterium tuberculosis – From Single Cells to Systems
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Eric J. Rubin, Harvard School of Public Health, USA

Heran Darwin, New York University School of Medicine, USA
Pedal to the Metal: Copper Resistance in Mycobacterium tuberculosis

Bree B. Aldridge, Tufts University, USA
Short Talk: Back to Basics: Diversity through Growth and Division in Mycobacteria

Veronique Anne Dartois, Public Health Research Institute, USA
Pharmacology: The Fate of TB Drugs from Plasma to Lesions and Single Cells

Johnjoe McFadden, University of Surrey, UK
Systems-Based Metabolic Analysis of Intracellular Growth of the TB bacillus

Dany J. V. Beste, University of Surrey, UK
Short Talk: 13C Isotopomer Spectral Analysis of Cholesterol Metabolism by Mycobacterium tuberculosis Growing in vitro and within Macrophages

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—15:30
On Own for Lunch and Recreation

15:30—16:00
Coffee Available

16:00—17:00
Keynote Address - TB: The Continuing Challenge (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Andrea M. Cooper, Trudeau Institute, USA

Chris Dye, World Health Organization, Switzerland
TB: The Continuing Challenge

17:00—19:00
How Do Innate Cells Respond to Mtb (II) (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: Mononuclear phagocytes are recognized as the host cells for Mtb but what do they really do? Neutrophils have been largely ignored as actors in tuberculosis, what do these cells do to contribute to disease? This session addresses these questions.

Carl F. Nathan, Weill Cornell Medical College, USA
Can Macrophages Be Super-Activated?

Anne O'Garra, MRC National Institute for Medical Research, UK
Systems Approach to Understand the Immune Response in Tuberculosis

David G. Russell, Cornell University, USA
Chemical and Genetic Perturbation of the Intracellular Survival Strategies of Mycobacterium tuberculosis

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


FRIDAY, MARCH 15

07:00—08:00
Breakfast

08:00—11:00
Acquired Immunity - Beyond the CD4 T Cell/Macrophage Paradigm?
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: While antigen-specific CD4 T cells are the target of current vaccines, it is not clear that these cells are the best mediators of protective immunity.

Eric G. Pamer, Memorial Sloan-Kettering Cancer Center, USA
Ly6Chi Monocytes and Immune Defense Against Mycobacterium tuberculosis Infection

* Samuel M. Behar, Brigham and Women's Hospital, USA
CD8+ T Cells and Protective Immunity to Tuberculosis

Ramakrishna Vankayalapati, University of Texas Health Center at Tyler, USA
Short Talk: A Subpopulation of CD4+CD25+Foxp3+ T-Cells Inhibits Growth of Mycobacterium tuberculosis

Peter Andersen, Statens Serum Institut, Denmark
Vaccine Induced Protection Against TB

Albanus O. Moguche, Seattle Biomedical Research Institute, USA
Short Talk: Intrinsic CXCR5 Expression Is Required to Maintain Antigen Specific CD4 T Cells during Chronic Mycobacterium tuberculosis Infection

Shabaana A. Khader, Children's Hospital of Pittsburgh, USA
Short Talk: Interleukin-17 Mediates Vaccine-Induced Immunity Against Tuberculosis

08:00—11:00
Mycobacterial Diversity and Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Graham F. Hatfull, University of Pittsburgh, USA

Nico C. Gey van Pittius, University of Stellenbosch, South Africa
Evolution of the PE and PPE Multi-Gene Families in the Mycobacteria

Thomas Ioerger, Texas A&M University, USA
What Comparative Genomics of Mycobacteria can Tell Us about Drug Resistance

Jeffery S. Cox, University of California, San Francisco, USA
The Ubiquitin Ligase PARKIN Is Required for Autophagy and Host Resistance to Intracellular Pathogens

Basim R.K. Al Shammari, Imperial College London, UK
Short Talk: Infection of MMP-1 Transgenic Mice with Virulent Mycobacterium tuberculosis Causes Human-Type Lung Pathology

Mireia Coscolla, Swiss Tropical and Public Health Institute, Switzerland
Short Talk: Adaptive Evolution in Different Lineages of the Mycobacterium tuberculosis Complex

Christophe Guilhot, Centre National de la Recherche Scientifique, France
Short Talk: Do Polymorphisms in phoPR Explain the Lower Virulence for Humans of africanum and Animal Strains of the Mycobacterium tuberculosis Complex?

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—16:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Host Susceptibility (Joint)

* Hardy Kornfeld, University of Massachusetts Medical School, USA

Thuong T. T. Nguyen, Oxford University Clinical Research Unit, Vietnam
A Genome–Wide Association Analysis Investigating the Contribution of Human and M. tuberculosis Genetics on Tuberculous Meningitis Susceptibility

Anna K. Coussens, Institute of Infectious Disease and Molecular Medicine, South Africa
Ethnicity Has a Greater Effect than Mycobacterial Lineage on the Identification of Biomarkers for TB

Joseph Keane, St. James's Hospital and Trinity College Dublin, Ireland
Cigarette Smoking Impairs Human Pulmonary Tuberculosis Immunity

Randall J. Basaraba, Colorado State University, USA
Altered Systemic Metabolism Contributes to TB Pathogenesis

Nathella Pavan Kumar, National Institute for Research in Tuberculosis, India
Expansion of Pathogen - Specific Th1 and Th17 Cells in Pulmonary Tuberculosis with Coincident Type 2 Diabetes Mellitus

Susan Realegeno, University of California, Los Angeles, USA
The Role of Vitamin D in IFN-gamma Induced Antimicrobial Responses Against Mycobacterium Infection in Human Macrophages

Philip Liu, University of California, Los Angeles, USA
Vitamin A Triggers a Human Antimicrobial Response Dependent on Cellular Cholesterol Composition

16:30—17:00
Coffee Available

17:00—19:00
Vaccination Against Mtb (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: The availability of patients in close proximity to high tech tools for analysis of immune responses has resulted in an increase in our understanding of the human response to Mtb infection.

* Tom H. M. Ottenhoff, Leiden University Medical Center, Netherlands

Alessandro D. Sette, La Jolla Institute for Allergy & Immunology, USA
Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed Against Three Antigenic Islands and Largely Contained in a CXCR3+CCR6+ Th1 Subset

Thomas G. Evans, Aeras, USA
Early Results of Vaccine Trials in Humans

Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology-Berlin, Germany
Vaccination Against Tuberculosis: Back to Basic Research or Forward with Clinical Trials?

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


SATURDAY, MARCH 16

07:00—08:00
Breakfast

08:00—11:00
The Consequences of the Immune Response in the Lung
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: Cellular responses in the lung start slowly 
following challenge with Mtb and the 
inflammatory site remains dynamic for the 
period of infection. Understanding the 
dynamics of the cellular response will allow 
for improved intervention.

Denise Kirschner, University of Michigan, USA
A Systems Biology Approach to Uncovering Mechanisms Governing Host-Mycobacterial Interactions during TB Infection in the Lung and Lymph Nodes

Clifton E. Barry III, NIAID, National Institutes of Health, USA
The Dynamics of Human Tuberculosis

Robert J. Francis, University of Surrey, UK
Short Talk: Selective ESAT6-Dependent Necrosis of Phosphatidylserine Externalised Neutrophils

* Jon Friedland, Imperial College London, UK
Matrix Metalloproteinases in Tuberculosis

Manuela Flórido, Centenary Institute, Australia
Short Talk: Influenza A Virus Infection Impairs Mycobacteria-Specific T Cell Responses and Mycobacterial Clearance in the Lung during Pulmonary Co-Infection

Melanie J. Harriff, Oregon Health & Sciences University/PVAMC, USA
Short Talk: Bronchial Epithelial Cells Take Up Mycobacterium tuberculosis into a Late Endosomal Compartment and Are Highly Efficient at Stimulating IFNgamma Release by CD8+ T Cells

08:00—11:00
Life and Death in Mycobacteria
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jeffery S. Cox, University of California, San Francisco, USA

Eric J. Rubin, Harvard School of Public Health, USA
Mycobacterial Proteins: Here Today, Gone… Some Other Time

Valerie Mizrahi, University of Cape Town, South Africa
Vitain B12 Metabolism in Mycobacteria

Marie I. Samanovic, New York University School of Medicine, USA
Short Talk: Proteasomal Regulation of Nitric Oxide Resistance in M. tuberculosis

Graham F. Hatfull, University of Pittsburgh, USA
Mycobacteriophages and Mycobacterium tuberculosis

Kerstin Williams, University of Surrey, UK
Short Talk: Global Response of Mycobacteria to Nitrogen Stress

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
A Global View of Infection (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: Unbiased techniques can highlight novel pathways and mechanisms of disease. This session will address the increased understanding of TB that these approaches have generated.

* Sébastien Gagneux, Swiss Tropical and Public Health Institute, Switzerland
Evolutionary Forces in Mycobacterium tuberculosis

Scarlet S. Shell, Harvard School of Public Health, USA
Short Talk: Widespread mRNA Processing Shapes the Mycobacterium tuberculosis Transcriptome

Tom H. M. Ottenhoff, Leiden University Medical Center, Netherlands
Short Talk: An Unbiased Genome-Wide Mycobacterium tuberculosis Gene-Expression Approach to Discover New Antigens for Human T Cells that Are Expressed during Pulmonary Infection

Jean-Laurent Casanova, Rockefeller University, USA
Toward a Genetic Theory of Infectious Diseases

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


SUNDAY, MARCH 17

07:00—08:00
Breakfast

07:30—08:00
Poster Setup

08:00—17:00
Poster Viewing

08:00—11:15
Tuberculosis and HIV
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: These two pathogens interact to create devastating effects for human health. What is the future for vaccination and control in areas with high incidence of both.

Robert J. Wilkinson, University of Cape Town, South Africa
The Heart, Mind and Breath of HIV-Associated Tuberculosis

* JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
Modeling HIV-TB Immune Interaction in Non-Human Primates

Marcelo Kuroda, Tulane University, USA
Short Talk: Macrophage Damage by SIV as the Cause of TB Reactivation in the TB/SIV Rhesus Co-Infection Model

Daniel L. Barber, NIAID, National Institutes of Health, USA
Mechanisms of Mycobacteria-Associated Immune Reconstitution Inflammatory Syndrome

Richard A. Koup, NIAID, National Institutes of Health, USA
HIV-Tuberculosis Interaction

Tracy R. Rosebrock, Harvard School of Public Health, USA
Short Talk: Single Cell Analysis Reveals Distinct Effects of HIV on Mycobacterium tuberculosis Survival in Co-Infected and Bystander Macrophages

08:00—11:00
The Bacterial Surface and its Interaction with the Host
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Sarah M. Fortune, Harvard School of Public Health, USA

Mary Jackson, Colorado State University, USA
Cell Envelope Glycoconjugates: Metabolism and Interaction with the Host

Keith M. Derbyshire, Wadsworth Center, New York State Department of Health, USA
ESX, its Role in Secretion, Sex and Mycobacterial Evolution

Michael Niederweis, University of Alabama at Birmingham, USA
Iron Utilization by M. tuberculosis

Christopher S. Ealand, University of the Witwatersrand, South Africa
Short Talk: The Role of Mycobacterial DD-Carboxypeptidases in Peptidoglycan Remodeling and Turnover

Ellen Foot Perkowski, University of North Carolina, USA
Short Talk: Exported In vivo Technology (EXIT) to Identify Mtb Proteins Exported during Infection

Jeppe Mouritsen, Institute of Molecular Systems Biology, Switzerland
Short Talk: Direct Protein Quantification Reveals that Cholesterol Is a Carbon Source of Mycobacterium tuberculosis during Infection

09:20—09:40
Coffee Break

11:15—12:00
Lunch

12:00—14:30
Poster Session 4

14:30—16:30
Workshop 3: Joint Workshop (Joint)

NOTE: Representation from European and NIH Consortia on Systems Biology of TB

* Heran Darwin, New York University School of Medicine, USA

* Andrea M. Cooper, Trudeau Institute, USA

Jonathan A. G. Cox, University of Birmingham, UK
Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

Allison J. Fay, Sloan-Kettering Institute, USA
A Nonredundant Essential Role for Mycobacterial DnaK in Native Protein Folding

Alexandre Gouzy, ICNRS-University of Toulouse, France
A Novel Amino Acid Permease System for M. tuberculosis Nitrogen Acquisition and Host Colonization

Ludovic P. Desvignes, New York University School of Medicine, USA
Dynamic Roles of Type I and Type II Interferons in Early Infection with Mycobacterium tuberculosis

Katrin D. Mayer-Barber, NIAID, National Institutes of Health, USA
IL-1 Driven Eicosanoids Mediate Host Resistance to Mycobacterium tuberculosis Infection

16:30—17:00
Coffee Available

17:00—18:45
Host Susceptibility to Disease (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

NOTE: What are the factors that allow disease to ?develop in some exposed individuals and not ?others?

* Robert J. Wilkinson, University of Cape Town, South Africa

Hardy Kornfeld, University of Massachusetts Medical School, USA
Diabetes and TB

Erwin Schurr, Montreal General Hospital, McGill University, Canada
Host Genetic Control of Resistance to Infection with M. tuberculosis

Helen McShane, University of Oxford, UK
Boosting BCG with MVA85A – Clinical Trials and Efficacy Data

18:45—19:30
Special Session: Panel Discussion of Results of the Recently Published Efficacy Trial of MVA85A Given as a Boost to BCG in South African Infants

* Willem A. Hanekom, Bill & Melinda Gates Foundation, USA

Helen McShane, University of Oxford, UK

Mark Hatherill, University of Cape Town, South Africa

Thomas J. Scriba, University of Cape Town, South Africa

19:30—20:30
Social Hour with Lite Bites

20:00—23:00
Entertainment


MONDAY, MARCH 18

 
Departure


*Session Chair †Speaker invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI104041-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

S. Karger AG - Respiration

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676