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This meeting took place in 2013



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Tuberculosis: Understanding the Enemy (X8)


Organizer(s) Eric J. Rubin, Sébastien Gagneux and Heran Darwin
March 13—18, 2013
Whistler Conference Centre • Whistler, British Columbia Canada
Abstract Deadline: Nov 13, 2012
Late Abstract Deadline: Dec 11, 2012
Scholarship Deadline: Nov 13, 2012
Early Registration Deadline: Jan 14, 2013

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation


Summary of Meeting:
Despite more than a century of research, tuberculosis (TB) remains one of the leading causes of death in the world. Although drug therapy is available, it remains cumbersome and difficult to administer in areas of the developing world where TB is most prevalent. Moreover, the rise of HIV and consequent marked increase in TB susceptibility and the increasing appearance of drug resistant bacterial strains has made management of infection far more difficult. New approaches to treatment and prevention could have an enormous impact on the disease. This meeting will bring together different disciplines, including microbial genomics and genetics, bacterial physiology, systems biology and drug development, to explore how Mycobacterium tuberculosis is transmitted and causes disease. In addition, the conference will be paired with a concurrent meeting that explores host responses to TB. Together, these two conferences will cover a breadth of TB biology and examine the interface between the host and pathogen. The conference will provide an opportunity for interactions among those from different fields and include many participants from disciplines that would not ordinarily participate in a meeting devoted exclusively to TB. We hope to stimulate new collaborations and introduce novel areas of biology so that the field will be positioned to tackle the many remaining challenges for combating this disease. The meeting will also provide an opportunity to develop and engage the next generation of researchers in the field by including junior and early stage investigators in the meeting format.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, MARCH 13

16:00—20:00
Arrival and Registration

Grand Foyer

THURSDAY, MARCH 14

07:00—08:00
Breakfast

Sea to Sky A, Garibaldi B/C
08:00—11:00
Mycobacterium tuberculosis – From Single Cells to Systems
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Eric J. Rubin, Harvard School of Public Health, USA

Heran Darwin, New York University School of Medicine, USA
Pedal to the Metal: Copper Resistance in Mycobacterium tuberculosis

Bree B. Aldridge, Tufts University, USA
Short Talk: Back to Basics: Diversity through Growth and Division in Mycobacteria

Veronique Anne Dartois, Public Health Research Institute, USA
Pharmacology: The Fate of TB Drugs from Plasma to Lesions and Single Cells

Johnjoe McFadden, University of Surrey, UK
Systems-Based Metabolic Analysis of Intracellular Growth of the TB bacillus

Dany J. V. Beste, University of Surrey, UK
Short Talk: 13C Isotopomer Spectral Analysis of Cholesterol Metabolism by Mycobacterium tuberculosis Growing in vitro and within Macrophages


Following Session is for Host Response in Tuberculosis (X7)

08:00—11:00
How Do Innate Cells Respond to Mtb (I)
Meeting has ended...abstracts no longer viewable online.
How does the lung respond to infection and how do the phagocyte and bacteria interact?

Sea to Sky B
* David G. Russell, Cornell University, USA

Larry S. Schlesinger, Texas Biomedical Research Institute, USA
Unique Immunoregulatory Factors in the Lung Alveolus during the Early Microbe-Host Encounter

Helen A. Fletcher, London School of Hygiene and Tropical Medicine, UK
Correlates of Risk of TB Disease in Infants Vaccinated with BCG

Jennifer Philips, Washington University School of Medicine, USA
EsxH ESCRTs TB to Safety by Arresting Phagosome Maturation

Ishita Bhattacharya, Garvan Institute for Medical Research, Australia
Short Talk: The Splice Variant of IL-12Rbeta1: A New Player in the IL-12 Signaling Network

Cliona M. Ni Cheallaigh, Trinity College Dublin, Ireland
Short Talk: My-D88 Adapter Like (Mal) Is Required for Effective Macrophage Responses to Mycobacterium tuberculosis

Alissa C. Rothchild, Center for Infectious Disease Research, USA
Short Talk: iNKT Cell Production of GM-CSF Inhibits Growth of Mycobacterium tuberculosis

09:20—09:40
Coffee Break

Grand Foyer
11:00—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
11:00—15:00
On Own for Lunch and Recreation

15:30—16:00
Coffee Available

Grand Foyer
16:00—17:00
Keynote Address: TB: The Continuing Challenge (Joint)
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B/C
* Andrea M. Cooper, University of Leicester, UK

Chris Dye, World Health Organization, Switzerland
TB: The Continuing Challenge

17:00—19:00
How do Innate Cells Respond to Mtb? (Joint)
Meeting has ended...abstracts no longer viewable online.
Mononuclear phagocytes are recognized as the host cells for Mtb but what do they really do? Neutrophils have been largely ignored as actors in tuberculosis, what do these cells do to contribute to disease?

Sea to Sky B/C
Carl F. Nathan, Weill Cornell Medical College, USA
Can Macrophages Be Super-Activated?

Anne O'Garra, Francis Crick Institute, UK
Systems Approach to Understand the Immune Response in Tuberculosis

David G. Russell, Cornell University, USA
Chemical and Genetic Perturbation of the Intracellular Survival Strategies of Mycobacterium tuberculosis

19:00—20:00
Social Hour with Lite Bites

Sea to Sky A
19:30—22:00
Poster Session 1

Sea to Sky A

FRIDAY, MARCH 15

07:00—08:00
Breakfast

Sea to Sky A, Garibaldi B/C
08:00—11:00
Mycobacterial Diversity and Disease
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Graham F. Hatfull, University of Pittsburgh, USA

Nico C. Gey van Pittius, University of Stellenbosch, South Africa
Evolution of the PE and PPE Multi-Gene Families in the Mycobacteria

Thomas Ioerger, Texas A&M University, USA
What Comparative Genomics of Mycobacteria can Tell Us about Drug Resistance

Jeffery S. Cox, University of California, Berkeley, USA
The Ubiquitin Ligase PARKIN Is Required for Autophagy and Host Resistance to Intracellular Pathogens

Basim R.K. Al Shammari, Imperial College London, UK
Short Talk: Infection of MMP-1 Transgenic Mice with Virulent Mycobacterium tuberculosis Causes Human-Type Lung Pathology

Mireia Coscolla, Swiss Tropical and Public Health Institute, Switzerland
Short Talk: Adaptive Evolution in Different Lineages of the Mycobacterium tuberculosis Complex

Christophe Guilhot, Centre National de la Recherche Scientifique, France
Short Talk: Do Polymorphisms in phoPR Explain the Lower Virulence for Humans of africanum and Animal Strains of the Mycobacterium tuberculosis Complex?


Following Session is for Host Response in Tuberculosis (X7)

08:00—11:00
Acquired Immunity - Beyond the CD4 T Cell/Macrophage Paradigm?
Meeting has ended...abstracts no longer viewable online.
While antigen-specific CD4 T cells are the target of current vaccines, it is not clear that these cells are the best mediators of protective immunity.

Sea to Sky B
Eric G. Pamer, Memorial Sloan Kettering Cancer Center, USA
Ly6Chi Monocytes and Immune Defense Against Mycobacterium tuberculosis Infection

* Samuel M. Behar, University of Massachusetts Medical School, USA
CD8+ T Cells and Protective Immunity to Tuberculosis

Krishna Vankayalapati, University of Texas Health Center, USA
Short Talk: A Subpopulation of CD4+CD25+Foxp3+ T-Cells Inhibits Growth of Mycobacterium tuberculosis

Peter Andersen, Statens Serum Institut, Denmark
Vaccine Induced Protection Against TB

Albanus Moguche, Seattle Biomed, USA
Short Talk: Intrinsic CXCR5 Expression Is Required to Maintain Antigen Specific CD4 T Cells during Chronic Mycobacterium tuberculosis Infection

Shabaana Khader, Washington University School of Medicine, USA
Short Talk: Interleukin-17 Mediates Vaccine-Induced Immunity Against Tuberculosis

09:20—09:40
Coffee Break

Grand Foyer
11:00—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
11:00—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Vaccination Against Mtb (Joint)
Meeting has ended...abstracts no longer viewable online.
The availability of patients in close proximity to high tech tools for analysis of immune responses has resulted in an increase in our understanding of the human response to Mtb infection.

Sea to Sky B/C
* Tom H. M. Ottenhoff, Leiden University Medical Center, Netherlands

Alessandro Sette, La Jolla Institute for Allergy & Immunology, USA
Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed Against Three Antigenic Islands and Largely Contained in a CXCR3+CCR6+ Th1 Subset

Thomas Evans, TomegaVax, USA
Early Results of Vaccine Trials in Humans

Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
Vaccination Against Tuberculosis: Back to Basic Research or Forward with Clinical Trials?

19:00—20:00
Social Hour with Lite Bites

Sea to Sky A
19:30—22:00
Poster Session 2

Sea to Sky A

SATURDAY, MARCH 16

07:00—08:00
Breakfast

Sea to Sky A, Garibaldi B/C
08:00—11:00
Life and Death in Mycobacteria
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Jeffery S. Cox, University of California, Berkeley, USA

Eric J. Rubin, Harvard School of Public Health, USA
Mycobacterial Proteins: Here Today, Gone… Some Other Time

Valerie Mizrahi, University of Cape Town, South Africa
Vitain B12 Metabolism in Mycobacteria

Marie I. Samanovic, New York University School of Medicine, USA
Short Talk: Proteasomal Regulation of Nitric Oxide Resistance in M. tuberculosis

Graham F. Hatfull, University of Pittsburgh, USA
Mycobacteriophages and Mycobacterium tuberculosis

Kerstin Williams, University of Surrey, UK
Short Talk: Global Response of Mycobacteria to Nitrogen Stress


Following Session is for Host Response in Tuberculosis (X7)

08:00—11:00
The Consequences of the Immune Response in the Lung
Meeting has ended...abstracts no longer viewable online.
Cellular responses in the lung start slowly 
following challenge with Mtb and the 
inflammatory site remains dynamic for the 
period of infection. Understanding the 
dynamics of the cellular response will allow 
for improved intervention.

Sea to Sky B
Denise Kirschner, University of Michigan, USA
A Systems Biology Approach to Uncovering Mechanisms Governing Host-Mycobacterial Interactions during TB Infection in the Lung and Lymph Nodes

Clifton E. Barry III, NIAID, National Institutes of Health, USA
The Dynamics of Human Tuberculosis

Robert J. Francis, University of Surrey, UK
Short Talk: Selective ESAT6-Dependent Necrosis of Phosphatidylserine Externalised Neutrophils

* Jon Friedland, Imperial College London, UK
Matrix Metalloproteinases in Tuberculosis

Manuela Flórido, Centenary Institute, Australia
Short Talk: Influenza A Virus Infection Impairs Mycobacteria-Specific T Cell Responses and Mycobacterial Clearance in the Lung during Pulmonary Co-Infection

Melanie J. Harriff, Oregon Health & Sciences University/PVAMC, USA
Short Talk: Bronchial Epithelial Cells Take Up Mycobacterium tuberculosis into a Late Endosomal Compartment and Are Highly Efficient at Stimulating IFNgamma Release by CD8+ T Cells

09:20—09:40
Coffee Break

Grand Foyer
11:00—13:00
Poster Setup

Sea to Sky A
13:00—22:00
Poster Viewing

Sea to Sky A
11:00—16:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Systems Biology in TB Research
Representation from European and NIH Consortia on Systems Biology of TB

Sea to Sky B/C
* Matthias Wilmanns, European Molecular Biology Laboratory Hamburg, Germany

Matthias T. Ehebauer, European Molecular Biology Laboratory, Germany
Integrating Structural Biology into Systems Biology: Unexpected Carboxylase Activities in Mycobacteria

Vítor Martins dos Santos, Wageningen University, Netherlands
Systems Approaches to Uncover the Cellular Wiring of Mycobacterium tuberculosis

Wei-Hua Chen, European Molecular Biology Laboratory, Germany
Transcriptome and Proteome Analyses of Mycobacterium tuberculosis

Christoph Grundner, Center for Infectious Disease Research, USA
Global Profiling of ATP Binding in M. tuberculosis

Kyle Minch, Center for Infectious Disease Research, USA
A Role for Transcriptionally Silent DNA Binding in Mycobacterium tuberculosis

Andrej Trauner, Harvard School of Public Health, USA
High-Throughput Discovery of Drug Mechanism by Gene Overexpression

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
A Global View of Infection (Joint)
Meeting has ended...abstracts no longer viewable online.
Unbiased techniques can highlight novel pathways and mechanisms of disease. This session will address the increased understanding of TB that these approaches have generated.

Sea to Sky B/C
* Sébastien Gagneux, Swiss Tropical and Public Health Institute, Switzerland
Evolutionary Forces in Mycobacterium tuberculosis

Scarlet S. Shell, Worcester Polytechnic Institute, USA
Short Talk: Widespread mRNA Processing Shapes the Mycobacterium tuberculosis Transcriptome

Tom H. M. Ottenhoff, Leiden University Medical Center, Netherlands
Short Talk: An Unbiased Genome-Wide Mycobacterium tuberculosis Gene-Expression Approach to Discover New Antigens for Human T Cells that Are Expressed during Pulmonary Infection

Jean-Laurent Casanova, Rockefeller University, USA
Toward a Genetic Theory of Infectious Diseases

19:00—20:00
Social Hour with Lite Bites

Sea to Sky A
19:30—22:00
Poster Session 3

Sea to Sky A

SUNDAY, MARCH 17

07:00—08:00
Breakfast

Sea to Sky A, Garibaldi B/C
07:30—08:00
Poster Setup

Sea to Sky A
08:00—17:00
Poster Viewing

Sea to Sky A
08:00—11:00
The Bacterial Surface and its Interaction with the Host
Meeting has ended...abstracts no longer viewable online.

Sea to Sky C
* Sarah M. Fortune, Harvard School of Public Health, USA

Mary Jackson, Colorado State University, USA
Cell Envelope Glycoconjugates: Metabolism and Interaction with the Host

Keith M. Derbyshire, Wadsworth Center, New York State Department of Health, USA
ESX, its Role in Secretion, Sex and Mycobacterial Evolution

Michael Niederweis, University of Alabama at Birmingham, USA
Iron Utilization by M. tuberculosis

Christopher S. Ealand, University of the Witwatersrand, South Africa
Short Talk: The Role of Mycobacterial DD-Carboxypeptidases in Peptidoglycan Remodeling and Turnover

Ellen Foot Perkowski, University of North Carolina, USA
Short Talk: Exported In vivo Technology (EXIT) to Identify Mtb Proteins Exported during Infection

Jeppe Mouritsen, Institute of Molecular Systems Biology, Switzerland
Short Talk: Direct Protein Quantification Reveals that Cholesterol Is a Carbon Source of Mycobacterium tuberculosis during Infection


Following Session is for Host Response in Tuberculosis (X7)

08:00—11:15
Tuberculosis and HIV
Meeting has ended...abstracts no longer viewable online.
These two pathogens interact to create devastating effects for human health. What is the future for vaccination and control in areas with high incidence of both.

Sea to Sky B
Robert J. Wilkinson, University of Cape Town, South Africa
The Heart, Mind and Breath of HIV-Associated Tuberculosis

* JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
Modeling HIV-TB Immune Interaction in Non-Human Primates

Marcelo Kuroda, Tulane University, USA
Short Talk: Macrophage Damage by SIV as the Cause of TB Reactivation in the TB/SIV Rhesus Co-Infection Model

Daniel L. Barber, NIAID, National Institutes of Health, USA
Mechanisms of Mycobacteria-Associated Immune Reconstitution Inflammatory Syndrome

Richard A. Koup, NIAID, National Institutes of Health, USA
HIV-Tuberculosis Interaction

Tracy R. Rosebrock, Harvard School of Public Health, USA
Short Talk: Single Cell Analysis Reveals Distinct Effects of HIV on Mycobacterium tuberculosis Survival in Co-Infected and Bystander Macrophages

09:20—09:40
Coffee Break

Grand Foyer
11:00—12:00
Lunch

Sea to Sky A, Garibaldi B/C
12:00—14:30
Poster Session 4

Sea to Sky A
14:30—16:30
Workshop 3: Joint Workshop (Joint)

Sea to Sky B/C
* Heran Darwin, New York University School of Medicine, USA

* Andrea M. Cooper, University of Leicester, UK

Jonathan A. G. Cox, University of Birmingham, UK
Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

Allison J. Fay, Sloan-Kettering Institute, USA
A Nonredundant Essential Role for Mycobacterial DnaK in Native Protein Folding

Alexandre Gouzy, ICNRS-University of Toulouse, France
A Novel Amino Acid Permease System for M. tuberculosis Nitrogen Acquisition and Host Colonization

Ludovic P. Desvignes, New York University School of Medicine, USA
Dynamic Roles of Type I and Type II Interferons in Early Infection with Mycobacterium tuberculosis

Katrin D. Mayer-Barber, NIAID, National Institutes of Health, USA
IL-1 Driven Eicosanoids Mediate Host Resistance to Mycobacterium tuberculosis Infection

16:30—17:00
Coffee Available

Grand Foyer
17:00—18:45
Host Susceptibility to Disease (Joint)
Meeting has ended...abstracts no longer viewable online.
What are the factors that allow disease to develop in some exposed individuals and not others?

Sea to Sky B/C
* Robert J. Wilkinson, University of Cape Town, South Africa

Hardy Kornfeld, University of Massachusetts Medical School, USA
Diabetes and TB

Erwin Schurr, Research Institute of the McGill University Health Centre, Canada
Host Genetic Control of Resistance to Infection with M. tuberculosis

Helen McShane, Jenner Institute, UK
Boosting BCG with MVA85A – Clinical Trials and Efficacy Data

18:45—19:30
Special Session: Panel Discussion of Results of the Recently Published Efficacy Trial of MVA85A Given as a Boost to BCG in South African Infants

Sea to Sky B/C
* Willem A. Hanekom, Bill & Melinda Gates Foundation, USA

Helen McShane, Jenner Institute, UK

Mark Hatherill, University of Cape Town, South Africa

Thomas J. Scriba, University of Cape Town, South Africa

19:30—20:30
Social Hour with Lite Bites

Sea to Sky A
20:00—23:00
Entertainment

Sea to Sky A

MONDAY, MARCH 18

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

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Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Bill & Melinda Gates Foundation

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI104008-01

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