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Beaver Run Resort Floorplan

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This meeting took place in 2013


Here are the related meetings in 2014:
Mobile Genetic Elements and Genome Evolution (C2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Precision Genome Engineering and Synthetic Biology: Designing Genomes and Pathways (C5)


Organizer(s) Dana Carroll and Jef D. Boeke
March 17—22, 2013
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Nov 14, 2012
Late Abstract Deadline: Dec 19, 2012
Scholarship Deadline: Nov 14, 2012
Early Registration Deadline: Jan 17, 2013

Sponsored by Life Technologies Corporation and Sangamo BioSciences, Inc.

Summary of Meeting:
Now that we know the sequences of many genomes, from a wide variety of organisms and even from individuals with unique characteristics, many researchers have turned to making intentional modifications of those genomes. Purposes of those modifications include: introducing mutations to evaluate gene function, production of models for human genetic disease, gene correction, radical redesign of genome structure, and the generation of novel cellular networks and pathways. With this conference, we propose to bring together scientists who are: 1) developing tools for precision genome engineering; 2) using those tools for specific purposes in a wide range of organisms, including humans; 3) creating whole synthetic genomes with prospects for wholesale reengineering; 4) engineering cells with novel pathways and properties. Exchange of cutting-edge information regarding approaches, accomplishments and ambitions will augment the capabilities of each group. The meeting will provide an outstanding forum for students, postdoctoral fellows, and senior investigators who envision careers in genome and pathway design.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 17

16:00—20:00
Arrival and Registration


MONDAY, MARCH 18

07:00—08:00
Breakfast

08:00—08:15
Welcome Remarks

Dana Carroll, University of Utah School of Medicine, USA

08:15—09:15
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jef D. Boeke, Johns Hopkins University School of Medicine, USA

Frances H. Arnold, California Institute of Technology, USA
Innovation by Evolution

09:15—11:30
Pathway Engineering
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Frances H. Arnold, California Institute of Technology, USA

Sang Yup Lee, Korea Advanced Institute of Science and Technology (KAIST), South Korea
Redesigning Cellular Metabolism for Chemicals Production

Stephen B. del Cardayre, LS9, Inc., USA
Scalpels to Chainsaws: A Practical Tool Belt for Industrial Synthetic Biology

Ron Weiss, Massachusetts Institute of Technology, USA
Synthetic Biology: From Parts to Modules to Therapeutic Systems

Lauren R. Polstein, Duke University, USA
Short Talk: Light-Inducible Genetic Control in Human Cells

09:55—10:15
Coffee Break

11:30—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:30
Zinc-Finger Nucleases and TALENs
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Philip D. Gregory, Sangamo BioSciences, Inc., USA

Dana Carroll, University of Utah School of Medicine, USA
Parameters Affecting ZFN- and TALEN-Mediated Gene Targeting

Daniel F. Voytas, University of Minnesota, USA
Targeted Modification of Plant Genomes

Thomas Lahaye, Ludwig Maximilians University Munich, Germany
TALE Like Proteins from Ralstonia solanacearum and their Potential to Improve Current TALE Technology

Toni Cathomen, University Medical Center Freiburg, Germany
ZFNs vs. TALENs – A Tight Race?

Marcus B. Noyes, Princeton University, USA
Short Talk: A Comprehensive Survey of the Cys2His2 Zinc Finger Domain and Selection of Fine-Tuned Specificity

19:30—20:30
Social Hour w/ Lite Bites


TUESDAY, MARCH 19

07:00—08:00
Breakfast

08:00—11:00
Engineering Genomes
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Edward M. Rubin, Lawrence Berkeley National Laboratory, USA

Daniel G. Gibson, J. Craig Venter Institute, USA
Building a Synthetic Cell and Advancing Synthetic Genomics Technology

Farren Isaacs, Yale University, USA
Programming Genomes to Re-Engineer Life’s Functional Repertoire

Sriram Kosuri, Wyss Institute, USA
Synthetic Approaches to Studying Cis-Regulatory Codes

Jef D. Boeke, Johns Hopkins University School of Medicine, USA
Synthetic Yeast Genome

Ahmad S. Khalil, Boston University, USA
Short Talk: A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—16:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Tools ‘n Fuels

* Virginia W. Cornish, Columbia University, USA

Jonathan R. Karr, Stanford University, USA
Design and Genome Optimization Using Whole-Cell Models

Todd Peterson, Life Technologies, USA
Genetic Design, Synthesis and Assembly Tools for Synthetic Biology Engineering

Klavs Riishede Hansen, Evolva Biotech A/S, Denmark
Exploring Chemical Diversity by Creative Combination of Metabolic Pathways

Leslie A. Mitchell, Johns Hopkins University School of Medicine, USA
The Telomerator: A New Tool for Chromosome Engineering

Neha Munjal, International Center for Genetic Engineering & Biotechnology (ICGEB), India
Native Pathway Engineering in E. coli for Production of Bioethanol from Pentose and Hexose Sugars

Thomas Armel, Booz Allen Hamilton, USA
Living Foundries: Tools and Infrastructure for Engineering Biology

Vítor Martins dos Santos, Wageningen University, Netherlands
Streamlining and Reprogramming a Bacterial Catalyst for the Production of Bulk and Fine Chemicals

16:30—17:00
Coffee Available

17:00—19:00
Genome Engineering in Humans and Other Animals
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Toni Cathomen, University Medical Center Freiburg, Germany

Scott C. Fahrenkrug, University of Minnesota, USA
Engineering the Genomes of Food Animals with TALENs

Angelo Lombardo, San Raffaele Telethon Institute for Gene Therapy, Italy
Gene Targeting in Human Stem Cells by ZFNs

Julien Valton, Cellectis SA, France
Short Talk: XPC Gene Therapy Using Nuclease-Assisted Targeted Approaches

Philip D. Gregory, Sangamo BioSciences, Inc., USA
ZFN-Edited CD4+ T Cells for HIV/AIDS Therapy: Phase 1 Trials of SB-728-T in HIV-Infected Subjects

19:30—20:30
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


WEDNESDAY, MARCH 20

07:00—08:00
Breakfast

08:00—11:15
Design in Synthetic Biology
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ron Weiss, Massachusetts Institute of Technology, USA

Tanja Kortemme, University of California, San Francisco, USA
Computational Design of Proteins, Interactions and Machines with New Functions

Petra Schwille, Max Planck Institute of Biochemistry, Germany
Design Features of Protein Clockworks

Jason W. Chin, MRC, Laboratory of Molecular Biology, UK
Reprogramming the Genetic Code

Yaakov (Kobi) Benenson, ETH Zürich, Switzerland
Biological Computing Meets Synthetic Biology: New Ways to Control Cells

Douglas Densmore, Boston University, USA
CAD for Synthetic Biology

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—16:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Designer Engineering of Genomes

David R. Edgell, University of Western Ontario, Canada
Monomeric Tev-TAL Nucleases for Genome Engineering Applications

Shengdar Q. Tsai, Massachusetts General Hospital, USA
Precise Editing of Human Genes Directed by ssDNA Oligonucleotides and TALENs

Nicholas Baltes, University of Minnesota, Twin Cities, USA
In Planta Gene Targeting with Viruses

* Gregory D. Davis, Sigma-Aldrich, USA
Enrichment of Genome Edited Cell Populations by Transient Co-Expression of Fluorescent Proteins and Zinc Finger Nucleases

Kamila S. Gwiazda, University of Washington, USA
Coupling Endonucleases with DNA End-Processing Enzymes to Promote Gene Disruption

Prashant Mali, Harvard Medical School, USA
RNA-Guided Human Genome Engineering

Andrew C. Mercer, The Scripps Research Institute, USA
Engineering a Framework for Active TALE Recombinases

Daniel Wattendorf, Defense Advanced Research Projects Agency (DARPA), USA
Towards a Genetic Jump Drive

16:30—17:00
Coffee Available

17:00—19:15
Targeting with Transposons, Integrases, Meganucleases and CRISPRs
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Daniel F. Voytas, University of Minnesota, USA

Nancy L. Craig, HHMI/Johns Hopkins University School of Medicine, USA
piggyBac Transposons for Genome Engineering

Michele P. Calos, Stanford University School of Medicine, USA
Site-Specific Gene Addition for Stem Cell Therapy of Muscular Dystrophy

Barry L. Stoddard, Fred Hutchinson Cancer Research Center, USA
Combining TAL Effectors and Homing Endonucleases for Gene Targeting

Rachel E. Haurwitz, Caribou Biosciences, Inc., USA
Short Talk: RNA-Guided Site-Specific Genome Editing Using Cas9

Jin-Soo Kim, Seoul National University, South Korea
Short Talk: Genome Editing in Cells and Organisms with ZFNs, TALENs, and RNA-Guided Endonucleases (RGENs)

19:15—20:15
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


THURSDAY, MARCH 21

07:00—08:00
Breakfast

08:00—11:00
Programming Organismal Behavior
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Yaakov (Kobi) Benenson, ETH Zürich, Switzerland

Christopher Voigt, Massachusetts Institute of Technology, USA
Programming Devices and Networks

Jeff Hasty, University of California, San Diego, USA
Gene Circuit Functionality.

Virginia W. Cornish, Columbia University, USA
Expanding the Synthetic Capabilities of Yeast

June I. Medford, Colorado State University, USA
Synthetic Signal Transduction and Design of New Traits

Timothy K. Lu, Massachusetts Institute of Technology, USA
Short Talk: Analog and Digital Platforms for Synthetic Biology

09:20—09:40
Coffee Break

11:00—16:30
On Own for Lunch and Recreation

15:30—16:00
Coffee Available

16:00—18:00
Engineering Biofuel and Specialty Chemical Production
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Timothy K. Lu, Massachusetts Institute of Technology, USA

Xiaoxia Nina Lin, University of Michigan, USA
Short Talk: Engineering Synthetic Microbial Consortia for Consolidated Bioprocessing

Edward M. Rubin, Lawrence Berkeley National Laboratory, USA
Synthetic Metagenomics

Jack D. Newman, Amyris, USA
Engineering Biofuel and Specialty Chemical Platforms in Yeast

18:00—19:00
Social Hour w/ Lite Bites

19:00—22:00
Entertainment


FRIDAY, MARCH 22

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Life Technologies Corporation Sangamo BioSciences, Inc.

We gratefully acknowledge additional support for this conference from:

GenScript USA Inc. Integrated DNA Technologies
Sigma Life Science
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Science Foundation (NSF)

Grant No. MCB-1265353

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the National Science Foundation; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



LS9, Inc.


Sangamo BioSciences, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Genetic Engineering & Biotechnology News

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676