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This meeting took place in 2013
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Meeting Details
RNA Silencing (C7)
Organizer(s) David C. Baulcombe and Irene Bozzoni
March 19 - March 24, 2013
Whistler Conference Centre • Whistler, British Columbia Canada
Abstract Deadline: November 15, 2012
Late Abstract Deadline: December 20, 2012
Scholarship Deadline: November 15, 2012
Early Registration Deadline: January 18, 2013
Sponsored by Cell Research
CME Information
Summary of Meeting:
RNA silencing systems are now well established as key components of regulation and control in many eukaryotes including animals and plants. The first flush of discoveries was focused around post-transcriptional regulation. It was anticipated that the small RNA specificity determinants of these silencing systems could be negative switches acting alongside transcription factors control of gene expression during growth, development and responses to external stimuli. More recently, the emphasis has shifted. In terms of post-transcriptional regulation, it is now recognized that there are only a few examples in plants and worms in which sRNAs are simple switches. These RNAs are now seen as modulators or fine tuners of post-transcriptional regulation that are often components of negative feedback loops or of control networks in which there are long RNA negative regulators of the sRNAs and secondary sRNAs. The sRNAs can be transported or secreted out of cells and so the RNA mediated control networks may extend beyond one cell. The anticipated potential of sRNA therapeutics has yet to be delivered but they are proving to be a powerful diagnostic tool in cancer and other diseases. A second emerging area is in the link between sRNAs and epigenetic regulation. This link was revealed first from plant work but it is now known in animals in connection with piwi-associated RNAs or piRNAs. These epigenetic sRNAs and piRNAs are certainly important in defense against transposable elements, but it is possible that they also influence genetic or epigenetic regulation in other cell types. In this complex array of sRNA functions, growing interest is now devoted also to the crucial role of long noncoding RNAs in processes of gene expression control both at the transcriptional and post-transcriptional levels. This Keystone Symposia meeting on RNA Silencing will focus on these emerging topics of network control systems and epigenetic regulation by various types of sRNA. The focus on RNA silencing in general provides an umbrella under which speakers from different areas of research (e.g., transcriptional regulation, cancer biology, development, epigenetics and virology) are being brought together in an environment that is highly conducive to cross-talk. Emphasis has also be placed on showcasing early stage investigators presenting on the program with a view to promoting the next generation of scientists in the RNA silencing field.
CME Information
RNA silencing systems are now well established as key components of regulation and control in many eukaryotes including animals and plants. The first flush of discoveries was focused around post-transcriptional regulation. It was anticipated that the small RNA specificity determinants of these silencing systems could be negative switches acting alongside transcription factors control of gene expression during growth, development and responses to external stimuli. More recently, the emphasis has shifted. In terms of post-transcriptional regulation, it is now recognized that there are only a few examples in plants and worms in which sRNAs are simple switches. These RNAs are now seen as modulators or fine tuners of post-transcriptional regulation that are often components of negative feedback loops or of control networks in which there are long RNA negative regulators of the sRNAs and secondary sRNAs. The sRNAs can be transported or secreted out of cells and so the RNA mediated control networks may extend beyond one cell. The anticipated potential of sRNA therapeutics has yet to be delivered but they are proving to be a powerful diagnostic tool in cancer and other diseases. A second emerging area is in the link between sRNAs and epigenetic regulation. This link was revealed first from plant work but it is now known in animals in connection with piwi-associated RNAs or piRNAs. These epigenetic sRNAs and piRNAs are certainly important in defense against transposable elements, but it is possible that they also influence genetic or epigenetic regulation in other cell types. In this complex array of sRNA functions, growing interest is now devoted also to the crucial role of long noncoding RNAs in processes of gene expression control both at the transcriptional and post-transcriptional levels. This Keystone Symposia meeting on RNA Silencing will focus on these emerging topics of network control systems and epigenetic regulation by various types of sRNA. The focus on RNA silencing in general provides an umbrella under which speakers from different areas of research (e.g., transcriptional regulation, cancer biology, development, epigenetics and virology) are being brought together in an environment that is highly conducive to cross-talk. Emphasis has also be placed on showcasing early stage investigators presenting on the program with a view to promoting the next generation of scientists in the RNA silencing field.
Conference Program Print | View meeting in 12 hr (am/pm) time
TUESDAY, MARCH 19
08:00—09:00
Welcome and Keynote Address
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*
David C. Baulcombe,
University of Cambridge, UK
Gary B. Ruvkun,
Massachusetts General Hospital, Harvard Medical School, USA
New Small RNA Pathway Genes from Functional Genomics and Phylogenetic Profiling
New Small RNA Pathway Genes from Functional Genomics and Phylogenetic Profiling
09:00—12:15
Posttranscriptional RNA Silencing Pathways in Diverse Organisms
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*
Irene Bozzoni,
University La Sapienza, Rome, Italy
Elisa Izaurralde,
Max Planck Institute for Developmental Biology, Germany
The Interactions of GW182 Proteins with PABP and Deadenylases are Required for Both Translational Repression and Degradation of miRNA Targets
The Interactions of GW182 Proteins with PABP and Deadenylases are Required for Both Translational Repression and Degradation of miRNA Targets
Annick Harel-Bellan,
Commissariat à l'Energie Atomique (CEA), Saclay, France
Argonaute Proteins Couple Chromatin Silencing to Alternative Splicing
Argonaute Proteins Couple Chromatin Silencing to Alternative Splicing
Craig P. Hunter,
Harvard University, USA
Mobile Silencing RNA in C. elegans
Mobile Silencing RNA in C. elegans
Olivier Voinnet,
Swiss Federal Institute of Technology, Switzerland
Antiviral RNA Interference in Mammalian Cells
Antiviral RNA Interference in Mammalian Cells
Jennifer A. Broderick,
University of Massachusetts Medical School, USA
Short Talk: Silencing Gene Expression by Recruiting RISC
Short Talk: Silencing Gene Expression by Recruiting RISC
Alla Grishok,
Columbia University Medical Center, USA
Short Talk: Positive Regulation of Gene Expression by CSR-1 RNAi Pathway in C. elegans
Short Talk: Positive Regulation of Gene Expression by CSR-1 RNAi Pathway in C. elegans
17:00—19:00
piRNAs and RNA-Mediated Epigenetic Modification I
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*
Eric A. Miska,
University of Cambridge, UK
Phillip D. Zamore,
University of Massachusetts Medical School, USA
What Fruit Flies Teach Us About RNA Silencing
What Fruit Flies Teach Us About RNA Silencing
René F. Ketting,
Institute for Molecular Biology, Germany
piRNA and mRNA Inheritance in Zebrafish
piRNA and mRNA Inheritance in Zebrafish
Alex Bortvin,
Carnegie Institution of Washington, USA
Short Talk: Mouse MAELSTROM Associates with piRNA Precursors
Short Talk: Mouse MAELSTROM Associates with piRNA Precursors
08:00—11:00
piRNAs and RNA-Mediated Epigenetic Modification II
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*
Phillip D. Zamore,
University of Massachusetts Medical School, USA
Hiten D. Madhani,
University of California, San Francisco, USA
Short Talk: Stalled Spliceosomes Are a Signal for RNAi-Mediated Genome Defense
Short Talk: Stalled Spliceosomes Are a Signal for RNAi-Mediated Genome Defense
Nicholas J. Proudfoot,
University of Oxford, UK
Nuclear RNA Interference Acts on Mammalian Genes
Nuclear RNA Interference Acts on Mammalian Genes
17:00—19:00
Long ncRNA
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*
Pier Paolo Pandolfi,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Gordon G. Simpson,
University of Dundee, UK
Aberrant Read-Through Transcription and Chimeric RNA Formation Is Controlled by Arabidopsis thaliana FPA and DICER-LIKE 1
Aberrant Read-Through Transcription and Chimeric RNA Formation Is Controlled by Arabidopsis thaliana FPA and DICER-LIKE 1
Sundeep Kalantry,
University of Michigan Medical School, USA
Short Talk: Dynamic Requirement of the Tsix Long Noncoding RNA in Regulating Mouse Imprinted and Random X-Inactivation
Short Talk: Dynamic Requirement of the Tsix Long Noncoding RNA in Regulating Mouse Imprinted and Random X-Inactivation
Ursula E. Schoeberl,
Institute of Molecular Biotechnology of the Austrian Academy of Science, Austria
Short Talk: Regulation of Noncoding RNA Transcription Involved in DNA Elimination in Tetrahymena
Short Talk: Regulation of Noncoding RNA Transcription Involved in DNA Elimination in Tetrahymena
08:00—11:15
ncRNA in Development and Disease I
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*
John L. Rinn,
Harvard University, USA
Pier Paolo Pandolfi,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Defining the ceRNA Rules: From Mathematical Modeling to in vivo Validation
Defining the ceRNA Rules: From Mathematical Modeling to in vivo Validation
Irene Bozzoni,
University La Sapienza, Rome, Italy
Role of Noncoding RNAs in Muscle Differentiation and in Neuromuscular Disorders
Role of Noncoding RNAs in Muscle Differentiation and in Neuromuscular Disorders
Xavier Estivill,
Center for Genomic Regulation and University Pompeu Fabra, Spain
Different Roles of Noncoding RNAs in Neurodegenerative Diseases
Different Roles of Noncoding RNAs in Neurodegenerative Diseases
Nikolaus Rajewsky,
Max Delbruck Center for Molecular Medicine, Germany
circRNAs
circRNAs
Pavel Sumazin,
Columbia University, USA
Short Talk: ceRNA Regulatory Interactions Cooperate with Genomic Variability to Modulate Drivers of Tumorigenesis
Short Talk: ceRNA Regulatory Interactions Cooperate with Genomic Variability to Modulate Drivers of Tumorigenesis
Hervé Seitz,
CNRS, France
Short Talk: Every Predicted miRNA Target Is Not Functionally Targeted: Revisiting the Nature of miRNA/mRNA Interaction
Short Talk: Every Predicted miRNA Target Is Not Functionally Targeted: Revisiting the Nature of miRNA/mRNA Interaction
17:00—19:00
ncRNA in Development and Disease II
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*
Valerio Orlando,
KAUST, Thuwal, Saudi Arabia/IRCCS Santa Lucia Rome, Italy
Yijun Qi,
Tsinghua University, China
DiRNAs: Discovery and Mechanism
DiRNAs: Discovery and Mechanism
Erik Larsson,
University of Gothenburg, Sweden
Short Talk: A Long Noncoding RNA Specifically Activated by Somatic DNA Amplification in Cancer
Short Talk: A Long Noncoding RNA Specifically Activated by Somatic DNA Amplification in Cancer
Charles E. Rogler,
Albert Einstein College of Medicine, USA
Short Talk: Two Small RNAs Derived from ncRNA, RMRP, Have Gene Regulatory Activity Relevant to Human Cartilage Hair Hypoplasia (CHH) Syndromes
Short Talk: Two Small RNAs Derived from ncRNA, RMRP, Have Gene Regulatory Activity Relevant to Human Cartilage Hair Hypoplasia (CHH) Syndromes
Gracjan P. Michlewski,
University of Edinburgh, UK
Short Talk: Tissue-Specific Control of MiRNA Biogenesis
Short Talk: Tissue-Specific Control of MiRNA Biogenesis
Heidi Schwarzenbach,
University Medical Center Hamburg-Eppendorf, Germany
Circulating microRNAs as Biomarkers in Cancer Patients
Circulating microRNAs as Biomarkers in Cancer Patients
08:00—11:15
ncRNA in Development and Disease III
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*
Xavier Estivill,
Center for Genomic Regulation and University Pompeu Fabra, Spain
Valerio Orlando,
KAUST, Thuwal, Saudi Arabia/IRCCS Santa Lucia Rome, Italy
A Genome-Wide Role for Nuclear Dicer1 and Ago1 in Transcriptional Regulation in Human Cells
A Genome-Wide Role for Nuclear Dicer1 and Ago1 in Transcriptional Regulation in Human Cells
Lin He,
University of California, Berkeley, USA
A Polycistronic miRNA Oncogene mir17-92 Confers Balance between Proliferation and Apoptosis
A Polycistronic miRNA Oncogene mir17-92 Confers Balance between Proliferation and Apoptosis
Reuven Agami,
Netherlands Cancer Institute, Netherlands
Alternative Cleavage and Polyadenylation of mRNAs in Genetic Diseases
Alternative Cleavage and Polyadenylation of mRNAs in Genetic Diseases
Keith T. Gagnon,
University of Texas Southwestern Medical Center, USA
Short Talk: Argonaute and RNAi in the Mammalian Cell Nucleus
Short Talk: Argonaute and RNAi in the Mammalian Cell Nucleus
Gabrielle Haas,
Institut de Biologie Moléculaire et Cellulaire (IBMC), France
Short Talk: Molecular Features Involved in miRNA Destabilization by Mouse Cytomegalovirus
Short Talk: Molecular Features Involved in miRNA Destabilization by Mouse Cytomegalovirus
17:00—19:00
RNA Silencing in Virus Disease
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*
David C. Baulcombe,
University of Cambridge, UK
Shou-Wei Ding,
University of California, Riverside, USA
Induction and Suppression of RNA Silencing during Mammalian Virus Infection
Induction and Suppression of RNA Silencing during Mammalian Virus Infection
John Cory Burnett,
Beckman Research Institute at the City of Hope, USA
Small Noncoding RNA Therapies for HIV-1
Small Noncoding RNA Therapies for HIV-1
Juan Alberto Mondotte,
Institut Pasteur, France
Short Talk: The RNAi Pathway Is a Key Factor Controlling Virus-Host Specificity in Drosophila melanogaster
Short Talk: The RNAi Pathway Is a Key Factor Controlling Virus-Host Specificity in Drosophila melanogaster
*Session Chair †Speaker invited, not yet responded.
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