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This meeting took place in 2013



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RNA Silencing (C7)


Organizer(s) David C. Baulcombe and Irene Bozzoni
March 19—24, 2013
Whistler Conference Centre • Whistler, British Columbia Canada
Abstract Deadline: Nov 15, 2012
Late Abstract Deadline: Dec 20, 2012
Scholarship Deadline: Nov 15, 2012
Early Registration Deadline: Jan 18, 2013

Sponsored by Cell Research

Summary of Meeting:
RNA silencing systems are now well established as key components of regulation and control in many eukaryotes including animals and plants. The first flush of discoveries was focused around post-transcriptional regulation. It was anticipated that the small RNA specificity determinants of these silencing systems could be negative switches acting alongside transcription factors control of gene expression during growth, development and responses to external stimuli. More recently, the emphasis has shifted. In terms of post-transcriptional regulation, it is now recognized that there are only a few examples in plants and worms in which sRNAs are simple switches. These RNAs are now seen as modulators or fine tuners of post-transcriptional regulation that are often components of negative feedback loops or of control networks in which there are long RNA negative regulators of the sRNAs and secondary sRNAs. The sRNAs can be transported or secreted out of cells and so the RNA mediated control networks may extend beyond one cell. The anticipated potential of sRNA therapeutics has yet to be delivered but they are proving to be a powerful diagnostic tool in cancer and other diseases. A second emerging area is in the link between sRNAs and epigenetic regulation. This link was revealed first from plant work but it is now known in animals in connection with piwi-associated RNAs or piRNAs. These epigenetic sRNAs and piRNAs are certainly important in defense against transposable elements, but it is possible that they also influence genetic or epigenetic regulation in other cell types. In this complex array of sRNA functions, growing interest is now devoted also to the crucial role of long noncoding RNAs in processes of gene expression control both at the transcriptional and post-transcriptional levels. This Keystone Symposia meeting on RNA Silencing will focus on these emerging topics of network control systems and epigenetic regulation by various types of sRNA. The focus on RNA silencing in general provides an umbrella under which speakers from different areas of research (e.g., transcriptional regulation, cancer biology, development, epigenetics and virology) are being brought together in an environment that is highly conducive to cross-talk. Emphasis has also be placed on showcasing early stage investigators presenting on the program with a view to promoting the next generation of scientists in the RNA silencing field.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, MARCH 19

16:00—20:00
Arrival and Registration


WEDNESDAY, MARCH 20

07:00—08:00
Breakfast

08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* David C. Baulcombe, University of Cambridge, UK

Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA
New Small RNA Pathway Genes from Functional Genomics and Phylogenetic Profiling

09:00—12:15
Posttranscriptional RNA Silencing Pathways in Diverse Organisms
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Irene Bozzoni, University La Sapienza, Rome, Italy

Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
The Interactions of GW182 Proteins with PABP and Deadenylases are Required for Both Translational Repression and Degradation of miRNA Targets

Annick Harel-Bellan, Commissariat à l'Energie Atomique (CEA), Saclay, France
Argonaute Proteins Couple Chromatin Silencing to Alternative Splicing

Craig P. Hunter, Harvard University, USA
Mobile Silencing RNA in C. elegans

Olivier Voinnet, Swiss Federal Institute of Technology, Switzerland
Antiviral RNA Interference in Mammalian Cells

Jennifer A. Broderick, University of Massachusetts Medical School, USA
Short Talk: Silencing Gene Expression by Recruiting RISC

Alla Grishok, Columbia University Medical Center, USA
Short Talk: Positive Regulation of Gene Expression by CSR-1 RNAi Pathway in C. elegans

09:40—10:00
Coffee Break

12:15—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
piRNAs and RNA-Mediated Epigenetic Modification I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Eric A. Miska, University of Cambridge, UK

Phillip D. Zamore, University of Massachusetts Medical School, USA
What Fruit Flies Teach Us About RNA Silencing

Haifan Lin, Yale University, USA
A Major Epigenetic Programming Mechanism Guided by piRNAs

René F. Ketting, Institute for Molecular Biology, Germany
piRNA and mRNA Inheritance in Zebrafish

Alex Bortvin, Carnegie Institution of Washington, USA
Short Talk: Mouse MAELSTROM Associates with piRNA Precursors

19:00—20:00
Social Hour with Lite Bites


THURSDAY, MARCH 21

07:00—08:00
Breakfast

08:00—11:00
piRNAs and RNA-Mediated Epigenetic Modification II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Phillip D. Zamore, University of Massachusetts Medical School, USA

Eric A. Miska, University of Cambridge, UK
Small RNAs: From Genome Maintenance to Innate Immunity

David C. Baulcombe, University of Cambridge, UK
Engineering Epigenetically Modified Plants

Hiten D. Madhani, University of California, San Francisco, USA
Short Talk: Stalled Spliceosomes Are a Signal for RNAi-Mediated Genome Defense

Nicholas J. Proudfoot, University of Oxford, UK
Nuclear RNA Interference Acts on Mammalian Genes

Steven E. Jacobsen, HHMI/University of California, Los Angeles, USA
RNA Directed DNA Methylation

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Long ncRNA
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA

John L. Rinn, Harvard University, USA
Linking RNA to Human Health and Disease

Gordon G. Simpson, University of Dundee, UK
Aberrant Read-Through Transcription and Chimeric RNA Formation Is Controlled by Arabidopsis thaliana FPA and DICER-LIKE 1

Sundeep Kalantry, University of Michigan Medical School, USA
Short Talk: Dynamic Requirement of the Tsix Long Noncoding RNA in Regulating Mouse Imprinted and Random X-Inactivation

Ursula E. Schoeberl, Institute of Molecular Biotechnology of the Austrian Academy of Science, Austria
Short Talk: Regulation of Noncoding RNA Transcription Involved in DNA Elimination in Tetrahymena

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


FRIDAY, MARCH 22

07:00—08:00
Breakfast

08:00—11:15
ncRNA in Development and Disease I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* John L. Rinn, Harvard University, USA

Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Defining the ceRNA Rules: From Mathematical Modeling to in vivo Validation

Irene Bozzoni, University La Sapienza, Rome, Italy
Role of Noncoding RNAs in Muscle Differentiation and in Neuromuscular Disorders

Xavier Estivill, Center for Genomic Regulation and University Pompeu Fabra, Spain
Different Roles of Noncoding RNAs in Neurodegenerative Diseases

Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine, Germany
circRNAs

Pavel Sumazin, Columbia University, USA
Short Talk: ceRNA Regulatory Interactions Cooperate with Genomic Variability to Modulate Drivers of Tumorigenesis

Hervé Seitz, CNRS, France
Short Talk: Every Predicted miRNA Target Is Not Functionally Targeted: Revisiting the Nature of miRNA/mRNA Interaction

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
ncRNA in Development and Disease II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Valerio Orlando, King Abdullah University of Science and Technology, Saudi Arabia

Yijun Qi, Tsinghua University, China
DiRNAs: Discovery and Mechanism

Erik Larsson, University of Gothenburg, Sweden
Short Talk: A Long Noncoding RNA Specifically Activated by Somatic DNA Amplification in Cancer

Charles E. Rogler, Albert Einstein College of Medicine, USA
Short Talk: Two Small RNAs Derived from ncRNA, RMRP, Have Gene Regulatory Activity Relevant to Human Cartilage Hair Hypoplasia (CHH) Syndromes

Gracjan P. Michlewski, University of Edinburgh, UK
Short Talk: Tissue-Specific Control of MiRNA Biogenesis

Heidi Schwarzenbach, University Medical Center Hamburg-Eppendorf, Germany
Circulating microRNAs as Biomarkers in Cancer Patients

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


SATURDAY, MARCH 23

07:00—08:00
Breakfast

08:00—11:15
ncRNA in Development and Disease III
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Xavier Estivill, Center for Genomic Regulation and University Pompeu Fabra, Spain

Valerio Orlando, King Abdullah University of Science and Technology, Saudi Arabia
A Genome-Wide Role for Nuclear Dicer1 and Ago1 in Transcriptional Regulation in Human Cells

Lin He, University of California, Berkeley, USA
A Polycistronic miRNA Oncogene mir17-92 Confers Balance between Proliferation and Apoptosis

Jørgen Kjems, University of Aarhus, Denmark
Circular miRNA Sponges - Implications in Human Diseases

Reuven Agami, Netherlands Cancer Institute, Netherlands
Alternative Cleavage and Polyadenylation of mRNAs in Genetic Diseases

Keith T. Gagnon, University of Texas Southwestern Medical Center, USA
Short Talk: Argonaute and RNAi in the Mammalian Cell Nucleus

Gabrielle Haas, Institut de Biologie Moléculaire et Cellulaire (IBMC), France
Short Talk: Molecular Features Involved in miRNA Destabilization by Mouse Cytomegalovirus

09:20—09:40
Coffee Break

11:15—16:30
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
RNA Silencing in Virus Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* David C. Baulcombe, University of Cambridge, UK

Shou-Wei Ding, University of California, Riverside, USA
Induction and Suppression of RNA Silencing during Mammalian Virus Infection

Eva H. Gottwein, Northwestern University, USA
Viral Mimics of Cellular microRNAs

John Cory Burnett, Beckman Research Institute at the City of Hope, USA
Small Noncoding RNA Therapies for HIV-1

Juan Alberto Mondotte, Institut Pasteur, France
Short Talk: The RNAi Pathway Is a Key Factor Controlling Virus-Host Specificity in Drosophila melanogaster

19:00—20:00
Social Hour with Lite Bites

20:00—23:00
Entertainment


SUNDAY, MARCH 24

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Cell Research

We gratefully acknowledge additional support for this conference from:

Exiqon A/S Integrated DNA Technologies

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HD075439-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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