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Granlibakken Resort Floorplan
This meeting took place in 2013
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Meeting Details
Growing to Extremes: Cell Biology and Pathology of Axons (C4)
Organizer(s) Valeria Cavalli, Michael Fainzilber and Jeffery L. Twiss
March 10 - March 15, 2013
Granlibakken Resort • Tahoe City, California USA
Abstract Deadline: November 8, 2012
Late Abstract Deadline: December 10, 2012
Scholarship Deadline: November 8, 2012
Early Registration Deadline: January 10, 2013
Supported by the Directors' Fund
CME Information
Summary of Meeting:
Neuronal communication is essential for every movement, sensation and thought in motile animals, and the axonal extensions of neurons provide all long-range communication to, from, and within the brain and spinal cord. Axons extend distances ranging from hundreds of microns to more than a meter in humans, lengths that both require specialized mechanisms for formation and maintenance, and increase the risk of degeneration and dysfunction upon injury or disease. Thus, diverse communities of basic researchers and clinicians must address problems rooted in axonal cell biology, but to date there is no meeting that serves as a central venue for this field. Axon biology meetings in the past have focused on specific sub-topics such as axon guidance, trophic factors, or neurodegeneration. This meeting will bring together the multiple disciplines required for accelerating progress in the field of axonal biology and pathology, providing a unique venue to bring together basic research on molecular and cellular biology of axons with clinical needs and industry interest. The conference will cover a broad spectrum of the latest developments in molecular and cellular axonal research, from development and maintenance, through to survival and repair, in both the central and peripheral nervous systems. Additional topics and late-breaking developments will be incorporated via talks selected from abstracts, specifically encouraging participation of junior researchers and those new to the field. The multidisciplinary theme and shared focus will facilitate communication across the entire continuum from basic to clinical neuroscience.
CME Information
Neuronal communication is essential for every movement, sensation and thought in motile animals, and the axonal extensions of neurons provide all long-range communication to, from, and within the brain and spinal cord. Axons extend distances ranging from hundreds of microns to more than a meter in humans, lengths that both require specialized mechanisms for formation and maintenance, and increase the risk of degeneration and dysfunction upon injury or disease. Thus, diverse communities of basic researchers and clinicians must address problems rooted in axonal cell biology, but to date there is no meeting that serves as a central venue for this field. Axon biology meetings in the past have focused on specific sub-topics such as axon guidance, trophic factors, or neurodegeneration. This meeting will bring together the multiple disciplines required for accelerating progress in the field of axonal biology and pathology, providing a unique venue to bring together basic research on molecular and cellular biology of axons with clinical needs and industry interest. The conference will cover a broad spectrum of the latest developments in molecular and cellular axonal research, from development and maintenance, through to survival and repair, in both the central and peripheral nervous systems. Additional topics and late-breaking developments will be incorporated via talks selected from abstracts, specifically encouraging participation of junior researchers and those new to the field. The multidisciplinary theme and shared focus will facilitate communication across the entire continuum from basic to clinical neuroscience.
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, MARCH 10
08:00—11:15
Axonal Specification, Cytoskeleton and Compartmentalization
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Valeria Cavalli,
Washington University, USA
Frank Bradke,
German Center for Neurodegenerative Diseases, Germany
ADF/Cofilin-Mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain
ADF/Cofilin-Mediated Actin Retrograde Flow Directs Neurite Formation in the Developing Brain
Matthew N. Rasband,
Baylor College of Medicine, USA
Molecular Mechanisms Regulating the Assembly of Subcellular Axonal Membrane Domains
Molecular Mechanisms Regulating the Assembly of Subcellular Axonal Membrane Domains
Caterina Tomba,
Institut Néel - CNRS, France
Short Talk: Actin Waves in Developing Neurons: Shapes, Mechanical Regulations and Axonal Polarization
Short Talk: Actin Waves in Developing Neurons: Shapes, Mechanical Regulations and Axonal Polarization
*
Niels Galjart,
Erasmus MC, Netherlands
Franck Polleux,
The Scripps Research Institute, USA
LKB1-NUAK1 Kinases Define a New Pathway Required for Terminal Axon Branching and Presynaptic Function in vivo
LKB1-NUAK1 Kinases Define a New Pathway Required for Terminal Axon Branching and Presynaptic Function in vivo
Kozo Kaibuchi,
Nagoya University Graduate School of Medicine, Japan
Neuronal Polarity in vitro and in vivo
Neuronal Polarity in vitro and in vivo
Pei-Lin Cheng,
Institute of Molecular Biology, Academia Sinica, Taiwan
Short Talk: Directional Axoplasmic Transport of Proteasome in Neuronal Polarization
Short Talk: Directional Axoplasmic Transport of Proteasome in Neuronal Polarization
17:00—19:00
Axonal Growth Modalities
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*
Nathalie Lamarche-Vane,
McGill University, Canada
Michael Fainzilber,
Weizmann Institute of Science, Israel
Intrinsic Mechanisms of Axon Growth Control
Intrinsic Mechanisms of Axon Growth Control
Douglas H. Smith,
University of Pennsylvania, USA
Extreme Stretch Growth of Integrated Axon Tracts: Tension Is Good for Your Nerves
Extreme Stretch Growth of Integrated Axon Tracts: Tension Is Good for Your Nerves
Giampietro Schiavo,
London Research Institute, UK
Bicaudal-D1 Regulates the Intracellular Sorting and Signaling of Neurotrophin Receptors
Bicaudal-D1 Regulates the Intracellular Sorting and Signaling of Neurotrophin Receptors
Mónica M. Sousa,
Instituto de Biologia Molecular e Celular- IBMC, Portugal
Short Talk: Increased Axonal Transport following Conditioning Lesion Underlies Gain of Axonal Regenerative Capacity
Short Talk: Increased Axonal Transport following Conditioning Lesion Underlies Gain of Axonal Regenerative Capacity
08:00—11:15
Molecular Motors and Axonal Transport Regulation
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*
Viki J. Allan,
University of Manchester, UK
Richard Vallee,
Columbia University, USA
Regulation of Cytoplasmic Dynein Transport
Regulation of Cytoplasmic Dynein Transport
Erika L. F. Holzbaur,
University of Pennsylvania, USA
Initiation and Regulation of Axonal Transport: Mechanisms of Motor Engagement and Motor Coordination
Initiation and Regulation of Axonal Transport: Mechanisms of Motor Engagement and Motor Coordination
Chen Gu,
Ohio State University, USA
Short Talk: Activation of Conventional Kinesin Motors in Clusters by Shaw Voltage-Gated Potassium Channels
Short Talk: Activation of Conventional Kinesin Motors in Clusters by Shaw Voltage-Gated Potassium Channels
*
Caitlin E. Hill,
Weill Medical College of Cornell University, USA
Valeria Cavalli,
Washington University, USA
Dual Role of HDAC5 in the Regulation of Axon Growth and Regeneration
Dual Role of HDAC5 in the Regulation of Axon Growth and Regeneration
Frédéric Saudou,
Institut Curie, France
Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport
Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport
Glenn F. Rall,
Fox Chase Cancer Center, USA
Short Talk: Intra- and Inter-Neuronal Trafficking of Measles Virus
Short Talk: Intra- and Inter-Neuronal Trafficking of Measles Virus
11:30—12:15
Round Table Discussions with NIH/NINDS Program Directors
Laura Mamounas,
NINDS, National Institutes of Health, USA
Robert D. Riddle,
NINDS, National Institutes of Health, USA
14:30—16:30
Workshop
*
Jeffery L. Twiss,
Drexel University, USA
Bradley T. Lang,
Case Western Reserve University, USA
Subcutaneous Injections of a Peptide Inhibitor of PTP-sigma Release CSPG Mediated Axonal Entrapment and Promote Robust Behavioral Recovery following Severe Contusive Spinal Cord Injury
Subcutaneous Injections of a Peptide Inhibitor of PTP-sigma Release CSPG Mediated Axonal Entrapment and Promote Robust Behavioral Recovery following Severe Contusive Spinal Cord Injury
Richard E. Zigmond,
Case Western Reserve University, USA
A New Phenotype for the Well Studied Wallerian Degeneration Slow Mouse
A New Phenotype for the Well Studied Wallerian Degeneration Slow Mouse
Rachel J. Allison,
Cambridge Institute for Medical Research, UK
Loss of the Hereditary Spastic Paraplegia Protein Spastin Alters Endosomal Morphology and Trafficking in Non-Polarized Cells and Axons
Loss of the Hereditary Spastic Paraplegia Protein Spastin Alters Endosomal Morphology and Trafficking in Non-Polarized Cells and Axons
Nicolas Unsain,
Montreal Neurological Institute, Canada
XIAP-Dependent Caspase Regulation in Degenerating Axons
XIAP-Dependent Caspase Regulation in Degenerating Axons
Biliana O. Veleva-Rotse,
Oregon Health & Science University, USA
Pseudokinases Contribute to Axogenesis in the Developing Cerebral Cortex
Pseudokinases Contribute to Axogenesis in the Developing Cerebral Cortex
Bianxiao Cui,
Stanford University, USA
Manipulating Axonal Transport Using Magnetic Forces
Manipulating Axonal Transport Using Magnetic Forces
Jung Eun Shin,
Washington University, USA
SCG10 is a JNK Target in the Axonal Degeneration Pathway
SCG10 is a JNK Target in the Axonal Degeneration Pathway
Thomas W. Gould,
University of Nevada at Reno, USA
Axon Degeneration Induced by Schwann Cell Ablation is Mediated by Activity-Regulated, Muscle-Derived Thrombin
Axon Degeneration Induced by Schwann Cell Ablation is Mediated by Activity-Regulated, Muscle-Derived Thrombin
17:00—19:00
Axonal Membrane Dynamics and Organelle Transport
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Eran Perlson,
Tel Aviv University, Israel
Britta J. Eickholt,
Charité – Universitätsmedizin Berlin, Germany
Spatial and Temporal Control of Neuronal PTEN and Associated Signaling Systems through Protein Scaffolds
Spatial and Temporal Control of Neuronal PTEN and Associated Signaling Systems through Protein Scaffolds
Rejji Kuruvilla,
Johns Hopkins University, USA
Regulation of Neuronal Development by Trafficking of Neurotrophins and their Receptors
Regulation of Neuronal Development by Trafficking of Neurotrophins and their Receptors
Thomas L. Schwarz,
Children's Hospital Boston and Harvard Medical School, USA
Regulating Mitochondrial Movement along Axons in Health and Disease
Regulating Mitochondrial Movement along Axons in Health and Disease
Paul L. McNeil,
Georgia Health Sciences University
Short Talk: Promotion of Plasma Membrane Repair by Curcumin: Implications for TBI Therapy
Short Talk: Promotion of Plasma Membrane Repair by Curcumin: Implications for TBI Therapy
08:00—11:15
RNA Targeting and Local Translation
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*
John Houle,
Drexel University College of Medicine, USA
Jeffery L. Twiss,
Drexel University, USA
mRNAs Compete for Limited Quantities of Axonal Transport Machinery
mRNAs Compete for Limited Quantities of Axonal Transport Machinery
Chang-Mei Liu,
Johns Hopkins University, USA
Short Talk: A Mutual-Negative Feedback Loop of microRNA-138 and SIRT1 Regulates Axon Regeneration
Short Talk: A Mutual-Negative Feedback Loop of microRNA-138 and SIRT1 Regulates Axon Regeneration
*
Dianna E. Willis,
Burke-Cornell Medical Research Institute, USA
Gianluca Gallo,
Temple University, USA
Short Talk: Embryonic Sensory Axons Exhibit Sites of Preferential mRNA Translation
Short Talk: Embryonic Sensory Axons Exhibit Sites of Preferential mRNA Translation
Ulrich Hengst,
Columbia University, USA
Short Talk: A Novel Role for Intra-Axonal Translation in Alzheimer’s Disease
Short Talk: A Novel Role for Intra-Axonal Translation in Alzheimer’s Disease
Anne Marion Taylor,
University of North Carolina at Chapel Hill, USA
Short Talk: Local Translation of beta-Catenin Regulates Synaptic Vesicle Release Dynamics
Short Talk: Local Translation of beta-Catenin Regulates Synaptic Vesicle Release Dynamics
17:00—19:00
Axonal Signaling
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*
Uwe Drescher,
King's College London, UK
David G. Ginty,
Johns Hopkins University School of Medicine, USA
Organization and Development of Neurons that Underlie the Sense of Touch
Organization and Development of Neurons that Underlie the Sense of Touch
Gary R. Lewin,
Max Delbrück Center for Molecular Medicine, Germany
A Transducosome for the Delivery of Pre-Assembled Mechanotransduction Components for Touch?
A Transducosome for the Delivery of Pre-Assembled Mechanotransduction Components for Touch?
Mark H. Tuszynski,
University of California, San Diego, USA
From Neuronal Signaling to Axon Regeneration
From Neuronal Signaling to Axon Regeneration
Naoya Yamashita,
Yokohama City University Graduate School of Medicine, Japan
Short Talk: A Retrograde Axonal Transport Elicited by Semaphorin3A Drives AMPA Receptor Subunit GluA2 to Dendrites
Short Talk: A Retrograde Axonal Transport Elicited by Semaphorin3A Drives AMPA Receptor Subunit GluA2 to Dendrites
08:00—11:15
Axonal Maintenance
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Andres Couve,
Universidad de Chile, Chile
Christine E. Beattie,
Ohio State University, USA
The Function of the Survival Motor Neuron Protein in Motor Axon Development
The Function of the Survival Motor Neuron Protein in Motor Axon Development
Avraham Yaron,
Weizmann Institute of Science, Israel
Mechanisms of Axonal Maintenance and Degeneration
Mechanisms of Axonal Maintenance and Degeneration
Takeshi Fujiwara,
Osaka University Graduate School of Medicine, Japan
Short Talk: Axonal Transport Proteins Implicated in the Pathology of Alzheimer’s Disease
Short Talk: Axonal Transport Proteins Implicated in the Pathology of Alzheimer’s Disease
*
Anthony Paul Barnes,
Oregon Health & Science University, USA
Joseph W. Lewcock,
Genentech, Inc., USA
Intracellular Pathways that Underlie Axon Degeneration in Development and Disease
Intracellular Pathways that Underlie Axon Degeneration in Development and Disease
Patrick Lüningschrör,
University of Wuerzburg, Germany
Short Talk: Functional Characterization of Plekhgh5 in the Nervous System
Short Talk: Functional Characterization of Plekhgh5 in the Nervous System
17:00—18:15
Axon-Glia Interactions
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
*
Michael Fainzilber,
Weizmann Institute of Science, Israel
Klaus-Armin Nave,
Max Planck Institute of Experimental Medicine, Germany
The Role of Glia in Axonal Development and Maintenance
The Role of Glia in Axonal Development and Maintenance
Bruce D. Carter,
Vanderbilt University School of Medicine, USA
Mechanisms Regulating Schwann Cell Differentiation and their Pathological Dysregulation
Mechanisms Regulating Schwann Cell Differentiation and their Pathological Dysregulation
Kelly R. Monk,
Washington University School of Medicine, USA
Short Talk: Adhesion-G Protein-Coupled Receptor Signaling in Myelination
Short Talk: Adhesion-G Protein-Coupled Receptor Signaling in Myelination
18:15—19:15
Closing Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Martin E. Schwab,
University of Zürich, Switzerland
Axon Growth and Regeneration: From Basics to Clinic
Axon Growth and Regeneration: From Basics to Clinic
*Session Chair †Speaker invited, not yet responded.
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