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This meeting took place in 2014



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The NF-kappaB System in Health and Disease (B4)


Organizer(s) Alexander Hoffmann and Louis M. Staudt
February 23—28, 2014
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 23, 2013
Abstract Deadline: Nov 22, 2013
Scholarship Deadline: Oct 23, 2013
Discounted Registration Deadline: Dec 19, 2013

Sponsored by AstraZeneca

Summary of Meeting:
The NF-kappaB System plays key roles in diverse physiological and pathological processes, involving innate and adaptive immunity, and many organs and cell types. The family of NF-kappaB transcription factors have overlapping and specific functions, and are regulated through numerous interconnected molecular mechanisms. The NF-kappaB System refers to the gene regulatory and signal regulatory networks (GRNs and SRNs), within which NF-kappaB transcription factors exert their activities. Those regulatory networks include mitogen-activated kinases, caspases and other apoptotic and necroptotic regulators, regulators of autophagy, cytoskeletal organization, and proliferation, as well as the interferon-regulatory innate immune network. Indeed understanding these processes as an interconnected system is paramount to studies of disease, as manifested by complex immunological, inflammatory, and tumor pathologies. To address these complexities and move towards a predictive understanding, this conference will emphasize the consideration of regulatory interactions, quantitative measurements, in silico modeling, and genome scale studies. It will provide an overview of the field and catalyze scientific interactions in the age of Systems Biology to advance post-genomic Immunology.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 23

16:00—20:00
Arrival and Registration

Keystone Lodge Lobby

MONDAY, FEBRUARY 24

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—09:10
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Alexander Hoffmann, University of California, Los Angeles, USA

* Louis M. Staudt, National Cancer Institute, NIH, USA

David Baltimore, California Institute of Technology, USA
NF-kappaB: Still Surprising

09:10—11:15
NF-kappaB within Gene Regulatory Networks
Meeting has ended...abstracts no longer viewable online.
The function of NF-kappaB transcription factors within the gene regulatory networks, and the mechanisms that mediate stimulus-specific and cell-type specific gene expression programs.

Grays Peak
* Alexander Hoffmann, University of California, Los Angeles, USA

Andrea Califano, Columbia University, USA
NF-kappaB Is a Master Regulator of Mutant-SOD1 Toxicity in an in vitro Model of ALS

Aviv Regev, Massachusetts Institute of Technology/Broad Institute, USA
Systems Biology of Inflammatory Gene Expression

Irina A. Udalova, University of Oxford, UK
The Specificity of the NF-kappaB Dimer Family

Benjamin E. Gewurz, Brigham and Women's Hospital, Harvard Medical School, USA
Short Talk: The Genomic Landscape of NF-kappaB Binding

David Spiller, University of Manchester, UK
Short Talk: Measuring the Interactions of NF-kappaB Proteins Inside Living Cells

09:40—10:00
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
11:15—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1 for Highly Innovative, Recent Studies to be Presented

Grays Peak
* Alexander Hoffmann, University of California, Los Angeles, USA

Trevor William Siggers, Boston University, USA
Gene Targeting by Irf3 and p65

Soumen Basak, National Institute of Immunology, India
Developmental Lymphotoxin-beta Receptor Reinforces TLR4 Triggered Inflammatory NF-kappaB Response through Signaling Crosstalk to Potentiate Pathogen Clearance

Véronique I. Baud, Institut Cochin, France
IKK Phosphorylates RelB to Modulate its Promoter Specificity and Promote Fibroblast Migration Downstream of TNF Receptors

Tom Huxford, San Diego State University, USA
Activation and Specificity of an Engineered Monomeric IKK2

Veronique Schaeffer, Goethe University, Germany
OTULIN Binds to the PUB domain of HOIP and Controls the NF-kappaB Signaling

Domagoj Vucic, Genentech, Inc., USA
Diverse Ubiquitin Modifications Regulate NF-kappaB Activation

Malini Sen, Indian Institute of Chemical Biology, India
Wnt5a-NFkappaB (p65) Homeostatic Circuitry Is Important for Innate Immunity

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
NF-kappaB Signaling System
Meeting has ended...abstracts no longer viewable online.
The NF-kappaB signaling system consists of more than a dozen dimers controlled by several IkappaB activities. Understanding how cell-type-specific and stimulus-specific control is achieved remains a challenge.

Grays Peak
* Sankar Ghosh, Columbia University, USA

Elizabeth A. Komives, University of California, San Diego, USA
IkappaB Control of NF-kappaB Activation and Inactivation

Jana Wolf, Max Delbrück Center for Molecular Medicine, Germany
Mathematical Modeling of Regulatory Modules in NF-kappaB Signaling

Gourisankar Ghosh, University of California, San Diego, USA
Understanding NF-kappaB Regulation from in vitro Experiments

Claus Scheidereit, Max Delbrück Center for Molecular Medicine, Germany
Short Talk: Precursor Cross-Talk and Nuclear Signatures of Non-Canonical NF-kappaB Activation

19:00—20:00
Social Hour with Lite Bites

Longs/Quandary Peaks
19:30—22:00
Poster Session 1

Longs/Quandary Peaks

TUESDAY, FEBRUARY 25

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:00
The Inflammatory Signaling Network
Meeting has ended...abstracts no longer viewable online.
NF-kappaB is one of several signaling systems within a larger network that controls inflammation. Understanding how signaling systems are coordinated remains an important challenge.

Grays Peak
* Genhong Cheng, University of California, Los Angeles, USA

Vishva M. Dixit, Genentech, Inc., USA
RIPK3: Role of the Kinase Activity in Necroptosis

Shao-Cong Sun, University of Texas MD Anderson Cancer Center, USA
Short Talk: Noncanonical NF-kappaB Signaling in Host Defense and Inflammation

Tomasz Kordula, Virginia Commonwealth University, USA
K63-linked Polyubiquitination of IRF1 is Essential for IL-1-Induced Production of Chemokines CCL5 and CXCL10

Averil I. Ma, University of California, San Francisco, USA
Attenuating Inflammation with Deubiquitinases

Roberto Nitsch, IMBA - Institute for Molecular Biotechnology, Austria
Short Talk: The Tumor Suppressor HACE1 Is a Critical Regulator of TNFR1 Mediated Cell Fate

Fumiyo Ikeda, IMBA - Institute of Molecular Biotechnology, Austria
Short Talk: Sharpin Prevents TNFR1-Induced Keratinocyte Apoptosis and Skin Inflammation by Linear Ubiquitination of FADD

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
11:00—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Innate Immune Signaling Networks
Meeting has ended...abstracts no longer viewable online.
NF-kappaB plays a critical role in innate immune responses when coordinated with other signaling systems. Understanding the molecular mechanisms and systems properties of the innate immune signaling networks remains an important challenge.

Grays Peak
* Shao-Cong Sun, University of Texas MD Anderson Cancer Center, USA

Takashi Fujita, Institute for Virus Research, Kyoto University, Japan
Regulation of Antiviral Innate Immunity by RIG-I-Like Receptors

Zhijian James Chen, University of Texas Southwestern Medical Center, USA
The cGAS-cGAMP-STING Pathway Detects Cytosolic DNA and Induces Type-I Interferons

Gregory M. Barton, University of California, Berkeley, USA
Toll-Like Receptors in Health and Disease

Rachel A. Gottschalk, NIAID, National Institutes of Health, USA
Short Talk: Integration of NF-kappaB and MAPK Activation Dynamics Determines TLR Ligand Sensitivity

19:00—20:00
Social Hour with Lite Bites

Longs/Quandary Peaks
19:30—22:00
Poster Session 2

Longs/Quandary Peaks

WEDNESDAY, FEBRUARY 26

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:15
Lymphoid Signaling Systems
Meeting has ended...abstracts no longer viewable online.
Within lymphoid cells, NF-kappaB plays critical roles in controlling survival and proliferation. Misregulated NF-kappaB is at the root of immunological diseases and malignancies.

Grays Peak
* Louis M. Staudt, National Cancer Institute, NIH, USA

Sankar Ghosh, Columbia University, USA
Understanding the Mechanism by which IkappaB Beta Is Regulated during the Inflammatory Response

Margot Thome, University of Lausanne, Switzerland
MALT1-Dependent Lymphoid Signaling and B-Cell Malignancy

Alexander Hoffmann, University of California, Los Angeles, USA
The NF-kappaB Signaling System within the Waddington Landscapes of Immune Cells

Robert C. Rickert, Pfizer, USA
Functional Specificity of NF-kappaB Pathways in B-Cell Fate Decisions

Ulrich K. Siebenlist, NIAID, National Institutes of Health, USA
Short Talk: The NF-kappaB Regulator Bcl-3 Profoundly Impacts Immune Responses in Health and Disease via Distinct, Cell-Specific Functions

Takuya Uehata, Osaka University Graduate School of Medicine, Japan
Short Talk: Malt-1 Mediated Cleavage of Regnase-1 Regulates CD4 T Activation

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
11:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Cell Decision Systems
Meeting has ended...abstracts no longer viewable online.
The NF-kappaB signaling system responds to a variety of noxious stimuli. How it participates in determining cellular responses and cellular decision making is studied effectively using the iterative Systems Biology approach.

Grays Peak
* Aviv Regev, Massachusetts Institute of Technology/Broad Institute, USA

Toby Lawrence, INSERM, France
NF-kB and Dendritic Cell Maturation

Suzanne Gaudet, Dana-Farber Cancer Institute/Harvard Medical School, USA
Measuring, Modeling and Leveraging Cell-to-Cell Variability in Responses to TNF

Shigeki Miyamoto, University of Wisconsin, Madison, USA
Genotoxic NF-kappaB Responses: Regulation of Nuclear NEMO Functions

Myong-Hee Mia Sung, NIA, National Institutes of Health, USA
Short Talk: Switching of Feedback Dominance in LPS Dose Discrimination by Macrophages

19:00—20:00
Social Hour with Lite Bites

Longs/Quandary Peaks
19:30—22:00
Poster Session 3

Longs/Quandary Peaks

THURSDAY, FEBRUARY 27

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:00
Signaling Systems in Cancer
Meeting has ended...abstracts no longer viewable online.
NF-kappaB has been implicated in the pathogenesis of many cancers. Its precise role seems to be cancer specific and depends on the contextual network.

Grays Peak
* Margot Thome, University of Lausanne, Switzerland

Michael Karin, University of California, San Diego, USA
NF-kappaB Revisited in Liver Cancer; from a Tumor Suppressor to a Key Factor in Viral Hepatitis and Non-Alcoholic Steato-Hepatitis (NASH) Related HCC

Louis M. Staudt, National Cancer Institute, NIH, USA
Oncogenic Signaling in Lymphoma

Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Inflammasomes in Health, Dysbiosis and Disease

Nicole Heise, Columbia University, USA
Short Talk: Conditional Ablation of the Canonical NF-kappaB Subunits RELA or c-REL in Germinal Center B Cells Abolishes the Generation of High-Affinity B Cells at Distinct Stages

James Wang, John Curtin School of Medical Research, Australia
Short Talk: Cooperative Effects of MYD88, BCL-2, CD79B and TNFAIP3 Mutations on B Cell Tolerance and NF-kappaB

David A. Barbie, Dana-Farber Cancer Institute, USA
Short Talk: Inhibition of KRAS-Driven Tumorigenicity by Interruption of an Autocrine Cytokine Circuit

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: For Highly Innovative, Recent Studies to be Presented

Grays Peak
Denis C. Guttridge, Ohio State University, USA
A20 Tumor Suppressor Activity in Sarcomas Is Regulated by a miR-29 Decoy Function on HuR

Christina M. Annunziata, NCI, National Institutes of Health, USA
CASPASE 8 Cooperates with IKKbeta to Protect Ovarian Cancer Cells from Necroptosis

* Thomas D. Gilmore, Boston University, USA
Evolution of NF-kappaB Signaling

William J. Housley, Yale University, USA
Genetic Variants Associated with Multiple Sclerosis Result in Enhanced NF-kappaB Signaling and Responses to Inflammatory Stimuli

Barbara Kaltschmidt, Bielefeld University, Germany
A Role of NF-kappaB in Stem Cells

Brian C. Schaefer, Uniformed Services University, USA
T Cell Receptor Signals to NF-kappaB Are Transmitted by a Cytosolic p62-Bcl10-Malt1-IKK Signalosome

Carter Van Waes, NIDCD, National Institutes of Health, USA
Genomic Alterations and Functional Targets in the NF-kappaB and Cell Death Signal Network in Head and Neck Cancer

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
NF-kappaB Systems Pharmacology
Meeting has ended...abstracts no longer viewable online.
The NF-kappaB signaling system is a critical regulator of many processes and hence a significant drug target. However, its functional pleiotropy harbors risks and regulatory buffering mechanisms pose challenges.

Grays Peak
Genhong Cheng, University of California, Los Angeles, USA
Gene Programs Involved in the Balance of Pro-Inflammatory and Anti-Inflammatory Responses during Acute and Chronic Infections

Albert S. Baldwin Jr., University of North Carolina School of Medicine, USA
IKK Signaling in Cancer and Disease

Frank Mercurio, BioTheryX, Inc., USA
Targeting NF-kappaB in the Clinic: Embrace the Complexity

Thomas H. Leung, University of Pennsylvania, USA
Short Talk: Topical Hypochlorite Ameliorates NF-kappaB-Mediated Skin Disease in Mice

19:00—19:15
Concluding Remarks
Meeting has ended...abstracts no longer viewable online.

Grays Peak
19:15—20:15
Social Hour with Lite Bites

Longs/Quandary Peaks
20:00—23:00
Entertainment

Longs/Quandary Peaks

FRIDAY, FEBRUARY 28

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

AstraZeneca

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI108137-01

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