Registered Attendees

Registered Attendees

Print This Page

Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online before the meeting...these abstracts will be available in the Abstract Book at the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

Close Window
Big Sky Resort Floorplan

Big Sky Resort Floorplan

Print This Page



Close Window

This meeting took place in 2014



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

The Ubiquitin System: From Basic Science to Drug Discovery (A2)


Organizer(s) Ingrid E. Wertz and David Komander
January 7—12, 2014
Big Sky Resort • Big Sky, Montana USA
Discounted Abstract Deadline: Oct 2, 2013
Abstract Deadline: Oct 24, 2013
Scholarship Deadline: Oct 2, 2013
Discounted Registration Deadline: Nov 7, 2013

Sponsored by Cell Research and Genentech, Inc.

Summary of Meeting:
Ubiquitination, the covalent ligation of target proteins by the 76-amino acid protein ubiquitin, regulates the fate and function of the substrate proteins. Aberrant ubiquitination promotes numerous disease states, but the mechanisms by which the ubiquitin system regulates cellular signaling and pathogenesis remain largely unknown. This meeting will: 1) Highlight recent basic science advances in the field of ubiquitin research; 2) Reveal gaps in our understanding of how the ubiquitin system regulates human disease, and how we can best apply our knowledge to answer these questions; and 3) Update attendees on the efficacy of drugs that target the ubiquitin/proteasome system. Initial plenary sessions will focus on the basic science of the ubiquitin system, including lectures describing ubiquitin modifications and the enzymology of the ubiquitin system. The role of ubiquitination in cellular signaling, with a focus on enzyme sub-classes and specific pathways, will next be explored. Workshops highlighting model systems and technological advances used to investigate the ubiquitin system are also incorporated. The meeting will culminate with sessions focused on the role of the ubiquitin system in human disease and as a drug target. The meeting format will encourage interaction between clinicians, translational researchers and basic scientists with interests ranging from the biophysics to the cellular biology of the ubiquitin system. The anticipated outcomes will be increased understanding of the interrelated roles that the ubiquitin system plays in normal homeostasis and in disease, and of the next steps required to target the ubiquitin system for patient benefit.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 7

16:00—20:00
Arrival and Registration


WEDNESDAY, JANUARY 8

07:00—08:00
Breakfast

08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ingrid E. Wertz, Genentech, Inc., USA

Raymond J. Deshaies, California Institute of Technology, USA
Exploiting Protein Homeostasis as a Target for Anti-Cancer Drugs

09:00—11:00
Ubiquitin Chains and Modifications
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Henning Walczak, University College London, Cancer Institute, UK

David Komander, Lister Institute of Preventive medicine, UK
Atypical Ubiquitin Chains

Michael Rape, University of California, Berkeley, USA
Tumor Suppression by Mitotic Quality Control

Ingrid E. Wertz, Genentech, Inc., USA
Ubiquitin Editing

09:40—10:00
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Technological Advances for Interrogating the Ubiquitin Proteasome System

* Ingrid E. Wertz, Genentech, Inc., USA

Marie-Pierre Bousquet-Dubouch, IPBS - CNRS, University of Toulouse, France
Determination of Proteasome Subcellular Distribution and Molecular Stoichiometry Using Formaldehyde Cross-Linking and Label-Free Quantitative Proteomics

Kevin G. Mark, University of California, San Francisco, USA
Ubiquitin Ligase Substrate Trapping Identifies an Scf-saf1 Mediated Pathway Targeting Unprocessed Vacuolar/Lysosomal Proteins

Gregg Siegal, Leiden University, Netherlands
Drugging DUBs with an NMR Pyramid

John S. Schneekloth, Jr., NCI, National Institutes of Health, USA
Discovery and Characterization of Small Molecule Probes of Sumoylation Enzymes

Reggy Ekkebus, Netherlands Cancer Institute, Netherlands
and

Paul Geurink, Netherlands Cancer Institute, Netherlands
and

Monique PC Mulder, Netherlands Cancer Institute, NKI, Netherlands
Probing Protein Ubiquitination: A Chemical Biology Approach

16:30—17:00
Coffee Available

17:00—19:15
Ubiquitin Proteasome System Enzymes: Structural Insights and Biophysical Mechanisms
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* David Komander, Lister Institute of Preventive medicine, UK

Brenda A. Schulman, St. Jude Children's Research Hospital, USA
Structural and Mechanistic Studies of Cullin-RING Ligases

Eric S. Fischer, Friedrich Miescher Institute for Biomedical Research, Switzerland
Short Talk: The Structure of an DDB1-CRBN Complex Bound to Thalidomide: Insights into CRL4 Inhibition by Small Molecules

Simin Rahighi, Stanford University, USA
Short Talk: Structural Basis for the Recognition of a Lys48-Linked Tri-Ubiquitin Chain by the Tandem UIMs of AIRAPL

R. Andrew Byrd, NCI, National Institutes of Health, USA
Short Talk: Dissecting a Processive Ubiquitination Machine: Dynamic Interplay and Allostery Associated with Secondary Binding Domains of the Ubiquitin RING-Finger Ligase gp78

Evan J. Worden, University of California, Berkeley, USA
Short Talk: Allosteric Regulation and Substrate Specificity of the Proteasome Deubiquitinase Rpn11

Vishva M. Dixit, Genentech, Inc., USA
Ubiquitin-Mediated Modulation of Epigenetics

19:15—20:15
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


THURSDAY, JANUARY 9

07:00—08:00
Breakfast

08:00—11:00
Ubiquitin-Like Proteins in Cellular Signaling
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Brenda A. Schulman, St. Jude Children's Research Hospital, USA

Christopher D. Lima, Memorial Sloan-Kettering Cancer Center, USA
Structure and Function in Ub/Ubl Conjugation Pathways

Marcus Groettrup, University of Konstanz, Germany
The Ubiquitin-Like Modifier FAT10 Shapes the T Lymphocyte Repertoire

Heran Darwin, New York University School of Medicine, USA
Latest Developments in the Pup-Proteasome System of Mycobacterium tuberculosis

Sreenivas Gannavaram, US Food and Drug Administration, USA
Short Talk: Ufm1 Mediated Protein Modification Pathway as Drug Target in the Human Protozoan Parasite Leishmania donovani

Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA
Why Is Addition and Removal of SUMO so Dynamic?

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:15
Regulation of Signaling Pathways by the Ubiquitin Proteasome System
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Cynthia Wolberger, Johns Hopkins University School of Medicine, USA

Henning Walczak, University College London, Cancer Institute, UK
Linear Ubiquitin: New Insight on its Role in Signaling and Development

Brittney M. Davidge, Portland State University, USA
Short Talk: The Cul3 Mutant Associated with Hypertension Is an Active Ubiquitin Ligase

Nicolas Bidère, INSERM, France
Short Talk: A Role for the LUBAC in Antigen Receptor-Mediated NF-kappaB Activation and in Lymphoma Survival

Arno F. Alpi, University of Dundee, UK
Short Talk: TRIAD1 and HHARI Modulate the Activity of Distinct Cullin Ring Ligase Complexes

Paula M. Oliver, University of Pennsylvania, USA
Short Talk: Activating Ubiquitin Complexes that Prevent Inflammation

Ivan Dikic, Goethe University Medical School, Germany
Regulation of Autophagy by Ubiquitin Networks

19:15—20:15
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


FRIDAY, JANUARY 10

07:00—08:00
Breakfast

08:00—11:30
Ubiquitin Ligases in Cellular Signaling
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Michael Rape, University of California, Berkeley, USA

Rachel Klevit, University of Washington, USA
How to Modulate Ub E3 Ligase Activity

Simona Polo, FIRC Institute of Molecular Oncology, Italy
The Ubiquitin Signaling Network at Work

Wenyi Wei, Beth Israel Deaconess Medical Center, USA
MC1R Deficiency Cooperates with BRaf V600E to Promote Melanomogenesis

Wolfgang Dubiel, Charité - Universitätsmedizin Berlin, Germany
Short Talk: The COP9 Signalosome is Essential for Adipogenesis

P. Ryan Potts, University of Texas Southwestern Medical Center, USA
Short Talk: Regulation of Cellular Metabolism by an Oncogenic MAGE-RING E3 Ubiquitin Ligase Targeting AMPK

Pengbo Zhou, Weill Cornell Medical College, USA
Short Talk: Recurrent Missense Mutations in the SPOP-CUL3 Ubiquitin Ligase in Prostate Cancer

Matthias Peter, ETH Zürich, Switzerland
Function and Regulation of CRL Complexes

09:20—09:40
Coffee Break

11:30—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:30—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Ubiquitin Proteasome System: Insights from Model Systems

* David Komander, Lister Institute of Preventive medicine, UK

* Adolfo García-Sastre, Mount Sinai School of Medicine, USA
Regulation of Innate Immunity by TRIM E3 Ligases

Pascale Cossart, Institut Pasteur, France
Role of SUMOylation in Listeria monocytogenes Infection

Wim Vandenberghe, University Hospitals Leuven, Belgium
Identification of a Deubiquitinase that Antagonizes Parkin-Mediated Mitochondrial Ubiquitination and Mitophagy

Michael A. Skinner, Imperial College London Faculty of Medicine, UK
Interaction of a Fowlpox Virus Modulator of Avian Interferon with the Chicken Cullin-1 and Skp1

Josua Schinke, Georg-August University Göttingen, Germany
Interplay between Den1 and CSN Deneddylases and the Phosphatase DipA in Filamentous Fungi

Christoph Geisen, Max Planck Institute for Biology of Ageing, Germany
BLMP-1/BLIMP-1 Is a Novel Substrate of DRE-1/FBXO11 Regulating Developmental Timing

16:30—17:00
Coffee Available

17:00—19:00
Deubiquitinase Enzymes in Cellular Signaling
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Xavier Jacq, MISSION Therapeutics Ltd., UK

Titia K. Sixma, Netherlands Cancer Institute, Netherlands
Regulation of DUB Activity by Protein-Protein Interaction

Paul J. Galardy, Mayo Clinic, USA
Short Talk: USP44 Is an Essential Regulator of Nucleotide Excision Repair

Nima Mosammaparast, Washington University in St. Louis, USA
Short Talk: Regulation of DNA Demethylation Repair by the OTUD4 Deubiquitinase

Judy Coulson, University of Liverpool, UK
Short Talk: The Deubiquitylase Ataxin-3 Restricts PTEN Transcription and PI3K Signaling

Cynthia Wolberger, Johns Hopkins University School of Medicine, USA
Cross-regulation by Deubiquitinating and E2 Enzymes

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


SATURDAY, JANUARY 11

07:00—08:00
Breakfast

08:00—11:00
The Ubiquitin Proteasome System as a Drug Target
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ivan Dikic, Goethe University Medical School, Germany

Gwen Nichols, Hoffmann-LaRoche, USA
Drugging E3 Ligases: MDM2 Antagonist Clinical Development

Christopher J. Kirk, Onyx Pharmaceuticals, USA
Peptide Epoxyketone Proteasome Inhibitors: Tools and Drugs

Jennifer A. Johnston, E3xBio, USA
Short Talk: Identification of Small Molecule Activators of Parkin Protein and Insight into Mechanisms of Enzyme Activation

Namrata D. Udeshi, Broad Institute of MIT and Harvard, USA
Short Talk: Lenalidomide Promotes CRBN-Mediated Ubiquitination and Degradation of IKZF1 and IKZF3

Derek F. Ceccarelli, Samuel Lunenfeld Research Institute, Canada
Short Talk: E2 Enzyme Inhibition by Stabilization of a Low Affinity Interface with Ubiquitin

Xavier Jacq, MISSION Therapeutics Ltd., UK
Identification of Selective DUB Inhibitors Targeting DDR Deficient Tumors

09:20—09:40
Coffee Break

11:00—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
The Ubiquitin Proteasome System in Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Titia K. Sixma, Netherlands Cancer Institute, Netherlands

Iannis Aifantis, HHMI/New York University School of Medicine, USA
Regulation of Leukemia Initiation and Progression by the Ubiquitin System

Alain Israël, Institut Pasteur, France
Ubiquitination in NF-kappaB Signaling

Khosrow Rezvani, University of South Dakota, USA
Short Talk: Ubiquitin-Like (UBX)-Domain-Containing Protein, UBXN2A, Promotes Cell Death by Interfering with the p53-Mortalin2 Interactions in Cancer Cells

Alexandre Orthwein, Mount Sinai Hospital, Canada
Short Talk: Mitotic Inhibition of RNF8/RNF168- Medicated Ubiquitylation Cascade Preserves Genomic Integrity

Daniel J. Finley, Harvard University, USA
Regulation of Proteasome Activity by Ubiquitin Chain Editing

19:00—19:15
Closing Remarks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

David Komander, Lister Institute of Preventive medicine, UK

19:15—20:15
Social Hour with Lite Bites

20:00—23:00
Entertainment


SUNDAY, JANUARY 12

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Cell Research Genentech, Inc.

We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Hoffmann-La Roche Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Biochemical Society / Biochemical Journal

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676