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This meeting took place in 2014


Here are the related meetings in 2018:
Aging, Inflammation and Immunity (X2)
Pushing the Limits to Healthspan and Longevity (D3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Aging - Pushing the Limits of Cellular Quality Control (A5)


Organizer(s) Andrew G. Dillin, Daniel E. Gottschling and Thomas Nyström
January 12—17, 2014
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Discounted Abstract Deadline: Oct 3, 2013
Abstract Deadline: Oct 28, 2013
Scholarship Deadline: Oct 3, 2013
Discounted Registration Deadline: Nov 13, 2013

Supported by the Directors' Fund

Summary of Meeting:
Aging is one of the highest risk factors known for most diseases of the modern era of humanity. Such age-related diseases are linked to the loss of performance of a large variety of homeostatic processes protecting the genome, proteome, lipidome or metabolome. One of the greatest challenges facing any organism is to coordinate the operation and maintenance of these different homeostatic processes and, in multicellular organisms, also to harmonize these functions across all cells and tissues. However, the highly interconnected nature of homeostatic machineries makes the system vulnerable to perturbations as the breakdown of one specific homeostatic process during aging or stress brings forth repercussions on other maintenance activities. In addition, as each cell or tissue must remain aware of the performance and wellbeing of distal cells and organelles, a breakdown in cell-to-cell and organelle-to-organelle communication can lead to critical macromolecular perturbations, including a loss of genome, proteome, lipidome, metabolome and endocrine functions leading to the inception of age-related disorders. The goal of this meeting is to bridge interdisciplinary approaches studying different aspects of cellular quality control and homeostasis with research on the aging soma and germline. We believe that deciphering the mechanisms of homeostatic control, its interconnective nature and homeostatic communication between cells and organelles may lead to a deeper understanding of the aging process – its onset, sequence of events and critical targets.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 12

16:00—20:00
Arrival and Registration

Foyer

MONDAY, JANUARY 13

07:00—08:00
Breakfast

Foyer/Rainbow/Twilight
08:00—11:00
Modern Bioenergetics. Session Sponsored by The Ellison Medical Foundation.
Meeting has ended...abstracts no longer viewable online.
Support for these organizer-selected speakers generously provided by this foundation.

Storm Peak/Mt. Werner
* Carsten Merkwirth, Ferring Research Institute, Inc, USA

Johan Auwerx, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
Mitonuclear Protein Balance as a Determinant of Health- and Lifespan

Adam Antebi, Max Planck Institut für Biologie des Alterns, Germany
Enhanced Hexosamine Pathway Flux Extends Lifespan and Protects Against Proteotoxicity

Benjamin Tu, University of Texas Southwestern Medical Center, USA
Master Metabolites and their Influence on Cell Proliferation and Survivability

Sean P. Curran, University of Southern California, USA
Short Talk: Dietary Adaptation Is Mediated by Mitochondrial Homeostasis during Normal Aging

William B. Mair, Harvard School of Public Health, USA
Short Talk: Communicating Longevity Neuro-Endocrine Regulation of Longevity by cric-1

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Sunshine
13:00—22:00
Poster Viewing

Sunshine
11:00—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Emerging Concepts

Storm Peak/Mt. Werner
* Kristan K. Steffen, University of California, Berkeley, USA

Dana M. Alessi Wolken, Columbia University, USA
Mitochondrial Remodeling through the Proteasome Is Critical for Mitochondrial Quality Control

Collin Y. Ewald, Joslin Diabetes Center, USA
Dauer-Independent Insulin/IGF-1 Signaling Implicates Collagens in Longevity

Supriya Srinivasan, The Scripps Research Institute, USA
Neuroendocrine Control of Energy Regulation in C. elegans

Scott Kennedy, University of Washington, USA
Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations that Are Inconsistent with Oxidative Damage

Ruth Kroschewski, Swiss Federal Institute of Technology, Switzerland
Asymmetric Segregation of Bacterial Plasmid DNA in Mammalian Cells

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Spatial Quality Control
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Nathan Baird, University of California, Berkeley, USA

Thomas Nyström, Göteborg University, Sweden
Factors Required for the Recognition, Partitioning, and Asymmetrical Inheritance of Protein Aggregates

Judith Frydman, Stanford University, USA
Pathways of Quality Control: Protein Folding and Misfolding in the Eukaryotic Cytosol

Joris Winderickx, KU Leuven, Belgium
Role of Vesicular Trafficking in Management of Folding Disease Proteins

Jeffrey S. Smith, University of Virginia School of Medicine, USA
Short Talk: Contributions of Histone Acetyltransferase Complexes SAGA and SLIK to Yeast Chronological Life span During Caloric Restriction

19:00—20:00
Social Hour with Lite Bites

Sunshine
19:30—22:00
Poster Session 1

Sunshine

TUESDAY, JANUARY 14

07:00—08:00
Breakfast

Foyer/Rainbow/Twilight
08:00—11:00
Mitochondrial Homeostasis
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Nathaniel Thayer, Fred Hutchinson Cancer Research Center, USA

Cole M. Haynes, University of Massachusetts Medical School, USA
Repairing and Regenerating Defective Mitochondria during the UPRmt

Jodi Nunnari, University of California, Davis, USA
The Behavior of Mitochondria

Thomas Langer, CECAD Research Center, Germany
Proteolytic Control of Mitochondrial Dynamics

Norbert Perrimon, Harvard Medical School, USA
Regulation of the Aging Process Pathways Involved in Organ Communication

Ryo Higuchi, Columbia University, USA
Short Talk: Role for Actin Dynamics in Mitochondrial Quality Control and Lifespan in Budding Yeast

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine
13:00—22:00
Poster Viewing

Sunshine
11:00—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Foyer
17:00—19:15
Evolution of Homeostasis
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* David Öling, Gothenburg University, Sweden

Thomas Kirkwood, Newcastle University, UK
The Evolvability of Stress Responses

Daniel E.L. Promislow, University of Washington, USA
Homeostasis and the Aging Network: An Interspecific Perspective

Adam Frost, University of California, San Francisco, USA
Functional Repurposing of Proteins through Evolution: How Organelle Homeostasis Mechanisms Vary between Species

Patrick C. Phillips, University of Oregon, USA
Short Talk: Using Experimental Evolution to Study the Molecular Quantitative Genomics of Stress Resistance and Longevity in the Nematode Caenorhabditis remanei

Bjoern Schumacher, University of Cologne, Germany
Short Talk: Activation of Somatic Proteostasis Confers Systemic Stress Resistance in Response to Genome Instability in Germ Cells

19:15—20:15
Social Hour with Lite Bites

Sunshine
19:30—22:00
Poster Session 2

Sunshine

WEDNESDAY, JANUARY 15

07:00—08:00
Breakfast

Foyer/Rainbow/Twilight
08:00—11:00
Lipid/Membrane Homeostasis
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Kiersten Amie Henderson, Fred Hutchinson Cancer Research Center, USA

Miriam Greenberg, Wayne State University, USA
The Central Role of the Mitochondrial Phospholipid Cardiolipin in Cellular Functions

Lois S. Weisman, University of Michigan, USA
Phosphatidylinositol 3,5-Bisphosphate, Membrane Trafficking, Metabolism and Disease

Malene Hansen, Sanford Burnham Prebys Medical Discovery Institute, USA
Understanding the Role of Autophagy in C. elegans Aging

Brandon H. Toyama, The Salk Institute, USA
Short Talk: Maintenance of Proteins with Exceptional Longevity through Aging

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Sunshine
13:00—22:00
Poster Viewing

Sunshine
11:00—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Foyer
17:00—19:30
Proteostasis
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Peter M. Douglas, University of California, Berkeley, USA

Richard I. Morimoto, Northwestern University, USA
Proteostasis Network Collapse in C. elegans Aging

Jonathan S. Weissman, University of California, San Francisco, USA
Monitoring Protein Synthesis One Codon at a Time through Ribosome Profiling

Bernd Bukau, Universität Heidelberg, Germany
Cellular Strategies for Coping with Protein Aggregation

F. Ulrich Hartl, Max Planck Institute of Biochemistry, Germany
Toxic Protein Aggregation and the Cellular Defense Against It

Thorsten Hoppe, University of Cologne, Germany
Short Talk: A Novel Mitochondrial Surveillance Response Orchestrates Ubiquitin-Dependent Proteolysis

19:30—20:30
Social Hour with Lite Bites

Sunshine
19:30—22:00
Poster Session 3

Sunshine

THURSDAY, JANUARY 16

07:00—08:00
Breakfast

Foyer/Rainbow/Twilight
08:00—11:00
Inter-Organelle Dynamics
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Vidhya Ramachandran, University of California, Berkeley, USA

Gerald S. Shadel, Yale School of Medicine, USA
Mitochondrial-Stress Signaling Regulates Nuclear Gene Expression and Longevity

Daniel E. Gottschling, Calico, USA
Organelle Deterioration with Age: The Limits of an Interconnected Cellular System

Scott D. Emr, Cornell University, USA
Plasma Membrane Protein Quality Control: Essential Role for Ubiquitin Ligase Adaptor Network

Amrita Mangalvedhekar Nargund, Sloan-Kettering Institute for Cancer Research, USA
Short Talk: ATFS-1 Coordinates Nuclear and Mitochondrial Transcription to Restore Respiratory Capacity during Stress

09:20—09:40
Coffee Break

Foyer
11:00—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Emerging Concepts II

Storm Peak/Mt. Werner
* Sandra Malmgren Hill, Gothenburg University, Sweden

Daniel Kaganovich, Hebrew University of Jerusalem, Israel
The Role of Inclusions, Cytoskeleton and Stress Foci in Spatial Quality Control

Prasad Kasturi, Max Planck Institute for Biochemistry, Germany
Age-Related Remodeling of the Proteostasis Network in C. elegans Revealed by Quantitative Proteomics

Koichi Iijima, National Center for Geriatrics and Gerontology, Japan
Epigenetic Modifications Reveal the Minimal Unit of UPR that Promotes ERAD and Protects against Age-Related Chronic Proteinopathy in the Brain

Thibault Mayor, University of British Columbia, Canada
The Rsp5 Ubiquitin Ligase Targets Cytosolic Misfolded Proteins for Proteasome Degradation

Warakorn Kulalert, Massachusetts Institute of Technology, USA
Cell Non-Autonomous Effects of Neuronal ER Stress on Larval Development in C. elegans

16:30—17:00
Coffee Available

Foyer
17:00—19:30
Novel Strategies for Germ and Stem Cell Quality Control
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Sarah Hanzén, Gothenburg University, Sweden

Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Hematopoietic Stem Cells Require a Highly Regulated Rate of Protein Synthesis

Yves P. Barral, ETH Zürich, Switzerland
Lateral Diffusion Barriers and the Segregation of Aging Factors during Mitosis

Mary-Rose Bufalino, University of Toronto, Canada
The Asymmetric Division of Damaged Proteins Is Stem Cell-Type Dependent and Influences Cell Fate

Pekka Aleksi Katajisto, University of Helsinki, Finland
Short Talk: Asymmetric Apportioning of Aged Mitochondria between Daughter Cells

Andrew G. Dillin, University of California, Berkeley, USA
Proteostasis of Germ and Stem Cells

19:30—20:30
Social Hour with Lite Bites

Sunshine
20:00—23:00
Entertainment

Sunshine

FRIDAY, JANUARY 17

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

The Ellison Medical Foundation Glenn Foundation for Medical Research

MitoKyne
Proteostasis Therapeutics, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676