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Beaver Run Resort Floorplan

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This meeting took place in 2014


Here are the related meetings in 2015:
Hypoxia: From Basic Mechanisms to Therapeutics (E3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Sensing and Signaling of Hypoxia: Interfaces with Biology and Medicine (A1)


Organizer(s) Peter J. Ratcliffe, L. Eric Huang, Michael Ohh and Cynthia M. Beall
January 7—12, 2014
Beaver Run Resort • Breckenridge, Colorado USA
Discounted Abstract Deadline: Oct 2, 2013
Abstract Deadline: Oct 24, 2013
Scholarship Deadline: Oct 2, 2013
Discounted Registration Deadline: Nov 7, 2013

Supported by the Directors' Fund

Summary of Meeting:
Hypoxia is an important component of most human diseases. This meeting will focus on advances in our understanding of the biochemistry and biology of hypoxia signaling and their impact on cell biology, physiology and medicine. Specific emphasis will be placed on the emerging interfaces of hypoxia biology with new areas of scientific progress including metabolic regulation, epigenetic signaling, stem cell biology, inflammation, immunity, tissue repair and cancer. The meeting will also aim to link these processes to the integrative physiology of hypoxia and act as a forum for interfacing reductionist molecular approaches with medical physiology. Key objectives are to: 1) Report key emerging research findings in hypoxia biology across a range of biomedical research fronts; 2) Promote and extend new areas of research into the impact of hypoxia on biological systems; and 3) Foster interdisciplinary research aimed at linking molecular and integrated physiology and defining therapeutic opportunities.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 7

16:00—20:00
Arrival and Registration


WEDNESDAY, JANUARY 8

07:00—08:00
Breakfast

08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Peter J. Ratcliffe, University of Oxford, UK

M. Celeste Simon, HHMI/University of Pennsylvania, USA
Hypoxia, Metabolism and Tumor Progression

09:00—11:15
Hypoxia Signaling
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Roland H. Wenger, University of Zürich, Switzerland

L. Eric Huang, University of Utah, USA
Non-Canonical HIF Signaling to Malignant Progression-Associated Genetic Alteration

Michael Ohh, University of Toronto, Canada
Mechanistic Insight into the E3 Ligase Activity of VHL Complex

Peter J. Ratcliffe, University of Oxford, UK
New Insights into Hypoxia Signalling Pathways

Cheng-Jun Hu, University of Colorado Denver, USA
Short Talk: Role of HIF in Regulating RNA Splicing of HIF Target Genes

09:40—10:00
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—14:00
On Own for Lunch and Recreation

14:00—16:00
Workshop 1: Junior Investigators and Late-Breaking News

* Max Gassmann, University of Zürich, Switzerland

Roland H. Wenger, University of Zürich, Switzerland
Second But Not Last: HIF-2 Regulated Gene Expression

Sarah Taylor, University of Liverpool, UK
HIF-2alpha Tracking in Living Cells Using Gold Nanoparticle Functionalisation and Photothermal Microscopy

Jolene Caifeng Ho, National University of Singapore, Singapore
Hypoxia Mediates Tumourigenesis Epigenetically via the H3K9 Methylation Regulators G9a and Jmjd1a

Kathryn E. Hacker, University of North Carolina at Chapel Hill, USA
The Interplay between VHL Inactivation and Chromatin Modifiers in ccRCC: How a Distinct Profile of Genetic Alterations Contributes to Tumorigenesis

Pardeep Heir, University of Toronto, Canada
Oxygen-Dependent Regulation of JAK/STAT Signal Transduction

Yihua Wang, Ludwig Institute for Cancer Research, UK
Regulation of FIH Function by Hypoxia and Ankyrin Repeats Containing Protein ASPP2

Karim Ullah, University of Oulu, Finland
Inactivation or Deletion of PHD1 Suppresses Inflammatory Response in Mice through p53 Mediated Apoptosis

Sonia Rocha, University of Dundee, UK
Role of PHD Enzymes in the Control of the Cell Cycle Machinery

16:00—16:30
Coffee Available

16:30—18:45
Hypoxia Signaling in Inflammation and Immunity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Michael Ohh, University of Toronto, Canada

Joaquín M. Espinosa, University of Colorado, Boulder, USA
Mechanisms of Transcriptional Regulation in the HIF Network

Yael Nevo-Caspi, Safra Children's Hospital, Sheba Medical Center, Israel
Short Talk: F11R Expression upon Hypoxia Is Regulated by RNA Editing

Randall S. Johnson, University of Cambridge, UK
Diverse Roles of Hypoxia Signaling in Inflammation

Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
HIF-1, Metabolism and T Cell Differentiation

Romain Vuillefroy de Silly, Centre of Oncology, Switzerland
Short Talk: Oxygen Tension as a Regulator of CD8+ T Cell Expansion and Function

18:45—19:45
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


THURSDAY, JANUARY 9

07:00—08:00
Breakfast

08:00—11:00
Genetic Adaption to Hypoxia
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Nanduri R. Prabhakar, University of Chicago, USA

Cynthia M. Beall, Case Western Reserve University, USA
Human Population Adaptation to Hypoxia at Altitude

Jay F. Storz, University of Nebraska, USA
Mechanisms of Hemoglobin Adaptation to Hypoxia in High-Altitude Vertebrates

Aashish R. Jha, University of Chicago, USA
Short Talk: Convergent Evolution of Hypoxia Adaptation in Laboratory Selected Drosophila melanogaster and in High Altitude Human Populations

Tatum S. Simonson, University of California, San Diego, USA
Genetic Selection of Hypoxia-Related Traits at Altitude

Choongwon Jeong, University of Chicago, USA
Short Talk: Admixture Facilitated Genetic Adaptations to High-Altitude in Tibet

Nimrat Chatterjee, Baylor College of Medicine, USA
Short Talk: Environmental Stress Induces Trinucleotide Repeat Instability in Human Cells

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—16:30
On Own for Lunch and Recreation

16:00—16:30
Coffee Available

16:30—19:00
Oxygen and Nutrient Signaling in Model Organisms
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Volker H. Haase, Vanderbilt University, USA

Utpal Banerjee, University of California, Los Angeles, USA
Drosophila as a Model System for Analyzing Hif Function

Christopher M. West, University of Oklahoma, USA
Ancient Roles of Prolyl Hydroxylases and Glycosyltransferases in Protist O2-Signaling

Peter J. Espenshade, Johns Hopkins University School of Medicine, USA
Regulation of the Hypoxic Response by the Ofd1 Prolyl Hydroxylase in Fission Yeast

Pablo Wappner, Fundacion Instituto Leloir, Argentina
Short Talk: The Drosophila FKBP38 Homologue ZONDA Is Involved in Autophagy

Yi-Hsien Su, Academia Sinica, Taiwan
Short Talk: Asymmetrical Stabilization of Hypoxia Inducible Factor alpha Regulates Dorsoventral Patterning in the Sea Urchin Embryo

John Flibotte, Children's Hospital of Philadelphia, USA
Short Talk: Neural Oxygen Sensing and Neuropeptide Signaling Influence Survival after Anoxia in C. elegans

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


FRIDAY, JANUARY 10

07:00—08:00
Breakfast

08:00—11:00
Signaling of Hypoxia in Health and Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Cynthia M. Beall, Case Western Reserve University, USA

Rubin M. Tuder, University of Colorado Denver, USA
New Insights into Hypoxia and Pulmonary Vascular Biology

Nanduri R. Prabhakar, University of Chicago, USA
Gasotransmitter Signaling: A Key Step in O2 Sensing by the Carotid Body

Lorna G. Moore, University of Colorado, Denver, USA
Trans-Generational Adaptation to Hypoxia at Altitude

Josef Prchal, University of Utah, USA
Short Talk: The Mechanisms Responsible for Neocytolysis in the Erythron

Kou-Juey Wu, National Yang-Ming University, Taiwan
Short Talk: Post-Translational Regulation of Hypoxia-Induced Epithelial-Mesenchymal Transition

Lital Bentovim, Weizmann Institute of Science, Israel
Short Talk: A Metabolic Switch Turns ON Bone Development

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—14:00
On Own for Lunch and Recreation

14:00—16:00
Workshop 2: Translational: Linking Molecular and Integrative Physiology

* Johanna Myllyharju, University of Oulu, Finland

Dörthe M. Katschinski, Georg August University, Germany
Overlapping and Non-Redundant Functions of PHD Isoforms

F. Aisha Chow, FibroGen Inc., USA
Therapeutic Benefit of HIF Prolyl Hydroxylase Inhibitors in Experimental Autoimmune Encephalomyelitis (EAE), a T-Cell Mediated Model of Multiple Sclerosis

Antonio Heras-Garvín, Instituto de Biomedicina de Sevilla, Spain
Microglia and Hypoxia: Implications in Alzheimer's Disease

Peppi Koivunen, University of Oulu, Finland
HIF Prolyl-4-Hydroxylase-2 Inhibition Protects Mice against Obesity and Metabolic Dysfunction

Waihay J. Wong, University of Pennsylvania, USA
Hypoxia Inducible Factors Regulate Filaggrin Expression and Epidermal Barrier Formation

Ben Wielockx, Technical University of Dresden, Germany
Loss of Epithelial HIF Prolyl Hydroxylase-2 (PHD2) Accelerates Skin Wound Healing in Mice

Pinelopi P. Kapitsinou, Vanderbilt University Medical Center, USA
Hypoxia-Inducible Factor-2 in Endothelial Cells Mediates Protection and Recovery from Ischemic Kidney Injury

Bing Zhou, University of Carolina at Chapel Hill, USA
Erythropoietin Promotes Breast Tumorigenesis through Tumor Initiating Cell Self-Renewal

16:00—16:30
Coffee Available

16:30—19:00
Metabolic Regulation and Hypoxia
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Lorenz Poellinger, Karolinska Institutet, Sweden

Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Metabolic Fluxes and Growth Control in Cancer

Wilhelm Krek, Institute of Molecular Health Sciences, ETH Zürich, Switzerland
The Role of Hypoxia Inducible Factors in Cardiac and Adipose Metabolism

Navdeep S. Chandel, Northwestern University, USA
Metabolic Signaling to and from the Mitochondrion

Tak W. Mak, Campbell Family Institute for Breast Cancer Research at Princess Margaret Hospital, University Health Network, Canada
Epigenetic Regulation of Hematopoiesis by 2-HG and TET Oxygenases

Lucy A. Godley, University of Chicago, USA
Short Talk: TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


SATURDAY, JANUARY 11

07:00—08:00
Breakfast

08:00—11:00
Cell Differentiation and Stem Cell Biology
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Dörthe M. Katschinski, Georg August University, Germany

Toshio Suda, Keio University, Japan
Metabolic Regulation of Hematopoietic Function

Emin Maltepe, University of California, San Francisco, USA
Short Talk: Non-Canonical HIF-2 Activity Can Regulate Stem Cell Fate in the Placenta

Lorenz Poellinger, Karolinska Institutet, Sweden
Short Talk: Regulation of the Cell Differentation Status by Hypoxia

Hannele Ruohola-Baker, University of Washington, USA
Role of Hypoxia Inducible Factors in Stem Cell Transitions

Amato J. Giaccia, Stanford University, USA
Unique Roles of the HIF/PHD Pathway in Normal Tissue Homeostasis and Protection against Stress

Bradly G. Wouters, Ontario Cancer Institute, Canada
Short Talk: Hypoxia Promotes Stemness and Poor Prognosis through Epigenetic Regulation of DICER

09:30—09:50
Coffee Break

11:00—16:30
On Own for Lunch and Recreation

16:00—16:30
Coffee Available

16:30—19:00
New Horizons for Hypoxia Signaling
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* L. Eric Huang, University of Utah, USA

Gregg L. Semenza, Johns Hopkins University School of Medicine, USA
Targeting HIFs for the Treatment of Cardiovascular Disease and Cancer

Stephen Lee, University of Ottawa, Canada
The Hypoxic Translation Machinery and Cellular Adaptation to Low Oxygen Tension

Ze'ev A. Ronai, Sanford-Burnham Medical Research Institute, USA
Short Talk: Linking the UPR and Hypoxia by the Ubiquitin Ligases Siah1/2

Christopher J. Schofield, University of Oxford, UK
Implications of the Expanding Biology of 2 Oxoglutarate-Dependent Oxygenases

Richard K. Bruick, University of Texas Southwestern Medical Center, USA
Selective Regulation of HIF-2alpha

19:00—19:15
Closing Remarks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Peter J. Ratcliffe, University of Oxford, UK
Concluding Remarks

19:15—20:15
Social Hour with Lite Bites

20:00—23:00
Entertainment


SUNDAY, JANUARY 12

 
Departure


*Session Chair †Speaker invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

BioSpherix, Ltd. Coy Laboratory Products Inc.
HypOxygen Landes Bioscience
Ruskinn Technology Ltd, a division of the Baker Company, Inc.
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL121862-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Hypoxia journal – Dove Medical Press


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676