Registered Attendees

Registered Attendees

Print This Page

Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online before the meeting...these abstracts will be available in the Abstract Book at the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

Close Window
Fairmont Banff Springs Floorplan

Fairmont Banff Springs Floorplan

Print This Page



Close Window

This meeting took place in 2014



For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Developmental Pathways and Cancer: Wnt, Notch and Hedgehog (J7)


Organizer(s) Frederic J. de Sauvage, Mariann Bienz and Jon C. Aster
February 2—7, 2014
Fairmont Banff Springs • Banff, Alberta Canada
Discounted Abstract Deadline: Oct 11, 2013
Abstract Deadline: Nov 6, 2013
Scholarship Deadline: Oct 11, 2013
Discounted Registration Deadline: Dec 3, 2013

Sponsored by Bayer HealthCare Pharmaceuticals, Cell Research, Genentech, Inc., OncoMed Pharmaceuticals, Inc., and Pfizer Inc.


Summary of Meeting:
Aberrant activation of the Wnt, Notch and Hedgehog pathways via mutations or ligand overexpression has been implicated in a large number of cancer types where they are involved in functions ranging from tumor initiation to cancer stem cell maintenance and angiogenesis. These findings have triggered intensive efforts in both academia and industry to identify targets in these pathways and develop drugs for the treatment of certain tumors. Agents targeting each one of these three pathways have now reached clinical trials, and the first one of these, Vismodegib, a Hedgehog Pathway Inhibitor, was approved in 2012 for the treatment of advanced basal cell carcinoma. This meeting will allow scientists from both academia and industry to review the latest results on the role of these pathways in cancer and share their experience with the development of drugs in preclinical models and in the clinic. Issues ranging from predicting clinical efficacy in animal models to identification of predictive diagnostics and potential mechanisms of acquired resistance are key to the success of these agents and will require a combined effort from the entire community studying these pathways.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 2

16:00—20:00
Arrival and Registration


MONDAY, FEBRUARY 3

07:00—08:00
Breakfast

08:00—11:15
Signaling Mechanisms at the Cell Surface
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Stefano Piccolo, University of Padua, Italy
Wnt Signaling through YAP and TAZ

Xi He, Harvard Medical School, USA
Understanding the Mechanism of Wnt/beta-Catenin Signaling

William I. Weis, Stanford University, USA
Short Talk: Structural Basis of GSK-3 Regulation by Autoinhibition and by the Wnt Receptor LRP6

* Stephen C. Blacklow, Harvard Medical School, USA
A Tail of Two Sites: Structural Basis for Recognition of Notch Ligands by Mind Bomb Proteins

Jeremy F. Reiter, University of California, San Francisco, USA
Restricted Access: The Transition Zone Controls Ciliary Composition and Vertebrate Hh Signaling

Yulu Cherry Liu, University of Toronto, Canada
Short Talk: The PPFIA1-PP2A Protein Complex Regulates Kif7 Ciliary Trafficking and Hedgehog Signaling


Following Session is for Stem Cells and Cancer (J8)

08:00—11:15
Signaling Pathways in Stem Cells
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Elaine V. Fuchs, HHMI/Rockefeller University, USA

Jürgen A. Knoblich, IMBA - Institute of Molecular Biotechnology, Austria
Using Drosophila as a Model System for Tumorigenesis and Cancer Stem Cells

Nick Barker, Institute of Medical Biology, Singapore
Short Talk: Lgr5+ve Gastric Stem Cells Divide Symmetrically to Effect Epithelial Homeostasis in the Pylorus

Pantelis Rompolas, Yale University School of Medicine, USA
Short Talk: Spatial Organization within a Niche as a Determinant of Stem Cell Fate

Thea D. Tlsty, University of California, San Francisco, USA
Stochastic Cellular States Associated with Malignancy

Geoffrey M. Wahl, The Salk Institute, USA
Investigating Human Breast Cancer through the Lens of Development

E. Alejandro Sweet-Cordero, Stanford University, USA
Identification and Characterization of Tumor Propagating Cells in a Mouse Model of NSCLC

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Signaling Mechanisms and Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Adolfo Ferrando, Columbia University, USA
An Oncogenic Metabolic Switch Mediates Resistance to NOTCH1 Inhibition in T-ALL

Holger Gerhardt, London Research Institute, UK
Dll4/Notch Dynamics in Vascular Branching

* Warren S. Pear, University of Pennsylvania, USA
Targeting the Notch:Myc Axis in Cancer

Madelon M. Maurice, University Medical Center Utrecht, Netherlands
Short Talk: Cancer Mutations Derail Wnt Signalling via Conformational Conversion of the Scaffold Protein Axin


Following Session is for Stem Cells and Cancer (J8)

17:00—19:00
Shared Signals in Stem Cells and Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Thea D. Tlsty, University of California, San Francisco, USA

Philip A. Beachy, HHMI/Stanford University, USA
The Jekyll and Hyde Nature of Hedgehog Signaling in Cancer: Insights from the Urinary Bladder

Carman Man Chung Li, Massachusetts Institute of Technology, USA
Short Talk: The Roles of Pulmonary and Gastrointestinal Developmental Programs in Regulating Lung Cancer Metastasis

Tannishtha Reya, University of California, San Diego, USA
Developmental Pathways in Stem Cells and Cancer

Elaine V. Fuchs, HHMI/Rockefeller University, USA
Signaling of Skin Stem Cells in Homeostasis and Cancer

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, FEBRUARY 4

07:00—08:00
Breakfast

08:00—11:15
Nuclear Responses and Tumorigenesis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jon C. Aster, Brigham and Women's Hospital, USA
Determinants of Notch Target Gene Activation and Notch-“Addiction” in Cancer

Raphael Kopan, University of Cincinnati College of Medicine,, USA
Can We Record the Nuclear Footprints of Notch Signaling in Single Cells?

Mariann Bienz, MRC Laboratory of Molecular Biology, UK
Nuclear Wnt Signaling

Marian Waterman, University of California, Irvine, USA
A New Link Between Wnt, Warburg Metabolism, Stem Cells and Cancer

Henner F. Farin, Hubrecht Institute, Netherlands
Short Talk: Wnt3 Gradient in Intestinal Epithelial Crypts Is Formed by Proliferative Dilution of Membrane-Associated Growth Factor

Joseph Rosenbluh, Broad Institute, USA
Short Talk: Global Detailed Characterization of WNT Dependencies


Following Session is for Stem Cells and Cancer (J8)

08:00—11:15
Cancer Cell of Origin
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* John E. Dick, Princess Margaret Cancer Centre, Canada

Robert J. Wechsler-Reya, Sanford-Burnham Medical Research Institute, USA
Stem Cells and the Origins of Medulloblastoma

Luis F. Parada, University of Texas Southwestern Medical Center, USA
Genetic Mouse Models of Neural Cancer: Unique Insights and Translational Tools for Therapeutic Development

Laetitia J. Seguin, University of California, San Diego, USA
Short Talk: beta3 Integrin/KRAS/RalB Complex Drives Tumor Stemness and Resistance to EGFR Inhibition

Menno J. Oudhoff, Biomedical Research Centre, Canada
Short Talk: Set7 at the Intersection between Hippo/Yap and Wnt/beta-Catenin Signalling in Intestinal Homeostasis, Regeneration and Cancer

Leonard I. Zon, HHMI/Children's Hospital Boston, USA
A Stem Cell Program Triggered at the Onset on Cancer

09:20—09:40
Coffee Break


Following Session is for Stem Cells and Cancer (J8)

11:15—12:30
Roundtable: Preclinical Models and Early Translation

* Craig T. Jordan, University of Colorado, Anschutz Medical Campus, USA

* Tannishtha Reya, University of California, San Diego, USA

Robert S. Kerbel, Sunnybrook Research Institute, Canada
Recapitulating Postsurgical Adjuvant or Metastatic Therapy in Mice as a Strategy to Improve Predicting Clinical Outcomes

Zena Werb, University of California, San Francisco, USA

Luis F. Parada, University of Texas Southwestern Medical Center, USA

David A. Cheresh, University of California, San Diego, USA

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:15
Developmental Pathways and Tumor Initiation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Freddy Radtke, EPFL SV ISREC UPRAD, Switzerland
Tumor Suppressive Roles of Notch in Epithelial Cells

Owen J. Sansom, Beatson Institute of Cancer Research, UK
mTORC1 Is Required Following Apc Loss

Rune C.M. Toftgard, Karolinska Institutet, Sweden
Hedgehog Signal Transduction and Cancer Initiation

Philip H. Jones, Cambridge University, UK
Short Talk: Inhibition of Notch Signaling Confers Clonal Dominance In Esophageal Epithelium


Following Session is for Stem Cells and Cancer (J8)

17:00—19:00
Cancer Stem Cells
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Sean J. Morrison, HHMI/University of Texas Southwestern Medical Center, USA
Hematopoietic Stem Cells Require a Highly Regulated Rate of Protein Synthesis

* John E. Dick, Princess Margaret Cancer Centre, Canada
Complex Mechanisms Underlie Intra-Tumoral Heterogeneity

Robert J. Vanner, Hospital for Sick Children, Canada
Short Talk: Quiescent Therapy Resistant Sox2+ Cells Drive Hierarchical Growth and Relapse in Shh-Subgroup Medulloblastoma

Jeffrey M. Rosen, Baylor College of Medicine, USA
Wnt and Fgf Signaling in Mammary Stem Cells and Breast Cancer

19:15—20:15
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, FEBRUARY 5

07:00—08:00
Breakfast

08:00—11:00
Stem Cells, Development and Cancer (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Tannishtha Reya, University of California, San Diego, USA

* Frederic J. de Sauvage, Genentech, Inc., USA

Cédric Blanpain, Université Libre de Bruxelles, Belgium
Keynote Address: Developmental Pathways Regulating Stemness in Skin Cancers

Roeland Nusse, HHMI/Stanford University, USA
Wnt Signaling and Stem Cell Control

Ciara Metcalfe, Genentech, USA
Short Talk: Lgr5+ Stem Cells are Indispensible for Radiation-Induced Intestinal Regeneration

Catriona H.M. Jamieson, University of California, San Diego, USA
The Niche Specific Role of RNA Editing in Leukemia Stem Cell Generation

David A. Cheresh, University of California, San Diego, USA
Reversing Cancer Stemness and Drug Resistance

09:30—09:50
Coffee Break

11:30—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—17:00
On Own for Lunch and Recreation


Following Session is for Stem Cells and Cancer (J8)

14:30—16:30
Workshop

* Lauren I. R. Ehrlich, University of Texas at Austin, USA

Ho-Chou Tu, Children's Hospital Boston, USA
The Pluripotency Factor LIN28 Promotes Colorectal Tumorigenesis and Progression

Andrew C. White, University of California, Los Angeles, USA
Stem Cell Quiescence Acts as a Tumor Suppressor Mechanism in Hair Follicle Initiated Squamous Tumors

Ching-Cheng Chen, City of Hope National Medical Center, USA
Acute Myeloid Leukemia-Derived Exosomes Transform Bone Marrow Niche into Leukemic Niche

Borhane Guezguez, McMaster Stem Cell and Cancer Research Institute, Canada
Modeling the Human Bone Marrow HSC Niche in vivo

Martin Lackmann, Monash University, Australia
Therapeutic Targeting of EphA3 in the Tumor Microenvironment Inhibits Cancer Growth

Gerald Schwank, Hubrecht Institute, Netherlands
Genome Editing by CRISPR/Cas9 in Intestinal Stem Cell Organoids

16:30—17:00
Coffee Available

17:00—19:00
Developmental Pathways in Cancer and Metastasis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Michael D. Taylor, Hospital for Sick Children, Canada
Heterogeneity and Therapeutic Resistance Amongst the Shh Medulloblastomas

Kimberly Stegmaier, Dana-Farber Cancer Institute, USA
Targeting Mutated NOTCH1 in Cancer

Joerg Huelsken, Ecole Polytechnique Fédérale de Lausanne, Switzerland
Targeting Tumor/Stroma Interactions to Overcome Metastasis

Taran S. Gujral, Harvard Medical School, USA
Short Talk: Wnt5-Fzd2 Signaling Drives Epithelial-Mesenchymal Transition, Tumor Progression, and Metastasis


Following Session is for Stem Cells and Cancer (J8)

17:00—19:15
Cancer in Context: The Microenvironment and Metastasis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jeffrey M. Rosen, Baylor College of Medicine, USA

Zena Werb, University of California, San Francisco, USA
Imaging the Immune Microenvironment in Mammary Development and Cancer

Lauren I. R. Ehrlich, University of Texas at Austin, USA
Short Talk: The Tumor Microenvironment Promotes Tumorigenesis in T-ALL

Jing Yang, University of California, San Diego, USA
Epithelial-Mesenchymal Plasticity in Carcinoma Metastasis

Manuel Valiente, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Serpins Promote Cancer Cell Survival and Vascular Cooption in Brain Metastasis

Carla F. Kim, Children's Hospital, Boston, USA
Microenvironmental Regulation of Lung Stem Cell Differentiation

19:15—20:15
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, FEBRUARY 6

07:00—08:00
Breakfast

08:00—11:15
Emerging Cancer Drug Targets in Development Pathways
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Weilan Ye, Genentech, Inc., USA
The Norrin-Mediated Canonical Wnt Signaling Pathway Regulates Vascular Integrity

Feng Cong, Novartis Institutes for BioMedical Research, USA
Control of Wnt Signaling by Ubiquitin and Tankyrase

Babita Madan, DUKE-NUS Graduate Medical School, Singapore
Short Talk: Novel Porcn Inhibitors Are Safe and Effective in the Treatment of Wnt-Dependent Cancers

Bradley E. Bernstein, Massachusetts General Hospital, Harvard Medical School, USA
Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-Like Cells

Austin Gurney, OncoMed Pharmaceuticals, Inc., USA
Targeting Stem Cell Pathways in Cancer

Raoul C.D.S. Coombes, Imperial College London, UK
Short Talk: Antibodies to Nicastrin inhibit Invasion and Metastasis in Models of Breast Cancer


Following Session is for Stem Cells and Cancer (J8)

08:00—11:15
New Regulatory Pathways in Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Zena Werb, University of California, San Francisco, USA

Andreas Trumpp, German Cancer Research Center, Germany
Mesenchymal and MDS Stem Cells Shape an Interactive Disease Unit in the Bone Marrow

Lewis A. Chodosh, University of Pennsylvania School of Medicine, USA
Mechanisms Controlling Tumor Dormancy and Recurrence

Vishva M. Dixit, Genentech, Inc., USA
Apoptosis and Cancer

Robert MacLeod, Isis Pharmaceuticals, Inc., USA
Short Talk: Preclinical and Early Clinical Evaluation of the Next Generation STAT3 Antisense Oligonucleotide STAT3rx/AZD9150

Daniel S. Pereira, Agensys, Inc, USA
Short Talk: AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody (MMAE) Drug Conjugate as a Potential Therapeutic for Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia

09:20—09:40
Coffee Break

11:15—12:15
Special Lecture: Keynote Address (Joint)

Irving L. Weissman, Stanford University, USA
Reversing Cancer Stemness and Drug Resistance

12:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Targeting Developmental Pathways: Clinical Experience
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Gavin O. Thurston, Regeneron Pharmaceuticals Inc., USA
Blockade of Dll4-Notch Signaling in Tumor Angiogenesis

Jean Y. Tang, Stanford University School of Medicine, USA
Hedgehog Pathway Inhibitor Clinical Trials

* Frederic J. de Sauvage, Genentech, Inc., USA
Innate and Acquired Resistance to Hedgehog Pathways Inhibitors

Lawrence Lum, University of Texas, Southwestern Medical Center, USA
Short Talk: Extra-Mitochondrial Bcl-2 Anti-Apoptotic Proteins Regulate Gli Transcriptional Activity


Following Session is for Stem Cells and Cancer (J8)

17:00—19:15
Targeting Cancer Stem Cells: Trials and Translation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Vishva M. Dixit, Genentech, Inc., USA

Craig T. Jordan, University of Colorado, Anschutz Medical Campus, USA
Targeting Metabolic Properties to More Effectively Eradicate Leukemia Stem Cells

Annette Friebe, Nexigen GmbH, Germany
Short Talk: Drugging the Undruggables - Cell-Permeable Peptide Antagonists Targeting the Wnt Signaling Pathway

Peter Chu, Bionomics Inc., USA
Short Talk: Therapeutic Targeting of Cancer Stem Cells with BNC101, a Functional Anti-LGR5 Monoclonal Antibody

Jeremy N. Rich, Cleveland Clinic, USA
Partners in Crime: Tumor Stem Cells and the Tumor Microenvironment

Michael F. Clarke, Stanford University, USA
Regulation of Normal and Cancer Stem Cell Self Renewal and Senescence by USP16

19:15—20:15
Social Hour with Lite Bites

20:00—23:00
Entertainment


FRIDAY, FEBRUARY 7

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Bayer HealthCare Pharmaceuticals Cell Research
Genentech, Inc. OncoMed Pharmaceuticals, Inc.
Pfizer Inc.
 

We gratefully acknowledge additional support for this conference from:

Bethyl Laboratories, Inc. CEDARLANE
Cell Signaling Technology, Inc. Educational grant from Lilly

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

EMBO (European Molecular Biology Organization)

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676