Keystone Resort Floorplan

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This meeting took place in 2014


Here are the related meetings in 2018:
Frontiers in Islet Biology and Diabetes (B3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Emerging Concepts and Targets in Islet Biology (D3)


Organizer(s) Rohit N. Kulkarni, Raghavendra G. Mirmira and Eckhard Lammert
April 6—11, 2014
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Dec 9, 2013
Abstract Deadline: Jan 14, 2014
Scholarship Deadline: Dec 9, 2013
Discounted Registration Deadline: Feb 5, 2014

Sponsored by Sanofi US.

Summary of Meeting:
This meeting focuses on signaling pathways that impact islet cell physiology via their ability to enhance the function, promote survival and/or increase proliferation of islet cells. This is a crucial area of islet biology that has not been the focus of recent scientific meetings and is therefore timely with respect to new therapeutic approaches to combat diabetes. The meeting includes a discussion of potential drug targets involving islet cells, both localized to the islet milieu and from different organ systems, as well as of genes newly discovered to be involved in islet dysfunction. In addition, since efforts aimed at assessing the efficacy of drug targeting require means to quantitatively assess islet responses in vivo, the meeting includes a session focused on non-invasive assessment of beta cell mass and function. Finally, workshops cover areas of major interest to the scientific community (academia and industry): drug targets currently in clinical trials; stem cell and iPS research investments; and the procurement and distribution of high-quality human islets and pancreas samples for research work.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, APRIL 6

16:00—20:00
Arrival and Registration

Keystone Lodge Lobby
16:00—20:00
Welcome Mixer

Tenderfoot Lounge

MONDAY, APRIL 7

07:00—08:00
Breakfast

Shavano/Torreys
08:00—08:05
Opening Remarks
Meeting has ended...abstracts no longer viewable online.

Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA

Raghavendra G. Mirmira, Indiana University School of Medicine, USA

Eckhard Lammert, Heinrich-Heine-University / German Diabetes Center, Germany

08:05—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Novel Signaling Pathways Relevant for Targeting Metabolism

09:00—11:15
New Insights into Beta Cells Signaling Pathways
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Raghavendra G. Mirmira, Indiana University School of Medicine, USA

Adolfo Garcia-Ocaña, Ichan School of Medicine at Mount Sinai, USA
PKC-Zeta Signaling in the Beta Cell

Carmella Evans-Molina, Indiana University, USA
Regulation of ER Calcium Homeostasis in the Diabetic beta Cell

Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA
New Concepts in Growth Factor Signaling in Islet Cells

Justin P. Annes, Stanford University, USA
Short Talk: Repurposing cAMP-Modulating Medications to Promote beta-Cell Replication

09:00—09:30
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
11:15—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Drug Targets in Clinical Trials

Grays Peak
* Sonya G. Fonseca, Novartis, USA

* Anke Schulte, Sanofi-Aventis, Germany

Dave Smith, AstraZeneca R&D, Sweden
Glucokinase Activators in Clinical Trials

Krister B. Bokvist, Sanofi-Aventis Deutschland GmbH, Germany
A Fixed Duration Combination Treatment with Gastrin and GLP-1 Analogues does not Result in Lasting Post-Treatment Improvements in Glycaemic Control in Type 2 Diabetes Patients

Freimut Schliess, Profil GmbH, Germany
The NMDA Receptor Antagonist Dextromethorphan Reduces OGTT-Related Glycaemia in Patients with T2DM: A Randomized, Double Blind, Placebo-Controlled, Fourfold Cross-Over Clinical Trial

Rowena Suriben, Genentech Inc., USA
Short Talk: Misregulated ETV Protein Levels in Cop1 Mutant beta-Cells Results in Defective Insulin Secretion and Diabetes

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
The Role of Non-Beta Cells in Glucose Homeostasis
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Patrick MacDonald, University of Alberta, Canada

Patrik Rorsman, Oxford Centre for Diabetes, Endocrinology and Metabolism, UK
Signaling in the Regulation of alpha-Cells: Role of Calcium and Ion Channels

Patricia M. Vuguin, Cohen Children's Hospital, North Shore / LIJ, Hofstra University, USA
Lack of Glucagon Receptor Signaling and its Implications beyond Glucose Homeostasis

Jeffrey M. Zigman, University of Texas Southwestern Medical Center, USA
Ghrelin Signaling in Modulation of Alpha Cells

Sofie S. Nielsen, University of Copenhagen, Denmark
Short Talk: The Effect of Bone Morphogenetic Protein 4 (BMP4) on Pancreatic Alpha Cell Function

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 1

Shavano/Torreys

TUESDAY, APRIL 8

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Novel Drug Targets to Enhance Beta Cell Function
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Maureen Gannon, Vanderbilt University, USA

Eckhard Lammert, Heinrich-Heine-University / German Diabetes Center, Germany
Targeting NMDA Receptors in Pancreatic Islets: A Novel Adjunct Treatment for Type 2 Diabetes

Bridget Wagner, Broad Institute, USA
Small Molecule-Induced Human Beta-Cell Proliferation

Vijay K. Yechoor, University of Pittsburgh, USA
Talk Title to be Announced

Mehboob Hussain, Johns Hopkins University School of Medicine, USA
A Liver-Derived Endocrine Inhibitor of Beta-Cell Function

Heiko Lickert, Institute of Diabetes and Regeneration, Germany
Short Talk: Targeting beta-Cell Heterogeneity in the Islet of Langerhans

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
11:00—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Update on Investments in Stem Cell and iPS Research

Grays Peak
* Melissa K. Thomas, Lilly Research Laboratories, USA

Mark C. Zimmerman, Janssen Research & Development, USA
Overview of the Use of ES and iPS Cells for Therapeutics

Jennifer E. Bruin, University of British Columbia, Canada
Treating Diabetes with Islets Derived from Human Embryonic Stem Cells

Adrianne Wong, Juvenile Diabetes Research Foundation, USA
Investments/Interests on iPS/ES Cells for Therapy

Brian Lu, Mayo Clinic, USA
Short Talk: Beta-Cell Targeted Gene Delivery for Enhanced beta-Cell Proliferation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Novel Drug Targets to Preserve and/or Promote Proliferation of Beta Cells
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Nils Billestrup, University of Copenhagen, Denmark

Raghavendra G. Mirmira, Indiana University School of Medicine, USA
The Role of Deoxyhypusine Synthase and mRNA Translation during beta Cell Stress

Maureen Gannon, Vanderbilt University, USA
Connective Tissue Growth Factor-Mediated Beta-Cell Proliferation and Regeneration

Fumihiko Urano, Washington University School of Medicine, USA
Targeting Endoplasmic Reticulum for Combating Wolfram Syndrome and Type 1 Diabetes

Karim Bouzakri, Geneva University, Switzerland
Short Talk: Protective Effects of Fractalkine (CX3CL1) on beta-Cells

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 2

Shavano/Torreys

WEDNESDAY, APRIL 9

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Targeting Extra-Pancreatic Tissues to Regulate Beta Cell Biology - Systemic Communication
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA

Gerard Karsenty, Columbia University Medical Center, USA
Insulin Resistance in Bone: Molecular Bases and Metabolic Consequences

Josephine Egan, NIA, National Institutes of Health, USA
Significance of Targeting Cannabinoids in the Periphery to Regulate Beta-Cell Function and Survival

Peng Yi, Joslin Diabetes Center, USA
Betatrophin

Rupangi C. Vasavada, Icahn School of Medicine at Mount Sinai, USA
A Novel Circulating Bone-Related Factor in the Regulation of Beta-Cells

Abdelfattah El Ouaamari, Joslin Diabetes Center, USA
Short Talk: Identification of a Novel beta-Cell Growth Factor Derived from the Liver

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
11:00—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Targeting Local Innervation and Vascularization to Regulate Beta Cell Biology - Intra-Islet Communication
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Eckhard Lammert, Heinrich-Heine-University / German Diabetes Center, Germany

Alejandro Caicedo, University of Miami, USA
Human Pancreatic Islets Are Less Nervous and More Self-Sufficient

Per-Ola Carlsson, Uppsala University, Sweden
Influence of Vascularization on Beta Cell Function and Mass

Marcela Brissova, Vanderbilt University, USA
Targeting Islet Vascularization to Regulate Beta Cell Biology

Richard KP Benninger, University of Colorado, USA
Short Talk: A Critical Balance between KATP Activity and Gap Junction Coupling Determines Islet Dysfunction and Diabetes

19:00—20:00
Social Hour with Lite Bites

Shavano/Torreys
19:30—22:00
Poster Session 3

Shavano/Torreys

THURSDAY, APRIL 10

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Non-Invasive Assessment of Beta Cell Function and Mass
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Stephan Speier, Technische Universität Dresden, Germany

Olof Eriksson, Uppsala University, Sweden
The Glucagon Like Peptide-1 Receptor as an Imaging Biomarker of Beta Cell Mass

Markus Stoffel, ETH Zürich, Switzerland
MicroRNAs in Beta Cells: Function and Diagnostic and Therapeutic Implications

Eckhard Wolf, Ludwig-Maximilians-Universität (LMU) Munich, Germany
The GIPRdn Pig as a Model to Identify Biomarkers of Subclinical Diabetes

Kevan C. Herold, Yale University, USA
Insulin Gene Methylation as a Marker of Beta Cell Death

Chunguang Chen, Technische Universität Dresden, Germany
Short Talk: In vivo Kinetics of Islet Compensation and Dysfunction in a Mouse Model of Diet-Induced Obesity and Insulin Resistance

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 3: Human Islet Procurement and Distribution

Grays Peak
Barbara Olack, City of Hope, USA
Perspectives from the Distributor: Logistics and Obstacles to Human Islet Isolation and Distribution

* Andrew F. Stewart, Mount Sinai School of Medicine, USA
Perspective from the User on Availability of High Quality Human Islets for Research

Andrew Rakeman, Juvenile Diabetes Research Foundation, USA
On the Importance of Studying Human Disease: Pancreas from Patients with T1D and the JDRF-nPOD Program

Julie Donaldson, ALPCO, USA
Short Talk: Development of Novel Broad Range, Highly Sensitive, Small Volume Chemiluminescent Assays for Beta-Cell Profiling

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Novel Genes Involved in Islet Dysfunction
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Markus Stoffel, ETH Zürich, Switzerland

Alan D. Attie, University of Wisconsin-Madison, USA
Sorcs1: From Diabetes QTL to Cellular Function

Michael German, University of California, San Francisco, USA
Transcriptional Cascade Controlling Beta-Cell Differentiation

Charlotte A. Ling, Lund University, Sweden
TFBM1 and its Variants as Regulators of Islet Function and Development of Diabetes

Franck Mauvais-Jarvis, Tulane University Health Sciences Center, USA
Short Talk: Novel Actions of the Androgen Receptor in Glucose-Stimulated Insulin Secretion in Males

19:00—19:05
Closing Remarks
Meeting has ended...abstracts no longer viewable online.

Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA

Raghavendra G. Mirmira, Indiana University School of Medicine, USA

Eckhard Lammert, Heinrich-Heine-University / German Diabetes Center, Germany

19:05—20:00
Social Hour with Lite Bites

Shavano/Torreys
20:00—23:00
Entertainment

Shavano/Torreys

FRIDAY, APRIL 11

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Sanofi US

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK084688-05

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

ALPCO Diagnostics

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Novartis Institutes for BioMedical Research


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676