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This meeting took place in 2014



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Epigenetic Programming and Inheritance (D2)


Organizer(s) Joseph H. Nadeau, Marisa S. Bartolomei, Peter Gluckman and Wolf Reik
April 6—10, 2014
Boston Park Plaza • Boston, Massachusetts USA
Discounted Abstract Deadline: Dec 5, 2013
Abstract Deadline: Jan 14, 2014
Scholarship Deadline: Dec 5, 2013
Discounted Registration Deadline: Feb 4, 2014

Supported by the Directors' Fund

Summary of Meeting:
Epigenetics is emerging as a fundamentally important area of biological and medical research with implications for our understanding of developmental and physiological processes, for childhood and adult disease, as well as for an unexpected and important new mode of inheritance. Epigenetics deals with phenotypic changes that are independent of the underlying DNA sequence. These mechanisms modulate gene expression, RNA biology and protein function throughout development and adulthood and are strongly influenced by both genetic and environmental factors. Anomalies can lead to birth defects, metabolic disease, cancer and behavioral changes. Recent evidence shows that epigenetic features can be transmitted across generations, suggesting that molecular changes in addition to DNA sequence differences control phenotypic variation and disease risk and therefore that epigenetics might be as important as genetics in organismal biology. This meeting will bring together both established researchers and rising stars; for the first time individuals focusing on molecular mechanisms can interact with those studying population consequences, with the hope that these two communities will begin to work together to understand epigenetics in the context of health and disease.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, APRIL 6

16:00—20:00
Arrival and Registration

18:00—20:00
Welcome Mixer


MONDAY, APRIL 7

07:30—08:30
Breakfast

08:00—08:30
Poster Setup

08:30—17:00
Poster Viewing

08:30—11:45
Epigenetic and Epigenomic Mechanisms I. Session sponsored by the journal, Development.
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Support for these organizer-selected speakers generously provided by this journal.

Joseph H. Nadeau, Pacific Northwest Research Institute, USA
Introduction and Welcome Remarks

* Bradley R. Cairns, HHMI/University of Utah, USA

Wolf Reik, Babraham Institute, UK
The Role of DNA Modifications in Epigenetic Reprogramming and Signaling

Gavin D. Kelsey, Babraham Institute, UK
DNA Methylation Establishment in the Germline

Alexander Meissner, Harvard University, Broad Institute, USA
DNA Methylation Dynamics in Stem Cells and Development

Antoine H.F.M. Peters, Friedrich Miescher Institute for Biomedical Research, Switzerland
Epigenetic Control of Mammalian Germ Line and Early Embryonic Development

Bluma J. Lesch, Whitehead Institute for Biomedical Research, USA
Short Talk: Genes Central to Embryogenesis Retain a Poised Chromatin State during Mammalian Germ Cell Development

Jerome Jullien, CRUK Wellcome Trust Gurdon Institute, UK
Short Talk: Sperm Is Programmed to Support Transcription of Developmentally-Important Embryonic Genes

09:50—10:10
Coffee Break

11:45—12:30
Lunch

12:00—14:30
Poster Session 1

16:30—17:00
Coffee Available

17:00—19:00
Epigenetic and Epigenomic Mechanisms II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Wolf Reik, Babraham Institute, UK

Bradley R. Cairns, HHMI/University of Utah, USA
Chromatin Strategies for Maintaining Pluripotency in Adult Germline Stem Cells and Mammalian Spermatogenesis

Mitinori Saitou, Graduate School of Medicine, Kyoto University, Japan
Mechanism and Reconstitution in vitro of Germ Cell Development in Mice

Eric L. Greer, Harvard Medical School, USA
Short Talk: A Histone Methylation Network Regulates Transgenerational Epigenetic Memory in C. elegans

19:00—
On Own for Dinner


TUESDAY, APRIL 8

07:30—08:30
Breakfast

08:30—11:45
Transgenerational Inheritance and Imprinting I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Joseph H. Nadeau, Pacific Northwest Research Institute, USA

Marisa S. Bartolomei, University of Pennsylvania Perelman School of Medicine, USA
Endocrine Disrupting Chemicals Exposure in Mouse: Genomic Imprinting, Physiology and Transgenerational Inheritance

Anne C. Ferguson-Smith, University of Cambridge, UK
Genomic Imprinting

John A. Stamatoyannopoulos, University of Washington, USA
Epigenetics and GWAS

Anne Brunet, Stanford University, USA
Metabolic and Epigenetic Regulation of Aging

Nicole L. Yohn, University of Pennsylvania, Perelman School of Medicine, USA
Short Talk: The Multigenerational Interaction of Nicotine and Chronic Stress on Anxiety and Stress Sensitivity in Mice

Brian G. Dias, Emory University, USA
Short Talk: Transgenerational Inheritance of Ancestral Olfactory Experience

09:50—10:10
Coffee Break

11:45—12:45
Career Development Workshop - “How to Choose Your Next Lab or Workplace”
"Choose Your Next Lab or Workplace” Grad students and postdocs frequently don’t choose a lab as if it were a major career decision, yet they spend 4-7 years working for one person in a small group. Choosing a lab is definitely worth a little preparation to make sure it will be a good fit and get junior investigators close to where they want to go in the future. This presentation gives practical tips about what to look for and how to find it when choosing a new lab. While geared to junior scientists, this talk will also help advisors understand their lab culture. Presented by Joanne Kamens, Ph.D., Executive Director, Addgene.

11:45—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:45—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Transgenerational Inheritance and Imprinting II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Marisa S. Bartolomei, University of Pennsylvania Perelman School of Medicine, USA

Oliver J. Rando, University of Massachusetts Medical School, USA
Paternal Effects on Gene Regulation in Mammals

Ueli Grossniklaus, University of Zürich, Switzerland
Epigenetic Maternal Regulation of Seed Development

Joseph H. Nadeau, Pacific Northwest Research Institute, USA
The Genetics of Epigenetic Inheritance

Louise E. Docherty, University of Southampton, UK
Short Talk: Using Genome-Wide DNA Methylation Analysis of Patients with Complex Imprinting Disorders to Identify Novel Candidate Imprinted Genes

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, APRIL 9

07:30—08:30
Breakfast

08:30—11:30
Developmental Origins and Epigenetic Epidemiology I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Terrence Forrester, University of the West Indies, Jamaica

Peter Gluckman, University of Auckland, New Zealand
Epigenetic Epidemiology: Its Application to the Challenge of the Developmental Origins of Health and Disease Hypothesis

Caroline L. Relton, Newcastle University, UK
Epigenetic Biomarkers and Causality in Complex Disease

Jonathan Mill, University of Exeter Medical School and King's College London, UK
Epigenetic Trajectories to Neuropsychiatric Disease

Bas T. Heijmans, Leiden University Medical Centre, Netherlands
The Prenatal Epigenome and Studies into Long-Term Health

Soetkin Versteyhe, Copenhagen University, Denmark
Short Talk: Obese Human have an Altered Spermatozoal Small RNA Expression Profile - Possible Contributors of Epigenetic Inheritance

09:50—10:10
Coffee Break

11:30—12:00
Workshop on Biological Applications of Epigenetics
Epigenetics methods and thinking are increasingly applied in many areas of exciting contemporary biology, such as developmental programming, neurosciences, and metabolic disorders. This discussion session explores links between the disciplines and how choice of methods and quality standards is important so that results can be widely compared, increasing confidence in the conclusions.

* Marisa S. Bartolomei, University of Pennsylvania Perelman School of Medicine, USA

* Wolf Reik, Babraham Institute, UK

12:00—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Developmental Origins and Epigenetic Epidemiology II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Peter Gluckman, University of Auckland, New Zealand

Terrence Forrester, University of the West Indies, Jamaica
Long-Term Consequences of Early-Life Malnutrition: Developmental Context

Cheryl L. Walker, Texas A&M Health Science Center, USA
Developmental (re)Programming by Endocrine Disruptors: Environmental Cross-Talk with the Epigenetic Machinery

Krishnendu Mukherjee, Fraunhofer Institute for Molecular Biology and Applied Ecology, Germany
Short Talk: Epigenetic Changes during Pathogen Infections, Trans-Generational Immune Priming and Metamorphosis in the Insect Model Galleria Mellonella

Marine Baptissart, INSERM, France
Short Talk: Paternal Bile Acids Exposure: a Dark Messenger throughout Generations

Mara C. Inniss, Harvard Medical School, USA
Short Talk: Synthetic Cellular Memory for Tracking Human Cell Fate

19:00—20:00
Social Hour with Lite Bites

20:00—23:00
Entertainment


THURSDAY, APRIL 10

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge additional support for this conference from:

Development, The Company of Biologists Ltd Escher Fund for Autism
Landes Bioscience March of Dimes Foundation Grant No. 4-FY14-469
Zymo Research Corporation
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



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