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Windsor Barra Hotel Floorplan

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This meeting took place in 2014



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Advancing Vaccines in the Genomics Era (T1)


Organizer(s) Bali Pulendran, Chris Wilson and Rino Rappuoli
October 31—November 4, 2013
Windsor Barra Hotel • Rio de Janeiro, Barra da Tijuca, Brazil
Discounted Abstract Deadline: Jun 27, 2013
Abstract Deadline: Jul 30, 2013
Scholarship Deadline: Jun 27, 2013
Discounted Registration Deadline: Aug 29, 2013

Sponsored by FAPERJ – Rio de Janeiro State Agency for Research Development. Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation.

Summary of Meeting:
A direct consequence of the Human Genome Project has been the development of so-called “omic” technologies (e.g. genomics, proteomics) that can be used to probe the molecular networks that control biological systems. Such technologies are beginning to be applied to vaccinology to obtain deeper insights about the molecular networks that orchestrate protective immunity induced by vaccination in humans. Such systems biological approaches are enhancing our understanding of the correlates of protective immunities, of the early innate immune signatures of vaccine efficacy, and guiding the rational design of novel and safer vaccines and adjuvants. This meeting will explore the potential of systems biology in vaccine design and development. Participants will include vaccinologists, immunologists, virologists, microbiologists, scientists using systems approaches in other areas of biomedical research, as well as individuals working in industry and health policy who are interested in the potential of genomics in vaccinology. The meeting will address how systems biology has provided insight into the immune response to vaccines, and will also discuss the technical and bioinformatic challenges associated with using systems biology approaches. Researchers will show 'systems vaccinology' approaches can be implemented in vaccine development and clinical trial monitoring.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, OCTOBER 31

16:00—20:00
Arrival and Registration


FRIDAY, NOVEMBER 1

07:30—08:30
Breakfast

08:30—11:15
Genetic Dissection of Immunity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Rafick-Pierre Sékaly, VGTI - Florida, USA

* J. Christopher Love, Massachusetts Institute of Technology, USA

Daniel Kastner, National Institutes of Health, USA
Understanding Human Immunity from Experiments of Nature

Thomas R. Hawn, University of Washington, USA
Genetic Dissection of Innate Immunity during BCG Vaccination

Mary Carrington, Frederick National Laboratory for Cancer Research, USA
Immunogenetics of Spontaneous Control of HIV

Petter Brodin, Stanford University, USA
Short Talk: Separating Genetic and Environmental Influences in the Human Immune System

Tomer Hertz, Fred Hutchinson Cancer Research Center, USA
Short Talk: HLA A*02 Modifies Vaccine Efficacy in the RV144 Thai Trial

09:20—09:40
Coffee Break

11:15—12:15
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Chris Wilson, Bill & Melinda Gates Foundation, USA

Rino Rappuoli, Novartis Vaccines and Diagnostics, Italy
Designing Vaccines for the 21st Century Society

12:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

14:30—16:00
Workshop 1: Immunity to Infections

* Andrew B. Ward, The Scripps Research Institute, USA

* Tomer Hertz, Fred Hutchinson Cancer Research Center, USA

Elizabeth Ernestina Godoy-Lozano, Instituto Nacional de Salud Pública, Mexico
B Cells Repertoire Analysis in Patients with Dengue Fever and Dengue Hemorrhagic Fever

Duane R. Wesemann, Brigham and Women's Hospital, USA
Microbial Colonization Influences Primary Immunoglobulin Diversification in the Gut Lamina Propria

Shaikh Meshbahuddin Ahmad, International Centre for Diarrhoeal Disease Research (icddr,b)
Vitamin A Supplementation during Pregnancy Interfere Passive Influenza Antibody Transfer to Infants

Juan C. Alvarez, Universidad de Antioquia, Colombia
Using Reverse Vaccinology to Identify Antigen Candidates for a Molecularly-Defined Vaccine Against Leishmania (Viannia) panamensis

Arman Bashirova, SAIC-Frederick, USA
LILRB2 Interaction with HLA Class I Correlates with Control of HIV-1 Infection

16:00—16:30
Coffee Available

17:30—19:30
Genomics of T Cell Responses to Vaccination
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland

* Scott D. Boyd, Stanford University, USA

Rafi Ahmed, Emory University School of Medicine, USA
Vaccination and Immune Memory

Rafick-Pierre Sékaly, VGTI - Florida, USA
Inflammation, a Driver of the Immune Response to Vaccines

J. Christopher Love, Massachusetts Institute of Technology, USA
Microtools for Probing T Cell Responses

Arno C. Andeweg, Erasmus MC, Netherlands
Short Talk: Dendritic Cell Vaccination of HIV-Infected Individuals Results in a Major and Sustained Shift of the Blood Transcriptome

19:30—20:30
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


SATURDAY, NOVEMBER 2

07:30—08:30
Breakfast

08:30—11:30
Systems Biological Approaches to Vaccination
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ofer Levy, Children's Hospital Boston, USA

* Jorg J. Goronzy, Stanford University School of Medicine, USA

Bali Pulendran, Emory University, USA
Systems Vaccinology

Alan Aderem, Seattle BioMed, USA
Systems Vaccinology: Using the Tools of Systems Biology to Enable Rational Vaccine Design

Mark M. Davis, Stanford University, USA
New Approaches and Analyses of Influenza Vaccination

Danilo R. Casimiro, Merck & Co. Inc, USA
Genome-Wide Transcriptional Analyses for Biomarker Discovery in Vaccine R&D

Junichi Ito, National Institute of Biomedical Innovation (NIBIO)
Short Talk: A Comprehensive Analysis of miRNA Expression Profile in Human Serum Collected from Type-A Influenza Vaccine Clinical Trial

09:40—10:00
Coffee Break

11:30—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Immunity to Vaccines

* Petter Brodin, Stanford University, USA

* Hana Golding, Center for Biologics Evaluation and Research, US Food and Drug Administration, USA

Helder I. Nakaya, Emory University, USA
Large Scale Network Modeling Reveals Distinctive Transcriptomic Programs in Vaccine Antibody Response

Luis M. Franco, Baylor College of Medicine, USA
Integrative Genomic Analysis of the Human Immune Response to Influenza Vaccination

Katie L. Flanagan, Monash University, Australia
Temporal Heterogeneity in the Systemic Immune Pathway Response to Measles Vaccination

Magali Matsumiya, University of Oxford, UK
The Immune Response to MVA85A in Infants

Gabriel C. Wu, University of Texas, Austin, USA
A Proteomic Analysis of the Human Antibody Response to the Seasonal Trivalent Influenza Vaccine

Anwar Hashem, King Abdulaziz University, Saudi Arabia
A Universal Influenza Vaccine Based on the HA2 Subunit of the Viral Hemaggultinin

Sylvie Bertholet, Novartis Vaccines and Diagnostics, Italy
Reinventing the Gene Vaccine: SAM® Vaccine Against Influenza

16:30—17:00
Coffee Available

17:00—19:15
Genomics of Antibody Responses to Vaccination
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Mark M. Davis, Stanford University, USA

* Scott Presnell, Benaroya Research Institute, USA

Scott D. Boyd, Stanford University, USA
Deep Sequencing of Human Antibody Repertoires during Influenza Vaccination Shows Convergent Antibody Rearrangements and Seroconversion Signatures

Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Dissecting the Antibody Response to Pathogens and Self Antigens

Hana Golding, Center for Biologics Evaluation and Research, US Food and Drug Administration, USA
Expanding the Antibody Repertoire and Avidity with Adjuvants

Brandon J. DeKosky, University of Texas, Austin, USA
Short Talk: Vaccine Response Analysis by High-Throughput Sequencing of the Paired Human Immunoglobulin Heavy and Light Chain Repertoire

Frances Eun-Hyung Lee, Emory University, USA
Short Talk: Heterogeneity of Antibody Secreting Cell Subsets in Blood after Vaccination and Bone Marrow in Healthy Adults: Identification of Human Long-Lived Plasma Cells

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


SUNDAY, NOVEMBER 3

07:30—08:30
Breakfast

08:30—11:30
Genomic and Structural Approaches to Antigen and Adjuvant Discovery, Design and Validation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Bonnie B. Blomberg, University of Miami School of Medicine, USA

* Danilo R. Casimiro, Merck & Co. Inc, USA

Peter D. Kwong, NIAID, National Institutes of Health, USA
Structural Vaccinology

Ian A. Wilson, The Scripps Research Institute, USA
Structural Insights into HIV and Influenza Antigen Design

Rhea N. Coler, Infectious Disease Research Institute, USA
Reverse Vaccinology for TB Antigen Discovery

Scott Presnell, Benaroya Research Institute, USA
Module Repertoire Analysis Applied to Vaccine Response Studies

Charalambos (Harry) D. Partidos, Inviragen, USA
Short Talk: Dissecting the Immune Responses to DENVax, a Novel Tetravalent Dengue Vaccine

09:40—10:00
Coffee Break

11:30—13:00
Poster Setup

13:00—22:00
Poster Viewing

 
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Lessons to Be Learned from Other Fields
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Chris Wilson, Bill & Melinda Gates Foundation, USA

* Rhea N. Coler, Infectious Disease Research Institute, USA

Mauro Martins Teixeira, Universidade Federal de Minas Gerais, Brazil
Mechanisms of Resistance and Disease in Dengue Infection

Ricardo T. Gazzinelli, Fundação Oswaldo Cruz-CPqRR, Brazil
Exploring Multi-Copy Gene Families in the Development of Trypanosoma cruzi as a Live Attenuated Vaccine Vector

Adrian V. S. Hill, Jenner Institute, University of Oxford, UK
Can Genes Help Design New Vaccines?

Andrew B. Ward, The Scripps Research Institute, USA
Short Talk: Cryo-EM Studies of HIV-1 Env

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 3


MONDAY, NOVEMBER 4

07:30—08:30
Breakfast

08:30—11:30
Immunology of Vaccination in the Young and Elderly
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Rino Rappuoli, Novartis Vaccines and Diagnostics, Italy

* Robert L. Coffman, Dynavax Technologies, USA

Jorg J. Goronzy, Stanford University School of Medicine, USA
Dissecting the T Cell Response in the Elderly

Bonnie B. Blomberg, University of Miami School of Medicine, USA
Biomarkers of Vaccine Efficacy in the Elderly

Ofer Levy, Children's Hospital Boston, USA
Microphysiologic Modeling of Immune Responses to Inform Age-Specific Vaccine Development

Andrew J. Pollard, University of Oxford, UK
Transcriptional Signatures of Adjuvanted Influenza Vaccines in Children

Thomas J. Scriba, University of Cape Town, South Africa
Short Talk: Correlates of Progression from Mycobacterium tuberculosis Infection to Tuberculosis Disease in Adolescents

09:40—10:00
Coffee Break

11:30—12:30
Lunch

12:30—14:30
Translation of Immunological Concepts to the Clinic
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ian A. Wilson, The Scripps Research Institute, USA

* Andrew J. Pollard, University of Oxford, UK

Lynda G. Tussey, VaxInnate Corporation, USA
Modifying the Agonist Properties of Flagellin to Improve Vaccine Performance

Ennio De Gregorio, Novartis Vaccines and Diagnostics, Italy
Vaccine Adjuvants: From Empiricism to Rational Design

Robert L. Coffman, Dynavax Technologies, USA
Advancing TLR9 Ligands as Vaccine Adjuvants in Humans

Wayne C. Koff, International AIDS Vaccine Initiative, USA
Short Talk: The Case for a Human Vaccines Project to Accelerate Global Disease Prevention

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Bill & Melinda Gates Foundation
FAPERJ – Rio de Janeiro State Agency for Research Development


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI108157-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Dynavax Technologies Corporation


Novartis Vaccines and Diagnostics


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676