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This meeting took place in 2014


Here are the related meetings in 2018:
T Cell Dysfunction, Cancer and Infection (A3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Tissue-Resident Memory T Cells (A4)


Organizer(s) Cornelia L. Trimble, Rachael A. Clark, Leo Lefrançois (in memoriam) and David Masopust
January 12—16, 2014
Snowbird Resort • Snowbird, Utah USA
Discounted Abstract Deadline: Oct 3, 2013
Abstract Deadline: Oct 28, 2013
Scholarship Deadline: Oct 3, 2013
Discounted Registration Deadline: Nov 13, 2013

Sponsored by BioLegend, Inc. Supported by an educational donation provided by Amgen.

Summary of Meeting:
Infections that are encountered through epithelial barrier tissues such as the skin, gut, lung and genitourinary tract generate a population of tissue-resident T cells that remain sessile long-term in the affected tissue, and are protective against re-infection. Indeed, most effector memory T cells reside in non-sterile barrier epithelial tissues, as opposed to the circulation. While tissue-resident T cells play a critical role in defending against infections and cancer, aberrant activation of these cells gives rise to inflammatory and autoimmune conditions, including psoriasis, multiple sclerosis and inflammatory bowel disease. Tissue-resident T cells are not simply T cells in an unexpected location; these cells have many phenotypic and functional differences that distinguish them from circulating T cells. This conference will bring together basic and translational immunologists to discuss tissue-localized mechanisms of immune cell recruitment, retention, activation and homeostasis. The major objectives will be to: 1) Explore the roles that tissue immune cells play in immune surveillance, including recall responses to infectious pathogens, and mechanisms of dysregulation leading to autoimmune disease; 2) Examine the mechanisms by which immune responses can be shaped by the local tissue microbiome; 3) Investigate the mechanisms by which immune responses can be subverted by chronic infections or early neoplastic lesions; and 4) Discuss the rationale for immunotherapeutic strategies targeting specific tissue sites. A better understanding of the biology of tissue-resident T cells will inform vaccination strategies for both infections and cancer, as well as novel therapies for inflammatory and autoimmune diseases.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 12

16:00—20:00
Arrival and Registration

Ballroom Lobby

MONDAY, JANUARY 13

07:00—08:00
Breakfast

Ballroom 1-2
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
Peter C. Doherty, University of Melbourne, Australia
Thinking about Memory

09:00—11:30
Tissue-Resident T Cells: What Are the Questions?
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Philip D. Greenberg, University of Washington, USA

Wolf-Hervé Fridman, Cordeliers Research Centre, France
Role of Tumor-Associated Tertiary Lymphoid Structures in the Generation and Shaping of Cancer-Controlling T Lymphocytes

Harlan Robins, Fred Hutchinson Cancer Research Center, USA
Immunosequencing Tumor-Infiltrating Lymphocytes in Ovarian and Colon Tumors

Nelson Glennie, University of Pennsylvania, USA
Short Talk: The Role of Skin-Localized Memory CD4 T Cells in Protection against Leishmania major

Jenny Thom, ETH Zürich, Switzerland
Short Talk: Cytomegalovirus Infection Results in the Formation of CD8+ and CD4+ Tissue Resident Memory T Cells in the Salivary Glands

Thomas S. Kupper, Brigham and Women's Hospital, USA
Barrier Epithelial Tissues as Immune Organs

11:30—00:30
Navigating NIAID: Funding Priorities, Processes and Resources

Ballroom 3
* Cheryl Lapham†, NIAID, DHHS, National Institutes of Health, USA

* Halonna Kelly, Division of Allergy, Immunology, and Transplantation, National Institutes of Health, USA

09:40—10:00
Coffee Break

Ballroom Lobby
11:30—13:00
Poster Setup

Ballroom 1-2
13:00—22:00
Poster Viewing

Ballroom 1-2
11:30—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1

Ballroom 3
Joshua T. Schiffer, Fred Hutchinson Cancer Research Center, USA
Contribution of Decay and Movement to CD8+ T-Cell Decline from Genital Tract Micro-Regions following Clearance of HSV-2 Infected Cells: Predictions from a Mathematical Model

Georg Stary, Harvard Medical School, USA
Induction of Tissue-Resident Memory CD4+ T Cells in the Genital Tract by Intranasal Application of a Nanoparticle-Based Chlamydia Vaccine

Elizabeth L. Frost, Pennsylvania State University College of Medicine, USA
Requirements for the Development and Maintenance of Mouse Polyomavirus-Specific Brain Resident Memory CD8+ T Cells

Tyler A. Landrith, University of California, Riverside, USA
Characterization of CD103+ CD8+ T Cell Populations Present in the Brain during Chronic Toxoplasma gondii Infection

Jennifer M. Lund, Fred Hutchinson Cancer Research Center, USA
Regulatory T Cells Shape the Resident Memory T Cell Response to Virus Infection in the Tissues

Pablo A. Romagnoli, University of Connecticut Health Center, USA
Memory gammadelta T Cells Orchestrate Response to Secondary Oral Lm Infection

* Marion Pepper, University of Washington, USA
Visualizing Allergen-Specific Lung-Resident CD4+ Th2 Memory Cells in Asthma

Kristin Anderson, University of Washington, USA
Recirculation and Residence of Memory CD8 T Cells in the Murine Lung

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Site-Specific: Reproductive Tract Mucosa
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Cornelia L. Trimble, Johns Hopkins University School of Medicine, USA
Tissue T Cells in Preinvasive HPV Disease

Nicolas Cuburu, NCI, National Institutes of Health, USA
Intravaginal Vaccination with Human Papillomavirus Vectors Against Herpes Simplex Virus 2 Infection

Norifumi Iijima, Yale University School of Medicine, USA
Short Talk: A Local Chemokine Network Sustains Tissue-Resident Memory T Cells Crucial for Antiviral Protection

Lawrence Corey, Fred Hutchinson Cancer Research Center, USA

19:00—20:00
Social Hour with Lite Bites

Ballroom 1-2
19:30—22:00
Poster Session 1

Ballroom 1-2

TUESDAY, JANUARY 14

07:00—08:00
Breakfast

Golden Cliffs/Eagles
08:00—11:15
Imprinting and Plasticity
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA
Transcriptional Basis of Dendritic Cell Diversity in T Cell Priming

David Masopust, University of Minnesota, USA
Characterization of Tissue-Resident Memory CD8 T Cells in Mice: Distribution, Differentiation, and Function

Brian J. Laidlaw, University of California, San Francisco, USA
Short Talk: CD4 Help Is Critical for the Formation of Tissue Resident Memory T Cells following Influenza Infection

Naomi A. Yudanin, Weill Cornell Medical College, USA
Short Talk: Mechanisms of Lung-Resident Memory CD4 T Cell Migration and Retention

Stephen C. Jameson, University of Minnesota Medical School, USA
Putting T Cells in their Place

* Marc K. Jenkins, University of Minnesota Medical School, USA
Origins of CD4+ Memory T Cells

09:20—09:40
Coffee Break

Ballroom Lobby
11:15—13:00
Poster Setup

Superior/Superior Lobby
13:00—22:00
Poster Viewing

Superior/Superior Lobby
11:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:15
Site-Specific: GI Tract
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* David Masopust, University of Minnesota, USA

Yasmine Belkaid, NIAID, National Institutes of Health, USA
Compartmentalized and Systemic Control of Tissue Immunity by Commensals

Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA
From Transcription Factors to Defense Mechanisms: Different Rules Apply for Mucosal Effector Memory T Cells

Livija Deban, Oxford BioTherapeutics, UK
Short Talk: RGS1 Is a Major Regulator of Intestinal TRM Cell Responsiveness

Charisse Petersen, University of Utah, USA
Short Talk: Direct Recognition of Commensals by T Cells Promotes Microbiota Selection by IgA to Prevent Dysbiosis

Gregory F. Sonnenberg, University of Pennsylvania, USA
Regulation of Host-Commensal Bacteria Relationships in Human Health and Disease

19:15—20:15
Social Hour with Lite Bites

Superior/Superior Lobby
19:30—22:00
Poster Session 2

Superior/Superior Lobby

WEDNESDAY, JANUARY 15

07:00—08:00
Breakfast

Ballroom 2
08:00—11:15
Site-Specific: Skin
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Rachael A. Clark, Brigham and Women's Hospital, Harvard Medical School, USA
Unique Features of Human Skin Resident T Cells

Wendy L. Havran, The Scripps Research Institute, USA
Crosstalk between Skin-Resident T Cells and their Neighbors

Shruti Naik, Rockefeller University, USA
Short Talk: Specific Commensal-Dendritic Cell Crosstalk Promotes Cutaneous IL-17A+ CD8 T Effectors

Erika J. Crosby, Duke University, USA
Short Talk: Bystander CD8 T Cells in the Skin Promote Increased Disease Severity during Leishmania Major Infection

Laura K. Mackay, University of Melbourne, Australia
Generation of Epithelial Resident Memory T Cells

Frank Oliver Nestle, Sanofi, USA
Regulation of Skin T Cells in Skin Homeostasis and Pathology

09:20—09:40
Coffee Break

Ballroom Lobby
11:15—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2

Ballroom 3
* Donna L. Farber, Columbia University Medical Center, USA

Marcia A. Blackman, Trudeau Institute, USA
Effect of Aging on Tissue-Resident Memory to Influenza Virus

Shiki Takamura, Kinki University Faculty of Medicine, Japan
CD69 Enhances the Recruitment of Memory CD8+ T Cells to the Lung Airways by Inhibiting S1P-Mediated Lymphocyte Egression from the Lung Parenchyma

Shalini Sharma, St. Jude Children's Research Hospital, USA
mCMV Alters the Airway Inflammatory Milieu Regulating Protective and Pathogenic Heterologous Immunity to Influenza A Virus Infection

Silvia Ariotti, Netherlands Cancer Institute, Netherlands
Induction of a Local Anti-Pathogen State by Tissue-Resident Memory CD8+ T Cells

Carmen Gerlach, Harvard Medical School, USA
Transitional Memory Cells (Ttm) – A Novel Subset of CD8+ Memory T Cells

Chang Hoon Lee, NIAID, National Institutes of Health, USA
Human CCR2+ MAIT Cells Demonstrate Efficient Transendothelial Migration that Depends on the Expression of Glycosyltransferases and Non-redundant Chemokine Receptors

Charles L. Dulberger, University of Chicago, USA
The Molecular Basis for MAIT Cell Recognition of Microbial Antigens Bound to MR1

Yujun Huang, La Jolla Institute for Allergy and Immunology, USA
Driving Pre-Existing Immunity at the Mucosal Borders of the Intestine

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—18:25
Site-Specific: Pulmonary
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* David L. Woodland, Keystone Symposia on Molecular and Cellular Biology, USA

Linda S. Cauley, University of Connecticut Health Center, USA
Protection by Tissue-Resident Memory CD8 T Cells in the Lungs

Jie Liu, NIAID, National Institutes of Health, USA
Short Talk: Pre-Existing Subdominant CD8 T Effectors Control Respiratory Syncytial Virus Lung Infection with Limited Immunopathology

Jacob E. Kohlmeier, Emory University, USA
Generation, Maintenance and Recall of Airway-Resident Memory T Cells

18:25—19:00
Closing Remarks
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
Peter C. Doherty, University of Melbourne, Australia
Closing Remarks with Acknowledgement of Leo Lefrançois

19:00—20:00
Social Hour with Lite Bites

Ballroom 2
20:00—23:00
Entertainment

Ballroom 2

THURSDAY, JANUARY 16

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Educational donation provided by Amgen. BioLegend, Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI109814-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:


Mucosal Immunology Studies Team (MIST), in memory of Dr. Leo LeFrancois


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676