Hilton Santa Fe Historic Plaza Hotel Floorplan

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This meeting took place in 2014


Here are the related meetings in 2018:
Myeloid Cells (D2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Molecular Cell Biology of Macrophages in Human Diseases (B2)


Organizer(s) Frederic Geissmann, Judith E. Allen and Christopher K. Glass
February 9—14, 2014
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, New Mexico USA
Discounted Abstract Deadline: Oct 15, 2013
Abstract Deadline: Nov 13, 2013
Scholarship Deadline: Oct 15, 2013
Discounted Registration Deadline: Dec 9, 2013

Sponsored by BioLegend, Inc., Novartis Institutes for BioMedical Research and Novo Nordisk A/S

Summary of Meeting:
In recent years, studies of the development, genetics, and molecular cell biology of macrophages has advanced our understanding of their major role in health and diseases. Many questions remain to be answered with respect to mechanisms that control macrophage development and function, particularly in the context of human genetic heterogeneity. Recent discoveries have also revealed greater heterogeneity in macrophage function and origins than previously appreciated. Answering these questions will have major implications for human health and disease. To help meet this challenge, this meeting will bring together leading and upcoming scientists in immunology, infectious diseases, metabolism, molecular biology and genetics, development, cancer, and cell migration with a common interest in macrophages and their roles in human diseases. In addition to the regular sessions, three “macrophage leading edge” workshops will provide a platform to discuss the findings of young scientists, selected from the submitted abstracts to present their work. These workshops will additionally help to focus the meeting on some of the fastest moving areas of macrophage biology.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 9

16:00—20:00
Arrival and Registration

Promenade

MONDAY, FEBRUARY 10

07:00—08:00
Breakfast

Chamisa/Ortiz
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Judith E. Allen, University of Manchester, UK

* Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA

Carl F. Nathan, Weill Cornell Medical College, USA
Revisiting Macrophage Activation

09:00—11:15
Genetics and Genomics of Macrophage Development and Function I
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
Christopher K. Glass, University of California, San Diego, USA
A Genome-Wide View of Macrophage Activation

Gioacchino Natoli, IEO, European Institute of Oncology, Italy
Epigenomic Control of Macrophage Gene Expression

Ellen V. Rothenberg, California Institute of Technology, USA
PU.1 and the Nexus of Lympho-Myeloid Developmental Decisions

Diego A. Jaitin, Weizmann Institute of Science, Israel
Short Talk: Ab Initio Characterization of the Immune System using Massively Parallel Single Cell RNA-Seq

09:40—10:00
Coffee Break

Promenade
11:15—13:00
Poster Setup

Mesa C
13:00—22:00
Poster Viewing

Mesa C
14:30—16:30
Workshop 1: Genetics of Macrophages

Mesa A-B
* Ellen V. Rothenberg, California Institute of Technology, USA

* Steffen Jung, Weizmann Institute of Science, Israel

Meera G. Nair, University of California, Riverside, USA
The Macrophage-Derived Proteins Murine RELMalpha and Human Resistin Regulate Host Immunity to Helminth Infection

Tiffany Horng, Harvard School of Public Health, USA
The TSC-mTOR Pathway Regulates Macrophage Polarization

Katie J. Woodcock, King's College London, UK
Macrophage Control of Metabolism and Longevity on Lipid-Rich Diet in Drosophila

James C. Cronk, University of Virginia, USA
Mecp2: An Unexpected Key Regulator of Tissue-Resident Macrophage Survival and Function

Andrew J. Martins, NIAID, National Institutes of Health, USA
Human Macrophage Activation Responses at the Single Cell Level

Bin Ni, Ohio State University, USA
Regulation of Human Macrophage IFN-gamma Responses by microRNAs

Kaur Alasoo, Wellcome Trust Sanger Institute, UK
Comparison of Transcriptional Response to Bacterial Lipopolysaccharide Stimulation in Induced Pluripotent Stem Cell-Derived and Monocyte-Derived Macrophages

16:30—17:00
Coffee Available

Promenade
17:00—19:00
Genetics and Genomics of Macrophage Development and Function II
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA

* Shigekazu Nagata, IFReC, Osaka University, Japan

Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA
Developmental Heterogeneity of Macrophages

David Traver, University of California, San Diego, USA
Ontogeny of Dendritic Cell Subsets in the Zebrafish

Michael H. Sieweke, Centre d'Immunologic Marseille-Luming, France
Mechanisms of Macrophage Self-Renewal and Activation

Balázs Enyedi, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Tissue Damage Detection by Osmotic Surveillance

19:00—20:00
Social Hour with Lite Bites

Chamisa/Ortiz
19:30—22:00
Poster Session 1

Mesa C

TUESDAY, FEBRUARY 11

07:00—08:00
Breakfast

Chamisa/Ortiz
08:00—11:15
Genetics and Genomics of Macrophage Development and Function III
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Michael H. Sieweke, Centre d'Immunologic Marseille-Luming, France

* Carl F. Nathan, Weill Cornell Medical College, USA

Philippe Gros, McGill University, Canada
IRFs, Macrophages and Infectious Diseases

Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
Detecting and Responding to Microbial Viability

Shigekazu Nagata, IFReC, Osaka University, Japan
Exposure of Phosphatidylserine in Apoptotic Cells

Anna Zagórska, Gilead Sciences Inc., USA
Short Talk: Clearing the Corpses – the Role of Axl Tyrosine Kinase in the Phagocytosis of Apoptotic Cells by Inflammatory Macrophages

Alexander Tarakhovsky, Rockefeller University, USA
Control of Gene Expression by Histone Mimics

Sonal Khare, Northwestern University, USA
Short Talk: POP3 Is a Novel Macrophage Specific Inhibitor of ALR Inflammasomes and Controls Antiviral Host Defense

09:20—09:40
Coffee Break

Promenade
11:15—13:00
Poster Setup

Mesa C
13:00—22:00
Poster Viewing

Mesa C
16:30—17:00
Coffee Available

Promenade
17:00—19:00
Macrophage Subsets and Effector Functions I
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Philippe Gros, McGill University, Canada

* Gioacchino Natoli, IEO, European Institute of Oncology, Italy

Judith E. Allen, University of Manchester, UK
Macrophage Activation in Th2 Immunity

Marie-Ève Tremblay, Laval University, Canada
Microglial Remodeling of Neuronal Circuits in Health and Disease

Philippe Herbomel, Institut Pasteur, France
Development of Tissue Resident Macrophage Populations in Zebrafish

Luke C. Davies, Cardiff University, National Cancer Institute, USA
Short Talk: Tissue Macrophage Phenotype and Proliferative Renewal Is Intrinsically Linked

19:00—20:00
Social Hour with Lite Bites

Chamisa/Ortiz
19:30—22:00
Poster Session 2

Mesa C

WEDNESDAY, FEBRUARY 12

07:00—08:00
Breakfast

Chamisa/Ortiz
07:30—08:00
Poster Setup

Mesa C
08:00—19:00
Poster Viewing

Mesa C
08:00—11:15
Macrophage Cell Biology and Migration
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Catherine (Lynn) Hedrick, La Jolla Institute for Allergy and Immunology, USA

* Marco Prinz, University of Freiburg, Germany

Valerie B. O'Donnell, Cardiff University, UK
Identification and Characterization of New Lipid Mediators Generated by Human and Murine Monocytes/Macrophages

Fiona J. Pixley, University of Western Australia, Australia
CSF-1R-Activated Pathways Controlling Macrophage Motility and Invasion

Ali A. Zarrin, Genentech, Inc., USA
Short Talk: CSF-1 and IL-34 Cytokines as Therapeutic Targets in Macrophage Driven Inflammation

Wolfgang Weninger, Centenary Institute, Australia
Perivascular Macrophages are Key Regulators of Neutrophil Recruitment during Skin Infection and are targeted by a Staphylococcus aureus Virulence Factor

Emma H. Wilson, University of California, Riverside, USA
Short Talk: Macrophage Production of AMCase Is a Novel Effector Mechanism Against Protozoan Infection in the Brain

Ira Mellman, Genentech, Inc., USA
Endosomes Are Signaling Platforms for Microbial Detection in Dendritic Cells and Macrophages

09:20—09:40
Coffee Break

Promenade
11:15—12:15
Lunch

Mesa C
12:00—14:30
Poster Session 3

Mesa C
14:30—16:30
Workshop 2: In vivo Imaging and Lineage Analysis

Mesa A-B
* Kathryn J. Moore, New York University Medical Center, USA

* Leonie S. Taams, King's College London, UK

Antigoni Triantafyllopoulou, Freiburg University Medical Center, Germany
Macrophage Polyploidization via Pathogen Recognition in Granulomatous Diseases

Francesca Peri, European Molecular Biology Laboratory, Germany
Brain Macrophages Go Live: How Do Microglia Find and Remove Dying Neurons

Daniel R. Saban, Duke University School of Medicine, USA
Intravital Multiphoton Imaging Reveals a Role for Neurosensory Transport of Antigen to Macrophages

Tjakko J. van Ham, Erasmus MC, Netherlands
Intravital Correlated Microscopy Reveals Differential Macrophage and Microglial Dynamics during Resolution of Neuroinflammation

Richard N. Hanna, MedImmune, USA
NR4A1 (Nur77) Regulation of Myeloid Cells in the Lung Inhibit Tumor Cell Invasion

Elisa Gomez Perdiguero, King's College London, UK
Myb-Independent Macrophages: A Family of Cells that Develops with their Tissue of Residence and Is Involved in its Homeostasis

Florent Ginhoux, Singapore Immunology Network, Singapore
The Embryonic Origin of Tissue-Resident Macrophages

16:30—17:00
Coffee Available

Promenade
17:00—19:00
Macrophage Subsets and Effector Functions II
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Tiffany Horng, Harvard School of Public Health, USA

* David Traver, University of California, San Diego, USA

Steffen Jung, Weizmann Institute of Science, Israel
Probing Functions of Gut and Brain Macrophages

Kristie I. Aamodt, Vanderbilt University Medical Center, USA
Short Talk: Macrophages Recruited to Pancreatic Islets in Response to Vascular Endothelial Growth Factor-A Promote beta Cell Proliferation

Ehud Zigmond, Tel Aviv Medical Center, Israel
Short Talk: Kupffer Cells and Infiltrating Macrophages Display Different Origins and Functions in Acute Liver Injury

Fabio M.V. Rossi, University of British Columbia, Canada
Interactions between MSCs and Monocyte/Macrophages in Tissue Regeneration and Degeneration

19:00
On Own for Dinner


THURSDAY, FEBRUARY 13

07:00—08:00
Breakfast

Chamisa/Ortiz
08:00—11:15
Macrophages in Inflammatory and Metabolic Diseases
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Kinya Otsu, , UK

* Fabio M.V. Rossi, University of British Columbia, Canada

Kathryn J. Moore, New York University Medical Center, USA
Macrophage Retention in Metabolic Diseases

Catherine (Lynn) Hedrick, La Jolla Institute for Allergy and Immunology, USA
Monocytes in Atherosclerosis

Ajay Chawla, University of California, San Francisco, USA
Anticipatory Inflammation: Physiologic Functions and Pathologic Consequences

Leonie S. Taams, King's College London, UK
Regulating Inflammation: Studying the Cross-Talk between Monocytes/Macrophages and CD4+ T Cells in Rheumatoid Arthritis

Alexander V. Misharin, Northwestern University, USA
Short Talk: Non-Classical Ly6C– Monocytes Are Required for the Initiation while Polarization of Tissue Macrophages Is Essential for Resolution of Sterile Joint Inflammation

Michael H. Askenase, University of Pennsylvania, National Institutes of Health Partnership, USA
Short Talk: Systemic Conditioning of Monocytes Imparts Critical Regulatory Functions Prior to Tissue Recruitment during Acute Mucosal Infection

09:20—09:40
Coffee Break

Promenade
14:30—16:30
Workshop 3: Nuclear Receptor Signaling Pathways and Lipid Metabolism

Mesa A-B
* Christopher K. Glass, University of California, San Diego, USA

* Valerie B. O'Donnell, Cardiff University, UK

Paul Huang, Geisel School of Medicine at Dartmouth, USA
Myeloid-Specific ACAT1 Gene Ablation Reduces Adipose Tissue Macrophage Content and Fat Cell Size and Improves Insulin Sensitivity in Mice

Iftach Shaked, La Jolla Institute for Allergy & Immunology, USA
The Nuclear Receptor NUR77 (Nr4a1) Controls Autoimmune Encephalitis in Mice by Limiting Myeloid Catecholamine Production

Stanley Ching-Cheng Huang, Washington University, USA
Macrophage-Intrinsic Lipolysis Is Essential for Alternative Activation

William N. Beavers, Vanderbilt University, USA
Global Analysis of Protein Adduction from the Endogenous Generation of Lipid Electrophiles by LPS-Activated RAW264.7 Macrophages

Katharina Jandl, Medical University of Graz, Austria
The Role of Prostaglandin D2 Receptors in Macrophage Function

Xiaohui Zha, Ottawa Hospital Research Institute, Canada
Cholesterol Modulates Inflammatory Response in Macrophages

16:30—17:00
Coffee Available

Promenade
17:00—18:15
Macrophages and Infectious, Inflammatory and Metabolic Diseases
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
* Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA

* Judith E. Allen, University of Manchester, UK

* Christopher K. Glass, University of California, San Diego, USA

Kinya Otsu, , UK
Mitochondrial DNA in the Development of Inflammation and Heart Failure

Andrew M. Smith, University College London, UK
The Role of Macrophages in the Causation of Crohn’s Disease

18:15—19:15
Closing Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mesa A-B
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Macrophages: A Distributed Control System for Homeostasis and Inflammation

20:00—21:00
Social Hour with Lite Bites

Promenade/Mesa Ballroom
20:00—23:00
Entertainment

Mesa Ballroom

FRIDAY, FEBRUARY 14

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

BioLegend, Inc. Novartis Institutes for BioMedical Research
Novo Nordisk A/S
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI109775-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


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Phone:+1 970-262-2690

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