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This meeting took place in 2014



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The Ins and Outs of Viral Infection: Entry, Assembly, Exit and Spread (C6)


Organizer(s) Karla Kirkegaard, Mavis Agbandje-McKenna and Eric O. Freed
March 30—April 4, 2014
Beaver Run Resort • Breckenridge, Colorado USA
Discounted Abstract Deadline: Dec 2, 2013
Abstract Deadline: Jan 7, 2014
Scholarship Deadline: Dec 2, 2013
Discounted Registration Deadline: Jan 29, 2014

Sponsored by Astellas Pharma Inc.

Summary of Meeting:
Viruses can enter cells by mechanisms such as the classic virus-receptor interactions, cell-cell fusion and newly observed pathways that are currently being investigated. Similarly, viral exit from infected cells can follow the paradigms of cell lysis or viral budding, but new mechanisms such as unconventional secretion and exosome formation are emerging. Viruses in the process of entering or exiting cells should be especially vulnerable to antivirals because of their accessibility and because the formation of oligomeric structures that mix drug-susceptible and drug-resistant capsids can suppress the emergence of drug-resistant viruses. However, these steps are more difficult to target biochemically due to the lack of readily assayed enzymatic activity. In this meeting, we will bring together structural biologists, geneticists, cell biologists and mathematic modeling to address the mechanisms and consequences of the different modes of viral travel.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 30

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer

Foyer

MONDAY, MARCH 31

07:00—08:00
Breakfast

Summit Gallery
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Karla A. Kirkegaard, Stanford University School of Medicine, USA

Geoffrey L. Smith, University of Cambridge, UK
Vaccinia Virus Propulsion and Repulsion: A Portrait of a Poxvirus

09:00—11:00
Mechanisms of Cell Entry I
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Eric O. Freed, NCI, National Institutes of Health, USA

Sean P. Whelan, Harvard Medical School, USA
VSV Entry

Mavis Agbandje-McKenna, University of Florida, USA
Non-Enveloped Capsid Calisthenics

Yasmine Baktash, University of Chicago, USA
Short Talk: Single Particle Tracking Analysis of Hepatitis C Virus Entry into Polarized Three-Dimensional Hepatoma Organoids

Mathieu Mateo, Mayo Clinic, USA
Short Talk: Measles Virus Appropriates the Adhesive Surface of Nectins to Enter the Respiratory Epithelium

09:40—10:00
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
11:00—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Entry

Peaks 4-5
Luk H. Vandenberghe, Harvard Medical School, USA
Ancestral Reconstruction of Adeno-Associated Virus Particles to Circumvent Pre-Existing Immunity

* Colin R. Parrish, Cornell University, USA
Parvoviruses, Receptors and Antibodies – Host-Specific Interactions and their Controls

Dennis T. Brown, North Carolina State University, USA
Alphavirus Entry

Kathryn Twigg Arrildt, University of North Carolina at Chapel Hill, USA
Features of Macrophage-Tropic HIV-1 Entry Phenotype

Long Gui, University of Washington, USA
Membrane Deformations during Influenza Virus Fusion Imaged by Electron Cryo-Tomography

Joseph R. Pasquarella, University of Wisconsin, Madison, USA
Human Cytomegalovirus Enters Latency via Macropinocytosis

16:30—17:00
Coffee Available

Foyer
17:00—19:15
Mechanisms of Cell Entry II
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Julie K. Pfeiffer, University of Texas Southwestern Medical Center, USA

Carolyn B. Coyne, University of Pittsburgh, USA
Three-Dimensional Cell Models for the Study of Virus Entry and Infection

Matthew J. Evans, Icahn School of Medicine at Mount Sinai, USA
The Complexities of Hepatitis C Virus Cell Entry

Jason Mercer, ETH Zürich, Switzerland
From Screen to Gene: Unraveling the Mystery of Poxvirus Genome Uncoating

Ben Berkhout, University of Amsterdam, Academic Medical Center, Netherlands
Short Talk: HIV-1 Resistance and Dependence on Peptidic Fusion Inhibitors

Shan-Lu Liu, Ohio State University, USA
Short Talk: Restriction of Viral Entry by Interferon-Induced Transmembrane Protein 1 (IFITM1)

19:15—20:15
Social Hour with Lite Bites

Peaks 1-3
19:30—22:00
Poster Session 1

Peaks 1-3

TUESDAY, APRIL 1

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Virion Assembly and Post-Assembly Maturation
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Shan-Lu Liu, Ohio State University, USA

Andrea Gamarnik, Fundación Instituto Leloir, Argentina
Dengue Virus Capsid Functions: Encapsidation and Uncoating

Brett D. Lindenbach, Yale University School of Medicine, USA
An Insider’s Guide to an Outbound Virus: The Structure and Assembly of HCV Particles

Jack Johnson, The Scripps Research Institute, USA
Virus Particle Maturation: Insights into Elegantly Programmed Nano Machines

Eric O. Freed, NCI, National Institutes of Health, USA
Recent Progress in Developing Potent and Broadly Active HIV-1 Maturation Inhibitors

Anastasia A. Aksyuk, NIAMS, National Institutes of Health, USA
Short Talk: Structural Studies of Herpes Simplex Virus 1 Procapsids and Maturation Intermediates

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
11:00—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Foyer
17:00—19:15
Cell Exit I
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Johnson Mak, Deakin University, Australia

Ryland F. Young, Texas A & M University, USA
Phage Lysis: The "Hole" Story

Hyeryun Choe, The Scripps Research Institute, USA
Exiting to Enter: Phosphatidylserine and its Receptors in the Entry of Enveloped Viruses

Karla A. Kirkegaard, Stanford University School of Medicine, USA
Lytic and Non-Lytic Viral Spread

Maria Guadalupe Martinez, Albert Einstein College of Medicine, USA
Short Talk: Imaging the Alphavirus Exit Pathway

Charles Grose, University of Iowa, USA
Short Talk: Autophagy Facilitates Cell-to-Cell Spread by Varicella-Zoster Virus

19:15—20:15
Social Hour with Lite Bites

Peaks 1-3
19:30—22:00
Poster Session 2

Peaks 1-3

WEDNESDAY, APRIL 2

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Virus Structure
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Mavis Agbandje-McKenna, University of Florida, USA

Johnson Mak, Deakin University, Australia
Structural Rearrangement during HIV Entry

Z. Hong Zhou, University of California, Los Angeles, USA
A New Topology of the HK97-Like Fold Revealed in Bordetella Bacteriophage by cryoEM at 3.5Å Resolution

Félix Rey, Institut Pasteur, France
Ancestral Genes Used for Virus-Cell and Cell-Cell Fusion Identified by Structural Studies

John P. Moore, Weill Medical College of Cornell University, USA
The HIV-1 Env Trimer: The Key to Virus Entry and its Prevention by a Vaccine

Wei Cheng, University of Michigan, USA
Short Talk: Optical Trapping and Multi-Parameter Analysis of Single HIV-1 in Culture Media Reveal the Positive Cooperativity of Envelope Spikes in Mediating Viral Infection

Halil Aydin, University of Toronto, Canada
Short Talk: General Structural Features and Determinants Required for the Stabilization of Class I Viral Fusion Glycoproteins

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
11:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Cell Exit II
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Akira Ono, University of Michigan, USA

Juan Martin-Serrano, King's College London School of Medicine, UK
Multiple Roles of the ESCRT Machinery in Viral Replication

Rebecca Dutch, , USA
Human Metapneumovirus Assembly and Transmission

Katya E. Heldwein, Tufts University School of Medicine, USA
Short Talk: Membrane Deformation and Scission by the HSV-1 Nuclear Egress Complex

Keisuke Tabata, Research Institute for Microbial Diseases, Osaka University, Japan
Short Talk: Involvement of ESCRT Factors in Flavivirus Propagation

Jeremy Rossman, University of Kent, UK
Short Talk: M2-Mediated Influenza Virus Budding

19:00—20:00
Social Hour with Lite Bites

Peaks 1-3
19:30—22:00
Poster Session 3

Peaks 1-3

THURSDAY, APRIL 3

07:00—08:00
Breakfast

Summit Gallery
08:00—11:30
Virus Spread I
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Andrew Mehle, University of Wisconsin, Madison, USA

Brenda G. Hogue, Arizona State University, USA
Role of Coronavirus Envelope (E) Viroporin in Assembly at Intracellular Membranes

Alasdair C. Steven, NIAMS, National Institutes of Health, USA
Genome Transport and Iron Storage: A Jack of Several Trades

Alan S. Perelson, Los Alamos National Laboratory, USA
Modeling Viral Spread

Erica Ollmann Saphire, The Scripps Research Institute, USA
Structural Transformation Begets Multiple Functions in the Viral Life Cycle

Katharine G. Harris, University of Chicago, USA
Short Talk: Coxsackievirus B3 Cleaves Receptor-Interacting Protein Kinase 3 (RIP3) to alter Host Cell Death and Toll-Like Receptor Signaling

Roy Duncan, Dalhousie University, Canada
Short Talk: Reovirus FAST Proteins Usurp Host Exosome Biogenesis to Enhance Cell-Cell Fusion and Virus Dissemination

Matthew P. Taylor, Montana State University, USA
Short Talk: Analysis of Neurotropic Virus Axon-to-Cell Spread

09:20—09:40
Coffee Break

Foyer
11:30—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Assembly and Exit

Peaks 4-5
* Sara W. Bird, Stanford University, USA
Non-Lytic Viral Spread Enhanced by Autophagy Components

* Philip R. Tedbury, National Cancer Institute, USA
HIV-1 Envelope Glycoprotein Incorporation Requires Matrix Trimerization

Shu-Jung Chang, National Yang-Ming University, Taiwan
Crystal Structure of Vaccinia Viral A27 Protein Reveals a Novel Structure Critical for its Function and Complex Formation with A26 Protein

David C.J. Carpentier, University of Cambridge, UK
Vaccinia Virus F12/E2 Preferentially Interacts with the KLC2 Isoform of Kinesin-1

Mathieu Dubé, Albert Einstein College of Medicine, USA
Calcium Is Required for Rubella Virus Fusion, Membrane Interaction and Infection

Ian B. Hogue, Princeton University, USA
Live-Cell Fluorescence Imaging of Pseudorabies Virus Egress from Infected Cells by Exocytosis

Giridhar Murlidharan, University of North Carolina at Chapel Hill, USA
Glycan Binding Affinity Determines Adeno-Associated Viral Spread and Cellular Tropism in the Brain

Coyne G. Drummond, University of Pittsburgh, USA
The Role of Receptor-Interacting Protein Kinase 3 in Coxsackievirus B-Induced Necrosis

16:30—17:00
Coffee Available

Foyer
17:00—19:15
Virus Spread II
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Michael S. Caffrey, University of Illinois, USA

Julie K. Pfeiffer, University of Texas Southwestern Medical Center, USA
How Gut Microbes Enhance Enteric Virus Infectivity

Lynn W. Enquist, Princeton University, USA
Imaging Alpha Herpesvirus Invasion of the Mouse Peripheral Nervous System

Akira Ono, University of Michigan, USA
HIV-1 Assembly and Spread: Roles Played by Phospholipids and Cell Polarity

Alison W. Ashbrook, Vanderbilt University, USA
Short Talk: Residue 82 of the Chikungunya Virus E2 Attachment Protein Modulates Viral Dissemination and Arthritis in Mice

Andrew Mehle, University of Wisconsin, Madison, USA
Short Talk: The Influenza Virus Polymerase Is a Hot Spot for Adaptation during Evolution in Bat Cells

19:15—20:15
Social Hour with Lite Bites

Peaks 1-3
20:00—23:00
Entertainment

Peaks 1-3

FRIDAY, APRIL 4

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Astellas Pharma Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI109804-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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