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This meeting took place in 2014


Here are the related meetings in 2015:
Systems Biology of Lipid Metabolism (B4)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Lipid Pathways in Biology and Disease (C3)


Organizer(s) Michael P. Czech, Tobias C. Walther and Morris J. Birnbaum
March 19—24, 2014
Royal Dublin Society • Dublin, Ireland
Discounted Abstract Deadline: Nov 19, 2013
Abstract Deadline: Dec 18, 2013
Scholarship Deadline: Nov 19, 2013
Discounted Registration Deadline: Jan 21, 2014

Organized in collaboration with Science Foundation Ireland

Summary of Meeting:
Lipids are hydrophobic small molecules required for life that carry out a multitude of critical functions. Lipids can act as hormones, intermediate signaling molecules, vitamins, structural elements in biological membranes and vehicles for energy storage. Disruptions in their levels of expression, as in obesity, diabetes, autoimmunity or certain inborn errors of lipid metabolism, promote profound disease states derived from dysfunctions in a broad spectrum of human organs. Key gaps in our understanding of these dysfunctions include the signaling cascades in which lipid intermediates operate, missing steps in regulatory mechanisms that control lipid synthesis and storage, and poorly described processes whereby various cell types respond to lipid overload. Thus the goals of this conference are to attract researchers at all career stages from multiple disciplines of lipid biology, and to address several central problems in the field: 1. How do disrupted lipid signaling pathways integrate with metabolic regulation to cause cellular dysfunction and metabolic/cardiovascular disease? 2. What are the mechanisms that control the cell biology of lipid storage and release? 3. How do genetic and epigenetic mechanisms control lipid metabolism and related disease? 4. How do various routes of adipogenesis control lipid-related energy expenditure? Of particular interest will be discussion of new technologies for lipid analysis and function in biology and medicine, for which a workshop will be included from abstract submissions. There will also be optimal opportunities for oral presentations of the latest data on all of the above topics to be selected from submitted abstracts.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, MARCH 19

16:00—20:00
Arrival and Registration


THURSDAY, MARCH 20

07:30—08:30
Breakfast

08:30—09:40
Keynote Session
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Michael P. Czech, University of Massachusetts Medical School, USA

* Tobias C. Walther, Yale University, USA

Stephen O'Rahilly, University of Cambridge, UK
Human Metabolic Disease: Lessons from Genetics

Luke A. J. O'Neill, Trinity College Dublin, Ireland
New Frontiers in Inflammation Research

09:40—12:15
Lipids as Signaling Molecules I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Tobias C. Walther, Yale University, USA

* Morris J. Birnbaum, Pfizer, Inc, USA

Sarah Spiegel, Virginia Commonwealth University School of Medicine, USA
Sphingosine-1-Phosphate in Cell Biology and Diseases

Scott A. Summers, Duke-NUS Graduate Medical School, Singapore
Ceramide Signaling and Metabolic Disease

George Kunos, NIAAA, National Institutes of Health, USA
Endocannabinoid/CB1 Receptor Signaling in Peripheral Tissues as a Therapeutic Target in Type 2 Diabetes

Michael P. Czech, University of Massachusetts Medical School, USA
Lipid Signaling in Adipocytes

10:00—10:20
Coffee Break

12:15—17:00
On Own for Lunch and Recreation

12:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

16:30—17:00
Coffee Available

17:00—19:15
Lipids as Signaling Molecules II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Paul F. Pilch, Boston University School of Medicine, USA

Daniele Piomelli, University of California, Irvine, USA
The Thrifty Lipids: Endocannabinoid Regulation of Energy Balance

Charles N. Serhan, Brigham and Women's Hospital, USA
Resolvins Are Novel Pro-Resolving Mediators in Inflammation

Garret A. FitzGerald, University of Pennsylvania, USA
Prostaglandins and Inflammatory Responses

Wolfram Goessling, Brigham and Women's Hospital-Harvard Medical School, USA
Short Talk: Prostaglandin E2 Regulates Liver versus Pancreas Cell Fate Decisions and Endodermal Differentiation

Marieke Guurtje Schooneman, Academic Medical Center, Netherlands
Short Talk: Plasma Acylcarnitine Levels Poorly Reflect Tissue Acylcarnitine Levels and Have Limited Predictive Value for Metabolic Derangements

19:15—20:15
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


FRIDAY, MARCH 21

07:30—08:30
Breakfast

08:30—09:00
Poster Setup

09:00—17:00
Poster Viewing

08:30—11:45
Linking Metabolism to Gene Expression
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Irfan J. Lodhi, Washington University School of Medicine, USA

Jay D. Horton, University of Texas Southwestern Medical Center, USA
Post-Transcriptional Regulators of Lipogenesis

Rosalind A. Coleman, University of North Carolina at Chapel Hill, USA
Journal of Lipid Research Lectureship: Acyl-CoA Synthesis, Metabolism and Signaling

Amy K. Walker, University of Massachusetts Medical School, USA
Short Talk: Limitations in Methylation Capacity Affect Lipogenesis and Host Response to Pathogens

Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Glycolytic Regulation of Cell Proliferation and Survival

Morris J. Birnbaum, Pfizer, Inc, USA
Signaling Pathways Regulating Hepatic Lipid Metabolism

Amit R. Majithia, Massachusetts General Hospital, USA
Short Talk: Making Sense of Sequence Variation in PPARG: A Comprehensive Experimental Approach

09:50—10:10
Coffee Break

11:45—12:30
Lunch

12:00—14:30
Poster Session 2

14:30—16:30
Workshop: Breaking Stories in Lipogenesis, Immunometabolism and Adipogenesis

* Jan Nedergaard, Stockholm University, Sweden

* Morris J. Birnbaum, Pfizer, Inc, USA

Sarah M. Turpin, Max Planck Institute for Neurological Research, Germany
The Role of Ceramide Synthase 6 in Metabolic Tissue Function

Andreas Prokesch, Medical University of Graz, Austria
Aspartoacylase (Aspa) Regulates the Phenotype of Brown Adipocytes

Valerio Chiurchiù, I.R.C.C.S. Santa Lucia Foundation, Italy
Endocannabinoids as “Master Regulatory Bioactive Lipids” of Innate and Adaptive Immunity

Christopher C. Church, Yale University, USA
Dietary Fatty Acids Activate Adipocyte Precursors in Obesity

Cynthia Hong, University of California, Los Angeles, USA
IDOL Regulation of Cholesterol Metabolism

Niklas Mejhert, Karolinska Institutet, Sweden
Systematic Identification of Transcriptional Regulators Controlling Lipolysis and/or Lipid Droplet Morphology in Human Adipocytes

Jessica P. Otis, Carnegie Institute, USA
Visualization of ApoA-I and Reverse Cholesterol Transport in Live Zebrafish

16:30—17:00
Coffee Available

17:00—19:15
Packaging Neutral Lipids into Lipid Droplets
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Robert V. Farese Jr., Harvard School of Public Health, USA

Tobias C. Walther, Yale University, USA
Triglyceride Synthesis and Storage in Lipid Droplets

Hongyuan Yang, University of New South Wales, Australia
Seipin Function in Adipogenesis and Lipid Droplet Expansion

David B. Savage, University of Cambridge, UK
Genetic Disorders of Lipid Storage

Anne Gaebler, University of Bonn, Germany
Short Talk: Engineering Alkyne Lipids and Fluorescent Detection Reagents for Lipid Imaging by Microscopy

Madeleine Goeritzer, University of Graz, Austria
Short Talk: TG-Rich Lipid Droplet Accumulation in CGI-58-/- Macrophages Leads to a Pro-Inflammatory Macrophage Phenotype and Aggravates Atherosclerosis Susceptibility

19:15—
On Own for Dinner


SATURDAY, MARCH 22

07:30—08:30
Breakfast

08:30—11:45
Unconventional Lipid Droplet Functions
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Dawn L. Brasaemle, Rutgers University, USA

Michael A. Welte, University of Rochester, USA
Lipid Droplets as Sites to Sequester Proteins from Other Cellular Compartments

Carole Sztalryd, VAH and University of Maryland School of Medicine, USA
Lipid Droplet Coat: An Adaptation to Cellular Energetic Needs

Cedric Moro, Institute of Metabolic and Cardiovascular Diseases, France
Short Talk: Regulation of Skeletal Muscle Lipolysis and Oxidative Metabolism by G0/G1 Switch Gene 2

Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center, USA
Sterol and Nonsterol Signals Regulating ER-Associated Degradation of HMG CoA Reductase

John McLauchlan, University of Glasgow, UK
Lipid Droplet Function in Hepatitis C Virus Infection

S.R. Murthy Madiraju, Montreal Diabetes Research Center, CR-CHUM, Canada
Short Talk: Alpha/beta-Hydrolase Domain-6, a Monoacylglycerol Lipase, Regulates Insulin Secretion and Sensitivity, Adipose Browning, Body Weight, Locomotor Activity and Fuel Homeostasis

09:50—10:10
Coffee Break

11:45—17:00
On Own for Lunch and Recreation

11:45—13:00
Poster Setup

13:00—22:00
Poster Viewing

16:30—17:00
Coffee Available

17:00—19:00
New Insights into Control of Lipogenesis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Helen M. Roche, UCD Conway Institute of Food and Health, Ireland

Mitchell A. Lazar, University of Pennsylvania School of Medicine, USA
Circadian Transcriptional Regulation of Metabolism

Camella G. Wilson, University of California, San Francisco, USA
Short Talk: CD36 Regulates Hepatic Lipid Accumulation and Whole Body Insulin Sensitivity in Mice

Catherine Postic, Institut Cochin, France
Molecular Mechanisms Linking Hepatic Steatosis to Steatohepatitis Transition: Dual Roles of ChREBP and LXR

Cecilie Hundahl, University of Copenhagen, Denmark
Short Talk: Hormone-Sensitive Lipase in the Hypothalamus is Involved in Regulation of Food Intake and Energy Balance

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


SUNDAY, MARCH 23

07:30—08:30
Breakfast

08:30—11:45
Lipids in Human Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gerald I. Shulman, HHMI/Yale University School of Medicine, USA

Kitt F. Petersen, Yale University School of Medicine, USA
Ectopic Lipid Accumulation and Insulin Resistance

Barbara B. Kahn, BIDMC and Harvard Medical School, USA
Systemic Metabolic Effects of Adipose Tissue Lipogenesis

Guadalupe Sabio Buzo, Spanish National Centre for Cardiovascular Research, Spain
Short Talk: Lack of p38gamma/detla in Myeloid Cells Protect Against Liver Steatosis

Juleen R. Zierath, Karolinska Institutet, Sweden
Lipid Pathways and Regulation of Skeletal Muscle

Daniel J. Rader, University of Pennsylvania, USA
New Pathways in Hepatic Lipid Metabolism

Jonathan Y. Xia, University of Texas Southwestern Medical Center, USA
Short Talk: Role of Acid Ceramidase Action in Regulating Hepatic Lipid Metabolism and Whole Body Insulin Sensitivity

09:50—10:10
Coffee Break

11:45—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Adipogenesis and "Britening" of White Fat
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Silvia Corvera, University of Massachusetts Medical School, USA

Barbara Cannon, Stockholm University, Sweden
White Fat, Brown Fat and Brite Fat

David A. Guertin, University of Massachusetts Medical School, USA
Short Talk: New Insights into Adipocyte Origins and in vivo Drivers of Adipogenesis

Sheila Collins, Sanford-Burnham Medical Research Institute, USA
Signaling Networks "Britening" Adipocytes: Some Old, Some New

James G. Granneman, Wayne State University School of Medicine, USA
Tracing the Recruitment of Bipotential Adipocyte Progenitors in White Adipose Tissue

19:00—20:00
Social Hour with Lite Bites

20:00—23:00
Entertainment


MONDAY, MARCH 24

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Science Foundation Ireland

We gratefully acknowledge additional support for this conference from:


Journal of Lipid Research

Avanti Polar Lipids, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

EMBO (European Molecular Biology Organization)

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676