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This meeting took place in 2014



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Complications of Diabetes (X7)


Organizer(s) Michael A. Brownlee, Matthew D. Breyer and Susan Quaggin
March 23—28, 2014
Whistler Conference Centre • Whistler, British Columbia Canada
Discounted Abstract Deadline: Nov 21, 2013
Abstract Deadline: Dec 19, 2013
Scholarship Deadline: Nov 21, 2013
Discounted Registration Deadline: Jan 23, 2014

Sponsored by Arena Pharmaceuticals, Inc., AstraZeneca and Novo Nordisk A/S


Summary of Meeting:
The global burden of diabetes and its complications represents an emerging pandemic. Progress in understanding the fundamental mechanisms contributing to vascular disease, nephropathy, retinopathy and neuropathy has yet to translate into effective therapeutics. This meeting will assemble scientists from diverse backgrounds to provide new perspectives on underlying biology relevant to diabetic complications. These presentations will provide fresh insights that stimulate new ideas about answering the major unsolved questions about diabetic complications. These include effects of diabetes on stem cells and tissue repair, new concepts about biological pathways involved in diabetic tissue damage, and identification of new experimental and clinical paradigms for studying the pathogenesis of diabetic complications and for developing therapeutics. The meeting content seeks to challenge current research paradigms by introducing novel concepts and experimental approaches, addressing questions about the genetics of complications, for example, with discussions of gene interactions, epigenetics, and networks. Experts in metabolism, stem cell biology, mitochondrial biology, model organisms, and clinical complications will be brought together to provide new perspectives for scientists focused on the problem of developing new approaches to the prevention and treatment of diabetic complications. This will be the third time Keystone held a meeting on this topic. As a result of these prior meetings, the diverse community of scientists previously focused on various different diabetic complications is just now forming an interactive and cross-fertilizing network. There is no other meeting of a similar nature providing a venue devoted to discussion of the diverse aspects of tissue dysfunction and damage caused by diabetes. This meeting will have several joint sessions with the simultaneous Keystone meeting on Innate Immunity, Metabolism and Vascular Injury.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 23

16:00—20:00
Arrival and Registration

18:00—20:00
Welcome Mixer


MONDAY, MARCH 24

07:00—08:00
Breakfast

08:00—08:15
Opening Remarks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Michael A. Brownlee, Albert Einstein College of Medicine, USA

08:00—09:00
Opening Remarks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Ajay Chawla, University of California, San Francisco, USA

Peter Tontonoz, HHMI/University of California, Los Angeles, USA

Gwendalyn J. Randolph, Washington University, USA

08:15—09:15
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Susan Quaggin, Northwestern University, USA

Michael A. Brownlee, Albert Einstein College of Medicine, USA
The Molecular Basis of Diabetic Complications

09:15—11:30
Metabolic Dysregulation and the Pathogenesis of Diabetic Cardiovascular Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Dysreguation of metabolism and impaired heart and vascular function. Defining the pathways contributing to impaired cardiovascular function and opportinuties to correct this will be the focus of this session.

* Susan Quaggin, Northwestern University, USA

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adipocyte Origin of Insulin Resistance, Chronic Inflammation and Lipotoxicity

Richard J.M. Coward, University of Bristol, UK
Insulin Resistance and the Kidney

Christopher B. Newgard, Duke University Medical Center, USA
Metabolomics and Cardiometabolic Disease Mechanisms

Kyoungmin Park, Joslin Diabetes Center, USA
Short Talk: Direct Demonstration that Overexpression of IRS1 and Enhanced Insulin Actions in Vascular Endothelial Cells Can Reduce Atherosclerosis via a Novel Pathway to Activate eNOS

08:15—10:45
Monocytes: Development and Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gwendalyn J. Randolph, Washington University, USA

Frederic Geissmann, King's College London, UK
Developmental and Functional Heterogeneity of Macrophages

Filip K. Swirski, Massachusetts General Hospital, USA
The Monocyte Lineage in Atherosclerosis

Alan R. Tall, Columbia University, USA
Regulation of Hematopoiesis by Cholesterol

Tiffany Horng, Harvard School of Public Health, USA
Short Talk: The TSC-mTOR Pathway Regulates Macrophage Polarization

Partha Dutta, Massachusetts General Hospital Harvard Medical School, USA
Short Talk: Activation of CCR2+ Hematopoietic Stem Cells after Myocardial Infarction

09:40—10:00
Coffee Break

11:30—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:30—17:00
On Own for Lunch and Recreation

14:30—16:30
Workshop 1

* Ichiro Manabe, University of Tokyo, Japan

Miyako Tanaka, Tokyo Medical and Dental University, Japan
Mincle, a Novel Pathogen Sensor in Macrophages, Underlies Obesity-Induced Adipose Tissue Fibrosis in Mice

Joel D. Schilling, Washington University School of Medicine, USA
Inflammatory-Metabolic Crosstalk in Macrophages: The Role of the Lysosome

Bruno M. Carvalho, University of Pernambuco, Brazil
Splenic Monocytes and Macrophages Mediate Insulin Resistance in Obesity

Dario A. Gutierrez, German Cancer Research Center, Germany
Kit Deficiency, But Not Lack of Mast Cells, Has a Profound Effect on Adiposity and Obesity-Induced Insulin Resistance

Anca Dana E. Dobrian, Eastern Virginia Medical School, USA
Signal Transducer and Activator 4 (STAT4) Deficiency in Subsets of Hematopoietic Cells Improves Metabolic Phenotype by Reducing Adipose Tissue and Islet Inflammation in Obesity and Insulin Resistance

Jonathan R. Brestoff, Perelman School of Medicine, University of Pennsylvania, USA
Group 2 Innate Lymphoid Cell Responses in White Adipose Tissue Are Conserved in Mice and Humans

16:30—17:00
Coffee Available

17:00—19:00
Stem Cells in Diabetic Tissue Repair I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Impaired tissues repair is a hallmark of the diabetic state. Recent studies suggest impaired stem cell mobilization may contribute. This session overview the contribution of stem-cell "opathy" to diabetic complications.

* Michael A. Brownlee, Albert Einstein College of Medicine, USA

Rohit N. Kulkarni, Joslin Diabetes Center, Harvard Medical School, USA
Using iPS Cells to Investigate Complications in Type 1 Diabetes

Geoffrey C. Gurtner, Stanford University, USA
Stem Cell Defects and Impaired Diabetic Wound Healing

Andras Nagy, Mount Sinai Hospital, University of Toronto, Canada
Alternative Sources of Stem Cells for Tissue Repair

Mattia Albiero, Venetian Institute of Molecular Medicine, Italy
Short Talk: Diabetes Causes Bone Marrow Autonomic Neuropathy and Impairs Stem Cell Mobilization via Dysregulated p66Shc and Sirt1

17:00—19:00
Genomics of Myeloid Cells
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Alan R. Tall, Columbia University, USA

Christopher K. Glass, University of California, San Diego, USA
A Genome-Wide View of Macrophage Activation

Laszlo Nagy, Sanford-Burnham Medical Research Institute at Lake Nona, USA
The Genomic Basis of a Retinoid X Receptor-Induced Angiogenic Macrophage Phenotype

Chih-Hao Lee, Harvard University School of Public Health, USA
Serum Lipidome in Metabolic and Immune Functions

Ekaterina K. Koltsova, Fox Chase Cancer Center, USA
Short Talk: Interleukin-27 Signaling Curbs Inflammation in Atherosclerosis

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, MARCH 25

07:00—08:00
Breakfast

08:00—11:15
Macrophages and Vascular Inflammation (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Christopher K. Glass, University of California, San Diego, USA

Kathryn J. Moore, New York University Medical Center, USA
The NLRP3 Inflammasome in Atherosclerosis and Diabetes: Activation from Within

Christoph J. Binder, Medical University of Vienna, Austria
Innate Sensors of Oxidative Stress

Ira Tabas, Columbia University, USA
Defective Inflammation Resolution in Atherosclerosis: Mechanisms and Therapeutic Opportunities

Peter Tontonoz, HHMI/University of California, Los Angeles, USA
Integration of Metabolism and Inflammation by LXRs

Qian Li, Joslin Diabetes Center, USA
Short Talk: Acceleration of Atherosclerosis by Specific Deletion of Protein Kinase C Isoform in Macrophages: An Anti-Atherosclerotic Role for its Activation in Diabetes

José J. Fuster, Boston University School of Medicine, USA
Short Talk: Non-Canonical Wnt Signaling Promotes Inflammatory Abdominal Aortic Aneurysm Formation

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Emerging Targets for the Treatment of Diabetic Complications
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Karl Tryggvason, Karolinska Institutet, Sweden

Susan Quaggin, Northwestern University, USA
Targeting the Tie2 Pathway for Diabetic Nephropathy

Dean Li, University of Utah, USA
Vascular Inflammation

Martin Friedlander, The Scripps Research Institute, USA
Endothelial Progenitor Cells and Diabetic Retinopathy

Ulf P.E. Eriksson, Karolinska Institutet, Sweden
Short Talk: Targeting VEGF-B as a Treatment of Insulin Resistance, Type 2 Diabetes and Diabetic Co-Morbidities

17:00—19:00
Inflammasomes in Metabolic Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Kathryn J. Moore, New York University Medical Center, USA

Jorge A. Henao-Mejia, Yale School of Medicine, USA
Talk Title to be Announced

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
Fatty Acid Activation of the Inflammasomes

Vishva M. Dixit, Genentech, Inc., USA
The Inflammasome

Jon A. Hagar, University of North Carolina at Chapel Hill, USA
Short Talk: Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, MARCH 26

07:00—08:00
Breakfast

08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ajay Chawla, University of California, San Francisco, USA

Ruslan M. Medzhitov, HHMI/Yale University School of Medicine, USA
Inflammation and Diseases of Homeostasis

08:00—11:00
Clinical Therapies on the Horizon for Diabetic Complications
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Several novel therapeutics are in phase 2 clinical trials. These trials should be completed by 2014 or earlier. This session will overview the rationale for and results of these trials.

* David E. Kelley, Merck & Co., Inc., USA

Daniel J. Drucker, Lunenfeld Tanenbaum Research Institute, Canada
Cardiovascular Effects of GLP1R Agonists

Matthew D. Breyer, Eli Lilly and Company, USA
Discovery of Novel Treatments for Diabetic Nephropathy

James W. Russell, University of Maryland, USA
Nicotinamide Precursors as a Treatment in the Diabetic Nervous System

Edward P. Feener, Joslin Diabetes Center, USA
Plasma Kallikrein Inhibitors for Diabetic Macular Edema

Kevin G. Peters, Aerpio Therapeutics, USA
Short Talk: Novel Approach to Treatment of Diabetic Macular Edema: Activating Tie2 by Inhibition of Vascular Endothelial Protein Tyrosine Phosphatase (VE-PTP)

09:00—11:30
Innate Inflammation and Insulin Resistance
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ira Tabas, Columbia University, USA

Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Targeting Inflammation to Treat Metabolic Disease

Richard M. Locksley, HHMI/University of California, San Francisco, USA
Innate Helper Type 2 Cells (ILC2) and Metabolic Homeostasis

Ajay Chawla, University of California, San Francisco, USA
Anticipatory Inflammation: Physiologic Functions and Pathologic Consequences

Da Young Oh, University of California, San Diego, USA
Short Talk: LTB4 Causes Macrophage-Mediated Inflammation and Directly Induces Insulin Resistance

James C. Lo, Brigham and Women's Hospital, USA
Short Talk: Adipsin Is an Adipokine that Improves beta Cell Function in Diabetes

09:20—09:40
Coffee Break

11:00—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—18:25
Mitochondrial Biology
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* James W. Russell, University of Maryland, USA

Navdeep S. Chandel, Northwestern University, USA
Physiological Roles of Mitochondrial Reactive Oxygen Species

Melinda T. Coughlan, Baker IDI Heart & Diabetes Institute, Australia
Impaired Mitophagy Activity in Diabetic Nephropathy

Moshe Levi, University of Colorado Health Sciences Center, USA
Short Talk: G Protein Coupled Receptor TGR5 Activation Prevents Kidney Disease in Mice with Obesity and Diabetes

17:00—19:00
Apoptosis and Necrosis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Peter Tontonoz, HHMI/University of California, Los Angeles, USA

Yoshihiro Ogawa, Tokyo Medical and Dental University, Japan
Role of Parenchymal-Stromal Cell Interaction in Metabolic Diseases

Shigekazu Nagata, Kyoto University, Japan
Exposure of Phosphatidylserine and Phosphatidylserine-Dependent Engulfment of Apoptotic Cells

Andrés Hidalgo, Fundación CNIC, Spain
Clearance of Aged Neutrophils

A. Phillip West, Yale University School of Medicine, USA
Short Talk: Altered Mitochondrial DNA Dynamics Elicit a Cell-Intrinsic Antiviral Signaling Program

19:00—20:00
Social Hour with Lite Bites


THURSDAY, MARCH 27

07:00—08:00
Breakfast

08:00—11:15
Where Are the Missing Genetics in Diabetic Complications? (Joint)
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Karl Tryggvason, Karolinska Institutet, Sweden
Search for Diabetic Nephropathy Susceptibility Genes

Caroline Fox, NHLBI, National Institutes of Health, USA
Using GWAS, Exome ChIP and Exome Sequencing as Tools for Understanding Kidney Disease

Michael G. Rosenfeld, HHMI, University of California, San Diego, USA
Enhancer Codes and Regulated Gene Transcription in Development and Disease

Fredrik Bäckhed, University of Gothenburg, Sweden
Altered Gut Metagenome in Diabetes - Cause or Consequence

Claudiu V. Komorowsky, University of Michigan Medical School, USA
Short Talk: Systems Genetics Facilitates Driver Identification in Human Diabetic Kidney Disease

Alexandre Stewart, University of Ottawa Heart Institute, Canada
Short Talk: IRF2BP2, A Novel Transcriptional Regulator of Innate Immunity and Cholesterol Metabolism

09:20—09:40
Coffee Break

11:15—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop: External Funding for Diabetes Complications Research

Teresa Jones, NIDDK, National Institutes of Health, USA

Christian Ketchum, NIDDK, National Institutes of Health, USA
Diabetic Complications Consortium (DiaComp)

Tracy Rankin, NIDDK, National Institutes of Health, USA

Helen D. Nickerson, Juvenile Diabetes Research Foundation, USA
JDRF Strategy and Priorities in Diabetic Complications

14:30—16:30
Workshop 2

* Christoph J. Binder, Medical University of Vienna, Austria

Xin Rong, HHMI/University of California, Los Angeles, USA
LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition

Mark A. Gillespie, Institute for Systems Biology, USA
A Systems Approach to Identifying Promoter-Bound LXR Coregulators in Atherosclerosis

Siroon Bekkering, Radboud UMC, Netherlands
oxLDL Augments Long-Term Pro-Inflammatory Cytokine Production and Foam Cell Formation via Epigenetic Histone Modifications of Monocytes

Suneil K. Koliwad, University of California, San Francisco, USA
Saturated Fats Engage an IRE1 alpha-Dependent Pathway to Activate the NLRP3 Inflammasome in Murine Myeloid Cells

Ryan Snodgrass, Goethe University, Germany
Hypoxia Augments Palmitate-Induced Proinflammatory Activation of Primary Human Macrophages

Joseph J. Boyle, Imperial College London, UK
AMPK-ATF1 Regulated Transcription Integrates Iron and Lipid Metabolism in Mhem Macrophages in Vascular Self-Protection from Hemorrhage and Pharmacological Protection with Metformin

Maroof Hasan, University of Texas Southwestern Medical Center, USA
The Role of Trex1 in Immunometabolism and Autoimmune Disease

16:30—17:00
Coffee Available

17:00—19:00
Model Systems for Diabetic Complications
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
The complexity of the systemic effects of chronic hyperglycemia on the organism cannot be reproduced by cell culture. This session will review novel biological systems that can faciliate the study of diabetic complications.

* Matthew D. Breyer, Eli Lilly and Company, USA

Ross L. Cagan, Mount Sinai School of Medicine, USA
Modeling Diabetic Complications in Drosophila

Jens Kroll, Medical Faculty Mannheim, Heidelberg University and DKFZ-ZMBH Alliance, Germany
Modeling Diabetic Complications in Zebrafish

Thomas M. Coffman, Duke University Medical Center, USA
Humanized Mouse Models of Diabetic Nephropathy

Hermann Haller, Hannover Medical School, Germany
Short Talk: A Novel Rapid Animal Model in Zebrafish to Analyse Molecular Mechanisms of Proteinuria and to Identify and to Evaluate Drugs for CKD and Diabetic Nephropathy

17:00—19:00
Progressing Fat and Regressing Cholesterol
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ajay Chawla, University of California, San Francisco, USA

Karine Clément, INSERM UMR 1166, France
Extracellular Matrix Remodeling of Adipose Tissue and Metabolic Homeostasis

Edward A. Fisher, New York University School of Medicine, USA
HDL and Atherosclerosis Regression: Getting Rid of Cholesterol and Macrophages from the Plaque

Gwendalyn J. Randolph, Washington University, USA
Blood and Lymphatic Vasculature Inflammation in Crohn's Disease

Rachel J. Roth Flach, University of Massachusetts Medical School, USA
Short Talk: Endothelial MAP4K4 Is a Novel Regulator of Vascular Inflammation and Atherosclerosis

19:00—19:15
Concluding Remarks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Michael A. Brownlee, Albert Einstein College of Medicine, USA

Matthew D. Breyer, Eli Lilly and Company, USA

Susan Quaggin, Northwestern University, USA

19:00—19:15
Concluding Remarks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Ajay Chawla, University of California, San Francisco, USA

Peter Tontonoz, HHMI/University of California, Los Angeles, USA

Gwendalyn J. Randolph, Washington University, USA

19:15—20:15
Social Hour with Lite Bites

20:00—23:00
Entertainment


FRIDAY, MARCH 28

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Arena Pharmaceuticals, Inc. AstraZeneca
Novo Nordisk A/S
 

We gratefully acknowledge additional support for this conference from:

Educational grant from Lilly

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK084688-05

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Concert Pharmaceuticals, Inc.


Eli Lilly and Company


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676