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Sagebrush Inn & Suites Floorplan

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This meeting took place in 2014



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Nuclear Receptors: Biological Networks, Genome Dynamics and Disease (A3)


Organizer(s) Kevin P. White, Donald P. McDonnell and Gordon L. Hager
January 10—15, 2014
Sagebrush Inn & Suites • Taos, New Mexico USA
Discounted Abstract Deadline: Oct 3, 2013
Abstract Deadline: Oct 28, 2013
Scholarship Deadline: Oct 3, 2013
Discounted Registration Deadline: Nov 12, 2013

Supported by the Directors' Fund

Summary of Meeting:
Nuclear receptors (NRs) represent a large superfamily of transcription factors that function as ligand-dependent sensors for a diverse set of fat-soluble hormones, vitamins and dietary lipids. Together, NRs govern expression of genes involved in a broad range of reproductive, developmental, metabolic and immune response programs. For this reason, NRs have been investigated for over 20 years as promising targets for drugs to treat a multitude of therapeutic indices, including cancer, diabetes, obesity, cardiovascular disease, hypertension, inflammation and cholestasis. However, despite the success of numerous NR-based therapies, there remain significant hurdles exploiting NRs to develop newer classes of therapies that achieve targeted benefits with reduced side effects. Thus, understanding the mechanisms, transcriptional targets and networks of physiologic pathways that govern NR action has become an important new strategy for evaluating the role of NRs in health and disease. This effort is now beginning to produce exciting new avenues of research in the field. This meeting will bring together a key group of junior and senior investigators who are exploring these new directions and will provide participants with a matrix of unique possibilities for them to investigate in both academic and pharmaceutical laboratory settings.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, JANUARY 10

16:00—20:00
Arrival and Registration


SATURDAY, JANUARY 11

07:00—08:00
Breakfast

08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Kevin P. White, University of Chicago, USA

B. Franklin Pugh, Pennsylvania State University, USA
ChIP-exo: Precision Genome-Wide Mapping of Transcription Factors

09:00—11:15
Genome-Wide Organization of NR Response Elements
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Myles Brown, Dana-Farber Cancer Institute, USA
Nuclear Receptor Cistromics

Kevin P. White, University of Chicago, USA
Mining NR Networks to Predict and Control Gene Regulation in Cancer

Michael J. Garabedian, New York University School of Medicine, USA
Combinatorial Regulation of Neuronal Gene Expression by Glucocorticoids and BDNF

Scott A. Coonrod, Cornell University, USA
Short Talk: Targeted Histone H3R26 Deimination Facilitates ER Binding by Modifying Nucleosome Structure

Hector L. Franco, University of Texas Southwestern Medical Center, USA
Short Talk: Genome-Wide Analysis of the Molecular Crosstalk between Mitogenic and Proinflammatory Signaling in Breast Cancer Cells

09:40—10:00
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Hot Topics

* Donald P. McDonnell, Duke University School of Medicine, USA

Ronald N. Margolis, NIDDK, National Institutes of Health, USA
Biomedical Big Data

Subhamoy Dasgupta, Baylor College of Medicine, USA
SRC-2 Controls Metabolic Reprogramming to Promote Tumorigenesis

Maryem Hussein, New York University, School of Medicine, USA
Effects of Hyperglycemia on LXR-Mediated Gene Expression

Lilia Magomedova, University of Toronto, Canada
Arginine and Glutamate Rich 1 Is a Novel Glucocorticoid Receptor Coactivator Involved in Gluconeogenesis

Yukimasa Takeda, NIEHS, National Institutes of Health, USA
Retinoic Acid-Related Orphan Receptor gamma (RORgamma) Coordinates the Circadian Regulation of Hepatic Gluconeogenesis and Insulin Sensitivity

Yumiko Oishi-Tanaka, Tokyo Medical and Dental University, Japan
Coordinated Regulation of Inflammation and Lipid Homeostasis in Macrophage

Raymond E. Soccio, University of Pennsylvania, USA
Single Nucleotide Polymorphisms between Inbred Mouse Strains Affect PPARgamma Binding Sites in White Adipose Tissue

16:30—17:00
Coffee Available

17:00—19:15
Systems Biology of NR Action
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Mitchell A. Lazar, University of Pennsylvania School of Medicine, USA

Maryam Ahmadian, The Salk Institute, USA
Nuclear Receptors and the Hunger Game: From Feast to Famine

Benita S. Katzenellenbogen, University of Illinois at Urbana-Champaign, USA
Integrative Genomics of Gene and Metabolic Regulation by Estrogen Receptors and Collaborating Partners

Michael A. Mancini, Baylor College of Medicine, USA
Visualizing Mechanisms of Nuclear Receptor Function by Quantitative High-Throughput Imaging

Johan Auwerx, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland
Mitonuclear Protein Balance as a Determinant of Health- and Lifespan

19:15—20:15
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


SUNDAY, JANUARY 12

07:00—08:00
Breakfast

08:00—11:15
Co-Regulators
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Nancy Lynn Weigel, Baylor College of Medicine, USA

Bert W. O'Malley, Baylor College of Medicine, USA
Proteomic Analysis of Coregulators Bound to ERalpha on Nucleosomes Reveals Undiscovered Stages and Substeps of Transcription

Donald P. McDonnell, Duke University School of Medicine, USA
Moving from Empirical to Mechanism-Based Discovery Approaches in the Search for Molecules that Disrupt Androgen Signaling in Prostate Cancer

Inez Rogatsky, Weill Medical College of Cornell University, USA
Getting a GRIP on Gene Regulation

Michael R. Stallcup, University of Southern California, USA
Molecular and Physiological Roles of Coregulators in Transcriptional Regulation by Steroid Hormone Receptors

Catharine L. Smith, University of Arizona, USA
Short Talk: Class I KDACs Facilitate Transactivation by Glucocorticoid Receptor

Nevzat Kazgan, National Institute of Environmental Health Sciences, USA
Short Talk: Intestine-Specific Deletion of SIRT1 Impairs DCoH2/HNF1alpha/FXR Signaling Pathway and Alters Systemic Bile Acid Homeostasis

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Hot Topics

* Benita S. Katzenellenbogen, University of Illinois at Urbana-Champaign, USA

Nicholas D'Amato, University of Colorado Anschutz Medical Campus, USA
Targeting Androgen Receptor to Inhibit ER+ Breast Cancer Growth

Diana A. Stavreva, NCI, National Institutes of Health, USA
Dynamic Chromatin Transitions and Gene Regulation in Response to Glucocorticoid Signaling

Hong-Jian Jin, Northwestern University, USA
Androgen Receptor-Independent and -Opposing Mechanisms Dictate FOXA1 Function in Prostate Cancer

Francoise B. Lenfant, INSERM U1048, France
Mutation of the Palmitoylation Site C451 of Estrogen Receptor ERalpha in vivo Reveals Tissue-Specific Roles for Membrane versus Nuclear Actions

Kelly Ann Holmes, University of Cambridge, UK
FOXA1 as a Target for the Treatment of Tamoxifen-Resistant Breast Cancer

Chien-Cheng Chen, University of Texas Southwestern Medical Center, USA
Progesterone Receptor (PR) DNA-Binding Domain (DBD) Is Required for Progesterone Repression of NF-kappaB Transcriptional Activity

Wendy M. Swetzig, Roswell Park Cancer Institute, USA
Functional Protein Interactions between ERalpha, p53, MDM2, and MDMX Negatively Regulate p53 Function in Human Breast Cancer Cells

16:30—17:00
Coffee Available

17:00—19:00
Dynamics of Receptor Action - The Fourth Dimension
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Susanne Mandrup, University of Southern Denmark, Denmark

Gordon L. Hager, NCI, National Institutes of Health, USA
Integration of Steroid Hormone Signals on Multiple Time Scales

Ueli Schibler, University of Geneva, Switzerland
Systemic Regulation of Circadian Gene Expression

W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Characterizing the Estrogen-Regulated Transcriptome

Daniel R. Larson, NCI, National Institutes of Health, USA
Short Talk: Direct Observation of Frequency Modulated Transcription in Single Cells by Steroid Receptors

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


MONDAY, JANUARY 13

07:00—08:00
Breakfast

08:00—11:00
Physiology
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* David D. Moore, Baylor College of Medicine, USA

Jason S. Carroll, Cancer Research UK, University of Cambridge, UK
Understanding Estrogen Receptor Transcription in Breast Cancer

Philip W. Shaul, University of Texas Southwestern Medical Center, USA
Estrogen Receptors and Cardiometabolic Health and Disease: Location, Location, Location

Sheue-Yann Cheng, NCI, National Institutes of Health, USA
Corepressors Confer the in vivo Actions of TRalpha1 Mutants

Christopher E. Wall, The Salk Institute for Biological Studies, USA
Short Talk: Mitochondrial Stress Improves Systemic Metabolism in the POLG Mutator Mouse

Goldis Malek, Duke University, USA
Short Talk: Aryl Hydrocarbon Receptor (AhR) Deficiency Causes Dysregulated Cellular Matrix Metabolism and Age-Related Macular Degeneration (AMD)-Like Pathology

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Nuclear Receptors, Metabolism and Metabolic Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Kenneth S. Korach, NIEHS, National Institutes of Health, USA

Susanne Mandrup, University of Southern Denmark, Denmark
Nuclear Receptors in Hotspots and Super-Enhancers

David J. Mangelsdorf, HHMI/University of Texas Southwestern Medical Center, USA
Catching Fire: Surviving the Hunger Games through Nuclear Receptor/FGF Signaling

David D. Moore, Baylor College of Medicine, USA
Nutrient Sensing Nuclear Receptors Coordinate Autophagy

Ira G. Schulman, University of Virginia Health System, USA
Short Talk: Differential Regulation of Gene Expression by LXRs

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


TUESDAY, JANUARY 14

07:00—08:00
Breakfast

08:00—11:15
Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Jan-Åke Gustafsson, University of Houston, USA
LXRbeta – Structure and Function

Orla M. Conneely, Baylor College of Medicine, USA
Chemical Genomics Approaches to Identify Small Molecule Activators of NR4A Tumor Suppressors in Acute Myeloid Leukemia

* Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA
Controlling AR in Prostate Cancer: the SAGA Continues

Elisabeth D. Martinez, University of Texas Southwestern Medical Center, USA
Don't Ju Wanna Know about Jumonji?

Jennifer K. Richer, University of Colorado Anschutz Medical Campus, USA
Short Talk: Role of Androgen Receptors in Estrogen Receptor Negative Breast Cancer

Weiyi Toy, Memorial Sloan-Kettering Cancer Center, USA
Short Talk: Estrogen Receptor Ligand Binding Domain Mutations Are Associated with Hormone Resistant Breast Cancer

09:20—09:40
Coffee Break

11:15—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 3: Hot Topics

* Sheue-Yann Cheng, NCI, National Institutes of Health, USA

Kristina B. Martinez, University of Chicago, USA
Gut Microbes Regulate Hepatic Nuclear Receptor Expression

Dawn X. Zhang, University of California, San Diego, USA
Rev-Erbs Modulate a Macrophage Wound Healing Program

Rucha H. Patel, University of Toronto, Canada
Crosstalk between GR and LXRbeta Is Critical for Promoting Glucocorticoid-Mediated Metabolic Effects

Xiaoyong Zhi, Van Andel Institute, USA
Structural Basis for Gene Repression by Orphan Nuclear Receptors

Sylvia C. Hewitt, NIEHS, National Institutes of Health, USA
Biological Roles for ERalpha Tethering Revisited: Real World Revelations from in Vivo Mouse Models

Jonathan F. Goodwin, Thomas Jefferson University, USA
AR-DNA Repair Interplay: Mechanisms and Impact on Cancer Progression

16:30—17:00
Coffee Available

17:00—19:00
Circadian and Ultradian Rhythms
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ueli Schibler, University of Geneva, Switzerland

Adriana Maggi, University of Milan, Italy
Estrogens and the Indissoluble Link between Energy Metabolism and Reproduction

Mitchell A. Lazar, University of Pennsylvania School of Medicine, USA
Novel Physiological Functions of Nuclear Receptors

Li Wang, University of Connecticut, USA
Short Talk: SHP-Mediated Regulation of Metabolism Rhythmicity and Circadian Behavior

Martin L. Privalsky, University of California, Davis, USA
Short Talk: Alternative Splicing of NCoR Corepressor Counteracts Otherwise Pro-Diabetic Changes in Mice to Confer Proper Glucose Homeostasis

19:00—20:00
Social Hour with Lite Bites

20:00—23:00
Entertainment


WEDNESDAY, JANUARY 15

 
Departure


*Session Chair †Speaker invited, not yet responded.



We gratefully acknowledge additional support for this conference from:


Orphagen Pharmaceuticals

Inventiva

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 5R13DK084688-05

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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