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Eldorado Hotel & Spa Floorplan

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This meeting took place in 2014


Here are the related meetings in 2015:
Long Noncoding RNAs: From Evolution to Function (C7)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Long Noncoding RNAs: Marching toward Mechanism (B5)


Organizer(s) Thomas R. Cech, Edith Heard and Ronald R. Breaker
February 27—March 4, 2014
Eldorado Hotel & Spa • Santa Fe, New Mexico USA
Discounted Abstract Deadline: Oct 29, 2013
Abstract Deadline: Dec 4, 2013
Scholarship Deadline: Oct 29, 2013
Discounted Registration Deadline: Jan 7, 2014

Sponsored by Cell Research and Isis Pharmaceuticals, Inc.

Summary of Meeting:
Much of the mammalian genome is transcribed into long non-coding RNAs, but their biological roles -- such as transcriptional regulation via recruitment of histone-modifying enzymes – are only beginning to be discovered. At the same time, bacterial non-coding RNAs are being found to function as small-molecule-sensing riboswitches and as elements of the CRISPR defense system. For all of these biological systems, a key remaining problem is to understand the detailed mechanism of action. Listing and comparing all of the long ncRNAs, riboswitches, and CRISPR elements genome-wide and among species is useful, but how does the RNA function in each of these systems? The goal of this Keystone Symposium is to stimulate conversations between scientists who work on these very diverse RNA systems, so they can share conceptual frameworks and experimental techniques. This goal will be accomplished by convening an exceptional group of academic and industrial scientists and students to share their insights.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, FEBRUARY 27

16:00—20:00
Arrival and Registration


FRIDAY, FEBRUARY 28

07:00—08:00
Breakfast

08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Thomas R. Cech, HHMI/University of Colorado, USA

Phillip A. Sharp, Massachusetts Institute of Technology, USA
The Synthesis and Functions of Noncoding RNAs

09:00—11:30
Epigenetics and ncRNAs
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Anton Wutz, ETH Zürich, Switzerland
Xist Induced Chromatin Modifications in Development and Embryonic Stem Cells

Jeannie T. Lee, Massachusetts General Hospital, USA
X-Chromosome Inactivation: A Model to Study Epigenetic Regulation by Long Noncoding RNA

Alena Shkumatava, Institut Curie-Centre de Recherche, France
Conserved Functions of lincRNAs in Vertebrate Development

Igor Ulitsky, Weizmann Institute of Science, Israel
Short Talk: Common and Distinct Features of Short Translated ORFs in lincRNAs and 5'UTRs

Olga Villamizar, Southern Illinois University School of Medicine, USA
Short Talk: LncRNA Saf Interacts with SPF45 to Promote Alternative-Splicing of Fas Receptor Pre-mRNA and Resistance to Apoptosis

09:40—10:00
Coffee Break

11:30—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:30—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
ncRNAs and Transcriptional Control
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* John L. Rinn, Harvard University, USA

Danny F. Reinberg, HHMI/New York University, USA
Histone Modification and Long ncRNAs

Ingrid Grummt, German Cancer Research Center, Germany
rRNA Regulation by ncRNAs

Edith Heard, Institut Curie, France
X-Chromosome Inactivation: A Paradigm of Epigenetic Regulation via Noncoding RNA

Céline Vallot, UMR 7216-Centre National de la Recherche Scientifique, France
Short Talk: XACT – a Supportive Coat for X-Chromosome Activity in Human?

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


SATURDAY, MARCH 1

07:00—08:00
Breakfast

07:30—08:00
Poster Setup

08:00—19:00
Poster Viewing

08:00—11:00
Bacterial ncRNAs
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jennifer A. Doudna, HHMI/University of California, Berkeley, USA

Ronald R. Breaker, Yale University, USA
Large ncRNAs in Bacteria

Gisela T. Storz, National Institutes of Health, USA
Dual Function Regulatory RNAs in Bacteria

Karen M. Wassarman, University of Wisconsin-Madison, USA
6S RNA in E. coli, B. subtilis, and Beyond . . .

James W. Nelson, Yale University, USA
Short Talk: Riboswitch Receptors for Bacterial Second Messengers

Thomas Hermann, University of California, San Diego, USA
Short Talk: A Guanine-Triggered Conformational Switch in a Highly Conserved Domain of the Hepatitis C Virus IRES

09:20—09:40
Coffee Break

11:00—12:00
Lunch

12:00—14:30
Poster Session 2

14:30—16:30
Workshop 1: LincRNAs in Differentiation and Development

* Ingrid Grummt, German Cancer Research Center, Germany

Federico D. Ariel, Institut des Sciences du Végétal, France
Noncoding Transcription by Alternative RNA Polymerases Regulates Chromatin Loop Dynamics

Riki Kurokawa, Saitama Medical University, Japan
Mechanism of Transcription of Long Noncoding RNA

Ezgi Hacisuleyman, Harvard University, USA
Topological Organization of Multi-Chromosomal Regions by Firre

Nianwei Lin, Sanford-Burnham Medical Research Institute, USA
An Evolutionarily Conserved Long Noncoding RNA TUNA Controls Pluripotency and Neural Lineage Commitment

Matthew G. Schwartz, Harvard Medical School, USA
The Role of Long Noncoding RNAs in Regulating Chicken Limb Patterning

H. Scott Stadler, Shriners Hospital, Oregon Health & Science University, USA
The Novel Long Noncoding RNA, Hotchon, Regulates Chondrogenic Programming in Limb Mesenchyme and Mesenchymal Stem Cells

16:30—17:00
Coffee Available

17:00—19:00
Riboswitches and CRISPR
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Ronald R. Breaker, Yale University, USA

Jennifer A. Doudna, HHMI/University of California, Berkeley, USA
RNA-Guided Genome Defense and Engineering by CRISPR Systems

Samuel H. Sternberg, University of California, Berkeley, USA
Short Talk: DNA Interrogation by the CRISPR RNA-Guided Endonuclease Cas9

Beatrix Suess, Technical University Darmstadt, Germany
Mechanistic Insights into Engineered Riboswitches

Robert T. Batey, University of Colorado, Boulder, USA
Structure and Mechanism of Bacterial Cobalamin Riboswitches

19:00—
On Own for Dinner


SUNDAY, MARCH 2

07:00—08:00
Breakfast

08:00—11:00
RNA Methods, Diagnostics and Therapeutics
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Anna Marie Pyle, Yale University, USA

Howard Y. Chang, Stanford University, USA
Genome Regulation by Long Noncoding RNAs

Larry Gold, SomaLogic Inc., USA
Nucleic Acid SOMAmers for Diagnostics and Therapeutics

Bruce A. Sullenger, Duke University, USA
Clinical Applications of Antithrombotic Noncoding RNAs

Jeannie T. Lee, Massachusetts General Hospital, USA

Ming Lei, Institute of Biochemistry and Cell Biology, China
Structural Basis for Protein-RNA Recognition in Telomerase

09:20—09:40
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:15—17:00
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Catalytic RNAs and RNPs
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Lara Szewczak, Cell Press, USA

Anna Marie Pyle, Yale University, USA
Structure Determination and Functional Analysis of Long Intergenic Noncoding RNAs (lincRNAs)

Peter Baumann, HHMI/Stowers Institute for Medical Research, USA
Telomerase Biogenesis and Regulation

Joachim Lingner, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland
Telomere Functions of TERRA ncRNA

Isabel López de Silanes, Spanish National Cancer Research Centre, Spain
Short Talk: Identification of the Subtelomeric Sequence of the Long Noncoding RNA TERRA Unveils its Role at Telomeres

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 3


MONDAY, MARCH 3

07:00—08:00
Breakfast

08:00—11:00
Genome-Wide Analysis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jeannie T. Lee, Massachusetts General Hospital, USA

John L. Rinn, Harvard University, USA
Linking RNA to Cellular Differentiation

Nicholas Ingolia, University of California, Berkeley, USA
Exploring Translation Outside of Canonical Protein Coding Region with Ribosome Profiling

Thomas R. Gingeras, Cold Spring Harbor Laboratory, USA
RNA Based Communication Inside and Outside Cells

Julia Questa, John Innes Centre, UK
Linking Antisense RNA and Chromatin in Flowering Control

Jing Crystal Zhao, Sanford-Burham Medical Research Institute, USA
Short Talk: N6-Methyladenosine Modification Destabilizes Developmental Regulators in Embryonic Stem Cells

Alexandra Lusser, Innsbruck Medical University, Austria
Short Talk: Identification and Characterization of Cytosine Methylation in Mammalian lncRNAs

09:20—09:40
Coffee Break

11:00—14:30
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Emerging Technologies for LncRNA Research

* Howard Y. Chang, Stanford University, USA

Timothy G. Johnstone, Yale University School of Medicine, USA
Ribosome Footprinting Defines the Coding Potential of the Vertebrate Genome

Amanda Birmingham, Dharmacon, GE Healthcare, USA
Targeting and Off-Targeting of Long Non-Coding RNAs by siRNAs

Moran Nataly Cabili, Harvard and The Broad Institute, USA
A Single Molecule, single Cell RNA Localization Catalog Reveals Abundance and Cellular Localization Patterns of lincRNAs

Lalith S. Gunawardane, Case Western Reserve University, USA
Analysis of the Interactome of a Long Non-Coding RNA: lncRNA-Protein Interactions Capture by AntiSense Oligonucleotides (lncRNA- PICASO)

Liangliang Hao, Northwestern University, USA
Spherical Nucleic Acids for Noncoding RNA Therapeutics

Peter Mouritzen, Exiqon A/S, Denmark
Efficient Silencing of lncRNA with LNA™ Antisense Oligonucleotides

Mitchell R. O'Connell, University of California, Berkeley, USA
Programmable RNA Targeting and Cleavage by CRISPR/Cas9 Enzymes

Karissa Y. Sanbonmatsu, Los Alamos National Laboratory, USA
Structural Studies of Intact Long Noncoding RNAs in Plants and Mammals

16:30—17:00
Coffee Available

17:00—19:00
Long ncRNAs and Chromatin
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Edith Heard, Institut Curie, France

Chen Davidovich, University of Colorado, USA
Short Talk: Promiscuous RNA Binding by PRC2: A Model for Scanning through Active Genes and Maintaining Repressed Chromatin

Thomas R. Cech, HHMI/University of Colorado, USA
Cooperative RNA Binding by FUS Nucleates Higher-Order Protein Assemblies

Lawrence J. Hayward, University of Massachusetts Medical School, USA
Short Talk: Transgenic Mouse Models of FUS/TLS-Mediated ALS

Daniel H. Kim, California Institute of Technology, USA
Short Talk: Single-Cell Transcriptome Analysis of Long Noncoding RNAs during Cellular Reprogramming

Mridula (Millie) K. Ray, Harvard University, Massachusetts General Hospital, USA
Short Talk: lncRNAs Interact with PRC1 to Impact PcG Gene-Regulatory Networks

19:00—19:15
Closing Comments
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Ronald R. Breaker, Yale University, USA

Edith Heard, Institut Curie, France

Thomas R. Cech, HHMI/University of Colorado, USA

19:15—20:15
Social Hour with Lite Bites

20:00—23:00
Entertainment


TUESDAY, MARCH 4

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Cell Research Isis Pharmaceuticals, Inc.

We gratefully acknowledge additional support for this conference from:


RaNA Therapeutics

BioVentures, Inc. Exiqon A/S
Landes Bioscience
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HD078065-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



RaNA Therapeutics


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676