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This meeting took place in 2014



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The Brain: Adaptation and Maladaptation in Chronic Pain (E3)


Organizer(s) Frank Porreca, David Borsook and David W. Dodick
June 15—20, 2014
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Feb 13, 2014
Abstract Deadline: Mar 13, 2014
Scholarship Deadline: Feb 13, 2014
Discounted Registration Deadline: Apr 30, 2014

Sponsored by Regeneron Pharmaceuticals, Inc.

Summary of Meeting:
SIGNIFICANCE: The Institutes of Medicine indicate that pain affects more than 100 million Americans and costs more than an estimated $540-630 billion, a number predicted to only increase as our population ages and is influenced by lifestyle. We have few effective treatments for migraine or chronic pain. GOALS: Understanding the complexities of brain circuits involved in pain and migraine headache has been a major challenge in neurobiology that has limited the discovery of new therapies. For decades, the pain and headache communities have separately focused on peripheral mechanisms. INNOVATION: This conference brings together the world’s leading experts in brain systems neuroscience to highlight the advances in understanding brain systems relevant to the neurobiology of migraine and chronic pain. We wish to explore neurobiology of pain and headache together with contributions and attendance from both communities. APPROACH: A conversation of a number of new technologies has opened new opportunities to better understand the neural networks involved in the emotional, cognitive and sensory components of pain and consequent suffering. New technologies have opened doors to revolutionize our concepts of the impact of pain on the brain. OPPORTUNITY: Bringing together scientists from different disciplines related to, but not exclusively connected to pain and headache as a key to integration and bridging of disciplines and advancement of knowledge in these areas of clinical need. Accumulating functional and imaging data implicate headache and chronic pains as diseases of the brain – either primarily or secondarily as a consequence of peripheral damage. OUTCOME: We are at an exciting moment in the neurosciences where new understanding of brain function promises to change paradigms for drug discovery for neurological disorders. The promise is great, and the next decade of brain sciences research will redefine disease states, including predictive and personalized medicine, allow imaging the brain during pain and its relief by treatments in the individual patients suffering from pain.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JUNE 15

16:00—20:00
Arrival and Registration

18:00—20:00
Mixer


MONDAY, JUNE 16

07:30—08:30
Breakfast

08:30—08:45
Opening Remarks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

David W. Dodick, Mayo Clinic, USA

David Borsook, Children's Hospital, USA

Frank Porreca, University of Arizona, USA

08:45—09:45
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Frank Porreca, University of Arizona, USA

Michael W. Salter, Hospital for Sick Children and University of Toronto, Canada
Neuron-Glia Signaling in Pain Neuroplasticity

09:45—12:15
Plasticity of Brain Neurons, Glia and Other Processes
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Stephen B. McMahon, King's College London, UK

Ru-Rong Ji, Duke University, USA
Microglial and Astroglial Signaling in Persistent Pain

Magdalena Luciuk, University of Sydney, Australia
Short Talk: Microglial Phenotype in the Medullary Reticular Region in Chronic Pain

Manuel Graeber, University of Sydney, Australia
What Is Neuroinflammation?

Amanda L. Ellis, University of Colorado, USA
Short Talk: Administering Morphine following Spinal Cord Injury Amplifies Central Neuropathic Pain

Giorgio A. Ascoli, George Mason University, USA
Neuronal Morphology Goes Digital: A Research Hub for Cellular and System Neuroscience

10:10—10:30
Coffee Break

12:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

12:15—14:00
On Own for Lunch

14:00—15:30
Workshop: New Technologies to Understand the Brain in Pain

* David Borsook, Children's Hospital, USA

Yves De Koninck, Université Laval, Quebec Mental Health Institute, Canada
Towards an All-Optical Functional Dissection of Pain Pathways

Katja Wiech, University of Oxford, UK

Jon-Kar Zubieta, University of Michigan, USA
Effects of tDCS on Endogenous Opioid Mechanisms

Tor D. Wager, University of Colorado at Boulder, USA
Towards fMRI-Based Biomarkers for Pain and Emotion

15:30—16:00
Coffee Available

16:00—18:00
New Technologies to Image the Human Brain Structure and Function
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Robert C. Coghill, Wake Forest University School of Medicine, USA

Yves De Koninck, Université Laval, Quebec Mental Health Institute, Canada
Probing the Brain with Light

Jing Wang, New York University School of Medicine, USA
Short Talk: Optogenetic Activation of Corticostriatal Circuitry Regulates Chronic Neuropathic Pain

Katja Wiech, University of Oxford, UK
Imaging Pain

Richard Hargreaves, RJ Hargreaves Consulting LLC, USA
Imaging to Optimize Analgesic Drug Discovery and Development

18:00—19:00
Social Hour with Lite Bites

19:00—21:30
Poster Session 1


TUESDAY, JUNE 17

07:30—08:30
Breakfast

08:30—09:30
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Frank Porreca, University of Arizona, USA

Howard L. Fields, University of California, San Francisco, USA
Mesolimbic Circuits: Where Pain and Pleasure Interact

09:30—11:45
Dissecting Basic Brain Circuits Involved in Pain Behaviors
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* A. Vania Apkarian, Northwestern University, USA

Mark Tommerdahl, University of North Carolina, USA
Role of the Primary Somatosensory Cortex in Pain

Robert C. Coghill, Wake Forest University School of Medicine, USA
The Role of the Posterior Parietal Cortex in Pain

Karen Davis, University of Toronto/ Toronto Western Research Institute, Canada
Pain-Attention Brain Circuitry Phenotypes: Potential for Personalized Therapeutics?

Neil Schwartz, Stanford University, USA
Short Talk: Decreased Motivation during Chronic Pain Requires Depression of the Nucleus Accumbens Indirect Pathway

10:00—10:20
Coffee Break

13:00—22:00
Poster Viewing

11:45—15:30
On Own for Lunch

15:30—16:00
Coffee Available

16:00—18:15
Preclinical to Clinical Evaluation of Pain - Garnering a Better Approximation to the Human Condition
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Maria Fitzgerald, University College London, UK

Frank Porreca, University of Arizona, USA
Reward Circuits and Pain

Andrew Charles, University of California, Los Angeles, USA
Translational Models of the Migraine Brain State

Mirko Santello, University of Bern, Switzerland
Short Talk: Dysfunction of Dendritic Properties of Cortical Pyramidal Neurons in a Chronic Pain Model

Gary R. Strichartz, Harvard Medical School, Brigham and Women's Hospital, USA
Short Talk: Critical Role of the RVM in Chronic Pain after Thoracotomy

Chas Bountra, University of Oxford, UK
Working Together Pre-Competitively, Exploring Novel Epigenetic Proteins and Using Human Cells to Increase the Probability of Discovering New Analgesics

18:15—19:15
Social Hour with Lite Bites

19:15—19:30
Transportation to Silverthorne

19:30—21:00
Local Community Panel Discussion on Pain

NOTE: Drs. David Dodick and Frank Porreca, along with a local physician, Dr. Ross Dickstein, will present a community panel discussion on “Pain” at the Silverthorne Community Center in Silverthorne CO. The discussion, which is targeted at a lay audience, is part of a Keystone Symposia outreach program to bring interesting science to our local community in Summit County. Bus transportation will be available for a limited number of conference participants who would like to attend the panel discussion.


WEDNESDAY, JUNE 18

07:30—08:30
Breakfast

08:30—09:30
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* David W. Dodick, Mayo Clinic, USA

David Borsook, Children's Hospital, USA
Pain in Neurological Disease

09:30—12:00
Pain in Neurological Disease States
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Giandomenico Iannetti, University College London, UK

Emeran Mayer, University of California, Los Angeles, USA
Brain Networks in Chronic Visceral Pain

Todd J. Schwedt, Mayo Clinic, USA
The Interictal Migraine Brain: Hypersensitive, Hypervigilant and Hyperactive

A. Vania Apkarian, Northwestern University, USA
The Neurological basis of Chronic Pain: Causes and Consequences

Vasco Galhardo, Faculdade de Medicina - Universidade do Porto, Portugal
Short Talk: Dopaminergic Reversal of Pain-Related Working Memory Deficits

Catherine D. Chong, Mayo Clinic Arizona, USA
Short Talk: Atypical Age-Related Cortical Thinning in Episodic Migraine

10:10—10:30
Coffee Break

12:00—15:30
On Own for Lunch

15:30—16:00
Coffee Available

16:00—18:00
Altered Processing of Pain
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Rami Burstein, Harvard Medical School, USA

Herta Flor, Medical Faculty Mannheim, Heidelberg University, Germany
Brain Circuits Involved in Phantom Limb Pain

Rami Burstein, Harvard Medical School, USA
Neurochemical Pathways that Modulate Thalamic Trigeminovascular Neurons

Jon Levine, University of California, San Francisco, USA
Mirror Mirror on the Wall, Who Is the Sexiest of Them All

Dustin Green, University of Texas Health Science Center at San Antonio, USA
Short Talk: Role of Endogenous TRPV1 Agonists in a Post-Burn Pain Model of Partial-Thickness Injury

18:00—19:00
Social Hour with Lite Bites

19:00—21:30
Poster Session 2


THURSDAY, JUNE 19

07:30—08:30
Breakfast

08:30—09:30
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* David Borsook, Children's Hospital, USA

Fabrizio Benedetti, University of Turin, Italy
Placebos and Drugs: What's the Difference?

09:30—11:15
The Brain and Self-Trickery in Pain and Analgesia
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Karen Davis, University of Toronto/ Toronto Western Research Institute, Canada

Jon-Kar Zubieta, University of Michigan, USA
Opioid Mechanisms, Pain Regulation and Placebo Analgesia

Giandomenico Iannetti, University College London, UK
Pain and Perception

Tor D. Wager, University of Colorado at Boulder, USA
Neuroimaging of the Generation and Regulation of Pain

Richard D. Lane, University of Arizona, USA
Short Talk: Neural Correlates of Deficits in Pain-Related Affective Meaning Construction in Patients with Chronic Pain Disorder

10:10—10:30
Coffee Break

11:15—15:30
On Own for Lunch

15:30—16:00
Coffee Available

16:00—18:15
The Brain in Development
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Tor D. Wager, University of Colorado at Boulder, USA

Maria Fitzgerald, University College London, UK
Pain in the Young Brain Becomes Pain in the Older Brain

Stephen B. McMahon, King's College London, UK
Pain Genetics and Epigenetics

P. Ellen Grant, Boston Children's Hospital, USA
Human Brain Measures in Development

Lorenzo Fabrizi, University College London, UK
Short Talk: How Does Nociceptive Processing in the Human Infant Brain Compare with That in Adults?

Dusica Bajic, Boston Children's Hospital, USA
Short Talk: Rat Periaqueductal Gray Neurotransmitter Gene Expression with Development and Chronic Morphine

18:15—19:15
Social Hour with Lite Bites

19:00—23:00
Entertainment


FRIDAY, JUNE 20

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Regeneron Pharmaceuticals, Inc.

We gratefully acknowledge additional support for this conference from:

Educational grant from Lilly

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS087854-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


SAGE: Cephalalgia

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676