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Clarion Hotel Sign Floorplan

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This meeting took place in 2014



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Adult Neurogenesis (E1)


Organizer(s) Jonas Frisén and Fred H. Gage
May 12—17, 2014
Clarion Hotel Sign • Stockholm, Sweden
Discounted Abstract Deadline: Jan 13, 2014
Abstract Deadline: Feb 13, 2014
Scholarship Deadline: Jan 13, 2014
Discounted Registration Deadline: Mar 12, 2014

Organized in collaboration with Knut and Alice Wallenberg Foundation and Science for Life Laboratory - Stockholm. Sponsored by Curemark LLC.

Summary of Meeting:
Contrary to a longstanding dogma, it is now well established that new neurons are generated throughout life. New neurons are supplied in adulthood in most mammals in two regions of the brain: the dentate gyrus of the hippocampus, by locally residing neural stem cells, and the olfactory bulb, by neural stem cells present in the lateral ventricle wall. The new neurons confer plasticity to the circuitry and increasing evidence has established a role for adult neurogenesis in specific brain functions. The discovery of neural stem cells and neurogenesis in the adult mammalian central nervous system changed our view of the plasticity and function of the brain, and spurred enthusiasm for trying to harness their regenerative potential in new therapies for conditions such as depression and stroke. Our understanding of neural stem cells has increased dramatically over the past few years, but there are still many major outstanding questions. Topics such as the origin of new neurons, their function, alterations of adult neurogenesis in disease and potential therapeutic modulation will all be covered at this conference.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, MAY 12

16:00—20:00
Arrival and Registration

18:00—20:00
Mixer


TUESDAY, MAY 13

07:30—08:30
Breakfast

08:30—09:30
Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Fred H. Gage, The Salk Institute for Biological Studies, USA

Anders Björklund, Lund University, Sweden
Helping the Brain to Repair Itself

09:30—12:00
The Neural Stem Cell Lineage
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Magdalena Götz, University of Munich, Germany
How to Use Neural Stem Cells for Repair – Adequate Network Integration and Long-Term Survival

Hongjun Song, Johns Hopkins University School of Medicine, USA
Clonal Analysis of Neural Stem Cells in the Adult Mouse Hippocampus

Grigori Enikolopov, Cold Spring Harbor Laboratory, USA
Modes of Division and Differentiation of Adult Neural Stem Cells

Darcie L. Moore, University of Zürich, Switzerland
Short Talk: A Mechanism for the Segregation of Age in Mammalian Neural Stem Cells

Terry C. Burns, Stanford University, USA
Short Talk: Limited Repopulation of the Vacated Quiescent Neural Stem Cell Niche

10:10—10:30
Coffee Break

12:00—13:00
Poster Setup

B3
13:00—22:00
Poster Viewing

B3
12:00—14:30
On Own for Lunch

14:30—16:30
Workshop 1

* Hongjun Song, Johns Hopkins University School of Medicine, USA

Robert F. Hevner, Seattle Children's Research Institute, USA
Basal Progenitor Migration and Proliferation in Developing and Adult Dentate Gyrus

Alexander Lazutkin, Moscow Institute of Physics and Technology, Russia
Three-Dimensional Visualization and Analysis of Neurogenesis in the Adult Mouse Brain

Jose L. Nieto-González, Universidad de Sevilla, Spain
CSP-alpha Is Essential to Maintain the Quiescence of Radial-Glia-Like Stem Cells in Adult Neurogenesis

Simona Parrinello, Imperial College London, UK
Direct Cell-Cell Contact with the Vascular Niche Maintains Quiescent Neural Stem Cells

Anabelle Planques, INSERM U1050, Collège de France, France
Choroid Plexus Otx2 Homeoprotein and Adult Neurogenesis

Tijana Radic, Goethe University Frankfurt, Germany
Retroviral Labeling of Postnatally-Born Dentate Granule Cells in Organotypic Entorhino-Hippocampal Slice Cultures

Renata Santos, IBENS, INSERM U1024, France
A Novel Tracing System for Adult Neural Stem Cells in the Subventricular Zone

Isabel Fariñas, Universidad de Valencia, Spain
Neurotrophins Meet Neural Stem Cells at the Neurovascular Interface

16:30—17:00
Coffee Available

17:00—19:00
Non-Mammalian Models for Neural Stem Cells and Adult Neurogenesis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Arturo Alvarez-Buylla, University of California, San Francisco, USA

András Simon, Karolinska Institutet, Sweden
Neurogenesis in the Adult Newt Brain: Regulation and Evolution

Michael Brand, Technische Universität Dresden, Germany
Regeneration of the Adult Zebrafish Brain: An Essential, Positive Role for Inflammation

Elly M. Tanaka, Technische Universität Dresden, Germany
Constitutive and Injury-Responsive Neurogenesis in the Salamander Spinal Cord

Alessandro Alunni, CNRS, France
Short Talk: Notch 3 Signaling Gates Cell Cycle Entry and Limits Neural Stem Cell Amplification in the Zebrafish Adult Pallium

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1

B3

WEDNESDAY, MAY 14

07:30—08:30
Breakfast

08:30—11:45
Molecular Regulation of Adult Neurogenesis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Magdalena Götz, University of Munich, Germany

Sebastian Jessberger, University of Zürich, Switzerland
EMBO Young Investigator Lecture: Metabolic Regulation of Adult Neurogenesis

Jenny Hsieh, University of Texas Southwestern Medical Center at Dallas, USA
Transcriptional/Epigenetic Circuitry to Maintain the Adult Hippocampal Stem Cell Pool

D. Chichung Lie, University of Erlangen, Germany
Impact of Mitochondrial Function on Adult Hippocampal Neurogenesis

Gerd Kempermann, Technische Universität Dresden, Germany
Genes X Environment Interactions in Regulating Adult Hippocampal Neurogenesis

David Petrik, Helmholtz Zentrum München, Germany
Short Talk: The Role of Chromatin Remodeling Factor Brg1 in Postnatal Hippocampal Neurogenesis in vivo and in vitro

Noelia Urban, National Institute for Medical Research, UK
Short Talk: Huwe1 Control of Ascl1 Levels Regulates Stem Cells Proliferation and Neurogenesis in the Adult Hippocampus

09:50—10:10
Coffee Break

11:45—13:00
Poster Setup

B3
13:00—22:00
Poster Viewing

B3
11:45—17:00
On Own for Lunch

16:30—17:00
Coffee Available

17:00—19:00
Olfactory Bulb Neurogenesis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Benedikt Berninger, University Medical Center Johannes Gutenberg University Mainz, Germany

Pierre-Marie Lledo, Pasteur Institute, France
Top-Down Feedback Influences on Olfactory Processing Mediated by Adult-Born Neurons

Arturo Alvarez-Buylla, University of California, San Francisco, USA
Embryonic Origins of Adult Neural Stem Cells Specification

H. Georg Kuhn, University of Gothenburg, Sweden
Adult Olfactory Bulb Neurogenesis in Health and Disease

Malin Åkerblom, Lund University, Sweden
Short Talk: microRNA-125 Distinguishes Developmentally-Generated and Adult-Born Olfactory Bulb Interneurons

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 2

B3

THURSDAY, MAY 15

07:30—08:30
Breakfast

08:00—08:30
Poster Setup

B3
08:30—17:00
Poster Viewing

B3
08:30—11:45
Neurogenesis and Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Rene Hen, Columbia University, USA

Guo-li Ming, Johns Hopkins University, USA
Adult Neurogenesis and Psychiatric Neurodevelopmental Disorders

Olle Lindvall, University of Lund, Sweden
Neurogenesis after Stroke

Beate Winner, FAU Erlangen-Nurnberg, Germany and The Salk Institute, USA
Adult Neurogenesis in Parkinson’s Disease

Jonas Frisén, Karolinska Institutet, Sweden
Adult Neurogenesis in Humans

Helena Mira, Instituto de Salud Carlos III, Spain
Short Talk: Neurogenesis in the Senescence Accelerated Mouse Model SAMP8: From Healthy Aging to Alzheimer's Disease-Like Pathology

Nambirajan Govindarajan, German Center for Neurodegenerative Diseases, Germany
Short Talk: Adult Hippocampal Neurogenesis in Alzheimer’s Disease

09:50—10:10
Coffee Break

11:45—12:30
Lunch

12:30—15:00
Poster Session 3

B3
15:00—15:30
Coffee Available

15:30—17:30
The Functional Role of Adult Hippocampal Neurogenesis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Alessandro Treves, SISSA, Italy

Alejandro F. Schinder, Fundación Instituto Leloir, Argentina
The Role of Immature Granule Cells in Information Processing

Rene Hen, Columbia University, USA
Hippocampal Neurogenesis and Pattern Separation: Impact on Cognition and Mood

D. Nora Abrous, INSERM U862, France
Specific Contribution of Adult-Born Hippocampal Neurons to Spatial Navigation

Rose-Marie Karlsson, NIMH, National Institutes of Health, USA
Short Talk: Progressive Ratio Responding to Palatable High Sucrose Food in Mice Lacking Adult Hippocampal Neurogenesis

17:30—21:30
On Own for Dinner


FRIDAY, MAY 16

07:30—08:30
Breakfast

08:30—11:45
System-Level Regulation
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jonas Frisén, Karolinska Institutet, Sweden

Henriette van Praag, NIA, National Institutes of Health, USA
Physical Activity and New Neuron Connectivity

Brian R. Christie, University of Victoria, Canada
Effects of Prenatal Ethanol Exposure on Synaptic Plasticity, Neurogenesis and Learning: Benefits of Exercise and Nutrition

Paul W. Frankland, University of Toronto, Canada
Hippocampal Neurogenesis and Forgetting

Fred H. Gage, The Salk Institute for Biological Studies, USA
Regulation and Function of Neurogenesis in the Adult Hippocampus

Nicolas Toni, University of Lausanne, Switzerland
Short Talk: Astrocytes Locally Control the Synaptic Integration of Adult-Born Hippocampal Neurons

Matteo Bergami, University of Cologne, Germany
Short Talk: Experience-Dependent Remodelling of Adult-Born Neuron Presynaptic Connectivity

09:50—10:10
Coffee Break

11:45—14:30
On Own for Lunch

14:30—16:30
Workshop 2

* Pierre-Marie Lledo, Pasteur Institute, France

Thomaz Lüscher Dias, Universidade Federal de Minas Gerais, Brazil
Effect of Odor-Enriched Environment and Social Isolation on Hippocampal and Olfactory Bulb Neurogenesis of Adult Mice

Lida Katsimpardi, Harvard University, USA
Rejuvenation of the Cerebral Vasculature and Neurogenesis in the Aged Brain by Young Systemic Factors

Sarah E. Latchney, University of Texas Southwestern Medical Center, USA
Inducible Knockout of MEF2A/C/D from Nestin+ Stem Cells, Progenitors and their Progeny Impairs Hippocampal Neurogenesis in vivo

Amar Sahay, Harvard Medical School, USA
Re-Engineering Memory Circuits through Neuronal Competition

Friederike Klempin, Max Delbrück Center for Molecular Medicine, Germany
Serotonin Mediates the Hippocampal Neurogenic Effect on Running

Paloma Pérez-Domper, Cajal Institute, Spain
GSK -3 Inhibition Has Proneurogenic and Antidepressant Effects: Might this Inhibition Be a Key Target in Major Depression’s Treatment?

Fanny Boehme, DZNE Dresden, Germany
CADASIL Model Reveals Novel Insights into Notch3 Function in Adult Hippocampal Neurogenesis

Varunika Goyal, Universitäts Klinikum, Jena, Germany
Cognitive Performance in Aged Neurogenesis Deficient Cyclin D2 Knock Out (cD2KO) Mice and Influence of Environmental Enrichment

16:30—17:00
Coffee Available

17:00—19:00
Computational Modeling
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Gerd Kempermann, Technische Universität Dresden, Germany

James Bradley Aimone, Sandia National Laboratories, USA
Are New Neurons in Humans Important? How Scale Affects Neurogenesis Function

Suzanna (Sue) Becker, McMaster University, Canada
The Role of Neurogenesis in Minimizing Interference: Evidence from Computational Models, Rodent and Human Studies

Alessandro Treves, SISSA, Italy
The Role of New Neurons in an Old Circuitry

Zeina Nicola, DZNE-Deutsches Zentrum für Neurodegenerative Erkrankungen, Germany
Short Talk: Development of the Neurogenic Niche in the Hippocampus of Adult Mice

19:00—20:00
Social Hour with Lite Bites

B3
20:00—23:00
Entertainment

B3

SATURDAY, MAY 17

 
Departure


*Session Chair †Speaker invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Science for Life Laboratory - Stockholm Knut and Alice Wallenberg Foundation
Curemark LLC
 

We gratefully acknowledge additional support for this conference from:

Chroma Technology Corporation

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS086102-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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