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This meeting took place in 2015



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MicroRNAs and Noncoding RNAs in Cancer (E5)


Organizer(s) Frank J. Slack, Manel Esteller and Lin He
June 7—12, 2015
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Feb 5, 2015
Abstract Deadline: Mar 5, 2015
Scholarship Deadline: Feb 5, 2015
Discounted Registration Deadline: Apr 7, 2015

Sponsored by Journal of Molecular Cell Biology (JMCB) and Merck & Co., Inc.

Summary of Meeting:
MicroRNAs and other noncoding RNAs have recently emerged as key regulators of gene expression during development and are frequently mis-expressed in human disease states, in particular cancer. MicroRNAs act to promote or repress cell proliferation, migration and apoptosis during development, all processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. Their small size and molecular properties make microRNAs amenable as targets and therapeutics in cancer treatment. MicroRNAs thus present a paradigm shift in thinking about gene regulation during development and disease and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer. However, while hundreds of human microRNAs and noncoding RNAs are known, relatively little is known about their roles and targets, and there is still a limited literature on using these molecules in the clinic. The specific aims of this meeting serve to address these deficiencies and are as follows: 1) Focus on the exciting biology of microRNAs and noncoding RNAs in controlling developmental and cancer processes like cell proliferation, differentiation, cell cycle, apoptosis and metastasis. This meeting will highlight the best current research into the role that miRNAs play in these fundamental processes and provide the basic understanding that will drive the invention of powerful clinical tools; 2) Focus on the latest efforts to harness the power of these RNAs as agents in the fight against cancer. Discussions will range from use of miRNAs as diagnostic and prognostic markers in cancer, to SNPs providing risk factors for cancer, to the delivery and effectiveness of small RNA therapeutics in clinically relevant settings; 3) Attract the best researchers working in small RNAs and cancer to one place for critical discussions that will advance the field and accelerate the benchside to bedside use of this technology; and 4) Provide a stimulating environment where students, postdocs and junior investigators can present and discuss their research with the best minds in the field.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JUNE 7

16:00—20:00
Arrival and Registration

Keystone Lodge Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Keystone Lodge-Bighorn Bar

MONDAY, JUNE 8

07:30—08:30
Breakfast

Longs/Quandary Peaks
08:30—09:15
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Frank J. Slack, BIDMC Cancer Center/Harvard Medical School, USA

Joan A. Steitz, HHMI, Yale University, USA
Noncoding RNAs in Viral Biology

10:00—10:20
Coffee Break

Longs Peak Foyer
09:15—12:30
Small RNAs in Development
Meeting has ended...abstracts no longer viewable online.

Grays Peak
Kevin V. Morris, Center for Gene Therapy, City of Hope, USA
MYCNOS Functions as an Antisense RNA Regulating MYCN

Lin He, University of California, Berkeley, USA
miR-34/449 miRNAs Promote Motile Ciliogenesis through Direct Regulation of Cp110 in Multiciliated Airway Cells

Sohail F. Tavazoie, Rockefeller University, USA
Small-RNA Regulation of Metastatic Progression

Jaimee E. Hoefert, University of Colorado Boulder, USA
Short Talk: The miR-200 microRNA Family Orchestrates Hair Follicle Development by Governing Migration and Proliferation of Hair Follicle Progenitors

Rui Zhou, Sanford-Burnham Medical Research Institute, USA
Short Talk: SmD1 Modulates the miRNA Pathway Independently of Its Pre-mRNA Splicing Function

George Q. Daley, HHMI/Boston Children's Hospital, USA
The LIN28/let-7 Axis in Development and Disease

12:30—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
12:30—14:30
On Own for Lunch

14:30—16:30
Workshop 1: miRNA Biogenesis/Turnover/Mechanism

Grays Peak
* Richard I. Gregory, Harvard Medical School, USA

Justin T. Roberts, University of Colorado Anschutz Medical Campus, USA
RNA Editing Alters MiR Targeting in Human Breast Cancer

Tsung-Cheng Chang, University of Texas Southwestern Medical Center, USA
A Genome-Wide Atlas of microRNA Primary Transcript Structure

Laurent Delva, INSERM U866, France
Dicer Controls the Maintenance of Genome Integrity in Hematopoietic Stem/Progenitor Cells through a Non-Conventional Pathway

John T. Powers, Boston Children's Hospital, USA
Multiple Distinct Mechanisms Disrupt let-7 microRNA Biogenesis and Function in Neuroblastoma

Francesco Ghini, Istituto Italiano di Tecnologia - IIT@SEMM, Italy
Uncovering microRNA Degradation Dynamics through Metabolic Labeling

Yi-Jia Li, Beckman Research Institute of City of Hope, USA
Regulation of Let-7a and miR-34b/c Expression by SUMOylation

Deni Subasic, University of Zürich, Switzerland
Cooperative Target mRNA Destabilization and Translation Inhibition by miR-58 microRNA Family in C. Elegans

Alexander Svoronos, Yale University, USA
OncomiR or Tumor Suppressor? Modeling the Effects of miR-125b on the Apoptosis Pathway

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
MicroRNAs in Development
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Irene Bozzoni, University La Sapienza, Rome, Italy

Amy E. Pasquinelli, University of California, San Diego, USA
The Primary Target of let-7 MicroRNA

Anita G. Seto, miRagen Therapeutics, USA
Oligonucleotides as MicroRNA-Based Therapeutics

Helge Großhans, Friedrich Miescher Institute - FMI, Switzerland
The Yin and Yang of miRNAs and their Targets

Xiling Shen, Cornell University, USA
Short Talk: Versatile microRNA Regulation of Normal and Cancer Stem Cell Asymmetric Division

Zhiji Ren, University of Massachusetts Medical School, USA
Short Talk: C. elegans let-7 Family microRNAs Act in Innate Immune Response Circuits and Confer Robust Developmental Cell Fates Under Pathogen Stress

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
19:30—22:00
Poster Session 1

Longs/Quandary Peaks

TUESDAY, JUNE 9

07:30—08:30
Breakfast

Longs/Quandary Peaks
08:00—08:30
Poster Setup

Longs/Quandary Peaks
08:30—17:00
Poster Viewing

Longs/Quandary Peaks
08:30—11:45
MicroRNAs in Animal Development
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Amy E. Pasquinelli, University of California, San Diego, USA

Silvia Monticelli, Institute for Research in Biomedicine, Switzerland
MicroRNA-Mediated Regulation of T Lymphocyte Activation

Eran Hornstein, Weizmann Institute of Science, Israel
MicroRNAs Maintain Cellular Identity and the Differentiated State

Markus Stoffel, ETH Zürich, Switzerland
MicroRNAs and Insulin Secretion and Signaling

Aurora Esquela-Kerscher, Eastern Virginia Medical School, USA
MicroRNAs and the Prostate

Xiying Fan, University of Colorado Boulder, USA
Short Talk: MicroRNA-205, a Basal Layer Specific microRNA, Is Crucial for Tumorigenesis of Both Basal and Luminal Layers of the Prostate Gland

Vanessa Mondol, Yale University, USA
Short Talk: Splicing Remodels Primary let-7 miRNA for Recognition by the Microprocessor

09:50—10:10
Coffee Break

Longs Peak Foyer
11:45—12:30
Lunch

Longs/Quandary Peaks
12:00—14:30
Poster Session 2

Longs/Quandary Peaks
14:30—16:30
Workshop 2: Industry Applications

Grays Peak
* Eva M. Hernando, New York University Cancer Center, USA

Bryce Alves, Active Motif, USA
Toolbox to Study Expression, Regulation and Targeting of Long ncRNAs

Barbara R. Gould, Exiqon, Inc., USA
Effective and Long Lasting KD of Nuclear Retained lncRNA in a Broad Range of Mouse Tissues Achieved with Single Stranded LNA Enhanced Antisense Oligonucleotides

Angela M. Schoolmeesters, Dharmacon, USA
Scaffold Design, Function and Over-Expression of Lentiviral-Based microRNAs

Sabrina Shore, TriLink Biotechnologies, USA
Improved Small RNA Library Preparation Workflow for Next-Generation Sequencing Allows Low Inputs and Does Not Require Gel Purification

Ricardo Jose Soares, Bioneer, Denmark
Sensitive in situ Hybridization Technologies to Detect lncRNAs in Cells

Ngoc B. Tran, Novartis Institutes for Biomedical Research, USA
RNAi Off-Target effects Reveal Endogenous miRNAs Regulating Cellular Pathways

Paloma del C Monroig-Bosque, MD Anderson Cancer Center, USA
Targeting microRNAs with Small Molecules: A Novel Approach for Breast Cancer (BC) Therapy

Wei-Lin W. Wang, miR Diagnostics, USA
Prostate Cancer Diagnosis Using Sentinel ncRNA Signatures

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
MicroRNAs and Cancer I
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Manel Esteller, Belvitge Biomedical Research Institute (IDIBELL), Spain

Frank J. Slack, BIDMC Cancer Center/Harvard Medical School, USA
MicroRNAs as Targeted Therapeutics and Therapeutic Targets in Cancer

Joshua T. Mendell, HHMI/University of Texas Southwestern Medical Center, USA
MicroRNAs and lncRNAs in Mammalian Physiology and Cancer

Eva M. Hernando, New York University Cancer Center, USA
miRNA as Functional Players and Predictive Biomarkers in Melanoma Metastasis

Molly A. Taylor, AstraZeneca, UK
Short Talk: microRNAs Distinguish Lung Squamous Cell Carcinoma Tumor Subtypes with Distinct Therapeutic Response Profiles

Katrien Van Roosbroeck, University of Texas MD Anderson Cancer Center, USA
Short Talk: A miR-155/TP53 Regulatory Feedback Loop Involved in Resistance to Therapy in Carcinomas and Leukemias

19:15
On Own for Dinner


WEDNESDAY, JUNE 10

07:30—08:30
Breakfast

Longs/Quandary Peaks
08:30—11:45
Noncoding RNA in Development and Physiology
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Anton Wutz, ETH Zürich, Switzerland

Michael G. Rosenfeld, HHMI/University of California, San Diego, USA
Regulation of Estrogen-Activated or Repressed Enhancers

Mitchell Guttman, California Institute of Technology, USA
lncRNAs: Function and Mechanism in Controlling Cellular Identity

David L. Spector, Cold Spring Harbor Laboratory, USA
Probing the Role of the Long Non-Coding RNA Malat1 in Breast Cancer Progression

Irene Bozzoni, University La Sapienza, Rome, Italy
Long Noncoding RNAs in Muscle Differentiation and Diseases: Biogenesis and Function of Linear and Circular Species

Gregory J. Goodall, SA Pathology, Australia
Short Talk: The RNA Binding Protein Quaking Regulates Formation of circRNAs

Esteban A. Orellana, Purdue University, USA
Short Talk: Enhancing the Anti-Proliferative Activity of miRNA-34a: A Combinatorial Approach to miRNA-Based Therapeutics

09:50—10:10
Coffee Break

Longs Peak Foyer
11:45—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
11:45—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Long ncRNAs and Cancer
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* David L. Spector, Cold Spring Harbor Laboratory, USA

Anton Wutz, ETH Zürich, Switzerland
Exploring the Gene Silencing Pathway of Xist in Development and Cancer

John L. Rinn, University of Colorado, Boulder, USA
Linking RNA to Cancer in vivo

Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
In vivo Analysis of Linear and Circular ceRNAs in Tumorigenesis

Alexander Pertsemlidis, UT Health Science Center at San Atonio, USA
Short Talk: miRNA Regulation of Neuroblastoma Cell Viability

Quan Zhu, The Salk Institute of Biological Studies, USA
Short Talk: Aberrant Overexpression of Heterochromatic Repetitive RNA Causes Genomic Instability and Tumor Formation in Mice

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
19:30—22:00
Poster Session 3

Longs/Quandary Peaks

THURSDAY, JUNE 11

07:30—08:30
Breakfast

Longs/Quandary Peaks
08:30—11:45
MicroRNAs and Cancer II
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Joshua T. Mendell, HHMI/University of Texas Southwestern Medical Center, USA

Manel Esteller, Belvitge Biomedical Research Institute (IDIBELL), Spain
Epigenetic and Genetic Disruption of ncRNAs in Human Disease

George A. Calin, University of Texas MD Anderson Cancer Center, USA
About Chomsky, Patterns, Noncoding RNAs and Cancer Patients

Andrea Ventura, Memorial Sloan Kettering Cancer Center, USA
Using Noncoding RNAs to Create Better Mouse Models of Human Cancer

Xiao-Fan Wang, Duke University Medical Center, USA
MiR-215 Is Induced Post-Transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B

Yejing Ge, Rockefeller University, USA
Short Talk: In vivo Screen for Oncogenic miRNAs Identifies Novel oncomiRs as Drivers in Skin Cancer

Carmit Levy, Tel-Aviv University, Israel
Short Talk: The Microenvironmental Trigger of Melanoma Metastasis

09:50—10:10
Coffee Break

Longs Peak Foyer
11:45—14:30
On Own for Lunch

14:30—16:30
Workshop 3: Breaking News

Grays Peak
* Andrea Ventura, Memorial Sloan Kettering Cancer Center, USA

Brian D. Adams, Yale University, USA
Re-Introduction of Tumor-Suppressor miR-34a Shows Therapeutic Efficacy in Triple Negative Breast Cancer

Jessica Tytell, Firefly, an Abcam Company, USA
High-Throughput miRNA Profiling from Cells, Tissues and Biofluids

Sambasivarao Damaraju, University of Alberta/Cross Cancer Institute, Canada
Piwi-Interacting RNAs (piRNAs) as Novel Prognostic Markers for Breast Cancer

Anindya Bagchi, University of Minnesota, USA
Long Noncoding RNA PVT1 Augments MYC in Human Cancer

Dimple Chakravarty, Weill Cornell Medical College, USA
The Role of the Long Noncoding RNA NEAT1 in Therapy Resistant Prostate Cancer

Florian A. Karreth, Weill Cornell Medical College, USA
The BRAF Pseudogene Is a Proto-Oncogenic Competitive Endogenous RNA

Xiaochao Tan, MD Anderson Cancer Center, USA
ZEB1-microRNA Axes Control a Golgi Polarization Switch that Regulates Cell Migration

Samantha McElyea, Indiana University School of Medicine, USA
Novel Nanoplasmonic-Based microRNA Sensing for Cancer Diagnosis

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:15
MicroRNAs and Cancer III
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Lin He, University of California, Berkeley, USA

Richard I. Gregory, Harvard Medical School, USA
microRNA Regulation in Stem Cells and Cancer

Elsa R. Flores, University of Texas MD Anderson Cancer Center, USA
Regulation of MicroRNAs by the p53 Family in Cancer

18:15—19:00
Closing Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays Peak
Carlo M. Croce, Ohio State University, USA
MicroRNAs and Cancer

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grays Peak
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Longs/Quandary Peaks

FRIDAY, JUNE 12

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Journal of Molecular Cell Biology (JMCB) Merck & Co., Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA196164-01

Funding for this conference was made possible (in part) by 1R13CA196164-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Abcam plc Exiqon A/S
miRagen Therapeutics TriLink Biotechnologies

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676