Beaver Run Resort Floorplan

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This meeting took place in 2015


Here are the related meetings in 2018:
Selective Autophagy (Z2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Autophagy (E6)


Organizer(s) Eric H. Baehrecke and Jayanta Debnath
June 19—24, 2015
Beaver Run Resort • Breckenridge, Colorado USA
Discounted Abstract Deadline: Feb 17, 2015
Abstract Deadline: Mar 17, 2015
Scholarship Deadline: Feb 17, 2015
Discounted Registration Deadline: Apr 21, 2015

Sponsored by Cell Research, Merck & Co., Inc. and Novartis Institutes for BioMedical Research

Summary of Meeting:
Autophagy is an essential catabolic process that plays important roles in cell stress management and nutrient homeostasis. Following the landmark discoveries of the molecules controlling autophagy in yeast, genetic studies in multicellular organisms have revealed diverse roles for autophagy in development, physiology and in the etiology and pathogenesis of multiple age-associated disorders. Hence, interest in manipulating autophagy to treat human disease has rapidly intensified. The aims of this conference are to: 1) Gather experts together with junior scientists and researchers new to this field in a setting that supports structured and casual interactions; 2) Promote exchange of cutting edge, innovative and unpublished science relevant to the roles of autophagy in healthy, aging and pathologic cell contexts; and 3) Expedite discoveries that advance mechanistic knowledge of autophagy and facilitate clinical opportunities for the treatment and diagnosis of diseases caused by the mis-regulation of this process. This symposium explores the frontiers of autophagy research, with themes that focus on newly discovered molecules, pathways and mechanisms that specify forms of autophagy in development and disease. We propose multiple novel session topics based on recent discoveries in this field. Emphasis will be placed on how our emerging understanding of autophagy may influence disease. Interdisciplinary leaders of the autophagy field will gather together with junior scientists to share discoveries and exchange ideas. The collegial atmosphere of this conference is designed to enable brainstorming and promote collaborations to advance our understanding of the basic mechanisms controlling autophagy, and how altered autophagy may influence disease course and treatment.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, JUNE 19

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

SATURDAY, JUNE 20

07:30—08:30
Breakfast

Summit Gallery
08:00—08:30
Poster Setup

Breckenridge Ballroom
08:30—17:00
Poster Viewing

Breckenridge Ballroom
08:30—09:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Eric H. Baehrecke, University of Massachusetts Medical School, USA

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Chaperone-Mediated Autophagy: Who Would Have Thought!

09:30—11:45
Regulators of Autophagy
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Vojo Deretic, University of New Mexico Health Sciences Center, USA

Sharon A. Tooze, Francis Crick Institute, UK
Mechanisms Controlling Autophagosome Formation in Mammals

Hong Zhang, Chinese Academy of Sciences, China
O-GlcNAc-Modification of SNAP-29 Regulates Autophagosome Maturation

Xuejun Jiang, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Regulation of Autophagy by Coordinated Action of mTORC1 and Protein Phosphatase 2A

Noboru Mizushima, University of Tokyo, Japan
Novel Insights into Physiological Roles of Autophagy in Mice

10:10—10:30
Coffee Break

Foyer
11:45—12:30
Lunch

Breckenridge Ballroom
12:00—14:30
Poster Session 1

Breckenridge Ballroom
14:30—16:30
Workshop 1: Late-Breaking Topics in Molecular Regulation and Cellular Functions of Autophagy

Colorado Ballroom
* Sharon A. Tooze, Francis Crick Institute, UK

Michael J. Ragusa, Dartmouth College, USA
Organizing the Autophagy-Specific Phagophore Assembly Site

Xiaojun Tan, University of Wisconsin-Madison, USA
PtdIns(4,5)P2 Regulation of ATG14 and Autophagy

Megan L. Goodall, University of Colorado Denver, USA
Autophagy Regulation of Necroptosis

Emily S. Bell, McGill University, Canada
An Autophagy-Mediated Switch in HGF-Induced Cell Migration

Weili Cai, NICHD, National Institutes of Health, USA
Context-Specific Requirements for Individual GATOR2 Subunits in Drosophila

Josh Lyon Andersen, Brigham Young University, USA
14-3-3zeta Interactomics Reveals an AMPK- and ULK1-Mediated Phosphorylation on mAtg9A that Governs Induction of Autophagy

Ian G. Ganley, University of Dundee, UK
mTOR Activates the VPS34-UVRAG Complex to Regulate Lysosomal Tubulation and Cell Survival during Autophagosome-Lysosome-Reformation

16:30—17:00
Coffee Available

Foyer
17:00—19:00
New Roles for Lysosomes in Autophagy Regulation
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Mondira Kundu, St. Jude Children's Hospital, USA

Li Yu, Tsinghua University, China
Autophagic Lysosome Reformation: Insight from in vitro Reconstitution

Roberto Zoncu, University of California, Berkeley, USA
The Lysosome in Nutrient Sensing and Growth Control

Alyssa Johnson, University of California, San Francisco, USA
Short Talk: VCP-Dependent Muscle Degeneration Is Linked to Defects in a Dynamic Tubular Lysosomal Network in vivo

Rushika M. Perera, University of California, San Francisco, USA
Lysosomes and Nutrient Scavenging in Pancreatic Cancer

19:00
On Own for Dinner


SUNDAY, JUNE 21

07:30—08:30
Breakfast

Summit Gallery
08:30—11:45
Selective Autophagy
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Ivan Dikic, Goethe University Medical School, Germany

Suresh Subramani, University of California, San Diego, USA
Activation of the Pexophagy Receptor via Phosphorylation through Interactions with Peroxisomal Biogenesis and Pexophagy Proteins

Anne Simonsen, University of Oslo, Norway
Regulation of Selective Autophagy by Nuclear Shuttling of ALFY

Jessica Huber, Deutsches Krebsforschungszentrum DKFZ, Germany
Short Talk: Specific Interaction of the Human ATG8 Proteins with the KBTBD6 and KBTBD7 LIR Provides a Platform for the Regulation of TIAM1 RAC1 Signaling

Qing Zhong, University of Texas Southwestern Medical Center, USA
Mechanism of Autophagy-Regulated Ciliogenesis

Werner J. Kovacs, ETH Zürich, Switzerland
Short Talk: Hif-2alpha Promotes Degradation of Mammalian Peroxisomes by Pexophagy

Tamotsu Yoshimori, Osaka University, Japan
New Insights into Membrane Dynamics and Role of Autophagy

09:50—10:10
Coffee Break

Foyer
11:45—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
11:45—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Autophagy, Neuronal Health and Neurodegenerative Disorders
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Ana Maria Cuervo, Albert Einstein College of Medicine, USA

Ai Yamamoto, Columbia University, USA
Exploring the Role of Selective Macroautophagy in the Brain

Zhenyu Yue, Mount Sinai Medical Center, USA
Regulation of Selective Autophagy through Autophagy Receptors in Neurodegenerative Disease

Constanza J. Cortes, University of California, San Diego, USA
Short Talk: TFEB Expression in Skeletal Muscle Enhances Autophagy and Induces Insulin Signaling

Ralph A. Nixon, New York University, Langone Medical Center, USA
Genetic Pathways to Autophagy Dysfunction in Alzheimer's Disease

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 2

Breckenridge Ballroom

MONDAY, JUNE 22

07:30—08:30
Breakfast

Summit Gallery
08:30—11:45
Non-Traditional Functions for Autophagy-Related Proteins
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Herbert (Skip) W. Virgin, Washington University School of Medicine, USA

Douglas R. Green, St. Jude Children's Research Hospital, USA
Noncanonical Autophagy and Phagocytosis: Two Ancient Pathways Converge on Inflammation, Innate Immunity and Aging

Monica Kim, University of California, San Francisco, USA
Autophagy Proteins Regulate Engulfment Mechanisms that Promote Nutrient Scavenging

Min Zhang, University of California, Berkeley, USA
Short Talk: Molecular Mechanism for Autophagy-Mediated Secretion of Interleukin-1beta

Vojo Deretic, University of New Mexico Health Sciences Center, USA
Role of TRIM Proteins in Autophagy

Akhila Rajan, Harvard Medical School, USA
Short Talk: Unconventional Autosecretion in Response to Alterations in Lipid Stores Regulates Adipokine Secretion

Jayanta Debnath, University of California, San Francisco, USA
How Autophagy in Stromal Fibroblasts Impacts the Tumor Microenvironment—A Role for Secretion?

09:50—10:10
Coffee Break

Foyer
11:45—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
11:45—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Autophagy and Cancer
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Andrew M. Thorburn, University of Colorado AMC, USA

Alec Kimmelman, New York University Langone Medical Center, USA
Autophagy, Metabolism and Pancreatic Cancer

Kevin M. Ryan, Beatson Institute for Cancer Research, UK
Mechanisms of Autophagy in Cell Death and Cancer

Vinay Verghese Eapen, Harvard Medical School, USA
Short Talk: Dissection of the DNA Damage-Induced Autophagy Pathway in Budding Yeast

Eileen P. White, Rutgers University, USA
Autophagy, Metabolism and Cancer

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 3

Breckenridge Ballroom

TUESDAY, JUNE 23

07:30—08:30
Breakfast

Summit Gallery
08:30—11:45
Ubiquitin and Ubiquitin-Like Molecules in Autophagy
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Jayanta Debnath, University of California, San Francisco, USA

Leon O. Murphy, Third Rock Ventures, USA
NCOA4 and Ferritin Regulation

Joseph D. Mancias, Beth Israel Deaconess Medical Center, USA
Short Talk: Role of NCOA4-Mediated Ferritinophagy in Iron Metabolism

Mondira Kundu, St. Jude Children's Hospital, USA
Regulation and Function of ULK1

Ivan Dikic, Goethe University Medical School, Germany
Regulation of Endoplasmic Reticulum Turnover by Selective Autophagy

Danielle Sliter, NINDS, National Institutes of Health, USA
Short Talk: Optineurin and NDP52 Function Upstream of LC3 in PINK1/Parkin-Mediated Mitophagy

Eric H. Baehrecke, University of Massachusetts Medical School, USA
Ubiquitination and Control of Atg7-Independent Autophagy

09:50—10:10
Coffee Break

Foyer
11:45—17:00
On Own for Lunch

14:30—16:30
Workshop 2: Late-Breaking Topics in Autophagy and Disease

Colorado Ballroom
* Kevin M. Ryan, Beatson Institute for Cancer Research, UK

Christina L. Stallings, Washington University School of Medicine, USA
Unique Role for ATG5 in Neutrophil-Mediated Immunopathology during Mycobacterium tuberculosis Infection

Petra Paul, University of Zürich, Switzerland
The Role of Macroautophagy in the Immune Response against Influenza A Infection

Catarina Veltrini Horta, University of São Paulo - Ribeirão Preto Medical School, Brazil
Pattern Recognition Receptors Favor Autophagy Induction for Restriction of Trypanosoma cruzi Infection

Alexandra Boeske, Forschungszentrum Jülich, Germany
GABARAPs Mediate Anterograde Transport and Secretion of HIV-1 Nef via Mechanisms Related to Unconventional Protein Secretion

Sandhya Sanduja, Whitehead Institute, USA
AMPK-Mediated Autophagy Promotes Drug Tolerance in BRAF Mutant Melanoma

Alice C. Newman, IGMM, University of Edinburgh, UK
Autophagy of TRAF3 Inhibits TGFbeta-Driven Cytokine Expression in Cancer Cells

Julian J. Lum, British Columbia Cancer Agency, Canada
Autophagy-Dependent Reprogramming of Metabolism in CD8+ Effector T Cell Survival and Development of Memory

16:30—17:00
Coffee Available

Foyer
17:00—18:45
Autophagy in Infection and Immunity
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Douglas R. Green, St. Jude Children's Research Hospital, USA

Jeffery S. Cox, University of California, Berkeley, USA
cGAS Detects Mycobacterium tuberculosis DNA to Activate both Type I Interferon and Autophagy

Sara R. Cherry, University of Pennsylvania School of Medicine, USA
Viruses and Autophagy

Herbert (Skip) W. Virgin, Washington University School of Medicine, USA
Gene-, Cell-Type-, and Pathogen-Specific Roles of Autophagy Genes in Inflammation and Immunity

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Breckenridge Ballroom

WEDNESDAY, JUNE 24

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Cell Research Merck & Co., Inc.
Novartis Institutes for BioMedical Research
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA196137-01

Funding for this conference was made possible (in part) by 1 R13 CA 196137 - 01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Adipogen International Cayman Chemical Company
Cell Signaling Technology, Inc. Promega Corporation

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Pfizer Global Research & Development


Pfizer Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676