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This meeting took place in 2015



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Hematopoiesis (B6)


Organizer(s) Timm Schroeder, Hanna K.A. Mikkola and Patricia Ernst
February 22—27, 2015
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 22, 2014
Abstract Deadline: Nov 20, 2014
Scholarship Deadline: Oct 22, 2014
Discounted Registration Deadline: Dec 18, 2014

Sponsored by H3 Biomedicine Inc., Incyte Corporation and Regeneron Pharmaceuticals, Inc.

Summary of Meeting:
Over recent decades, several important principles have emerged about the development, proliferation, survival and lineage choice in the hematopoietic system. Integration of years of hematological clinical experience with basic hematopoiesis research continues to push technological and conceptual advances in both basic and clinical research. In this tradition, this Keystone Symposia meeting will bring together a spectrum of basic to clinical researchers who cover various aspects of hematopoiesis encompassing stem and progenitor cell development, maintenance and differentiation during homeostasis, stress and disease. How these processes are governed by signaling pathways, epigenetic mechanisms, transcriptional and miRNA networks, metabolic and local or systemic niche factors will be discussed by experts from different career stages and continents. The integration of innovative tools such as single-cell quantification and novel imaging technologies in different model systems will be an important aspect throughout the meeting. In recent years, there has been renewed excitement in analyzing basic mechanisms of hematopoiesis which led to a greatly improved understanding of the embryonic and adult hematopoietic cellular hierarchy and of the molecular control of hematopoiesis. Some of these discoveries have very quickly been translated into therapeutic approaches that are already tested in clinical trials. This meeting will provide a forum for cross-fertilization between investigators pursuing diverse approaches such that participants benefit from the latest technological developments and insights from different model systems, and pursue their research challenges with new insight and collaborations.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 22

16:00—20:00
Arrival and Registration

Keystone Lodge Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Keystone Lodge-Bighorn Bar

MONDAY, FEBRUARY 23

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Timm Schroeder, ETH Zürich, Switzerland

John E. Dick, Princess Margaret Cancer Centre, Canada
Stem Cells in Cancer: Do They Matter?

09:00—11:30
Architecture of the Hematopoietic System
Meeting has ended...abstracts no longer viewable online.

Grays Peak
Connie J. Eaves, British Columbia Cancer Agency, Canada
Transitioning from Monistic to Pluralistic Models of Hematopoiesis

E. Camilla Forsberg, University of California, Santa Cruz, USA
Hematopoietic Stem and Progenitor Differentiation Pathways

Irving L. Weissman, Stanford University, USA
Normal and Malignant Hematopoiesis

Jianlong Sun, Children's Hospital Boston, Harvard Medical School, USA
Short Talk: Clonal Features of Native Hematopoiesis Revealed by Transposon-Mediated Cellular Barcoding

Dennis E. Discher, University of Pennsylvania, USA
Short Talk: HSC Myosin-IIB Explains Asymmetric Division, and HSC Nuclear Rigidity Explains their Marrow Enrichment

09:40—10:00
Coffee Break

Longs Peak Foyer
11:30—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
11:30—14:30
On Own for Lunch

14:30—16:30
Workshop 1: Normal and Malignant Lymphoid Biology

Grays Peak
* Trista E. North, Beth Israel Deaconess Medical Center, USA

* Jian Xu, University of Texas Southwestern Medical Center, USA

James DeGregori, University of Colorado Denver School of Medicine, USA
Suppression of Inflammation Maintains B-Progenitor Fitness in Chronologically Aged Mice and Abrogates Oncogenic Adaptation

Kathrin M. Bernt, Children's Hospital of Philadelphia, USA
Targeting MN1 Driven AML through Epigenetic Modulation of the Cell of Origin

Bidisha Chanda, Tokai University School of Medicine, Japan
A Single Micro-RNA Can Completely Rescue B-Cell Differentiation Arrest due to EBF1 Deficiency — Can Micro-RNA Control Cell Fate as a Potential Alternative of Transcriptional Factor?

Alya Zriwil, University of Lund, Sweden
Role of Colony Stimulating Factor 1 Receptor in Fetal B Lymphopoiesis

Mamle Quarmyne, Bayer Healthcare, USA
Protein Tyrosine Phosphatase-Sigma (PTP?) Regulates Hematopoietic Stem Cell Repopulating Capacity

Martijn A. Nolte, Sanquin Blood Supply, Netherlands
Bone Marrow Memory CD8+ T Cells Support the Function of HSCs

Louise M. Treanor, Novartis Institutes for BioMedical Research, USA
Bromodomain Inhibitor Efficacy in Murine ETP-ALL Is Mediated by Inhibition of Lmo2 Expression and Super-Enhancer Deregulation

Anastasia N. Tikhonova, New York University Medical School, USA
CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Development of the Hematopoietic System
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Patricia Ernst, University of Colorado Anschutz Medical Center, USA

Nancy A. Speck, University of Pennsylvania, USA
Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Resistance to Genotoxic Stress

David Traver, University of California, San Diego, USA
Pathways Controlling the Emergence of Hematopoietic Stem Cells

Hanna K.A. Mikkola, University of California, Los Angeles, USA
Establishment of Self-Renewal during HSC Development

Ann C. Zovein, University of California, San Francisco, USA
Short Talk: Cell Fate Decisions in Hemogenic Endothelium

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
19:30—22:00
Poster Session 1

Longs/Quandary Peaks

TUESDAY, FEBRUARY 24

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:15
Transcriptional Cell Fate Control
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* E. Camilla Forsberg, University of California, Santa Cruz, USA

Stuart H. Orkin, Dana-Farber Cancer Institute, USA
Molecular Identification and Control of Hematopoietic Cell Types

Claus Nerlov, University of Oxford, UK
Heterogeneity of Hematopoietic Stem Cells: Implications for Regeneration and Aging

Timm Schroeder, ETH Zürich, Switzerland
Intrinsic and Extrinsic Regulation of Hematopoietic Lineage Choice

Atsushi Iwama, Graduate School of Medicine, Chiba University, Japan
Epigenetic Regulation of Hematopoiesis and Disease

Alan B. Cantor, Boston Children’s Hospital and Dana-Farber Cancer Institute, Harvard Medical Center, USA
Short Talk: An SCF-Fbw7 Ubiquitin Ligase Mediated Feedback Loop Facilitates GATA Factor Switching and Reinforces Commitment to Terminal Erythroid Maturation

Jian Xu, University of Texas Southwestern Medical Center, USA
Short Talk: GATA Switch-Controlled Alternative Polycomb Subunit Composition Mediates Non-Canonical Functions during Hematopoiesis

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Directed Development of Hematopoietic Cells
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Hanna K.A. Mikkola, University of California, Los Angeles, USA

Gordon M. Keller, University Health Network, MaRS Centre, Canada
Generation of Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Pathways Regulating Stem Cell Induction, Self-Renewal and Engraftment

Kateri Ann Moore, Ichan School of Medicine at Mount Sinai, USA
Direct Reprogramming of Fibroblasts into Hemogenic Cells Informs the Identification of Hemogenic Precursor Cells in Vivo

Sergei Doulatov, Boston Children's Hospital, USA
Short Talk: Tailored Combinations of Transcription Factors for Generating Multipotential and Lineage-Specific Progenitors from Human iPS Cells

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
19:30—22:00
Poster Session 2

Longs/Quandary Peaks

WEDNESDAY, FEBRUARY 25

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:15
Microenvironment
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Emmanuelle Passegué, Columbia University, USA

Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Hematopoietic Stem and Progenitor Cells Regulate the Regeneration of their Niche by Secreting Angiopoietin-1

Paul S. Frenette, Albert Einstein College of Medicine, USA
Analysis of HSC Niche Constituents in Bone Marrow and the Developing Fetal Liver

Utpal Banerjee, University of California, Los Angeles, USA
Local and Systemic Signaling in Maintenance of Hematopoietic Progenitors

Louise E. Purton, St. Vincent's Institute of Medical Research, Australia
Cytotoxic Therapies Cause Irreversible Damage to the Niches for Multipotent Progenitor Cells, Resulting in Impaired Long-Term Repopulating Potential of Bone Marrow

Katja Brückner, University of California, San Francisco, USA
Short Talk: An Inducible Signal from Sensory Neurons Regulates the Self-Renewing Blood Cell Pool in Drosophila

Wilson K. Clements, St. Jude Children's Research Hospital, USA
Short Talk: Somite-Derived Vascular Smooth Muscle Cell Precursors Form the Hematopoietic Stem Cell Specification Niche

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 2: New Frontiers in HSC Biology

Grays Peak
* Matthias Stadtfeld, New York University School of Medicine, USA

* Julien Y. Bertrand, University of Geneva, School of Medicine, Switzerland

Andrea Ditadi, SR-TIGET, Italy
Human Definitive Hemogenic Endothelium and Arterial Vascular Endothelium Represent Distinct Lineages

Ah Ram Kim, University of Rochester, USA
Bmi-1 Is a Critical Regulator of Erythroid Self-Renewal

Jonathan E. Henninger, Boston Children's Hospital, USA
Zebrabow Clonal Analysis with Fate-Mapping Defines the Number of Stem Cells Arising during Hematopoietic Development

Larry L. Luchsinger, Columbia University, USA
Mitochondrial Dynamics Regulates Hematopoietic Stem Cell Function

Christopher P. Dillon, St. Jude Children's Research Hospital, USA
Caspase-8 Regulates Hematopoiesis via RIP Kinases at Two Distinct Stages during Embryonic Development

Marieke Essers, Deutsches Krebsforschungszentrum DKFZ / HI-STEM, Germany
Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-Like Megakaryocyte Progenitors

Eric M. Pietras, University of California, San Francisco, USA
Interleukin-1 Drives Hematopoietic Stem Cells toward Precocious Myeloid Differentiation at the Expense of Self-Renewal

Eirini P. Papapetrou, Icahn School of Medicine at Mount Sinai, USA
Haploinsufficient Gene Discovery with iPSC Models of del(7q)-Myelodysplastic Syndrome

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Systemic Signals Controling HSC Behavior
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Nancy A. Speck, University of Pennsylvania, USA

Andreas Trumpp, German Cancer Research Center, Germany
Expression Landscape of HSCs and its Progeny and Analysis of the MDS Niche

Markus G. Manz, University Hospital Zürich, Switzerland
Hematopoietic Stem and Progenitor Cell Response to Bacterial Stimuli

Margaret A. Goodell, Baylor College of Medicine, USA
DNA Methyltransferases in Normal and Malignant Hematopoiesis

Trista E. North, Beth Israel Deaconess Medical Center, USA
Short Talk: Developmental Vitamin D Availability Regulates Hematopoietic Stem Cell Production and Expansion

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
19:30—22:00
Poster Session 3

Longs/Quandary Peaks

THURSDAY, FEBRUARY 26

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:15
Self-Renewal in Normal and Malignant Hematopoietic Cells
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Atsushi Iwama, Graduate School of Medicine, Chiba University, Japan

Guy Sauvageau, IRIC/Université de Montréal, Canada
Pharmacological Manipulation of HSC Self-Renewal

Patricia Ernst, University of Colorado Anschutz Medical Center, USA
Pathways and Mechansims Coordinating HSC Self-Renewal by the MLL1 Epigenetic Regulator

Koichi Akashi, Kyushu University, Japan
TIM-3 Signaling and Human Myeloid Leukemia Stem Cell Development

Anthony R. Green, University of Cambridge, UK
Myeloproliferative Neoplasms – Tweaking the Hematopoietic Rheostat

Michael A. Rieger, Goethe University Frankfurt, Germany
Short Talk: STAT5-Regulated miRNA-193b Controls Hematopoietic Stem and Progenitor Cell Expansion by Modulating Cytokine Receptor Signaling

Daisuke Nakada, Baylor College of Medicine, USA
Short Talk: AMPK Confers Metabolic Stress Resistance to Acute Myeloid Leukemia-Initiating Cells

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:45
Hematopoiesis in Aging and Stress
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Hans-Willem E. Snoeck, Columbia University Medical Center, USA

Gerald de Haan, University Medical Center Groningen, Netherlands
Aging of Hematopoietic Stem Cells

Iannis Aifantis, New York University School of Medicine, USA
The Role of Ubiquitination and Protein Stability in the Control of Blood Stress Responses

Emmanuelle Passegué, Columbia University, USA
DNA Repair and Stress Control in HSCs

18:45—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grays Peak
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Longs/Quandary Peaks

FRIDAY, FEBRUARY 27

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

H3 Biomedicine Inc. Incyte Corporation
Regeneron Pharmaceuticals, Inc.
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK104605-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-2676