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This meeting took place in 2015



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The Hippo Pathway: Signaling, Development and Disease (E4)


Organizer(s) Fernando D. Camargo, Kun-Liang Guan and Helen McNeill
May 17—21, 2015
Sagebrush Inn & Suites • Taos, New Mexico USA
Discounted Abstract Deadline: Jan 20, 2015
Abstract Deadline: Feb 19, 2015
Scholarship Deadline: Jan 20, 2015
Discounted Registration Deadline: Mar 17, 2015

Sponsored by Bayer HealthCare Pharmaceuticals and OncoMed Pharmaceuticals, Inc.

Summary of Meeting:
SIGNIFICANCE - The study of developmental signaling pathways has transformed our understanding of disease. The Hippo signaling pathway is a relatively novel signaling network that controls organ size, stem cell activity, and tumorigenesis. Therefore, the Hippo cascade and its components are attractive targets for the development of regenerative medicine and cancer drugs. The emerging paradigm in the field indicates that the Hippo pathway is a central sensor of multiple biological inputs, including cell adhesion, polarity, mechanical forces, and secreted ligands. These findings highlight the unique interdisciplinary nature of the field as the work from Drosophila geneticists, mammalian signalers, bioengineers, and developmental and cancer biologists needs to be integrated. These emerging paradoxes, the cancer and stem cell relevance of the pathway, and need for a larger forum to bring experts from multiple fields together prompted us to propose this meeting. The specific goals of this conference are to: 1) Identify and integrate evolutionary conserved inputs that control this cascade; 2) Define the transcriptional targets of the pathway that drive growth; 3) Understand the roles of Hippo in the physiology of multiple tissues; and 4) Define targets for chemical inhibitors and activators within pathway components. INNOVATION - This meeting follows on the 2013 Hippo Keystone meeting, which has been received with tremendous interest. This is the only conference specific to the Hippo field. The meeting will bring together Drosophila geneticists, basic and clinical cancer researchers, and the developmental and stem cell research community. It should consolidate the emerging field and have an impact on development of new cancer therapies.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MAY 17

16:00—20:00
Arrival and Registration

Sagebrush Lobby & Cantina
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Sagebrush Lobby & Cantina

MONDAY, MAY 18

07:30—08:30
Breakfast

Sagebrush Lobby & Cantina
08:30—09:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
Duojia D.J. Pan, HHMI/Johns Hopkins University School of Medicine, USA
Control of Organ Size and Tumor Suppression by the Hippo Signaling Pathway

09:30—12:45
Membrane and Upstream Inputs
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Fernando D. Camargo, Boston Children's Hospital, USA

Jin Jiang, University of Texas Southwestern Medical Center, USA
Genetic Dissection of Hpo Signaling Pathway in Organ Size Control and Stem Cell Regulation

Kun-Liang Guan, University of California, San Diego, USA
Regulation of Hippo-YAP Pathway by Energy Stress and Cancer Mutations

Kenneth Irvine, Rutgers University, USA
Mechanical Control of Hippo Signaling in vivo

Iswar K. Hariharan, University of California, Berkeley, USA
The Hippo Pathway: Inputs and Outputs

Liliana Attisano, University of Toronto, Canada
Short Talk: Multidimensional High-throughput Screening Identifies Hippo Pathway Regulators

Jimmy Hu, University of California, San Francisco, USA
Short Talk: The Role of Hippo Signaling and YAP/TAZ in the Incisor Stem Cell Niche

10:10—10:30
Coffee Break

Chamisa Lobby
12:45—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
12:45—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Hippo in Flies and Mammals: Signaling and Integration
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Georg A. Halder, Katholieke Universiteit Leuven, Belgium

Jeffrey L. Wrana, Mount Sinai Hospital, Canada
Integration of Developmental Signaling Pathways

Bin Zhao, Zhejiang University, China
Identification of a MicroRNA-Mediated Feed Forward Loop of the Hippo Pathway

Helen McNeill, Lunenfeld-Tanenbaum Research Institute, Canada
Regulation of Epithelial Structure and Branching Morphogenesis in the Developing Mouse Kidney

Christopher A. Johnston, University of New Mexico, USA
Short Talk: Warts Phosphorylates Mud to Promote Pins-Mediated Spindle Orientation in Drosophila

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

TUESDAY, MAY 19

07:30—08:30
Breakfast

Sagebrush Lobby & Cantina
08:30—11:45
Transcriptional Outputs
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Kun-Liang Guan, University of California, San Diego, USA

Stefano Piccolo, University of Padua, Italy
Transcriptional Control by YAP/TAZ

Nicolas Tapon, Francis Crick Institute, UK
Growth Regulation by the Hippo Pathway

Georg A. Halder, Katholieke Universiteit Leuven, Belgium
Regulation of the Hippo Pathway

Fernando D. Camargo, Boston Children's Hospital, USA
Hippo/YAP Signaling in Somatic Stem Cells and Cancer

Andrew G. Cox, Peter MacCallum Cancer Centre, Australia
Short Talk: Yap Reprograms Glutamine Metabolism and Supports Growth during Liver Development and Tumorigenesis

Kenneth H. Moberg, Emory University School of Medicine, USA
Short Talk: The Ecdysone Receptor Coactivator Taiman Links Yorkie to Transcriptional Control of Germline Stem Cell Factors in Somatic Tissue

09:50—10:10
Coffee Break

Chamisa Lobby
11:45—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2
11:45—14:30
On Own for Lunch

14:30—16:30
Workshop: Emerging Concepts in Hippo Regulation

Chamisa Ballroom 1
* Kenneth Irvine, Rutgers University, USA

Kieran F. Harvey, Peter MacCallum Cancer Centre, Australia
RNA Interference Screens: A Cautionary Tale from the Hippo Pathway

Joseph L. Kissil, The Scripps Research Institute, USA
The Role of YAP in Neurofibromatosis Type 2

Cathie M. Pfleger, Mount Sinai School of Medicine, USA
Exploiting “Synthetic Lethality” Phenomena as Therapeutic Points of Entry in Hippo-Associated Cancers

Sudha Veeraraghavan, University of Maryland, USA
Unexpected Insights into Hippo Signaling from the Crystal Structures of TEAD in Complex with Target DNA

Aleksander D. Szymaniak, Boston University School of Medicine, USA
Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap

Barry J. Thompson, Cancer Research UK, UK
The Spectrin Cytoskeleton Regulates the Hippo Pathway

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Hippo Signaling in Stem Cells and Regeneration
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Helen McNeill, Lunenfeld-Tanenbaum Research Institute, Canada

Hiroshi Sasaki, Osaka University, Japan
Roles of Tead Family Proteins in Cell Competition in Mouse NIH3T3 Embryonic Fibroblasts

James F. Martin, Baylor College of Medicine, USA
Hippo Signaling in Heart Regeneration

Dae-Sik Lim, Korea Advanced Institute of Science and Technology, KAIST, South Korea
Hippo Signaling in Liver Development

Jennifer L. Cotton, University of Massachusetts Medical School, USA
Short Talk: Specific Requirement of YAP and TAZ in Mammalian Gastrointestinal Development

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

WEDNESDAY, MAY 20

07:30—08:30
Breakfast

Sagebrush Lobby & Cantina
08:30—11:45
Hippo Pathway and Cancer Biology
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Kieran F. Harvey, Peter MacCallum Cancer Centre, Australia

Helena E. Richardson, Peter MacCallum Cancer Centre, Australia
Polarity Control of Hippo Signaling in Tumorigenesis

Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute, Canada
Phospho-Recognition in the Human Hippo Pathway

Barry M. Gumbiner, University of Virginia School of Medicine, USA
Regulation of the Hippo Pathway by Adhesion Receptors

Henning Wackerhage, University of Aberdeen, Scotland
Persistent YAP Hyperactivity Results in Mitotic Defects and Tumors with Complex Genomes

Cecile Chartier, OncoMed Pharmaceuticals, USA
Short Talk: YAP Inhibits Tumor Growth through Potentiation of BMP Signaling

Wenqi Wang, University of Texas MD Anderson Cancer Center, USA
Short Talk: Identify the Regulators for the Human Hippo Pathway

09:50—10:10
Coffee Break

Chamisa Lobby
11:45—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—18:45
Drugging the Hippo Pathway
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 1
* Duojia D.J. Pan, HHMI/Johns Hopkins University School of Medicine, USA

Anwesha Dey, Genentech, Inc., USA
Targeting Hippo Pathway Members in Cancer

Wanjin Hong, Institute of Molecular and Cell Biology, Singapore
Targeting the Central Hydrophobic Pocket in TEAD Transcription Factors as a Cancer Therapeutic Strategy

Claudia Fromond, Inventiva, France
A Rational Approach for Discovery of Inhibitors of YAP-TEAD Interaction

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom1
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Chamisa Ballroom 2
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Chamisa Ballroom 2

THURSDAY, MAY 21

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Bayer HealthCare Pharmaceuticals OncoMed Pharmaceuticals, Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA196195-01

Funding for this conference was made possible (in part) by 1R13CA196195-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Inventiva

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Inventiva


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676