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This meeting took place in 2015



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Mechanisms of Pro-Inflammatory Diseases (Z4)


Organizer(s) Virginia Pascual, Mark S. Anderson and Daniel Kastner
April 19—24, 2015
Resort at Squaw Creek • Olympic Valley, California USA
Discounted Abstract Deadline: Dec 18, 2014
Abstract Deadline: Jan 21, 2015
Scholarship Deadline: Dec 18, 2014
Discounted Registration Deadline: Feb 19, 2015

Sponsored by AbbVie Inc., Janssen R&D: Pharmaceutical Companies of Johnson & Johnson, Journal of Molecular Cell Biology (JMCB), Merck & Co., Inc. and Theravance Biopharma. Supported by an educational grant from Celgene Corporation.


Summary of Meeting:
Inflammation is a physiological process that repairs tissues in response to harmful endogenous or exogenous stimuli and involves the movement of plasma and leukocytes to the injured site. While acute inflammatory responses are generally protective, chronic states of inflammation have detrimental consequences and lead to tissue destruction and disease. Indeed, chronic inflammatory diseases, such as MS, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and diabetes are major clinical problems today. This meeting brings together clinical and basic scientists interested in inflammation and translational research with a view to understanding basic mechanisms of inflammation and identifying novel approaches for therapeutic intervention, leveraging recent advances in basic immunology, genomics and systems biology. A particular emphasis is on human autoimmune and autoinflammatory diseases. Opportunities for interdisciplinary interactions are significantly enhanced by the concurrent meeting on "Innate Immunity and Determinants of Microbial Pathogenesis," which shares a keynote address and three plenary sessions with this meeting.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, APRIL 19

16:00—20:00
Arrival and Registration

Lobby Alcove
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Lobby Alcove

MONDAY, APRIL 20

07:00—08:00
Breakfast

Alpine Ballroom
08:00—09:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.

Grand Sierra A-D
* Robert L. Modlin, University of California, Los Angeles, USA
Introduction

Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Inflammasomes in Health, Dysbiosis and Disease

Zhijian James Chen, University of Texas Southwestern Medical Center, USA
Innate Immune Sensing of Cytosolic Nucleic Acids

09:50—12:00
Innate Immunity (Joint)
Meeting has ended...abstracts no longer viewable online.

Grand Sierra A-D
* Virginia Pascual, Cornell University, USA

Vishva M. Dixit, Genentech, Inc., USA
New Pathways of Inflammasome Activation

Yong-Jun Liu, Sanofi, USA
Sensing of DNA and RNA

Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
NLRs in Inflammasome and Non-Inflammasome Functions

Pedro Moura-Alves, Max Planck Institute for Infection Biology, Germany
Short Talk: PAMPing AhR

Scott W. Canna, Children's Hospital of Pittsburgh, University of Pittsburgh, USA
Short Talk: Activating Mutations in NLRC4 Cause Recurrent Macrophage Activation Syndrome: Blame it on IL-18?

09:40—10:00
Coffee Break

Sierra Prefunction
12:00—13:00
Poster Setup

Alpine Ballroom
13:00—22:00
Poster Viewing

Alpine Ballroom
12:00—14:30
On Own for Lunch

14:30—16:30
Workshop 1: Innate Immunity and Disease

Grand Sierra CD
* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA

Irving C. Allen, Virginia Tech, USA
NLRX1 Attenuates Inflammation and Tumorigenesis through the Negative Regulation of AKT and NF-kappaB Signaling

Po-Lin Huang, Academia Sinica, Taiwan
Skeletal Muscle IL-15/IL-15Ralpha Promotes CD8+ T-Cell Function and Autoimmune Myositis

Sebastian Günther, University of Maryland School of Medicine, USA
Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor

Teja Celhar, Singapore Immunology Network, Singapore
Elimination of the NLRP3 Inflammasome Prevents the Development of Lupus-Associated Traits in a Mouse Model of Autoimmunity

Rachel A. Gottschalk, NIAID, National Institutes of Health, USA
Distinct Sensitivities of NFkappaB and MAPK to TLR Ligation Support Robust Low-Noise Inflammatory Responses

Sebastien Tauzin, University of Wisconsin-Madison, USA
Redox and Src Family Kinase Signaling Control Macrophage-Mediated Resolution of Inflammation

14:30—16:30
Workshop 1: IFN

Grand Sierra AB
* Jae U. Jung, Keck School of Medicine of University of Southern California, USA

Emily M. Eshleman, University of Colorado School of Medicine, USA
Myeloid Cell IFNGR1 Down Regulation Exacerbates Bacterial Infections

Matteo Gentili, Institut Curie, France
Intercellular Transmission of Innate Immune Signaling by Packaging of the Second Messenger cGAMP in Viral Particles

Jarrod S. Johnson, Seattle Biomedical Research Institute, USA
HIV-1 Alters the Threshold for Type I Interferon Signaling in Dendritic Cells

Ken Chung-Ren Pang, Walter and Eliza Hall Institute of Medical Research, Australia
Sidt2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

Jan Rehwinkel, Weatherall Institute of Molecular Medicine, University of Oxford, UK
Lentiviruses Transfer the Antiviral Second Messenger cGAMP between Cells

Beiyun Caitlin Liu, Tufts University, USA
Type-I IFN-Independent Induction and Activation of Caspase-11 toward L. pneumophila

Clinton J. Bradfield, Yale University, USA
Human GBPs Recognize a New Class of DAMPs to Mobilize Cell-Autonomous Immunity to Bacterial Pathogens

Jessica F. Almine, University of Dundee, UK
IFI16 and cGAS Co-Operate in DNA Sensing in Human Keratinocytes

16:30—17:00
Coffee Available

Sierra Prefunction
17:00—19:00
Innate Triggers of Adaptive Immunity
Meeting has ended...abstracts no longer viewable online.

Grand Sierra CD
* John J. O'Shea, NIAMS, National Institutes of Health, USA

Mark S. Anderson, University of California, San Francisco, USA
Control of Immune Tolerance by Aire-Expressing Cells

Hideki Ueno, Icahn School of Medicine at Mount Sinai, USA
T Follicular Helper Cells in Autoimmunity in Humans

Averil I. Ma, University of California, San Francisco, USA
Short Talk: A20 Restricts IL1b Ubiquitination and NLRP3 Inflammasome Activity

Simone Caielli, Baylor Institute for Immunology Research, USA
Short Talk: Oxidized Mitochondrial DNA Is a Powerful Activator of Human pDCs and Induces a Lupus-Specific CD4 T Cell Phenotype

17:00—19:00
Innate Immune Sensing and Consequences in Microbial Infection
Meeting has ended...abstracts no longer viewable online.

Grand Sierra AB
* Alan Sher, NIAID, National Institutes of Health, USA

Jae U. Jung, Keck School of Medicine of University of Southern California, USA
Roles of Pattern Recognizing Receptors and Autophagy in Antiviral Immune Response

Stanley M. Lemon, University of North Carolina at Chapel Hill, USA
Type 1 Interferon Responses Determine Permissiveness and Host Species Range of Human Hepatitis A Virus

Genhong Cheng, University of California, Los Angeles, USA
Balancing Inflammatory Responses during Acute and Chronic Infections

Arun K. Mankan, University of Bonn, Institute of Molecular Medicine, Germany
Short Talk: Cytosolic RNA:DNA Hybrids Activate the cGAS-STING Axis

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Alpine Ballroom
19:30—22:00
Poster Session 1

Alpine Ballroom

TUESDAY, APRIL 21

07:00—08:00
Breakfast

Alpine Ballroom
08:00—11:15
Innate Immunity in Inflammation and Disease (Joint)
Meeting has ended...abstracts no longer viewable online.

Grand Sierra A-D
* Foo Y. Liew, University of Glasgow, UK

Shizuo Akira, Osaka University, Japan
Control of the Inflammatory and Immune Responses by the Ribonuclease, Regnase-1

Daniel Kastner, National Institutes of Health, USA
Dissecting New Inflammatory Pathways through Genetics

Virginia Pascual, Cornell University, USA
Novel Insights into Human SLE Pathogenesis

Robert L. Modlin, University of California, Los Angeles, USA
Innate Immunity in TB

Hubertus Hochrein, Bavarian Nordic, Germany
Short Talk: IFN-lambda Production of CD8 cDCs in Response to DNA-Viruses, Transfected dsDNA or Cyclic-di-Nucleotides Depends on STING

Seth L. Masters, Walter and Eliza Hall Institute, Australia
Short Talk: Aberrant Actin Depolymerization Triggers the Pyrin Inflammasome and Autoinflammatory Disease that Is Dependent on IL-18, not IL-1beta

09:20—09:40
Coffee Break

Sierra Prefunction
11:15—13:00
Poster Setup

Alpine Ballroom
13:00—22:00
Poster Viewing

Alpine Ballroom
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 2: Biomarkers and Mechanisms of Disease

Grand Sierra CD
* Raphaela Theresia Goldbach-Mansky, NIAID, LCID, National Institutes of Health, USA

Nagaraj Kerur, University of Kentucky, USA
Innate Immune Mechanisms of Alu RNA-Induced Age-Related Macular Degeneration

Siobhán A-L Smith, Royal College of Surgeons in Ireland, Ireland
Altered miRNA Expression in Monocytes Contributes to Dysregulated IL-16 Levels in SLE

Marcel F. Nold, Monash Institute of Medical Research, Australia
Serum Interleukin 38 Is Associated with Disease Severity and Organ Involvement in Systemic Lupus Erythematosus

Romain F. Banchereau, Baylor Institute for Immunology Research, USA
Longitudinal Immunoprofiling of SLE Patients Identifies Transcriptional Biomarkers of Disease Activity and Response to Treatment

Nelson Gekara, Umeå University, Sweden
DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

Nadia Jeremiah, Institute Imagine, France
An IntereSTING Germline Mutation Underlying a Familial Inflammatory Syndrome with Lupus-Like Manifestations

Dong-Ming Su, University of North Texas Health Science Center, USA
Thymic Involution Perturbs Negative Selection Leading to Increased Release of Self-Reactive T Cells that Induce Chronic Inflammation in the Elderly

Hye-Lin Ha, NIAID, National Institutes of Health, USA
IL-17 Drives Psoriatic Inflammation via Distinct, Target Cell-Specific Mechanisms

14:30—16:30
Workshop 2: Mycobacteria

Grand Sierra AB
* John D. MacMicking, Yale University, USA

André Alves Dias, Oswaldo Cruz Foundation, Brazil
The Role of TLR9 Activation in the Host Immune Response during Type II Reaction in Leprosy

Robert O. Watson, Texas A&M Health Science Center, USA
cGAS Detects Mycobacterium tuberculosis DNA to Activate both Type I Interferon and Autophagy

Trude Helen Flo, Norwegian University of Science, Norway
Keap1 Regulates Inflammatory Signaling in M. avium-Infected Human Macrophages

Jennifer R. Honda, University of Colorado Anschutz Medical Campus, USA
Polar Lipids of Nontuberculous Mycobacteria Likely Contribute to Neutralization of Cathelicidin

Susan Realegeno, University of California, Los Angeles, USA
Identifying TLR and IFN-g Inducible Antimicrobial Responses Against Mycobacteria in Human Macrophages

Leonardo Ribeiro Batista Silva, Fundação Oswaldo Cruz, Brazil
Insulin-Like Growth Factor-I (IGF-I) Signaling Pathway Inhibits the STAT1 Activation via SOCS3 in Mycobacterium leprae-Stimulated Macrophases

Kirsten E. Wiens, New York University School of Medicine, USA
Differential Type I Interferon Induction by Distinct Mycobacterium tuberculosis Strains Despite Similar Access to the Host Cytosol

Chien-Hsiung Yu, University of Queensland Diamantina Institute, Australia
RP105 Dependent Activation of PI3Kdelta Promotes Cytokine Trafficking in Mycobacteria-Infected Macrophages

16:30—17:00
Coffee Available

Sierra Prefunction
17:00—19:15
Sterile Nucleic Acid Sensing and Disease
Meeting has ended...abstracts no longer viewable online.

Grand Sierra CD
* Mark S. Anderson, University of California, San Francisco, USA

Yanick Crow, Institut Imagine, France
Human Type I Interferonopathies

Gregory M. Barton, University of California, Berkeley, USA
Regulation of Toll-Like Receptors

Glen N. Barber, University of Miami, USA
STING and Sterile Inflammation

Matthew G. Blango, University of Utah, USA
Short Talk: Identification of Hyper-Edited, Immune-Relevant RNA in Activated Macrophages

17:00—19:00
Innate Regulation of Adaptive Immunity
Meeting has ended...abstracts no longer viewable online.

Grand Sierra AB
* Cathryn Nagler, University of Chicago, USA

Foo Y. Liew, University of Glasgow, UK
The Role of Cytokines in Infection and Inflammation

Alan Sher, NIAID, National Institutes of Health, USA
Cytokine and Lipid Mediator Cross-Talk in the Innate Immune Response to Mycobacterium tuberculosis

Marco Colonna, Washington University School of Medicine, USA
Innate Lymphoid Cells in Immunity

Jesse C. Nussbaum, University of California, San Francisco, USA
Short Talk: Group 2 Innate Lymphocytes Are Early Effectors that Cooperate with Adaptive Immunity after Helminth Infection

Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne, Switzerland
Short Talk:

19:15—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Alpine Ballroom
19:30—22:00
Poster Session 2

Alpine Ballroom

WEDNESDAY, APRIL 22

07:00—08:00
Breakfast

Alpine Ballroom
08:00—11:00
Novel Players in the Control of Inflammation
Meeting has ended...abstracts no longer viewable online.

Grand Sierra CD
* Daniel Kastner, National Institutes of Health, USA

Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Metabolic Control of Inflammtion

Michael L. Stitzel, The Jackson Laboratory for Genomic Medicine, USA
Enhancers and Type II Diabetes

Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital, USA
Regulators of Inflammatory Responses

Benjamin Fowler, University of Kentucky, USA
Short Talk: Nucleoside Reverse Transcriptase Inhibitors Possess Intrinsic Anti-Inflammatory Activity

08:00—11:00
Systems Biology/Immunomics of Innate Immunity
Meeting has ended...abstracts no longer viewable online.

Grand Sierra AB
* Yasmine Belkaid, NIAID, National Institutes of Health, USA

Alan Aderem, Center for Infectious Disease Research, USA
A Systems Approach to Dissecting Immunity

Ronald N. Germain, NIAID, National Institutes of Health, USA
Single Cell and Systems Level Analysis and Modeling of Innate Immunity

Iain D.C. Fraser, NIAID, National Institutes of Health, USA
Interrogating Immune Signaling Systems with High-Throughput, High-Content Screening

T. Sam Xiao, Case Western Reserve University, USA
Short Talk: Structure and Regulation of IFI16

Roi Avraham, Broad Institute, USA
Short Talk: Single Cell Expression Analysis Reveals Co-Variation of Bacterial and Host Factors that Control Infection Outcome

Johan Van Weyenbergh, KU Leuven, Belgium
Short Talk: Systemic and in situ Transcriptomics Reveal an Innate/Type I IFN Link between Oxidative Burst, Cell Death and Inflammation in Human Cutaneous Leishmaniasis

09:20—09:40
Coffee Break

Sierra Prefunction
11:00—13:00
Poster Setup

Alpine Ballroom
13:00—22:00
Poster Viewing

Alpine Ballroom
11:00—14:30
On Own for Lunch

14:30—16:30
Workshop 3

Grand Sierra CD
* Yanick Crow, Institut Imagine, France

Sarah L. Doyle, Trinity College Dublin, Ireland
IL-18 Immunotherapy for Neovascular AMD; Tolerability and Efficacy in Non-Human Primates

Kate Schroder, University of Queensland, Australia
Neutrophil Inflammasomes Selectively Drive IL-1beta Maturation but not Cell Death

Eric P. Hanson, National Institutes of Health, USA
Recruitment of A20 by the C-Terminal Ubiquitin-Binding Domain of NEMO Prevents Severe Inflammatory Disease in Humans

Peter R. Bunyard, Redx Pharma, UK
Genetic Deletion of GPR18 Enhances Immune Responses to Pathogenic and Antigenic Challenge

Todd Douglas, McGill University, Canada
Inflammatory Caspases in the Pathogenesis of Chronic Proliferative Dermatitis in Mice

Kiyoshi Hirahara, Chiba University, Japan
Asymmetry of STAT Action in Driving IL-27 and IL-6 Transcriptional Outputs and Cytokine Specificity

Alma-Martina Cepika, Baylor Institute for Immunology Research, USA
A Blood Stimulation Assay Identifies Monocyte Hyperresponsiveness to Pro-Inflammatory Stimuli in Systemic-Onset Juvenile Idiopathic Arthritis

Irina Alexandra Leaf, Biogen, USA
Pericyte MyD88 Controls Inflammatory and Fibrotic Responses to Tissue Injury

14:30—16:30
Workshop 3: Effector Function

Grand Sierra AB
* Laurel L. Lenz, University of Colorado, USA

Jon A. Hagar, University of North Carolina at Chapel Hill, USA
Endotoxin Signaling Potentiates Insulin-Induced Acute Hypoglycemia

Damien Arnoult, Hopital Paul Brousse, France
Endomembranes Act as Platforms for Ubiquitylated Components of NF-kappaB and IRF3 Signaling

Marina Zaitseva, Center for Biologics Evaluation and Research, USA
Critical Role of GPR14 Receptor in Prostaglandin Production by Human Monocytes in Response to MDP

Sarah E. Clark, University of Colorado, USA
Regulation of Natural Killer Cell IL-10 Production during Listeria Infection

Mathias S. Dick, University of Basel, Switzerland
Oligomerization of ASC Serves as Signal Amplification Mechanism for Inflammasomes

Naohiro Inohara, University of Michigan Medical School, USA
Interleukin-22 Bridges Local Inflammation to Systemic Protection Against Pathobionts after Pathogen-Induced Intestinal Damage

Marijke Keestra-Gounder, University of Colorado, Denver, USA
The ER Stress-Induced Pro-Inflammatory Response Is Mediated by the NOD1/NOD2 Signaling Pathway

Shie-Liang Hsieh, Academia Sinica, Taiwan
Modulation of Influenza Virus-Induced Macrophage Activation by Decoy Receptor 3 (DcR3)

16:30—17:00
Coffee Available

Sierra Prefunction
17:00—19:00
Epigenetic Control of Inflammation
Meeting has ended...abstracts no longer viewable online.

Grand Sierra CD
Howard Y. Chang, Stanford University, USA
LncRNAs and Inflammation

Alexander Tarakhovsky, Rockefeller University, USA
Epigenetic Control of Inflammatory Cascades

John J. O'Shea, NIAMS, National Institutes of Health, USA
Epigenetic Control of T Cell Fate

Chrysothemis Brown, Kings College London, UK
Short Talk: Epigenetic Regulation of Th1 Plasticity by Retinoic Acid: A New Paradigm for the Ontogeny of Pathogenic Th17 Cells

17:00—19:00
Microbiome and Innate Immunity
Meeting has ended...abstracts no longer viewable online.

Grand Sierra AB
* Alan Aderem, Center for Infectious Disease Research, USA

Cathryn Nagler, University of Chicago, USA
Innate Immune Regulation of Sensitization to Dietary Antigens by Commensal Bacteria

Yasmine Belkaid, NIAID, National Institutes of Health, USA
T Cell Commensals

Sarkis K. Mazmanian, California Institute of Technology, USA
The Gut Microbiome Signals through Genetic Pathways Linked to IBD

Richard I. Tapping, University of Illinois, USA
Short Talk: Toll-Like Receptor 10 Is a B-Cell Intrinsic Suppressor of Adaptive Humoral Immune Responses

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Alpine Ballroom
19:30—22:00
Poster Session 3

Alpine Ballroom

THURSDAY, APRIL 23

07:00—08:00
Breakfast

Alpine Ballroom
08:00—11:15
Therapeutic Interventions in Autoinflammation and Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Grand Sierra CD
Raphaela Theresia Goldbach-Mansky, NIAID, LCID, National Institutes of Health, USA
Targeted Therapies in Autoinflammatory Diseases

* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Differential Activation of Myeloid Cells by Vaccines in Humans

Dhavalkumar D. Patel, Inflazome, Switzerland
IL17 Blockade in Psoriasis and Other Autoimmune Diseases

Christoph Klein, Ludwig-Maximilians-University Munich, Germany
Human Genetic Defects Predisposing to Hyperinflammation in the Intestinal Tract

Donghai Wang, Duke University Medical Center, USA
Short Talk: From Cholesterol Biosynthesis to Inflammation Molecular Pathogenesis of Mevalonate Kinase Deficiency

John A. Mo, AstraZeneca, Sweden
Short Talk: Radical Scavenging Nanoparticles for the Treatment of IBD

08:00—11:15
Intervention/Vaccines
Meeting has ended...abstracts no longer viewable online.

Grand Sierra AB
* Akiko Iwasaki, HHMI/Yale University School of Medicine, USA

Hana Golding, US Food and Drug Administration, USA
Impact of Adjuvants on Antibody Repertoires and Affinity Maturation Against Pandemic Influenza Vaccines

Eva Harris, University of California, Berkeley, USA
Antibodies to Dengue Virus Non-Structural Protein 1 Protect Against Endothelial Permeability and Lethal Vascular Leak

Robert L. Coffman, Dynavax Technologies, USA
Systems Biology Analysis of the Human Response to Hepatitis B Vaccines Using Alum or CpG Oligonucleotide Adjuvants

John D. MacMicking, Yale University, USA
Discovery of IFN-Induced GBPs in Inflammasome-Mediated Host Defense

Margherita Coccia, GlaxoSmithKline Vaccines, Belgium
Short Talk: Innate Immune Mechanisms and Early NK Cell Activation as a Result of MPL and QS-21 Combination Controls the Adjuvant Effect Induced by the Human Adjuvant System AS01

Ugo D'Oro, GlaxoSmithKline Vaccines, Italy
Short Talk: The Novel Adjuvant Alum-TLR7 Is Able to Potentiate the Immune Response to Glycoconjugate Vaccines

09:20—09:40
Coffee Break

Sierra Prefunction
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 4: Novel Therapies for Inflammatory Diseases

Grand Sierra CD
* Christoph Klein, Ludwig-Maximilians-University Munich, Germany

James S. Rush, Novartis Pharma AG, Switzerland
A Novel, Blocking, Fc-Silent Anti-CD40 Monoclonal Antibody Prolongs Non-Human Primate Renal Allograft Survival in the Absence of B Cell Depletion

Gerard M. McGeehan, Vitae Pharmaceuticals, USA
The RORgammat Blocker, VTP-43742, Suppresses Th17 Activity Providing Greater Benefit than IL-17A Blockade in an EAE Model of Autoimmunity

Xiaoyi Yuan, Baylor College of Medicine, USA
Complement C1q Regulates Inflammatory Responses in Cigarette Smoke-Induced Emphysema

Holly Legault, Biogen Idec, USA
Characterization of Novel IRAK4 Small Molecule Inhibitors

Elizabeth K. Brint, University College Cork, Ireland
An Anti-Tumorigenic Role for the IL-33/ST2 Axis in Colon Cancer

Sanja Arandjelovic, University of Virginia, USA
Engulfment Protein ELMO1 as a Novel Regulator of Rheumatoid Arthritis

Lucile E. Wrenshall, Wright State University, USA
Dimeric IL-2 Induces Necrosis of Interleukin-2 Receptor Positive Cells

Johanna Hol, Oslo University Hospital, Rikshospitalet, Norway
Inhibition of Endothelial Notch Signaling Attenuates Inflammation

14:30—16:30
Workshop 4: Systems Biology/Cytokine Pathway

Grand Sierra AB
* Sarkis K. Mazmanian, California Institute of Technology, USA

Manuella Bouttier, McGill University, Canada
Genomics Analysis Reveals Elevated LXRalpha Signaling Reduces M. tuberculosis Viability

Irina Tikhanovich, University of Kansas Medical Center, USA
Dynamic Arginine Methylation of TRAF6 Regulates TLR Signaling

Sakthimala Jagadeesan, MGH/Harvard Medical School, USA
Genome-Wide Screen Identifies Genes Involved in Gut Immunity and Homeostasis in C. elegans

Anneliese O. Speak, Wellcome Trust Sanger Institute, UK
High-Throughput Mutant Mouse Characterization Is a Powerful Tool to Identify Novel Immune Phenotypes

Jacob S. Yount, Ohio State University, USA
Chemoproteomics Reveals Toll-Like Receptor Fatty Acylation

Petr Broz, Biozentrum, University of Basel, Switzerland
GBPs Promote AIM2 Inflammasome Activation during Francisella Infection by Inducing Cytosolic Bacteriolysis and DNA Release

Claudia A. Nold-Petry, MIMR-PHI Institute of Medical Research, Australia
IL-37 Requires the Receptors IL-18Ralpha and IL-1R8 (SIGIRR) to Carry out its Multi-Faceted Anti-Inflammatory Program on Innate Signal Transduction

Helene Minyi Liu, National Taiwan University, Taiwan
Deacetylation-Dependent Regulation of RIG-I Activation by the HDAc6 Deacetylase Mediates Innate Anti-Viral Immunity

16:30—17:00
Coffee Available

Sierra Prefunction
17:00—18:45
Targets for Immunotherapy (Joint)
Meeting has ended...abstracts no longer viewable online.

Grand Sierra A-D
* Hana Golding, US Food and Drug Administration, USA

Thomas A. Waldmann, National Institutes of Health, USA
IL-15 in the Life and Death of Lymphocytes—Implications for Immunotherapy of Cancer and Autoimmune Disease

Maria Grazia Roncarolo, Stanford University School of Medicine, USA
Tr1 Cells in Inflammatory Diseases

Akiko Iwasaki, HHMI/Yale University School of Medicine, USA
Innate Defense Against Influenza Virus Infection

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grand Sierra A-D
Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
Closing Remarks

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Alpine Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Alpine Ballroom

FRIDAY, APRIL 24

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

AbbVie Inc.
Educational grant from Celgene Corporation
Janssen R&D: Pharmaceutical Companies of Johnson & Johnson Journal of Molecular Cell Biology (JMCB)
Merck & Co., Inc. Theravance Biopharma

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI115820-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

R&D Systems, a Bio-Techne brand

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Amgen Inc.


Novartis Institutes for BioMedical Research


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

The Journal of Rheumatology

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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