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This meeting took place in 2015



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Autoimmunity and Tolerance (B1)


Organizer(s) Jane L. Grogan, Joanne L. Viney and Gerald T. Nepom
February 3—8, 2015
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 2, 2014
Abstract Deadline: Nov 4, 2014
Scholarship Deadline: Oct 2, 2014
Discounted Registration Deadline: Dec 3, 2014

Sponsored by AbbVie Inc., AstraZeneca, BioLegend, Inc., Genentech, Inc., NeoStem, Inc. and Novo Nordisk A/S

Summary of Meeting:
Understanding immune regulation in autoimmunity and tolerance is important for delivering therapies to patients with uncontrolled autoimmune disease. Therefore, the goal of this Keystone Symposia meeting is to bring together scientists and clinicians to discuss what we are learning from pre-clinical mouse models and patient studies. In this regard, the past decade has seen the translation of our fundamental understanding of the immune response into clinical studies, with some success and also some failures. These clinical outcomes, coupled with more sophisticated techniques available to interrogate the human immune response, allow us to reassess and further explore pathways that are driving autoimmune disease. In this symposium, we cover the pathways in immunity and tolerance that lead to loss of immunological control, dysregulated immune responses and chronic inflammatory disease. We cover preclinical and clinical aspects of a diverse number of autoimmune and inflammatory diseases including lupus, multiple sclerosis, inflammatory bowel disease, psoriasis, transplantation and rheumatoid arthritis. Each session is designed to include a basic research talk followed by a mechanistic talk on mouse and human and clinical translation.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 3

16:00—20:00
Arrival and Registration

Keystone Lodge Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Keystone Lodge-Bighorn Bar

WEDNESDAY, FEBRUARY 4

07:00—08:00
Breakfast

Shavano/Torreys
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Jane L. Grogan, Genentech, Inc., USA
Welcome Remarks and Introduction

Maria Grazia Roncarolo, Stanford University School of Medicine, USA
New Strategies for T Cell Regulation: Lessons from the Clinic

09:00—11:30
Balancing Immune Homeostasis with Effector and Regulatory T Cells
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Jane L. Grogan, Genentech, Inc., USA

Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA
War and Peace at the Mucosal Front Line: A T Cell's Perspective

Andrea Itano, Evelo Biosciences, USA
The Balancing between Treg and Th17 Function: Targeting Pathways for Use in the Clinic

Jane H. Buckner, Benaroya Research Institute at Virginia Mason, USA
Human T Cell Checkpoints in Autoimmune Disease

Connor J. Dwyer, University of Miami Miller School of Medicine, USA
Short Talk: Expression of a Mutant Transgenic IL-2RBeta Subunit in NOD Mice to further Define the IL-2-Dependent Risk in T1D

Iona S. Schuster, University of Western Australia, Australia
Short Talk: TRAIL+ NK Cells Control CD4+ T Cell Responses during Chronic Viral Infection to Limit Autoimmunity

09:40—10:00
Coffee Break

Longs Peak Foyer
11:30—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
11:30—17:00
On Own for Lunch

14:30—16:30
Workshop 1: Breakthrough Innovations in Understanding Pathogenesis of Disease

Grays Peak
* Jennifer L. Gommerman, University of Toronto, Canada

* Joan Goverman, University of Washington, USA

Jessica L. Harakal, University of Virginia, USA
Loss of Regulatory T Cells Leads to Th2-Mediated Murine Autoimmune Gastritis

Eddie A. James, Benaroya Research Institute, USA
Recognition of Modified Epitopes in Human Autoimmune Disease

Hui Jin, Osaka University, Japan
Cellular Misfolded Proteins Rescued from Protein Degradation by MHC Class II Molecules Are Targets for Autoantibodies in Autoimmune Diseases

Noriko Komatsu, University of Tokyo, Japan
Pathogenic Conversion of Foxp3+ T Cells into TH17 Cells in Autoimmune Arthritis

Melissa D. LaJevic, Stanford University, USA
Chemerin/CMKLR1 Are Required for Maximal Skin Disease in Experimental Psoriasis

Dana E. Orange, Rockefeller University, USA
Rheumatoid Arthritis Patient T Cells Can Recognize Neutrophil NETs Presented by Dendritic Cells

John E. Connolly, Institute of Molecular and Cell Biology, Singapore
Dominant Immune Tolerance Is Characterized by Rapid Metabolic Reprograming

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Targeting Tolerogenic Pathways in Autoimmune Disease
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Gerald T. Nepom, Benaroya Research Institute, USA

Joan Goverman, University of Washington, USA
How Different Effector T Cell Subsets Shape Inflammatory Pattern in Multiple Sclerosis

Jeffrey V. Ravetch, Rockefeller University, USA
Inhibitory Fc Receptors for IgG Maintain Peripheral Tolerance

David Klatzmann, Pierre and Marie Curie Medical School, France
Immunoregulation without Immunosuppression: The Promises of Low Dose IL2

Nathalie E. Blachère, Rockefeller University, USA
Short Talk: A New Mode of Tolerance Dictates Immune Responses to the Paraneoplastic Cerebellar Degeneration Antigen cdr2

Kenneth S. Tung, University of Virginia, USA
Short Talk: Sertoli Cell that Controls Testicular Barrier also Exports “Sequestered” Germ Cell Antigens to Maintain Regulatory T Cell-Dependent Systemic Tolerance

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
19:30—22:00
Poster Session 1

Shavano/Torreys

THURSDAY, FEBRUARY 5

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
Cytokine Governance of Tolerance and Inflammation
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Joanne L. Viney, JLV Biotech Consulting, USA

Daniel J. Cua, Merck Research Laboratories, USA
Role of IL-17 in Multiple Immune Checkpoints in Preclinical Models

Jennifer E. Towne, Janssen Research & Development LLC, USA
Differential Roles for IL-23 and IL-17 in Intestinal Immunoregulation: Lessons Learned from Mouse and Man

Jennifer L. Gommerman, University of Toronto, Canada
Role of the TNFSF in Regulating Immune Responses in Murine Models

Frank Oliver Nestle, Sanofi, USA
Immune Sentinels and Pathogenesis in Psoriasis in the Clinic

Carlos A. Arbelaez, Amgen, USA
Short Talk: IL-7/IL-7R Signaling Differentially Affects Effector CD4+ T Cell Subsets Involved in Experimental Autoimmune Encephalomyelitis

Ester Planas-Rigol, Universitat de Barcelona, Spain
Short Talk: IL-35: A New Cytokine Involved in Vascular Inflammation

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
11:15—17:00
On Own for Lunch

14:30—16:30
Workshop 2: Innovative Therapeutic Approaches for Treating Disease

Grays Peak
* Maria Grazia Roncarolo, Stanford University School of Medicine, USA

* David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA

Jaya Prakash Chalise, Linköping University, Sweden
Interferon alpha-Induced Tolerance against Antigen-Induced Arthritis Is Mediated by Indoleamine 2, 3 Dioxygenase

Paul L. Bollyky, Stanford University, USA
Inhibition of Hyaluronan Synthesis Restores Immune Tolerance during Autoimmune Insulitis

Wanjun Chen, NIDCR, National Institutes of Health, USA
Generating Antigen-Specific Treg Cells in vivo to Treat Autoimmunity

Anne S. De Groot, EpiVax, Inc., USA
Tregitopes Induce Natural and iTreg Activation and Expansion: A Fully Synthetic Alternative to IgT for Autoimmune Disease?

Chie Hotta-Iwamura, National Institutes of Health, USA
DCIR2+ cDC2 Dendritic Cells and zbtb32 Expression Restore CD4 T Cell Tolerance and Inhibit Diabetes

Chantal Kuhn, VL37 inc., USA
Differential Role of APCs in Induction of Th3 Cells and Oral Tolerance

Alex F. Pellerin, Biogen Idec, USA
Anti-BDCA2 Monoclonal Antibody Inhibits Plasmacytoid Dendritic Cell Activation through Fc-Dependent and Independent Mechanisms

Natasha C. Ward, University of Miami Miller School of Medicine, USA
Selective Enhancement of Tregs and Tolerance by a Novel IL-2-Based Biologic

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Contribution of Antigen-Presenting Cells to Immune Homeostasis
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Jennifer L. Gommerman, University of Toronto, Canada

Boris Reizis, New York University Langone Medical Center, USA
The Role of Dendritic Cells in Experimental Models of Lupus

Clara Abraham, Yale University, USA
Unexpected Mechanisms for Disease-Associated Genes in Macrophage Regulation

Joanne L. Viney, JLV Biotech Consulting, USA
Modulating Plasmacytoid Dendritic Cell Function for Treating Autoimmune Disease

Bryan J. Vander Lugt, Genentech, Inc., USA
Short Talk: Programming of Immunoregulatory Properties in Migratory Dendritic Cells

Nathalie Cools, University of Antwerp, Belgium
Short Talk: Dendritic Cells in Multiple Sclerosis: Key Players in the Immune Pathogenesis, Key Players for New Cellular Immunotherapies

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
19:30—22:00
Poster Session 2

Shavano/Torreys

FRIDAY, FEBRUARY 6

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
Pathogenic and Regulatory B Cells in Autoimmune Disease
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Carla V. Rothlin, Yale University, USA

Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
Role of B Cells, TLR and Type 1 IFNs in Murine Models of Lupus

David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA
Altered B Cell Signaling Orchestrates Loss of Tolerance and Systemic Autoimmunity

Thomas F. Tedder, Duke University Medical Center, USA
Antigen-Specific B10 Cells Negatively Regulate Autoimmunity

Eoin McKinney, Cambridge Institute for Medical Research, Wellcome Trust, UK
Tired of Relapsing: T Cell Exhaustion and Outcome in Autoimmune Disease

Arya Biragyn, NIA, National Institutes of Health, USA
Short Talk: Regulatory Function of Cancer-Expanded MDSCs Requires Education from Cancer Bregs

Kira V. Rubtsova, Eli Lilly, USA
Short Talk: T-Bet Expressing B Cells Are Required for the Development of Autoimmunity

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
New Perspectives on Tolerance and Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Arlene H. Sharpe, Harvard Medical School, USA

Carla V. Rothlin, Yale University, USA
TAM Receptor Tyrosine Kinases Regulate the Magnitude of the Immune Response

Gerald T. Nepom, Benaroya Research Institute, USA
In Pursuit of Immune Tolerance

Robert H. Scannevin, Biogen Idec, USA
Immunomodulatory Pathways for Therapeutic Intervention in Multiple Sclerosis

Roberto A. Maldonado, Selecta Biosciences, USA
Short Talk: Tolerogenic Synthetic Nanoparticles for the Treatment of Autoimmune Diseases

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
19:30—22:00
Poster Session 3

Shavano/Torreys

SATURDAY, FEBRUARY 7

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:15
Positive and Negative Co-Stimulatory Pathways in Tolerance and Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Thomas R. Malek, University of Miami School of Medicine, USA

* Deborah J. Fowell, University of Rochester, USA

Arlene H. Sharpe, Harvard Medical School, USA
Control of T Follicular Regulatory Cells and Humoral Immunity by Co-Inhibitory Pathways

John Trowsdale, University of Cambridge, UK
Modulation of T Cells by Butyrophilin-Related Proteins

Jane L. Grogan, Genentech, Inc., USA
Inhibitory Receptor TIGIT Limits Anti-Viral and Anti-Tumor T Cell Responses

Dwight H. Kono, The Scripps Research Institute, USA
The Impact of Genes and Signaling Pathways in Systemic Lupus

Alexandria Huynh, Harvard Medical School/Massachusetts General Hospital, USA
Short Talk: PTEN-Mediated Control of PI-3 Kinase in Regulatory T Cells Is Required for Homeostasis and Lineage Stability

Georgina Espigol-Frigole, Hospital Clinic Barcelona, Spain
Short Talk: Identification of IL-23p19 as an Endothelial Pro-Inflammatory Peptide that Activates gp130-STAT3 Signaling

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—17:00
On Own for Lunch

14:30—16:30
Workshop 3: Novel in vitro and in vivo Models for Studying Disease

Grays Peak
* Boris Reizis, New York University Langone Medical Center, USA

* Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA

Marta E. Alarcón Riquelme, GENYO. Center for Genomics and Oncological Research, Spain
BANK1 Deficiency Ameliorates Lupus Phenotypes in B6.Sle1.yaa Mice

Wei Cao, UT MD Anderson Cancer Center, USA
Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon gamma Production from Natural Killer Cells

Oliver W. Gramlich, University of Iowa, USA
Adoptive Transfer of Immune Competent Cells Derived from a Glaucoma Mouse Model Causes Retinal Ganglion Cell Loss in Recipients

Pamela J. Lincez, University of British Columbia, Canada
MDA5 Establishes a Unique IFN-I Signature that Protects from T1D

Robin S. Lindsay, University of Colorado Denver and National Jewish Health, USA
T Cell Stimulation in the Islets Is Lost as Islet Infiltration Progresses during Type 1 Diabetes

Genita Metzler, University of Washington, USA
The Effect of Autoimmune-Associated Ptpn22 R619W Variant on B Cell Tolerance in a Murine Model

Anna-Marie Fairhurst, Singapore Immunology Network, Singapore
Elimination of the NLRP3 Inflammasome Prevents the Development of Lupus Associated Traits

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:45
Using Systems Biology to Interrogate Immune Regulation
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Frank Oliver Nestle, Sanofi, USA

Chris Cotsapas, Yale School of Medicine, USA
Talk Title to be Announced

Alan Aderem, Center for Infectious Disease Research, USA
A Systems Approach to Dissecting Immunity

Chun Ye, University of California, San Francisco, USA
Intersection of Population Variation and Autoimmunity Genetics in Human T Cell Activation

18:45—19:15
Meeting Wrap-Up: Outcomes and Future Directions
Meeting has ended...abstracts no longer viewable online.

Grays Peak
Jane L. Grogan, Genentech, Inc., USA

Joanne L. Viney, JLV Biotech Consulting, USA

Gerald T. Nepom, Benaroya Research Institute, USA

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Shavano/Torreys

SUNDAY, FEBRUARY 8

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

AbbVie Inc. AstraZeneca
BioLegend, Inc. Genentech, Inc.
NeoStem, Inc. Novo Nordisk A/S

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI114057-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Biogen Idec Opsona Therapeutics Ltd

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Amgen Inc.


Biogen Idec


Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

S. Karger A.G. - International Archives of Allergy and Immunology The Journal of Rheumatology

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676